S. Reis

发表

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Nathan T. Ross, Carol A. Mulrooney, Jeremy R. Duvall, 2010, Journal of the American Chemical Society.

The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome.

Mariette Schrier, J. Holstege, B. Oostra, 2003, Human molecular genetics.

PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

F. A. Schroeder, S. Haggarty, H. Wey, 2014, ACS chemical neuroscience.

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

F. A. Schroeder, S. Haggarty, Wen-Ning Zhao, 2013, PloS one.

In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs

F. A. Schroeder, S. Haggarty, H. Wey, 2014, Journal of medicinal chemistry.

Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.

S. Haggarty, L. Tsai, Wen-Ning Zhao, 2016, Bioorganic & medicinal chemistry letters.

The Fragile X Syndrome Protein FMRP Associates with BC1 RNA and Regulates the Translation of Specific mRNAs at Synapses

B. Oostra, C. Bagni, S. Reis, 2003, Cell.

Structural Basis for Achieving GSK-3 β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Steven H. Liang, S. Haggarty, X. Shao, 2019 .

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

S. Haggarty, J. Loring, L. Daheron, 2011, PloS one.

Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.

D. Nelson, B. Oostra, B. Bardoni, 2004, Human molecular genetics.

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

S. Haggarty, Wen-Ning Zhao, T. Lewis, 2011 .

Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling

S. Haggarty, Wen-Ning Zhao, T. Petryshen, 2018, bioRxiv.

TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

S. Haggarty, S. Erdin, M. Talkowski, 2020, Molecular Autism.

An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration

S. Haggarty, A. Petcherski, M. Ruonala, 2019, Cells.

Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.

S. Haggarty, Wen-Ning Zhao, T. Lewis, 2010, ACS medicinal chemistry letters.

Epigenetic Characterization of the FMR 1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

S. Haggarty, J. Loring, L. Daheron, 2011 .

Structural Basis for Achieving GSK-3 Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery.

Steven H. Liang, S. Haggarty, X. Shao, 2019, Journal of medicinal chemistry.

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

S. Haggarty, A. Goate, K. Kosik, 2019, Science Translational Medicine.

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.

I. Kurtser, S. Haggarty, B. Dickerson, 2017, Cell chemical biology.

Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes

J. A. Hendricks, J. Lamb, K. Ross, 2016, Nature chemical biology.

Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells

Mariette Schrier, B. Oostra, R. Willemsen, 2004, Experimental Neurology.

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

S. Haggarty, E. Scolnick, P. McCarren, 2014, Chemical science.

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.

S. Steinbacher, P. Reinemer, S. Haggarty, 2016, Bioorganic & medicinal chemistry.

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

S. Haggarty, S. Schreiber, L. Tsai, 2012, Neuropharmacology.

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

Eric T. Wang, Steven P. Angus, M. Sur, 2021, Scientific Reports.

Prospects of TAT-Mediated Protein Therapy for Fragile X Syndrome

B. Oostra, R. Willemsen, A. Hoogeveen, 2003, Journal of Molecular Histology.

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.

S. Haggarty, M. MacDonald, M. Moskowitz, 2011, Human molecular genetics.

Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging

J. A. Hendricks, J. Shah, B. Ghosh, 2014, Bioconjugate chemistry.

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

S. Haggarty, J. Steen, Wen-Ning Zhao, 2017, Nature Communications.

Isolation of mouse neuritic mRNAs

B. Oostra, R. Willemsen, S. Reis, 2006, Journal of Molecular Histology.

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

S. Haggarty, L. Tsai, E. Scolnick, 2014, Chemical science.

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.

S. Haggarty, M. MacDonald, M. Moskowitz, 2011, Human molecular genetics.

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

S. Haggarty, S. Schreiber, L. Tsai, 2012, Neuropharmacology.