A. Phillips

发表

Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.

D. Christianson, K. E. Cole, D. Dowling, 2011, Journal of the American Chemical Society.

Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

Sivaraman Dandapani, Stuart L. Schreiber, Marcus Bauser, 2016, ACS combinatorial science.

Total synthesis of aburatubolactam A.

A. Phillips, J. A. Henderson, 2008, Angewandte Chemie.

A synthesis of the bicyclo[3.3.0]octene core of geodin A

A. Phillips, A. C. Hart, J. A. Henderson, 2006 .

Marine Natural Products Synthesis

Jonathan C. Morris, A. Phillips, Victoria L Wilde, 2012 .

Pyrans and their Benzo Derivatives: Structure and Reactivity

A. Phillips, J. A. Henderson, K. L. Jackson, 2008 .

Apoptosis induced by environmental stresses and amphotericin B in Candida albicans

I. Sudbery, M. Ramsdale, A. Phillips, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans.

M. Ramsdale, A. Phillips, J. Crowe, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A Concise Synthesis of Carolacton

A. Phillips, W. Wuest, M. Hallside, 2014, Organic letters.

Targeted protein degradation and the enzymology of degraders.

S. Fisher, A. Phillips, 2018, Current opinion in chemical biology.

Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models

A. Nikonova, A. Deneka, D. Proia, 2021, Molecular Cancer Therapeutics.

CCR7 Sulfotyrosine Enhances CCL21 Binding

B. Volkman, R. Payne, A. Getschman, 2017, International journal of molecular sciences.

Nuclear magnetic resonance characterization of 6α-chloro-5β-cholestane-3β,5-diol formed from the reaction of hypochlorous acid with cholesterol

A. Carr, A. Abell, C. Winterbourn, 1997, Lipids.

Progress towards an intramolecular Diels–Alder ring-expansion approach to taxinine: the interplay of Lewis acids and high pressure

A. Abell, Jonathan C. Morris, A. Phillips, 2000 .

Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design.

A. Good, J. Patel, S. Fisher, 2021, ACS chemical biology.

Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.

M. Sixt, F. Peterson, Harley Pyles, 2015, Biochemistry.

Histone deacetylases (HDACs) and histone acetylases (HATs) are key players in regulating transcription and histone homeostasis(8). Transcription of tumor suppressor proteins is frequently silenced in tumor cells due the hyper- or aberrant activity of HDACs. Accordingly inhibiting histone deacetylati

A. Phillips, 2011 .

A family of small tyrosine rich proteins is essential for oogonial and oospore cell wall development of the mycoparasitic oomycete Pythium oligandrum.

P. van West, L. Grenville-Briggs, Neil R. Horner, 2013, Fungal biology.

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

G. Cline, R. Medzhitov, S. Eisenbarth, 2014, Nature.

Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway

Gabriel L. Lozano, Nichole A. Broderick, J. Handelsman, 2016, Front. Microbiol..

Ti-based subunit couplings: a concise, modular synthesis of routiennocin methyl ester

A. Phillips, Jamie M. McCabe, 2013 .

The Halichondrins and E7389

A. Phillips, J. A. Henderson, K. L. Jackson, 2009 .

Saprolegnia—Fish Interactions

P. West, Victoria L. Anderson, C. Secombes, 2008 .

Marine natural products: synthetic aspects.

Jonathan C. Morris, A. Phillips, 2008, Natural product reports.

Marine natural products: synthetic aspects.

A. Phillips, G. Nicholas, 2005, Natural product reports.

Titanium(II)-mediated cyclizations of (silyloxy)enynes: a total synthesis of (-)-7-demethylpiericidin A1.

A. Phillips, K. A. Keaton, 2006, Journal of the American Chemical Society.

Highly selective asymmetric acetate aldol reactions of an N-acetyl thiazolidinethione reagent.

A. Phillips, T. Sammakia, Ying-chao Zhang, 2004, Organic letters.

Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor.

David R. Williams, P. Wipf, D. Williams, 2000, Organic letters.

Titanium(II)-mediated Cyclization of (Silyloxy)enynes: A Synthesis of the C9–C19 Subunit of Dictyostatin-1

G. O'Neil, A. Phillips, 2004 .

1,1,1,3,3,3‐Hexafluoro‐2‐propanol

A. Phillips, 2010, Encyclopedia of Reagents for Organic Synthesis.

Marine natural products: synthetic aspects.

Jonathan C. Morris, A. Phillips, 2005, Natural product reports.

A synthesis of the C1-C15 domain of the halichondrins.

Jonathan C. Morris, A. Phillips, J. A. Henderson, 2008, Tetrahedron letters.

SYNTHESIS AND X-RAY STRUCTURE OF A 1,2,3,6-TETRAHYDROPYRIDINE-BASED PHENYLALANINE MIMETIC

A. Abell, W. Robinson, A. Phillips, 1998 .

Practical and highly selective oxazolidinethione-based asymmetric acetate aldol reactions with aliphatic aldehydes.

A. Phillips, N. Guz, 2002, Organic letters.

Highly Selective Asymmetric Acetate Aldol Reactions of an N‐Acetyl Thiazolidinethione Reagent.

A. Phillips, T. Sammakia, Ying-chao Zhang, 2004 .

Practical and highly selective oxazolidinethione-based asymmetric acetate aldol reactions with aliphatic aldehydes.

A. Phillips, N. Guz, 2002, Organic letters.

A total synthesis of (+/-)-trans-kumausyne.

A. Phillips, C. Chandler, 2005, Organic letters.

Conversion of cyanthiwigin U to related cyanthiwigins: total syntheses of cyanthiwigin W and cyanthiwigin Z.

A. Phillips, Matthew W B Pfeiffer, 2008, Tetrahedron letters.

Total synthesis of (+)-cyanthiwigin U.

A. Phillips, Matthew W B Pfeiffer, 2005, Journal of the American Chemical Society.

Synthesis of elaiolide and halichoblelide aglycone

G. O'Neil, A. Phillips, 2019, Tetrahedron Letters.

Titanium(II)-Mediated Cyclization of (Silyloxy)enynes: A Synthesis of the C9—C19 Subunit of Dictyostatin-1.

G. O'Neil, A. Phillips, 2004 .

Bis(2‐propanolato)[(1,2‐η)‐1‐propene]titanium

A. Phillips, 2003 .

Highly diastereoselective titanium(II)-mediated cyclizations of 1,7-(silyloxy)enynes

A. Phillips, Nicole Barbour, 2008 .

Toward the synthesis of spirastrellolide B: a synthesis of the C1-C23 subunit.

A. Phillips, K. A. Keaton, 2008, Organic letters.

A cyclopropanol-based strategy for subunit coupling: total synthesis of (+)-spirolaxine methyl ether.

A. Phillips, K. A. Keaton, 2007, Organic letters.

Ring-opening–ring-closing metathesis of bicyclo[2.2.2]octenes: a novel synthesis of decalins and hydrindanes

A. Phillips, Timothy L. Minger, 2002 .

The halichondrins and E7389.

A. Phillips, Katrina L Jackson, James A Henderson, 2009, Chemical reviews.

A total synthesis of norhalichondrin B.

A. Phillips, J. A. Henderson, K. L. Jackson, 2009, Angewandte Chemie.

Total synthesis of aburatubolactam A.

A. Phillips, J. A. Henderson, 2008, Angewandte Chemie.

Total synthesis of (+)-cylindramide A.

A. Phillips, A. C. Hart, 2006, Journal of the American Chemical Society.

Vinyl homologation via methyl migration to µ-vinyl at a diruthenium centre

A. Orpen, A. Phillips, S. Knox, 1990 .

Highly functionalized pyranopyrans from furans: a synthesis of the C27-C38 and C44-C53 subunits of norhalichondrin B.

A. Phillips, J. A. Henderson, K. L. Jackson, 2007, Organic letters.

Synthesis of butadiene via vinyl–ethylene combination at a diruthenium centre

A. Phillips, S. Knox, G. Bruce, 1990 .

Synthesis and phosphorus-31 NMR spectroscopy of trinuclear, phosphido-bridged iridium and rhodium clusters. Crystal and molecular structures of [M3(.mu.-PPh2)3(CO)nL2] (M = Ir or Rh, n = 3, L2 = 1,2-bis(diphenylphosphino)methane; M = Ir, n = 5, L = tert-BuNC)

A. Phillips, D. Berry, K. Dehghan, 1991 .

A concise and modular synthesis of pyranicin.

A. Phillips, N. D. Griggs, 2008, Organic letters.

New insights into animal pathogenic oomycetes.

P. van West, Victoria L. Anderson, C. Secombes, 2008, Trends in microbiology.

The solution structure of the forkhead box‐O DNA binding domain of Brugia malayi DAF‐16a

F. Peterson, A. Phillips, Christopher T. Veldkamp, 2014, Proteins.

The putative RxLR effector protein SpHtp1 from the fish pathogenic oomycete Saprolegnia parasitica is translocated into fish cells.

P. van West, Victoria L. Anderson, Stephan Wawra, 2010, FEMS microbiology letters.

Distinctive Expansion of Potential Virulence Genes in the Genome of the Oomycete Fish Pathogen Saprolegnia parasitica

B. Snel, B. Haas, J. Levin, 2013, PLoS genetics.

Dichloro(3,3‐diphenyl‐2‐propenylidene)‐bis(tricyclohexylphosphine)ruthenium

A. Phillips, 2003 .

High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

R. Improgo, S. Fisher, R. Pollock, 2021, SLAS discovery : advancing life sciences R & D.

Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis.

S. Strobel, J. Handelsman, E. Baraban, 2013, Tetrahedron letters.

Development of an AchillesTAG degradation system and its application to control CAR-T activity

Hannah J. Maple, M. Sowa, D. Proia, 2021 .

Small molecule probes to target the human Mediator complex.

D. Taatjes, A. Phillips, 2013, Israel journal of chemistry.

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition

Karl Mechtler, Brian F. Volkman, Michael Sixt, 2016, Science.

Abstract ND09: The discovery and characterization of CFT8634: A potent and selective degrader of BRD9 for the treatment of SMARCB1-perturbed cancers

L. Poling, R. Deibler, J. Yap, 2022, Cancer Research.

AWARD NUMBER: W81XWH-10-1-0990 TITLE: Largazole as a Novel and Selective Anti-Breast Cancer Agent PRINCIPAL INVESTIGATOR:

A. Phillips, 2015 .

Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1)

Xuedong Liu, Gan Zhang, C. Nasveschuk, 2012, PloS one.

Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor

Douglas A. Chapnick, Xuedong Liu, C. Nasveschuk, 2012, Journal of biomolecular screening.

Ring‐closing Metathesis of Nitrogen‐Containing Compounds: Applications to Heterocycles, Alkaloids, and Peptidomimetics

A. Abell, A. Phillips, 2000 .

Di‐μ‐chlorodichlorobis(η2‐ethene) diplatinum

A. Phillips, 2003 .

A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships.

Xuedong Liu, C. Nasveschuk, A. Phillips, 2008, Organic letters.

A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination

D. Proia, R. Deibler, S. Fisher, 2021, SLAS discovery : advancing life sciences R & D.

Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E

K. Gustafson, S. Strobel, D. Spakowicz, 2015, Natural product communications.

Total synthesis of (-)-dictyostatin.

G. O'Neil, A. Phillips, 2006, Journal of the American Chemical Society.

Total Synthesis of (‐)‐Dictyostatin.

G. O'Neil, A. Phillips, 2006 .

Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

Andrea I. Ramos, G. E. Jones, Abdullah A. Albarrak, 2022, The Lancet.

Synthesis of functionalized piperidinones.

A. Abell, A. Phillips, Mark E. Humphries, 2003, The Journal of organic chemistry.

Glycosylation of FGFR4 in cholangiocarcinoma regulates receptor processing and cancer signaling

A. Phillips, J. Mott, Ashley M. Mohr, 2022, Journal of cellular biochemistry.

TheputativeRxLRe ¡ ector proteinSpHtp 1 fromthe ¢ sh pathogenic oomyceteSaprolegnia parasitica is translocated into ¢ sh cells

P. West, Victoria L. Anderson, Stephan Wawra, 2010 .

Preclinical development of the class I selective histone deacetylase inhibitor OKI-179 for the treatment of solid tumors.

Michael K. Wendt, Xuedong Liu, S. Eckhardt, 2021, Molecular cancer therapeutics.

Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.

D. Christianson, K. E. Cole, D. Dowling, 2011, Journal of the American Chemical Society.

The halichondrins and E7389.

A. Phillips, J. A. Henderson, K. L. Jackson, 2009, Chemical reviews.

Dichloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene](tricyclohexylphosphine)ruthenium†

A. Phillips, 2002 .

A concise and modular synthesis of pyranicin.

A. Phillips, N. D. Griggs, 2008, Organic letters.