G. Basi

发表

Purification and cloning of amyloid precursor protein β-secretase from human brain

R. Barbour, Jun Zhao, L. McConlogue, 1999, Nature.

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

I. Kola, R. Motter, K. Johnson-wood, 2001, Human molecular genetics.

Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.

W. Earnshaw, C. M. Eischen, S. Kaufmann, 1997, Blood.

Animal Models of Alzheimer's Disease: Modeling Targets, Not Disease Accelerating Drug Discovery for Alzheimer's Disease: Best Practices for Preclinical Animal Studies

Kimberly Scearce-Levie, Patrick Sweeney, Dave Morgan, 2022 .

Amyloid β-Protein Precursor Juxtamembrane Domain Regulates Specificity of γ-Secretase-dependent Cleavages*

D. Schenk, G. Basi, Zhao Ren, 2007, Journal of Biological Chemistry.

A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites

D. Knighton, S. Taylor, J. Sowadski, 1993, Molecular and cellular biology.

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

J. Bonifacino, B. Strooper, M. Bollen, 2016, Cell.

Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab

W. Weis, J. Saldanha, D. Schenk, 2014, Alzheimer's Research & Therapy.

Recent Advances in the Understanding of the Processing of APP to Beta Amyloid Peptide

L. McConlogue, D. Schenk, E. Thorsett, 2000, Annals of the New York Academy of Sciences.

Evidence that Enzyme Processivity Mediates Differential Aβ Production by PS1 and PS2

D. Schenk, G. Basi, S. Pintchovski, 2013, Current Alzheimer research.

Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages.

D. Schenk, G. Basi, Zhao Ren, 2007, The Journal of biological chemistry.

Antibody Capture of Soluble Aβ Does Not Reduce Cortical Aβ Amyloidosis in the PDAPP Mouse

M. Pangalos, R. Motter, D. Kholodenko, 2008, Neurodegenerative Diseases.

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.

H. Sham, T. Yednock, M. Bova, 2009, Bioorganic & medicinal chemistry letters.

Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth

R. Jacobson, G. Basi, J. Schilling, 1987, Cell.

Alternative splicing of a Drosophila tropomyosin gene generates muscle tropomyosin isoforms with different carboxy-terminal ends

G. Basi, M. Boardman, R. Storti, 1984, Molecular and cellular biology.

Roles in Alzheimer Disease Apolipoprotein E and Apolipoprotein E Receptors : Normal Biology and Subject Collection The Biology of Alzheimer Disease Animal Models of Alzheimer Disease

D. Holtzman, J. Cummings, D. Selkoe, 2012 .

Antagonistic Effects of β-Site Amyloid Precursor Protein-cleaving Enzymes 1 and 2 on β-Amyloid Peptide Production in Cells*

Tam Doan, R. Barbour, L. McConlogue, 2003, Journal of Biological Chemistry.

Structure and DNA sequence of the tropomyosin I gene from Drosophila melanogaster.

G. Basi, R. Storti, 1986, The Journal of biological chemistry.

Identification of γ-Secretase Inhibitor Potency Determinants on Presenilin*

D. Schenk, K. Hu, Mike Lee, 2008, Journal of Biological Chemistry.

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis*

W. Earnshaw, S. Kaufmann, P. Svingen, 1997, The Journal of Biological Chemistry.

Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis.

W. Earnshaw, S. Kaufmann, P. Svingen, 1997, Blood.

Antibodies to soluble human T cell receptor beta chain recognize multiple epitopes on cell surface TcR.

G. Basi, K. Nash, M. Riggs, 1992, Journal of immunological methods.

Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions

J C Reed, S H Kaufmann, S. Srinivasula, 1999, The Journal of Biological Chemistry.

Treatment strategies targeting amyloid β-protein.

M. Pangalos, D. Schenk, G. Basi, 2012, Cold Spring Harbor perspectives in medicine.

Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab

W. Weis, J. Saldanha, D. Schenk, 2014, Alzheimer's Research & Therapy.

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System*S⃞

Normand L. Frigon, R. Motter, H. Sham, 2009, Journal of Biological Chemistry.

Caspase-mediated Cleavage of DNA Topoisomerase I at Unconventional Sites during Apoptosis*

E. Alnemri, J. Champoux, F. Durrieu, 1999, The Journal of Biological Chemistry.

Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease

T. Comery, M. Pangalos, W. Weis, 2009, The Journal of Biological Chemistry.

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

R. Motter, D. Kholodenko, R. Barbour, 2010, Alzheimer's Research & Therapy.

Immunotherapy Reduces Vascular Amyloid-β in PDAPP Mice

R. Barbour, P. Seubert, D. Schenk, 2008, The Journal of Neuroscience.

Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures

Richard M. Page, T Bonhoeffer, T. Bonhoeffer, 2013, Molecular Psychiatry.

Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells.

R. Barbour, L. McConlogue, G. Gordon, 2003, The Journal of biological chemistry.

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitor

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length

T. Golde, B. Cottrell, E. Koo, 2011, The Journal of Biological Chemistry.

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.

H. Sham, L. Latimer, M. Bova, 2013, Bioorganic & medicinal chemistry letters.

Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.

H. Sham, J. Sauer, P. Keim, 2010, Bioorganic & medicinal chemistry letters.

Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration

R. Motter, D. Kholodenko, K. Hu, 2010, Alzheimer's & Dementia.

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.

H. Sham, M. Bova, J. Sauer, 2010, Bioorganic & Medicinal Chemistry Letters.

Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.

H. Sham, M. Bova, J. Sauer, 2011, Bioorganic & medicinal chemistry letters.

Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.

M. Bova, J. Sauer, G. Basi, 2011, Bioorganic & medicinal chemistry letters.

Multiple polyadenylation sites in a Drosophila tropomyosin gene are used to generate functional mRNAs.

G. Basi, M. Boardman, R. Storti, 1985, Nucleic acids research.

Identification of gamma-secretase inhibitor potency determinants on presenilin.

D. Schenk, K. Hu, Mike Lee, 2008, The Journal of biological chemistry.

A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in rat CNS

E. Nedivi, R. Jacobson, G. Basi, 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.

H. Sham, M. Bova, J. Sauer, 2009, Bioorganic & medicinal chemistry letters.

O3-01-06: Evidence of vascular recovery after removal of vascular Aβ by passive immunotherapy in PDAPP mice

R. Barbour, P. Seubert, K. Khan, 2008, Alzheimer's & Dementia.

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.