Sivaraman Dandapani

发表

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Nathan T. Ross, Carol A. Mulrooney, Jeremy R. Duvall, 2010, Journal of the American Chemical Society.

Real-Time Biological Annotation of Synthetic Compounds

Bruce K. Hua, P. Clemons, S. Schreiber, 2016, Journal of the American Chemical Society.

Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.

Sivaraman Dandapani, Lisa A Marcaurelle, L. A. Marcaurelle, 2010, Nature chemical biology.

Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

Sivaraman Dandapani, Stuart L. Schreiber, Marcus Bauser, 2016, ACS combinatorial science.

Skeletal diversity through radical cyclization of tetrahydropyridine scaffolds.

M. Duduta, J. Porco, Sivaraman Dandapani, 2007, Organic letters.

Diversity‐Oriented Synthesis and Drug Development: Facilitating the Discovery of Novel Probes and Therapeutics

Jeremy R. Duvall, Eamon Comer, Sivaraman Dandapani, 2013 .

Selecting, Acquiring, and Using Small Molecule Libraries for High‐Throughput Screening

Noel Southall, J. Salvino, Sivaraman Dandapani, 2012, Current protocols in chemical biology.

Fluorous Mitsunobu reagents and reactions

D. Curran, Sivaraman Dandapani, 2002 .

Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Patrick W. Faloon, S. Schreiber, M. Krieger, 2015, Bioorganic & medicinal chemistry letters.

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Patrick W. Faloon, S. Schreiber, M. Krieger, 2015, Bioorganic & medicinal chemistry letters.

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.

S. Schreiber, A. Kong, B. Muñoz, 2013, Bioorganic & medicinal chemistry letters.

Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

L. A. Marcaurelle, Eamon Comer, Sivaraman Dandapani, 2011, The Journal of organic chemistry.

Non-invasive Imaging of Antisense Oligonucleotides in the Brain via In Vivo Click Chemistry

F. Rigo, M. Kaliszczak, Sivaraman Dandapani, 2022, Molecular Imaging and Biology.

Separation-friendly Mitsunobu reactions: a microcosm of recent developments in separation strategies.

D. Curran, Sivaraman Dandapani, 2004, Chemistry.

Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides.

Jeremy R. Duvall, M. Foley, L. A. Marcaurelle, 2013, The Journal of organic chemistry.

Identification of small-molecule inhibitors of Trypansoma cruzi replication.

Joshua A. Bittker, S. Schreiber, Ana Rodriguez, 2011, Bioorganic & medicinal chemistry letters.

Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia

S. Schreiber, D. Scadden, B. Muñoz, 2015 .

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.

Jeremy R. Duvall, S. Schreiber, Ana Rodriguez, 2014, ACS medicinal chemistry letters.

Identification of Diversity-Oriented Synthesis Derived Small Molecule, ML341, with Cidal Activity Against Trypanosoma cruzi

Ana Rodriguez, J. Gut, B. Muñoz, 2013 .

ML238: An Antimalarial Small Molecule of a Unique Structural Class

Carol A. Mulrooney, S. Schreiber, X. Su, 2011 .

High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling

S. Schreiber, B. Muñoz, M. Palmer, 2015, ACS infectious diseases.

Phenylbis[4‐(3,3,4,4,5,5,6,6,7,7,8,8,8‐ tridecafluorooctyl)phenyl]phosphine

Sivaraman Dandapani, 2004 .

Recent Applications of Fluorous Separation Methods in Organic and Bioorganic Chemistry

Sivaraman Dandapani, 2006 .

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

Nathan T. Ross, S. Schreiber, B. Muñoz, 2012, ACS medicinal chemistry letters.

Development of small-molecule probes that selectively kill cells induced to express mutant RAS.

Joshua A. Bittker, S. Schreiber, B. Stockwell, 2012, Bioorganic & medicinal chemistry letters.

Current strategies for diversity-oriented synthesis.

Sivaraman Dandapani, Lisa A Marcaurelle, L. A. Marcaurelle, 2010, Current opinion in chemical biology.

A Candidate Cell-Selective Anticancer Agent

M. Meyerson, S. Schreiber, H. Greulich, 2014 .

Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions.

Carol A. Mulrooney, Jeremy R. Duvall, D. Young, 2011, Tetrahedron.

Hits, leads and drugs against malaria through diversity-oriented synthesis.

Jeremy R. Duvall, B. Muñoz, Eamon Comer, 2012, Future medicinal chemistry.

Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.

Jen Q. Pan, D. E. Olson, S. Haggarty, 2016, ACS chemical biology.

Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine

S. Schreiber, B. Muñoz, M. Palmer, 2014, ACS chemical biology.

A Small Molecule Inhibitor of the MITF Molecular Pathway

Patrick W. Faloon, Carrie M. Mosher, S. Schreiber, 2014 .

Synthesis of all 16 stereoisomers of pinesaw fly sex pheromones--tools and tactics for solving problems in fluorous mixture synthesis.

D. Curran, Sivaraman Dandapani, M. Jeske, 2005, The Journal of organic chemistry.

Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets.

Sivaraman Dandapani, Bryan L Roth, Aaron B Beeler, 2006, The Journal of organic chemistry.

Second generation fluorous DEAD reagents have expanded scope in the Mitsunobu reaction and retain convenient separation features.

D. Curran, Sivaraman Dandapani, 2004, The Journal of organic chemistry.

Separation tagging with cyclodextrin-binding groups: Mitsunobu reactions with bis-(2-(1-adamantyl)ethyl) azodicarboxylate (BadEAD) and bis-(1-adamantylmethyl) azodicarboxylate (BadMAD)

D. Curran, Sivaraman Dandapani, Jeffery J. Newsome, 2004 .

Stereoisomer libraries: total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach.

D. Curran, Sivaraman Dandapani, M. Jeske, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase

Christine N. Galinski, Alissa A. Scalise, Lotte van Hessem, 2014 .

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

Joshua A. Bittker, S. Schreiber, S. Lindquist, 2013, Beilstein journal of organic chemistry.

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.

Joshua A. Bittker, S. Schreiber, S. Lindquist, 2012, Bioorganic & medicinal chemistry letters.

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.

Joshua A. Bittker, S. Schreiber, S. Lindquist, 2011, Bioorganic & medicinal chemistry letters.

The identification and characterization of non-reactive inhibitor of Keap1-Nrf2 interaction through HTS using a fluorescence polarization assay

S. Schreiber, B. Muñoz, M. Palmer, 2013 .

Table 3, Prior Art Substance Identifiers

Eric S. Lander, Benito Munoz, Stuart L. Schreiber, 2013 .

Table 1, Comparison of the Probe (ML239) to Project Criteria

Eric S. Lander, Sivaraman Dandapani, Benito Munoz, 2013 .

Table 2, Data from Additional Assays

Eric S. Lander, Sivaraman Dandapani, Benito Munoz, 2013 .

Table 3, Comparison of the Probe (ML243) to Project Criteria

Eric S. Lander, Sivaraman Dandapani, Benito Munoz, 2013 .

Discovery of Potent and Highly Selective Inhibitors of GSK3b

Jen Q. Pan, S. Haggarty, S. Schreiber, 2014 .

Skeletal diversity through radical cyclization of tetrahydropyridine scaffolds.

Sivaraman Dandapani, Mihai Duduta, M. Duduta, 2007, Organic Letters.

Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets.

B. Roth, P. Lan, J. Porco, 2006, Journal of Organic Chemistry.

Identification of a selective small molecule inhibitor of breast cancer stem cells.

E. Lander, S. Schreiber, Piyush B. Gupta, 2012, Bioorganic & medicinal chemistry letters.

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

Menghang Xia, Christopher P. Austin, Michel Weïwer, 2011, ACS medicinal chemistry letters.

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries

Paul A. Clemons, Willmen Youngsaye, Dennis Moccia, 2013, Journal of Computer-Aided Molecular Design.

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport

Patrick W. Faloon, S. Schreiber, M. Krieger, 2015, ACS medicinal chemistry letters.

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2

Joshua A. Bittker, S. Schreiber, B. Stockwell, 2011 .

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

E. Lander, S. Schreiber, Piyush B. Gupta, 2013, Bioorganic & medicinal chemistry letters.

Scheme D1, Synthesis of the Amgen Compound 1 (control)

James Spoonamore, Michel Weïwer, Jianqiang Wei, 2014 .

Fluorous Columns are Superior to Cyclodextrin Columns for Demixing in Fluorous Mixture Synthesis: When and Why to Use Fluorous Silica Gel

D. Curran, Sivaraman Dandapani, S. Werner, 2004 .

Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells

Jeremy R. Duvall, S. Schreiber, B. Wagner, 2011 .

A Systematic Investigation of the Scope of Transannular C-H Heteroarylation of Cyclic Secondary Amines for Synthetic Application in Medicinal Chemistry.

Sivaraman Dandapani, Zhe Li, M. Dechantsreiter, 2020, The Journal of organic chemistry.

Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

Eamon Comer, Sivaraman Dandapani, Jason T. Lowe, 2011, The Journal of organic chemistry.

Hits, leads and drugs against malaria through diversity-oriented synthesis.

Jeremy R. Duvall, B. Muñoz, Eamon Comer, 2012, Future medicinal chemistry.

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Patrick W. Faloon, S. Schreiber, M. Krieger, 2015, Bioorganic & medicinal chemistry letters.

Discovery of Two, Structurally Distinct Agonists of Vibrio cholerae Quorum Sensing Acting via the CqsS Membrane Receptor

Patrick W. Faloon, Carrie M. Mosher, S. Schreiber, 2013 .

Non-invasive Imaging of Antisense Oligonucleotides in the Brain via In Vivo Click Chemistry

F. Rigo, Sivaraman Dandapani, C. Plisson, 2022, Molecular Imaging and Biology.

Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3

Joshua A. Bittker, S. Schreiber, S. Lindquist, 2011 .