R. Scarpelli

发表

Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.

S. Altamura, M. Rowley, R. Laufer, 2009, Journal of medicinal chemistry.

2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.

S. Altamura, M. Rowley, Philip Jones, 2008, Bioorganic & medicinal chemistry letters.

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.

M. Bottomley, M. Rowley, A. Carfi, 2008, Bioorganic & medicinal chemistry letters.

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain*

M. Bottomley, R. De Francesco, A. Carfi, 2008, Journal of Biological Chemistry.

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

D. Hazuda, S. Harper, M. Rowley, 2007, Journal of medicinal chemistry.

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.

D. Hazuda, M. Rowley, V. Summa, 2008, Journal of medicinal chemistry.

Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain.

A. Duranti, G. Tarzia, D. Piomelli, 2014, Pharmacological research.

A Formal Total Synthesis of (+)‐Methyl Trachyloban‐18‐oate and (+)‐Methyl 16‐Oxo‐17‐norkauran‐18‐oate: Regio‐ and Diastereoselective Preparation of Methyl (13S)‐13‐Hydroxyisoatisiren‐18‐oate from (−)‐Abietic Acid

R. Scarpelli, M. Berettoni, G. Chiara, 1996 .

Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

C. Toniatti, S. Altamura, M. Rowley, 2009, Journal of medicinal chemistry.

Development of Fragment‐Based n‐FABS NMR Screening Applied to the Membrane Enzyme FAAH

D. Piomelli, T. Bandiera, E. Romeo, 2013, Chembiochem : a European journal of chemical biology.

Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.

M. Rowley, R. Laufer, Philip Jones, 2008, Bioorganic & medicinal chemistry letters.

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

G. Bottegoni, A. Reggiani, M. Mattioli, 2014, Oncogene.

Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.

G. F. Ruda, A. Duranti, A. Tontini, 2013, Journal of medicinal chemistry.

Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).

G. Bottegoni, M. Mor, D. Piomelli, 2013, Journal of medicinal chemistry.

Fluorine NMR‐Based Screening on Cell Membrane Extracts

D. Piomelli, T. Bandiera, E. Romeo, 2014, ChemMedChem.

Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti‐inflammatory drug‐dependent gastrointestinal damage

D. Piomelli, A. Armirotti, D. Habrant, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.

R. Bertorelli, A. Reggiani, D. Piomelli, 2012, Pharmacological research.

Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

A. Reggiani, D. Piomelli, C. Tassorelli, 2022, The Journal of Headache and Pain.

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors

R. Bertorelli, S. Ray, A. Armirotti, 2020, Journal of medicinal chemistry.

Chemical synthesis and biological properties of pyridine epothilones.

D. Zaharevitz, K. Nicolaou, K. Altmann, 2000, Chemistry & biology.

Title Multitarget Fatty acid amide hydrolase / cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage Permalink

D. Piomelli, A. Armirotti, D. Habrant, 2015 .

Iminophosphine-palladium(0) complexes as catalysts in the alkoxycarbonylation of terminal alkynes

R. Scarpelli, V. Beghetto, A. Scrivanti, 2001 .

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.

R. Heim, D. Piomelli, A. Armirotti, 2016, Angewandte Chemie.

Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors.

C. Toniatti, M. Rowley, Philip Jones, 2010, Bioorganic & medicinal chemistry letters.

Improved conversion of 6‐endo‐tosyloxybicyclo[2.2.2]octan‐2‐ones into 6‐exo‐acetoxy and 6‐exo‐benzoyloxybicyclo[2.2.2]octan‐2‐ones

R. Scarpelli, L. M. Migneco, R. M. Bettolo, 1999 .

ON THE DIASTEREOSELECTIVITY OF THE AQUEOUS-ACID-CATALYZED INTRAMOLECULAR ALDOL CONDENSATION OF 3-OXOCYCLOHEXANEACETALDEHYDES

G. Cerichelli, G. Fabrizi, A. Iamiceli, 1998 .

Studies for a Diastereoselective Synthesis of the Tetracyclic Diterpenic Diol Stemarin. A Model Work for the Preparation, from an 8( 9)-Podocarpen-14-one, of a Key Intermediate by the Wiesner Photochemical Method.

F. Catteruccia, R. Scarpelli, M. Berettoni, 1996 .

Improved Conversion of 6‐endo‐Tosyloxybicyclo[2.2.2]octan‐2‐ones into 6‐exo‐Acetoxy‐ and 6‐exo‐Benzoyloxybicyclo[2.2.2]octan‐2‐ones.

R. Scarpelli, L. M. Migneco, R. M. Bettolo, 2000 .

On the Diastereoselectivity of the Aqueous-Acid-Catalyzed Intramolecular Aldol Condensation of 3-Oxocyclohexaneacetaldehydes.

G. Cerichelli, G. Fabrizi, A. Iamiceli, 2010 .

Unprecedented Grob-type fragmentation of 5-dioxolan-bicyclo[4.2.0]octan-2-ones into 3-(methoxycarbonylmethyl)cyclohexanones

R. Scarpelli, M. D. Giacomo, R. M. Bettolo, 1997 .

Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy.

B. Grimaldi, R. Scarpelli, E. Torrente, 2015, Journal of medicinal chemistry.

Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.

Michael Rowley, Cristina Gardelli, Marco Ferrara, 2007, Journal of medicinal chemistry.

Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.

K. Nicolaou, B. Werschkun, D. Hepworth, 2000, Chemistry.

Development of a Multigram Synthesis of URB937, a Peripherally Restricted FAAH Inhibitor

D. Piomelli, T. Bandiera, R. Scarpelli, 2013 .

O‐(Triazolyl)methyl Carbamates as a Novel and Potent Class of Fatty Acid Amide Hydrolase (FAAH) Inhibitors

D. Piomelli, T. Bandiera, K. Jung, 2015, ChemMedChem.

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies.

D. Piomelli, A. Bach, R. Scarpelli, 2015, Journal of medicinal chemistry.

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease.

L. Polito, A. Cavalli, V. Andrisano, 2015, ACS chemical neuroscience.

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.

Andrea Armirotti, Paola Bisignano, Maria Laura Bolognesi, 2015, Angewandte Chemie.

Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors

E. Bongarzone, A. Armirotti, Min Liu, 2020, Journal of medicinal chemistry.

A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase.

Andrea Cavalli, Marco De Vivo, Daniele Piomelli, 2013, Journal of the American Chemical Society.

A binding site for non-steroidal anti-inflammatory drugs in FAAH

A. Cavalli, E. Romeo, M. Veronesi, 2013 .

Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.

D. Piomelli, A. Armirotti, D. Habrant, 2016, European journal of medicinal chemistry.

A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation

D. Piomelli, O. Sasso, R. Scarpelli, 2016, ChemMedChem.

Identification and characterization of carprofen as a multi-target FAAH/COX inhibitor

Angelo D. Favia, D. Piomelli, D. Habrant, 2013 .

Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.

Angelo D. Favia, A. Cavalli, D. Piomelli, 2012, Journal of medicinal chemistry.

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.

J. I. Hernando, S. Altamura, M. Rowley, 2011, Bioorganic & medicinal chemistry letters.

Fluorine nuclear magnetic resonance-based assay in living mammalian cells.

D. Piomelli, T. Bandiera, E. Romeo, 2016, Analytical biochemistry.

A series of novel, potent, and selective histone deacetylase inhibitors.

Michael Rowley, R. De Francesco, S. Altamura, 2006, Bioorganic & medicinal chemistry letters.

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.

R. Heim, D. Piomelli, A. Armirotti, 2016, Angewandte Chemie.

Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification.

Andrea Armirotti, Andrea Cavalli, Federico Falchi, 2016, Analytical chemistry.

Fluorine NMR-based assay in living mammalian cells

D. Piomelli, T. Bandiera, E. Romeo, 2015 .

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.

M. Bottomley, M. Rowley, A. Carfi, 2008, Bioorganic & medicinal chemistry letters.