S. Mahboobi

发表

Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.

T. Beckers, T. Ciossek, T. Maier, 2010, Journal of medicinal chemistry.

Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.

S. Mahboobi, A. Sellmer, F. Böhmer, 2008, European journal of medicinal chemistry.

Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.

S. Mahboobi, A. Sellmer, O. Krämer, 2018, European journal of medicinal chemistry.

2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.

T. Beckers, T. Ciossek, T. Maier, 2007, Journal of medicinal chemistry.

β‐Carbolinedione Derivatives as Topoisomerase I Inhibitors

S. Mahboobi, S. Eluwa, Sunil Kumar KC, 1999 .

Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases

T. Beckers, Mathias Schmidt, H. Fiebig, 2012 .

Diastereoselective synthesis of (−)-1-methyl-(3S,4R)-3,4-bis((2S)-N-(tert-butyloxycarbonyl)pyrrolidin-2-yl)-2-pyrrolidinone by an asymmetric Michael reaction

D. Schollmeyer, S. Mahboobi, T. Burgemeister, 1998 .

Development of Tubulin Inhibitors as Antimitotic Agents for Cancer Therapy

T. Beckers, S. Mahboobi, A. Sellmer, 2006 .

Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines.

T. Beckers, H. Fiebig, S. Mahboobi, 2005, European journal of medicinal chemistry.

Stent-based release of a selective PDGF-receptor blocker from the bis-indolylmethanon class inhibits restenosis in the rabbit animal model.

H. Figulla, S. Mahboobi, A. Berndt, 2010, Vascular pharmacology.

Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.

S. Dietrich, M. Tomicic, G. Schneider, 2017, Cellular signalling.

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

T. Möröy, F. Heyd, S. Mahboobi, 2021, bioRxiv.

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

T. Möröy, F. Heyd, S. Mahboobi, 2021, bioRxiv.

Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance

Aubry K. Miller, O. Witt, A. Hamacher-Brady, 2018, Scientific Reports.

Synthesis of Bis(indolylmaleimide) Macrocycles

D. Schollmeyer, S. Mahboobi, H. Pongratz, 2000 .

Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells.

W. Sippl, M. Christmann, S. Mahboobi, 2021, Cell chemical biology.

2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors.

U. Vanhoefer, T. Beckers, Mathias Schmidt, 2002, Cancer research.

Bis(1H‐indol‐2‐yl)methanones are effective inhibitors of FLT3‐ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro

M. Naumann, J. Duyster, F. Heidel, 2009, British journal of haematology.

How to Distinguish Between the Activity of HDAC1-3 and HDAC6 with Western Blot.

S. Mahboobi, O. Krämer, Mandy Beyer, 2017, Methods in molecular biology.

3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances.

S. Mahboobi, A. Sellmer, E. Eichhorn, 2006, European journal of medicinal chemistry.

Enantioselective synthesis and biological investigation of tetrahydro‐β‐carboline‐based HDAC6 inhibitors with improved solubility

S. Mahboobi, A. Sellmer, Elisabeth Grünstein, 2019, Archiv der Pharmazie.

Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents

T. Beckers, S. Mahboobi, A. Östman, 2010, Anti-cancer drugs.

Generation and Assessment of Fusions Between HDACi and TKi.

S. Mahboobi, A. Sellmer, Bernadette Pilsl, 2017, Methods in molecular biology.

Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.

T. Beckers, H. Fiebig, S. Mahboobi, 2001, Journal of medicinal chemistry.

A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer.

B. Kuster, R. Rad, S. Heinzlmeir, 2021, Bioorganic chemistry.

Synthesis of Esters of 3‐(2‐Aminoethyl)‐1H‐indole‐2‐acetic Acid and 3‐(2‐aminoethyl)‐1H‐indole‐2‐malonic acid (= 2‐[3‐(2‐aminoethyl)‐1H‐indol‐2‐yl]propanedioic acid) 4th communication on indoles, indolenines, and indolines

S. Mahboobi, K. Bernauer, 1988 .

Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.

R. Straub, S. Mahboobi, A. Sellmer, 2018, Journal of medicinal chemistry.

Synthesis of Naturally Occurring Pyrazine and Imidazole Alkaloids from Botryllus LeachiRID=”a”ID=”a” Dedicated to Prof. G. Märkl on the occasion of his 75th birthday

D. Schollmeyer, S. Mahboobi, A. Sellmer, 2004 .

[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines.

T. Beckers, Mathias Schmidt, T. Maier, 2006, Journal of medicinal chemistry.

Enantioselective Hydrosilylation of Prochiral 3,4‐Dihydro‐2H‐pyrrole Derivatives

S. Mahboobi, H. Brunner, W. Wiegrebe, 1985 .

Diastereoselective Spirocyclization of C‐(Alkyloxycarbonyl)formimines of 2‐Substituted 1HIndole‐3‐ethanamines (= Tryptamines): Basic Studies. 5th Communication on Indoles, Indolenines, and Indolines

S. Mahboobi, P. Schönholzer, K. Noack, 1990 .

Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.

T. Beckers, C. Schächtele, S. Teller, 2002, Journal of medicinal chemistry.

Removal of the Pyrrolidine Substituent by Dehydrogenation of 4‐Pyrrolidin‐2‐yl‐3,4‐dihydro‐and 1,2,3,4‐tetrahydroisoquinolines

S. Mahboobi, A. Karcher, W. Wiegrebe, 1994 .

Synthesis of pyrrolo[3′,4′:2,3]azepino[4,5,6-cd]indole-8,10-diones†

D. Schollmeyer, S. Mahboobi, S. Eluwa, 2000 .

Synthesis of Pyrrolo[3′,4′:2,3]azepino[4,5,6-cd]indole-8,10-diones.

S. Mahboobi, S. Eluwa, M. Koller, 2001 .

1,3-Dinitropropanes: Intermediates to 1,3-Diaminopropanes.

S. Mahboobi, G. Grothus, 1994 .

Synthesis of Pyrrolidin-2-ones and of Staurosporine Aglycon (K-252c) by Intermolecular Michael Reaction.

D. Schollmeyer, S. Mahboobi, Sunil Kumar KC, 1999, The Journal of organic chemistry.

Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.

C. Stocking, F. Heidel, T. Fischer, 2006, Journal of medicinal chemistry.

2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.

A. Brancale, G. Basso, G. Viola, 2009, Journal of medicinal chemistry.

A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.

B. Kuster, Susan Klaeger, H. Polzer, 2020, European journal of medicinal chemistry.

Pyrrolo[3,4-c]-beta-carboline-diones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.

T. Beckers, S. Teller, S. Mahboobi, 2000, European journal of medicinal chemistry.

Concepts to Target MYC in Pancreatic Cancer

G. Schneider, S. Mahboobi, M. Wirth, 2016, Molecular Cancer Therapeutics.

Human platelet lysate as validated replacement for animal serum to assess chemosensitivity.

F. Butter, S. Mahboobi, A. Sellmer, 2018, ALTEX.

Enantioselective Synthesis of Some Nicotiana Alkaloids

S. Mahboobi, W. Wiegrebe, 1988 .

Preparation and GC‐MS‐Identification of N‐Methyl‐Δ3‐pyrroline

S. Mahboobi, W. Wiegrebe, E. Eibler, 1988 .

Enantioselective Hydrosilylation and Hydrogenation of Alkaloid Precursors

S. Mahboobi, H. Brunner, A. Kürzinger, 1988 .

Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance

Aubry K. Miller, O. Witt, A. Hamacher-Brady, 2018, Scientific Reports.

A Single Amino Acid Exchange Inverts Susceptibility of Related Receptor Tyrosine Kinases for the ATP Site Inhibitor STI-571* 210

H. Serve, S. Mahboobi, S. Dove, 2003, The Journal of Biological Chemistry.

HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer

R. Rad, D. Saur, R. Schmid, 2017, Oncogene.

HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.

L. Kenner, A. Haitel, S. Mahboobi, 2017, Cellular signalling.

The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity.

E. Liu, S. Chandrasekharan, M. Welsh, 2004, The Biochemical journal.

Natural, semisynthetic and synthetic microtubule inhibitors for cancer therapy

T. Beckers, S. Mahboobi, 2003 .

Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3

A. Piée-Staffa, T. Nikolova, W. Brenner, 2021, Archives of Toxicology.

Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

M. Christmann, B. Kaina, F. Grebien, 2016, Archives of Toxicology.

Woodinine and its Stereomers ‐ Absolute Configuration

S. Mahboobi, W. Wiegrebe, T. Burgemeister, 1993 .

Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation

D. Schmidt-Arras, Dimitrios Tsitsipatis, R. Bauer, 2017, Oncotarget.

Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives--an extended structure-activity relationship study.

S. Mahboobi, A. Sellmer, M. Winkler, 2008, European journal of medicinal chemistry.

Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.

S. Mahboobi, A. Sellmer, E. Eichhorn, 2007, Bioorganic & medicinal chemistry.

Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3

T. Beckers, D. Small, H. Serve, 2002, Leukemia.

Drugging the HDAC6-HSP90 interplay in malignant cells.

S. Mahboobi, A. Sellmer, O. Krämer, 2014, Trends in pharmacological sciences.

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.

F. Totzke, T. Beckers, H. Fiebig, 2012, Bioorganic & medicinal chemistry.

Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues.

S. Mahboobi, S. Dove, T. Burgemeister, 1999, The Journal of organic chemistry.

Synthesis of the Preininger‐Alkaloid and its Enantioselective Reduction to Macrostomine

S. Mahboobi, W. Wiegrebe, 1991 .

Syntheses of (RS)‐ and (S)‐(−)‐Nazlinin and (RS)‐ and (+)‐6‐Azacyclodeca[5,4‐b]indol‐1‐amine

S. Mahboobi, T. Burgemeister, W. Wagner, 1995 .

Synthesis of the Preininger Alkaloid (I) and Its Enantioselective Reduction to Macrostomine.

S. Mahboobi, W. Wiegrebe, 1992 .

Synthesis of the Alkaloid Woodinine.

S. Mahboobi, 1992 .

Removal of the Pyrrolidine Group by Dehydrogenation of a 4‐Pyrrolidin‐2‐yl‐tetrahydroisoquinoline

S. Mahboobi, W. Wiegrebe, E. Seidl, 1992 .

Removal of the Pyrrolidine Group by Dehydrogenation of a 4-Pyrrolidin- 2-yltetrahydroisoquinoline.

S. Mahboobi, W. Wiegrebe, E. Eibler, 1993 .

Synthesis Of 2'-Amino-3'-Methoxyflavone (Pd 98059)

S. Mahboobi, H. Pongratz, 1999 .

Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.

S. Dietrich, M. Tomicic, G. Schneider, 2017, Cellular signalling.

Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.

T. Beckers, T. Ciossek, T. Maier, 2009, Journal of medicinal chemistry.

Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability.

C. Bařinka, Linda Schäker-Hübner, S. Mahboobi, 2024, European journal of medicinal chemistry.