G. Dondio

发表

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.

A. Mai, S. Minucci, C. Mercurio, 2010, Journal of medicinal chemistry.

Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.

S. Minucci, C. Mercurio, M. Varasi, 2013, European journal of medicinal chemistry.

Toward the identification of neuroprotective agents: g-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist.

D. Rossi, S. Collina, G. Cavaletti, 2016, Future medicinal chemistry.

In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective &agr;7 nicotinic acetylcholine receptor agonist with a spirocyclic &Dgr;2‐isoxazoline molecular skeleton

G. Dondio, D. Braida, M. Sala, 2018, European journal of pharmacology.

Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer

A. Tesei, D. Rossi, S. Collina, 2019, Front. Pharmacol..

Selective δ opioid receptor agonists for inflammatory and neuropathic pain

C. Parini, G. Dondio, D. Graziani, 2001 .

Development of novel pain relief agents acting through the selective activation of the delta-opioid receptor.

G. Dondio, 2000, Farmaco.

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

C. Martini, A. Coluccia, R. Silvestri, 2018, European journal of medicinal chemistry.

Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics

R. Moresco, S. Valtorta, M. Koch, 2022, Cancers.

Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2‐Amino‐7‐[4‐fluoro‐2‐(3‐pyridyl)phenyl]‐4‐methyl‐7,8‐dihydro‐6H‐quinazolin‐5‐one Oxime

S. Minucci, C. Mercurio, R. Amici, 2014, ChemMedChem.

Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992, Journal of medicinal chemistry.

Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.

G. Dondio, M. Sbacchi, V. Vecchietti, 1994, Journal of medicinal chemistry.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

S. Minucci, C. Mercurio, L. Moretti, 2016, European journal of medicinal chemistry.

Synthesis and Biological Characterization of Amidopropenyl Hydroxamates as HDAC Inhibitors

A. Mai, S. Minucci, C. Mercurio, 2010, ChemMedChem.

The antitussive activity of delta-opioid receptor stimulation in guinea pigs.

D. Underwood, G. Dondio, P. Petrillo, 2000, The Journal of pharmacology and experimental therapeutics.

Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.

A. Mai, S. Minucci, C. Mercurio, 2011, Journal of medicinal chemistry.

Potent and selective non-peptidic delta opioid ligands based on the novel heterocycle-condensed octahydroisoquinoline structure

G. Dondio, P. Petrillo, V. Vecchietti, 1994, Regulatory Peptides.

Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2).

B. Imbimbo, G. Villetti, G. Dondio, 2007, Journal of medicinal chemistry.

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.

S. Catinella, C. Bigogno, C. Parini, 2005, Journal of medicinal chemistry.

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.

S. Minucci, C. Mercurio, C. So, 2020, ACS medicinal chemistry letters.

Pharmacological profiles of selective non-peptidic δ opioid receptor ligands

G. Dondio, K. Chaturvedi, R. Howells, 2000 .

Spiro[chromane‐2,4′‐piperidine]‐Based Histone Deacetylase Inhibitors with Improved in vivo Activity

S. Minucci, C. Mercurio, M. Varasi, 2012, ChemMedChem.

Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

A. Coluccia, A. Ciogli, R. Silvestri, 2022, Journal of medicinal chemistry.

Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis.

D. Brooks, G. Dondio, M. Gellai, 1993, The Journal of pharmacology and experimental therapeutics.

Indole amide derivatives : synthesis, structure-activity relationships and molecular modelling studies of a new series of histamine H1-receptor antagonists

Federico Da Settimo, G. Primofiore, A. Marini, 1999 .

Non-peptide δ opioid agonists and antagonists (Part II)

G. Dondio, P. Petrillo, S. Ronzoni, 1999 .

Non-peptide δ opioid agonists and antagonists

G. Dondio, P. Petrillo, S. Ronzoni, 1997 .

Central & Peripheral Nervous Systems Non-peptide δ opioid agonists and antagonists

G. Dondio, P. Petrillo, S. Ronzoni, 1997 .

1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.

D. Trisciuoglio, L. Altucci, A. Mai, 2014, Journal of medicinal chemistry.

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

Ettore Novellino, Andrea Brancale, Ilaria Granata, 2011, Journal of medicinal chemistry.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

E. Novellino, L. Di Marcotullio, C. Martini, 2015, Journal of medicinal chemistry.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

Ettore Novellino, Andrea Brancale, Ruoli Bai, 2014, Journal of medicinal chemistry.

Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.

E. Novellino, A. Lavecchia, R. Silvestri, 2010, European journal of medicinal chemistry.

Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties.

Simone Brogi, C. Ghelardini, C. Bigogno, 2022, European journal of medicinal chemistry.

New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies.

C. Bigogno, G. Dondio, Chiara Bigogno, 2007, Journal of pharmaceutical and biomedical analysis.

Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1).

C. Bigogno, B. Imbimbo, G. Villetti, 2007, Journal of medicinal chemistry.

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.

S. Minucci, P. Pelicci, R. Amici, 2014, Journal of medicinal chemistry.

Substituted 1-(Aminomethyl)-2-(arylacetyl)-1,2,3,4- tetrahydroisoquinolines: A Novel Class of Very Potent Antinociceptive Agents with Varying Degrees of Selectivity for and μ Opioid Receptors.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992 .

In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial

V. Yardley, S. Croft, S. Romeo, 2017, Molecules.

Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.

A. Tesei, S. Franchini, D. Rossi, 2023, European journal of medicinal chemistry.

Enantiospecificity of kappa receptors: comparison of racemic compounds and active enantiomers in two novel series of kappa agonist analgesics.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992, Chirality.

Selective delta opioid receptor agonists for inflammatory and neuropathic pain.

C. Parini, G. Dondio, D. Graziani, 2001, Farmaco.

Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.

S Ronzoni, G. Dondio, M. Artico, 1997, Journal of medicinal chemistry.

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.

Andrea Rizzi, Paola Puccini, Gino Villetti, 2005, Journal of medicinal chemistry.

Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities

V. Yardley, S. Romeo, S. Parapini, 2023, Biomolecules.

Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent.

A. Coluccia, R. Silvestri, G. La Regina, 2023, ACS pharmacology & translational science.

Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators.

A. Coluccia, R. Silvestri, G. La Regina, 2023, Bioorganic chemistry.

Pyrrolooctahydroisoquinolines as potent and selective ° opioid receptor ligands: SAR analysis and docking studies

R. DesJarlais, G. Dondio, P. Petrillo, 1997 .

Molecular modelling comparison of potent and selective κ-agonists belonging to different chemical structures: A first attempt of κ-receptor mapping

G. Dondio, F. Bellucci, 1993 .

Pyrrolooctahydroisoquinolines as Potent and Selective δ Opioid Receptor Ligands: SAR Analysis and Docking Studies.

R. DesJarlais, G. Dondio, P. Petrillo, 1998 .

THE ROLE OF THE “SPACER" IN THE OCTAHYDROISOQUINOLINE SERIES: DISCOVERY OF SB 213698, A NON-PEPTIDIC, POTENT AND SELECTIVE DELTA OPIOID AGONIST

G. Dondio, P. Petrillo, V. Vecchietti, 1995 .

Evaluation of in vitro brain penetration: optimized PAMPA and MDCKII-MDR1 assay comparison.

C. Bigogno, Simone Carrara, G. Dondio, 2007, International journal of pharmaceutics.

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

U. Laforenza, A. Tesei, D. Rossi, 2023, Pharmaceuticals.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

E. Novellino, L. Di Marcotullio, A. Brancale, 2014, Journal of medicinal chemistry.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

Spiro[chromane‐2,4′‐piperidine]‐Based Histone Deacetylase Inhibitors with Improved in vivo Activity

S. Minucci, C. Mercurio, M. Varasi, 2012, ChemMedChem.

Pharmacological profiles of selective non-peptidic delta opioid receptor ligands.

G. Dondio, K. Chaturvedi, R. Howells, 2000, Brain research. Molecular brain research.