Madhusoodanan Mottamal

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Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents

Madhusoodanan Mottamal, Shilong Zheng, Tien L. Huang, 2015, Molecules.

The contribution of C alpha-H...O hydrogen bonds to membrane protein stability depends on the position of the amide.

Themis Lazaridis, T. Lazaridis, Madhusoodanan Mottamal, 2005, Biochemistry.

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Madhusoodanan Mottamal, Tien L. Huang, R. Brun, 2016, Pharmaceuticals.

From Pure Antagonists to Pure Degraders of the Estrogen Receptor: Evolving Strategies for the Same Target

Madhusoodanan Mottamal, Guangdi Wang, Borui Kang, 2021, ACS omega.

Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia

S. Kar, Madhusoodanan Mottamal, Rami A. Al-Horani, 2020, ChemistryOpen.

The In Vitro Effects of Pentamidine Isethionate on Coagulation and Fibrinolysis

Madhusoodanan Mottamal, Rami A. Al-Horani, D. Clemons, 2019, Molecules.

Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion.

M. Burow, Madhusoodanan Mottamal, Shilong Zheng, 2013, ACS medicinal chemistry letters.

GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models

Jiawang Liu, Shanchun Guo, Madhusoodanan Mottamal, 2020, Breast Cancer Research and Treatment.

Ethacrynic acid is an inhibitor of human factor XIIIa

S. Kar, Madhusoodanan Mottamal, R. Al‐Horani, 2021, BMC pharmacology & toxicology.

ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models

M. Ellis, Yong Wu, R. Houtman, 2018, OncoTarget.

Sulfonated non‐saccharide molecules and human factor XIa: Enzyme inhibition and computational studies

Madhusoodanan Mottamal, R. Al‐Horani, Elnaz Parsaeian, 2022, Chemical biology & drug design.

Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia

Madhusoodanan Mottamal, Liqiong Liu, T. Huckaba, 2017, PloS one.

Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs.

Yong-Yeon Cho, A. Bode, Z. Dong, 2012, Carcinogenesis.

Modification and Biological Evaluation of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion

J. Sridhar, Madhusoodanan Mottamal, Shilong Zheng, 2014, Journal of medicinal chemistry.

Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.

Arvind Kumar, D. Boykin, D. Maciejewska, 2015, Bioorganic & medicinal chemistry.

Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases.

A. Bode, Z. Dong, I. Kurinov, 2012, Cancer research.

Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents

Madhusoodanan Mottamal, Shilong Zheng, Guangdi Wang, 2014, Journal of medicinal chemistry.

Isoangustone A, A Novel Licorice Compound, Inhibits Cell Proliferation by Targeting PI3K, MKK4, and MKK7 in Human Melanoma

A. Bode, Z. Dong, S. Lim, 2013, Cancer Prevention Research.

Understanding the stereospecific interactions of 3-deoxyphosphatidylinositol derivatives with the PTEN phosphatase domain.

Qin Wang, M. Roberts, Madhusoodanan Mottamal, 2010, Journal of molecular graphics & modelling.

Limited Density of an Antigen Presented by RMA-S Cells Requires B7-1/CD28 Signaling to Enhance T-Cell Immunity at the Effector Phase

Madhusoodanan Mottamal, T. van Hall, M. Sluijter, 2014, PloS one.

Factor IX(a) inhibitors: an updated patent review (2003-present)

Madhusoodanan Mottamal, Daniel K. Afosah, R. Al‐Horani, 2022, Expert opinion on therapeutic patents.

Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K

A. Bode, Z. Dong, S. Jung, 2011, Cancer Prevention Research.

Sulfonated Nonsaccharide Heparin Mimetics Are Potent and Noncompetitive Inhibitors of Human Neutrophil Elastase

Madhusoodanan Mottamal, Kholoud F. Aliter, R. Al‐Horani, 2021, ACS omega.

Naringenin targets ERK2 and suppresses UVB‐induced photoaging

A. Bode, Z. Dong, Yun-Tai Kim, 2016, Journal of cellular and molecular medicine.

Sulphated penta-galloyl glucopyranoside (SPGG) is glycosaminoglycan mimetic allosteric inhibitor of cathepsin G

Madhusoodanan Mottamal, Daniel K. Afosah, Kholoud F. Aliter, 2023, RPS pharmacy and pharmacology reports.

Energetics of the native and non‐native states of the glycophorin transmembrane helix dimer

Themis Lazaridis, T. Lazaridis, Madhusoodanan Mottamal, 2006, Proteins.

Voltage-dependent energetics of alamethicin monomers in the membrane.

Themis Lazaridis, T. Lazaridis, Madhusoodanan Mottamal, 2006, Biophysical chemistry.

Design, Synthesis, and Evaluation of Niclosamide Analogs as Therapeutic Agents for Enzalutamide-Resistant Prostate Cancer

Shanchun Guo, Florastina Payton-Stewart, M. Bratton, 2023, Pharmaceuticals.

Bile Acid Conjugated DNA Chimera that Conditionally Inhibits Carbonic Anhydrase-II in the Presence of MicroRNA-21.

N. Zhang, Madhusoodanan Mottamal, Cooper H. Battle, 2015, Bioconjugate chemistry.

Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs.

Yong-Yeon Cho, A. Bode, Z. Dong, 2012, Carcinogenesis.

Discovery of Heparin Mimetic, Potent, and Selective Inhibitors of Human Clotting Factor XIIIa

Madhusoodanan Mottamal, Navneet Goyal, Daniel K. Afosah, 2024, ACS omega.