S. Short

发表

Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex.

R. Wolfenden, C. Carter, L. Betts, 1994, Journal of molecular biology.

Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.

D I Stuart, J Milton, D. Stuart, 2000, Structure.

Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.

D I Stuart, D. Stuart, D. Stammers, 2001, Journal of molecular biology.

Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

P P Chamberlain, D. Stammers, C. Nichols, 2004, Journal of molecular biology.

Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.

D. Stammers, L. Boone, S. Short, 2006, Journal of medicinal chemistry.

Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.

D. Stammers, L. Boone, Jingshan Ren, 2008, Journal of medicinal chemistry.

Active Site Amino Acids That Participate in the Catalytic Mechanism of Nucleoside 2′-Deoxyribosyltransferase (*)

S. Ealick, S. Short, S. Armstrong, 1996, The Journal of Biological Chemistry.

Regulation of peptide transport in Escherichia coli: induction of the trp-linked operon encoding the oligopeptide permease

S. Short, J. Andrews, T. C. Blevins, 1986, Journal of bacteriology.

Identification of the Active Site Nucleophile in Nucleoside 2-Deoxyribosyltransferase as Glutamic Acid 98 (*)

S. Short, D. J. Porter, B. Merrill, 1995, The Journal of Biological Chemistry.

The cloning of the Escherichia coli K-12 deoxyribonucleoside operon.

S. Short, M. Fischer, 1982, Gene.

Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution.

W. Cook, S. Ealick, S. Short, 1991, The Journal of biological chemistry.

Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.

D. Stammers, C. Nichols, Jingshan Ren, 2007, Journal of medicinal chemistry.

Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.

M. Lambert, I. McLay, Shawn P. Williams, 2004, Journal of medicinal chemistry.

Role of enzyme-ribofuranosyl contacts in the ground state and transition state for orotidine 5'-phosphate decarboxylase: a role for substrate destabilization?

R. Wolfenden, G. L. Butterfoss, S. Short, 2001, Biochemistry.

Role of glutamate-104 in generating a transition state analogue inhibitor at the active site of cytidine deaminase.

R. Wolfenden, S. Short, D. Carlow, 1996, Biochemistry.

Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis.

S. Thorgeirsson, C. Richards, S. Short, 1990, Cancer research.

Mechanisms of active transport in isolated bacterial membrane vesicles. 18. The mechanism of action of carbonylcyanide m-chlorophenylhydrazone.

H. Kaback, S. Short, J. Reeves, 1974, Archives of biochemistry and biophysics.

Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex.

R. Wolfenden, M. Snider, C. Borchers, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Mutations affecting transition-state stabilization by residues coordinating zinc at the active site of cytidine deaminase.

R. Wolfenden, S. Short, D. Carlow, 1994, Biochemistry.

Metabolism of Phosphatidylglycerol, Lysylphosphatidylglycerol, and Cardiolipin of Staphylococcus aureus

D. White, S. Short, S. A. Short, 1971, Journal of Bacteriology.

Crystallization of native and selenomethionyl yeast orotidine 5'-phosphate decarboxylase.

M. Milburn, A. Hassell, S. Short, 2000, Acta crystallographica. Section D, Biological crystallography.

Lyase activity of nucleoside 2-deoxyribosyltransferase: transient generation of ribal and its use in the synthesis of 2'-deoxynucleosides.

R. Wolfenden, S. Short, M. Smar, 1991, Biochemistry.

Immunochemical properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli.

H. Kaback, S. Short, L. Kohn, 1975, The Journal of biological chemistry.

Localization of D-lactate dehydrogenase in native and reconstituted Escherichia coli membrane vesicles.

H. Kaback, S. Short, L. Kohn, 1975, The Journal of biological chemistry.

D-lactate dehydrogenase binding in Escherichia coli dld- membrane vesicles reconstituted for active transport.

H. Kaback, S. Short, L. Kohn, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Preparative isolation of DNA and biologically active mRNA from diethylaminoethyl membrane

P. Lizardi, S. Short, R. Binder, 1984 .

Dissecting a Charged Network at the Active Site of Orotidine-5′-phosphate Decarboxylase*

R. Wolfenden, M. Snider, S. Short, 2001, The Journal of Biological Chemistry.

Mechanisms of active transport in isolated bacterial membrane vesicles. IX. The kinetics and specificity of amino acid transport in Staphylococcus aureus membrane vesicles.

H. Kaback, D. White, S. Short, 1972, The Journal of biological chemistry.

Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

L. Boone, S. Short, K. Weaver, 2004, Journal of medicinal chemistry.

Structural insights into mechanisms of non‐nucleoside drug resistance for HIV‐1 reverse transcriptases mutated at codons 101 or 138

D. Stammers, C. Nichols, Jingshan Ren, 2006, The FEBS journal.

Anti-Human Immunodeficiency Virus Type 1 Activity of the Nonnucleoside Reverse Transcriptase Inhibitor GW678248 in Combination with Other Antiretrovirals against Clinical Isolate Viruses and In Vitro Selection for Resistance

L. Boone, S. Short, K. Romines, 2005, Antimicrobial Agents and Chemotherapy.

Antiviral Activity of GW678248, a Novel Benzophenone Nonnucleoside Reverse Transcriptase Inhibitor

L. Boone, S. Short, K. Weaver, 2005, Antimicrobial Agents and Chemotherapy.

Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus

R. Kelly, I. Blumentals, S. Short, 1996, Journal of bacteriology.

Synthesis and antiviral activity of 2'-deoxy-4'-thio purine nucleosides.

S. Short, G. A. Freeman, G. Koszalka, 1996, Journal of medicinal chemistry.

Nucleoside 2-Deoxyribosyltransferase

S. Short, D. J. Porter, 1995, The Journal of Biological Chemistry.

Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site.

W. Cook, S. Ealick, S. Short, 1996, Structure.

Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12

J. Vanhooke, W. Hall, S. Short, 1988, Journal of bacteriology.

MOLECULAR ASPECTS OF ACTIVE TRANSPORT

P. Stroobant, G. Rudnick, S. Schuldiner, 1976 .

Active Transport in Isolated Bacterial Membrane Vesicles

H. Kaback, D. White, S. Short, 1974 .

Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene.

R. Wolfenden, C. Yang, S. Short, 1992, Biochemistry.

Mutant varicella-zoster virus thymidine kinase: correlation of clinical resistance and enzyme impairment

S. Short, R. Gaillard, J. A. Fyfe, 1991, Journal of virology.

Phospholipid Metabolism in Ferrobacillus ferrooxidans

D. White, S. Short, M. Aleem, 1969, Journal of bacteriology.

2-amino-9-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)-6-substituted-9H-purines: synthesis and anti-HIV activity.

S. Short, G. A. Freeman, J. L. Rideout, 1995, Bioorganic & medicinal chemistry.

Biosynthesis of Cardiolipin from Phosphatidylglycerol in Staphylococcus aureus

D. White, S. Short, S. A. Short, 1972, Journal of bacteriology.

Complementary truncations of a hydrogen bond to ribose involved in transition-state stabilization by cytidine deaminase.

R. Wolfenden, S. Short, D. Carlow, 1998, Biochemistry.

Transition-state selectivity for a single hydroxyl group during catalysis by cytidine deaminase.

R. Wolfenden, C. Carter, S. Xiang, 1995, Biochemistry.

Studies on deo operon regulation in Escherichia coli: cloning and expression of the cytR structural gene.

S. Short, C. Barbier, S. A. Short, 1984, Gene.

Allosteric Mechanism of Induction of CytR-regulated Gene Expression

D. F. Senear, S. Short, C. Barbier, 1997, The Journal of Biological Chemistry.

The structure of the cytidine deaminase-product complex provides evidence for efficient proton transfer and ground-state destabilization.

R. Wolfenden, C. Carter, S. Xiang, 1997, Biochemistry.

Major contribution of a carboxymethyl group to transition-state stabilization by cytidine deaminase: mutation and rescue.

R. Wolfenden, C. Yang, S. Short, 1995, Biochemistry.

Crystallization and preliminary X-ray investigation of recombinant Lactobacillus leichmannii nucleoside deoxyribosyltransferase.

W. Cook, S. Ealick, S. Short, 1990, The Journal of biological chemistry.

Genetic analysis of Escherichia coli oligopeptide transport mutants

S. Short, J. Andrews, S. A. Short, 1985, Journal of Bacteriology.

Amino acid substitutions in the CytR repressor which alter its capacity to regulate gene expression

S. Short, C. Barbier, S. A. Short, 1992, Journal of bacteriology.

AminoAcidSubstitutions intheCytRRepressor WhichAlterIts Capacity ToRegulate GeneExpression

S. Short, C. Barbier, 1992 .

Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol.

M. Hershfield, A. Mary, S. Short, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Hepatocarcinogenesis Cooperation in ras and myc Importance of c-Hepatoma Cell Line Hep G 2 : Additional Evidence for the Gene in the Human ras Characterization of a Transforming N-Updated

S. Thorgeirsson, C. Richards, S. Short, 2006 .

Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.

A M Hassell, R. Wolfenden, M. Milburn, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Product Release Is the Major Contributor tok cat for the Hepatitis C Virus Helicase-catalyzed Strand Separation of Short Duplex DNA*

M. Hanlon, S. Short, T. Consler, 1998, The Journal of Biological Chemistry.

Active transport in isolated bacterial membrane vesicles. V. The transport of amino acids by membrane vesicles prepared from Staphylococcus aureus.

H. Kaback, D. White, S. Short, 1972, The Journal of biological chemistry.

Metabolism of the Glucosyl Diglycerides and Phosphatidylglucose of Staphylococcus aureus

D. White, S. Short, S. A. Short, 1970, Journal of bacteriology.

ACTIVE TRANSPORT IN ISOLATED BACTERIAL MEMBRANE VESICLES: BINDING OF β‐GALACTOSIDES TO THE LAC CARRIER PROTEIN

H. Kaback, G. Rudnick, S. Schuldiner, 1975, Annals of the New York Academy of Sciences.

EVALUATION OF THE CHEMIOSMOTIC INTERPRETATION OF ACTIVE TRANSPORT IN BACTERIAL MEMBRANE VESICLES

H. Kaback, S. Short, J. Reeves, 1974, Annals of the New York Academy of Sciences.

Functional testing of putative oligopeptide permease (Opp) proteins of Borrelia burgdorferi: a complementation model in opp(-) Escherichia coli.

M. Klempner, S. Short, Linden T. Hu, 2001, Biochimica et biophysica acta.

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.

Shawn P Williams, N. Laping, Shawn P. Williams, 2007, Molecular endocrinology.

Mechanisms of active transport in isolated bacterial membrane vesicles. Further studies on amino acid transport in Staphylococcus aureus membrane vesicles.

H. Kaback, S. Short, S. A. Short, 1972, The Journal of biological chemistry.

opp-lac Operon fusions and transcriptional regulation of the Escherichia coli trp-linked oligopeptide permease

S. Short, J. Andrews, S. A. Short, 1986, Journal of bacteriology.

The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.

Shawn P. Williams, S. Short, T. Consler, 2009, Acta crystallographica. Section D, Biological crystallography.

Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5'-phosphate decarboxylase.

R. Wolfenden, M. Snider, S. Short, 2000, Biochemistry.

Cytidine deaminase complexed to 3-deazacytidine: a "valence buffer" in zinc enzyme catalysis.

R. Wolfenden, C. Carter, S. Xiang, 1996, Biochemistry.

Temperature effects on the catalytic efficiency, rate enhancement, and transition state affinity of cytidine deaminase, and the thermodynamic consequences for catalysis of removing a substrate "anchor".

R. Wolfenden, M. Snider, S. Gaunitz, 2000, Biochemistry.

Deletions in the beta3-beta4 hairpin loop of HIV-1 reverse transcriptase are observed in HIV-1 isolated from subjects during long-term antiretroviral therapy.

L. Boone, S. Short, R. Lanier, 2000, Journal of human virology.

2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.

D I Stuart, R J Ott, D. Stuart, 2001, Journal of medicinal chemistry.

Yeast orotidine-5'-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation.

S. Short, D. J. Porter, S. A. Short, 2000, Biochemistry.