M. Marek

发表

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.

W. Sippl, C. Romier, M. Jung, 2016, Journal of medicinal chemistry.

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

W. Sippl, S. Kannan, C. Romier, 2018, Molecules.

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.

H. Gohlke, C. Romier, F. Hansen, 2017, Journal of medicinal chemistry.

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.

H. Gohlke, C. Romier, F. Hansen, 2017, Journal of medicinal chemistry.

A catalytic mechanism for Renilla-type bioluminescence

Gaspar P. Pinto, J. Damborský, P. Chaiyen, 2022, bioRxiv.

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2).

A. Mai, C. Romier, M. Jung, 2019, Journal of medicinal chemistry.

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Tobias Rumpf, W. Sippl, C. Romier, 2014, Journal of molecular biology.

Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.

C. Romier, M. Jung, U. Kulandaivelu, 2014, Bioorganic chemistry.

Exploitation of FTA cartridges for the sampling, long-term storage, and DNA-based analyses of plant-parasitic nematodes.

M. Marek, O. Douda, M. Zouhar, 2014, Phytopathology.

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.

C. Romier, R. Pierce, M. Marek, 2016, Methods in molecular biology.

Engineering the protein dynamics of an ancestral luciferase

Gaspar P. Pinto, F. Hollfelder, U. Bornscheuer, 2020, Nature Communications.

Newly identified host range of European mountain ash ringspot‐associated virus (EMARaV) and its distribution in the Czech Republic

M. Marek, P. Ryšánek, L. Grimova, 2015 .

Isophthalic Acid‐Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni

W. Sippl, C. Romier, F. Hansen, 2017, Archiv der Pharmazie.

Baculovirus VP1054 Is an Acquired Cellular PURα, a Nucleic Acid-Binding Protein Specific for GGN Repeats

C. Romier, M. V. van Oers, O. Merten, 2013, Journal of Virology.

Cellular and humoral immune responses to chimeric EGFP-pseudocapsids derived from the mouse polyomavirus after their intranasal administration.

V. Holan, J. Forstová, M. Marek, 2008, Vaccine.

Baculovirus VP80 Protein and the F-Actin Cytoskeleton Interact and Connect the Viral Replication Factory with the Nuclear Periphery

J. Vlak, M. V. van Oers, O. Merten, 2011, Journal of Virology.

Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst†

J. Damborský, P. Carpentier, M. Marek, 2020, Chemical science.

Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family

Yukari Sato, J. Damborský, R. Chaloupkova, 2020, Computational and structural biotechnology journal.

Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

J. Damborský, R. Chaloupkova, M. Marek, 2020, Computational and structural biotechnology journal.

The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination

L. Drouard, C. Romier, Efil Bayam, 2021, Nucleic acids research.

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.

W. Sippl, C. Romier, S. Goldenberg, 2021, Cell reports.

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2).

A. Mai, C. Romier, M. Jung, 2019, Journal of medicinal chemistry.

Domino-like Effect of C112R Mutation on APOE4 Aggregation and Its Suppression by Alzheimer’s Disease Drug Candidate

J. Damborský, Z. Prokop, M. Marek, 2022, bioRxiv.

One-Atom-Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.

W. Sippl, C. Romier, M. Schutkowski, 2019, Biochemistry.

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 (HDAC6) Inhibitors

Dina, W. Sippl, C. Romier, 2019 .

Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase

J. Damborský, D. Nikitin, Z. Prokop, 2022, ACS Catalysis.

Extended Mechanism and Rate-Limiting Step of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis

J. Damborský, Z. Prokop, M. Marek, 2021 .

Using point mutations in rDNA for differentiation of bioraces of Ditylenchus dipsaci from the Czech Republic

M. Marek, M. Zouhar, P. Ryšánek, 2017 .

Illuminating the mechanism and allosteric behavior of NanoLuc luciferase

J. Damborský, Z. Prokop, M. Marek, 2022, bioRxiv.

Analysis of ITS sequences of nuclear rDNA and development of a PCR-based assay for the rapid identification of the stem nematode Ditylenchus dipsaci (Nematoda: Anguinidae) in plant tissues

M. Marek, 2005 .

Insights into the structure and phylogeny of the 28S rRNA expansion segments D2 and D3 of the plant-infecting nematodes from the genus Ditylenchus (Nematoda: Anguinidae).

M. Marek, O. Douda, M. Zouhar, 2013 .

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.

O. Witt, W. Sippl, C. Romier, 2016, Journal of medicinal chemistry.

Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts

Gaspar P. Pinto, J. Damborský, R. Chaloupkova, 2019, ACS Catalysis.

Engineering of baculovirus vectors for the manufacture of virion‐free biopharmaceuticals

Martin Marek, J. Vlak, M. V. van Oers, 2011, Biotechnology and bioengineering.

Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling

J. Damborský, E. Kool, R. Chaloupkova, 2022, JACS Au.

Encyclopedia of Autographa californica nucleopolyhedrovirus genes

Just M. Vlak, Martin Marek, J. Vlak, 2009, Virologica Sinica.

ANP32E is a histone chaperone that removes H2A.Z from chromatin

T. Mak, C. Romier, S. Dimitrov, 2014, Nature.

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.

W. Sippl, C. Romier, G. Oliveira, 2015, Future medicinal chemistry.

Schistosome sirtuins as drug targets.

W. Sippl, C. Romier, J. Schultz, 2015, Future medicinal chemistry.

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

W. Sippl, S. Kannan, C. Romier, 2013, PLoS pathogens.

Essential C-Terminal Region of the Baculovirus Minor Capsid Protein VP80 Binds DNA

M. V. van Oers, O. Merten, M. Marek, 2011, Journal of Virology.

Molecular basis and specificity of H2A.Z–H2B recognition and deposition by the histone chaperone YL1

C. Romier, S. Dimitrov, A. Hamiche, 2016, Nature Structural &Molecular Biology.

Catalytic mechanism for Renilla-type luciferases

Gaspar P. Pinto, J. Damborský, P. Chaiyen, 2023, Nature Catalysis.

Bioinformatics-assisted characterization of the ITS1-5·8S-ITS2 segments of nuclear rRNA gene clusters, and its exploitation in molecular diagnostics of European crop-parasitic nematodes of the genus Ditylenchus

M. Marek, O. Douda, M. Zouhar, 2010 .

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.

Takayoshi Suzuki, W. Sippl, C. Romier, 2018, Journal of medicinal chemistry.

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

J. Damborský, Joan Planas-Iglesias, Z. Prokop, 2023, bioRxiv.

Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation

Christophe Romier, Wolfgang Sippl, Jelena Melesina, 2014, J. Chem. Inf. Model..

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

W. Sippl, C. Romier, D. Christianson, 2019, Journal of medicinal chemistry.

Characterization and production of protein complexes by co-expression in Escherichia coli.

C. Romier, U. Schlattner, I. Berger, 2015, Methods in molecular biology.

The bright side and the dark side of computational protein stabilization

J. Damborský, R. Chaloupkova, Z. Prokop, 2021, Acta Crystallographica Section A: Foundations and Advances.

Computational Protein Stabilization Can Affect Folding Energy Landscapes and Lead to Domain-Swapped Dimers

J. Damborský, R. Chaloupkova, Joan Planas-Iglesias, 2021 .

Comparative molecular analysis of Bursaphelenchus vallesianus, a wood‐inhabiting nematode isolated from declining pine trees in the Czech Republic

M. Marek, V. Gaar, O. Douda, 2014 .

Increased Occurrence of Treponema spp. and Double-species Infections in Patients with Alzheimer’s Disease

J. Laczó, J. Hort, J. Damborský, 2021, bioRxiv.

Structural Biology of Epigenetic Targets: Exploiting Complexity

C. Romier, M. Marek, T. B. Shaik, 2019, Epigenetic Drug Discovery.

The Naticidae (Mollusca: Gastropoda) of Giglio Island (Tuscany, Italy): Shell characters, live animals, and a molecular analysis of egg masses (project)

M. Marek, I. Schmidt, S. Schmidt, 2014 .

Polyomavirus EGFP‐pseudocapsids: Analysis of model particles for introduction of proteins and peptides into mammalian cells

E. Bouřa, V. Holan, J. Forstová, 2005, FEBS letters.

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

A. Ganesan, W. Sippl, C. Romier, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

S. Fleishman, J. Damborský, R. Mikulík, 2022, Computational and structural biotechnology journal.

Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase.

J. Damborský, M. Marek, D. Bednář, 2022, Stroke.

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis

W. Sippl, C. Romier, M. Jung, 2018, ChemMedChem.

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.

O. Witt, W. Sippl, C. Romier, 2016, Journal of Medicinal Chemistry.

Fluorescence-Based Screening Assays for the NAD+-Dependent Histone Deacetylase smSirt2 from Schistosoma mansoni

W. Sippl, C. Romier, J. Schultz, 2015, Journal of biomolecular screening.

Multimeric structure of a subfamily III haloalkane dehalogenase‐like enzyme solved by combination of cryo‐EM and x‐ray crystallography

K. Diederichs, R. Read, J. Damborský, 2023, Protein science : a publication of the Protein Society.

Illuminating the mechanism and allosteric behavior of NanoLuc luciferase

J. Damborský, Z. Prokop, M. Marek, 2023, bioRxiv.

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Tobias Rumpf, W. Sippl, C. Romier, 2014, Journal of molecular biology.