C. Chou

发表

Histone Deacetylase Inhibitors with Enhanced Enzymatic Inhibition Effects and Potent in vitro and in vivo Antitumor Activities

Xuejian Wang, Lei Zhang, Wenfang Xu, 2014, ChemMedChem.

Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.

Yuping Jia, Wenfang Xu, Yingjie Zhang, 2015, Journal of medicinal chemistry.

Design of hydrazide-bearing HDACIs based on panobinostat and their p53 and FLT3-ITD dependency in anti-leukemia activity.

Y. Peterson, N. Dolloff, S. Halene, 2020, Journal of medicinal chemistry.

Development of N-Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with Indole-Containing Cap Group.

Penghui Yang, Xuejian Wang, Wenfang Xu, 2013, ACS medicinal chemistry letters.

Design and Synthesis of a Tetrahydroisoquinoline‐Based Hydroxamate Derivative (ZYJ‐34v), An Oral Active Histone Deacetylase Inhibitor with Potent Antitumor Activity

Xuejian Wang, Yuping Jia, Wenfang Xu, 2013, Chemical biology & drug design.

Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.

D. Menick, C. Chou, C. Crosson, 2014, Experimental eye research.

Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.

J. Gottesfeld, C. Chou, Fang-Le Hu, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups.

Wenfang Xu, Yingjie Zhang, C. Chou, 2017, Bioorganic & medicinal chemistry.

A Two-Hit Mechanism for Pre-Mitotic Arrest of Cancer Cell Proliferation by a Polyamide-Alkylator Conjugate

P. Dervan, J. Gottesfeld, L. Latella, 2006, Cell cycle.

Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs.

Y. Peterson, C. Chou, E. S. Inks, 2017, ACS chemical biology.

Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors.

Wenfang Xu, Yingjie Zhang, C. Chou, 2018, European journal of medicinal chemistry.

Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing.

Heather L. Plasterer, J. Gottesfeld, E. Soragni, 2009, Chemistry & biology.

Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis.

A. Rice, R. Holmes, G. Wisedchaisri, 2007, Biochemistry.

Vitamin K: a structural basis for the design of novel neuroprotective agents?

C. Chou, E. S. Inks, B. Josey, 2013, Future medicinal chemistry.

"The exact role of MK-4 in mammalian mitochondrial electron transfer chain is still unknown, and why the common mitochondrial electron carrier, CoQ10, cannot substitute for its activity is still not clear."

C. Chou, 2013 .

Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status.

Y. Peterson, Yingjie Zhang, C. Chou, 2018, Journal of medicinal chemistry.

Growth Arrest of BCR-ABL Positive Cells with a Sequence-Specific Polyamide-Chlorambucil Conjugate

S. Lefebvre, B. Druker, J. Tyner, 2008, PloS one.

Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo.

Min Li, C. Chou, Xiaoyang Li, 2021, Journal of medicinal chemistry.

Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model

M. Pandolfo, J. Gottesfeld, Glenn Barnes, 2010, PloS one.

Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as an Amide Source: Application in the Synthesis of an HDAC6 Inhibitor.

C. Chou, C. Zhang, Cheng Zhang, 2016, Organic letters.

Short Laminin Peptide for Improved Neural Stem Cell Growth

X. Wen, Ning Zhang, Xiaowei Li, 2014, Stem cells translational medicine.

Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis

A. Rice, R. Holmes, G. Wisedchaisri, 2007 .

Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension.

C. Chou, C. Crosson, Oday Alsarraf, 2014, Investigative ophthalmology & visual science.

Discovery of N-(2-Aminophenyl)-4-(bis(2-chloroethyl)amino)Benzamide as a Potent Histone Deacetylase Inhibitor

Qixiao Jiang, Li Zhang, Weiguo Song, 2019, Front. Pharmacol..

Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC

Yingjie Zhang, C. Chou, Jiangying Cao, 2020, Molecules.

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation.

C. Chou, Xiaoyang Li, Kairui Yue, 2022, Journal of medicinal chemistry.

Discovery of a Novel Hybrid of Vorinostat and Riluzole as a Potent Antitumor Agent

Yingjie Zhang, C. Chou, J. Zang, 2020, Frontiers in Cell and Developmental Biology.

Pimelic Diphenylamide 106 Is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases*

J. Gottesfeld, C. Chou, D. Herman, 2008, Journal of Biological Chemistry.

Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia.

Y. Peterson, C. Zhang, C. Chou, 2016, Journal of medicinal chemistry.

Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents.

Xuejun Wen, X. Wen, C. Chou, 2013, Journal of medicinal chemistry.

Silver-catalyzed direct thiolation of quinones by activation of aryl disulfides to synthesize quinonyl aryl thioethers.

C. Chou, J. McClure, Cheng Zhang, 2015, The Journal of organic chemistry.

Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates

Sherry M. Tsai, P. Dervan, Michelle E. Farkas, 2006, Nucleic acids research.

A novel class of small molecule inhibitors of HDAC6.

C. Chou, E. S. Inks, Sean R Jesinkey, 2012, ACS chemical biology.

Recombinant Expression of Aldehyde Dehydrogenase 2 (ALDH2) in Escherichia coli Nissle 1917 for Oral Delivery in ALDH2-Deficient Individuals

I. Huang, E. Kao, C. Chou, 2019, bioRxiv.

Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies.

Min Huang, M. Geng, Hong Liu, 2019, Journal of medicinal chemistry.

Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich’s Ataxia

J. Gottesfeld, E. Soragni, J. Rusche, 2015, Front. Neurol..

Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma

P. L. Bergsagel, N. Dolloff, M. Chesi, 2018, Leukemia.

Discovery of the First N-Hydroxycinnamamide-Based Histone Deacetylase 1/3 Dual Inhibitors with Potent Oral Antitumor Activity

Jian Zhang, Yingjie Zhang, C. Chou, 2014, Journal of medicinal chemistry.

Ischemic preconditioning, retinal neuroprotection and histone deacetylase activities.

N. C. Goodwin, D. Rice, C. Chou, 2016, Experimental eye research.

Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes

D. Menick, C. Chou, Sabina H. Wang, 2015, Nucleic acids research.

Discovery of the first Vitamin K analog as a potential treatment of pharmacoresistant seizures.

K. Wilcox, C. Chou, Xiaoyang Li, 2020, Journal of medicinal chemistry.

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.

M. Tsai, Yi-Chun Wu, C. Chou, 2001, Developmental cell.

Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers.

Navjot Shah, M. Ishii, Z. Ablonczy, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia

Sherry M. Tsai, P. Dervan, Michelle E. Farkas, 2008, Molecular Cancer Therapeutics.

Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model.

M. Scheiner, C. Sotriffer, M. Decker, 2021, Journal of medicinal chemistry.

Histone deacetylase inhibition by gut microbe-generated short chain fatty acids entrains intestinal epithelial circadian rhythms

Thomas J. Moutinho, Paul G. Mitchell, Andrew E. Rosselot, 2020, bioRxiv.

Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer's disease.

Jingde Wu, C. Chou, Xiaoyang Li, 2020, Bioorganic chemistry.

Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study.

Jingde Wu, Wenfang Xu, Yingjie Zhang, 2017, European journal of medicinal chemistry.

Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy

J. Rahn, C. Chou, E. S. Inks, 2014, Neuroscience.

Functional Studies of the Mycobacterium tuberculosis Iron-dependent Regulator*

R. Holmes, G. Wisedchaisri, C. Chou, 2004, Journal of Biological Chemistry.

LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice

J. Lemasters, C. Chou, Y. Krishnasamy, 2023, RPS pharmacy and pharmacology reports.

Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously.

Yuping Jia, Wenfang Xu, Yingjie Zhang, 2018, Journal of medicinal chemistry.

Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia

Sherry M. Tsai, P. Dervan, Michelle E. Farkas, 2008, Molecular Cancer Therapeutics.

A novel class of small molecule inhibitors of HDAC6.

C. Chou, B. Josey, Elizabeth S. Inks, 2012, ACS chemical biology.

Inhibition of HDAC2 protects the retina from ischemic injury.

D. Rice, C. Chou, C. Crosson, 2013, Investigative ophthalmology & visual science.