B. Clarke

发表

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines*

J. Trill, C. Dingwall, J. Skehel, 2001, The Journal of Biological Chemistry.

Host range of a plant pathogenic fungus determined by a saponin detoxifying enzyme

A. Osbourn, P. Bowyer, B. Clarke, 1995, Science.

Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism.

D. Tew, B. Clarke, E. Sternberg, 1999, Bioorganic & medicinal chemistry letters.

Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.

J. Frère, M. Galleni, S. Abdel-Meguid, 2000, Biochemistry.

Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators.

P. Woollard, K. Thewlis, S. Ward, 2011, Journal of medicinal chemistry.

6-(SUBSTITUTED METHYLENE)PENEMS, POTENT BROAD SPECTRUM INHIBITORS OF BACTERIAL β-LACTAMASE

N. F. Osborne, B. Clarke, K. Coleman, 1991 .

On the dual character of the fluorescence spectrum and lifetimes of acridine II

M. Shaw, B. Clarke, J. Williams, 1976 .

The relationship between crystallographic structure and luminescence in single crystals of acridine

John Meurig Thomas, B. Clarke, J. Williams, 1975 .

Structural imperfections and singlet exciton traps in crystalline anthracene

M. Shaw, John Meurig Thomas, B. Clarke, 1976 .

Structural traps for singlet excitons in doped anthracene single crystals and their photochemical significance

B. Clarke, J. Williams, 1977 .

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Brian Clarke, Phil Jeffrey, P. Jeffrey, 2008, Journal of medicinal chemistry.

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

C. Dingwall, J. Mosley, P. Rowland, 2010, Bioorganic & medicinal chemistry letters.

Bace-1 Inhibitors Using Novel Edge-to-Face Interaction with Arg-296

C. Howes, C. Dingwall, J. Mosley, 2010 .

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Possible nirmatrelvir/ritonavir-induced bradycardia in a patient with asymptomatic COVID-19

B. Clarke, F. Qadeer, Elizabeth DeMarco, 2023, SAGE open medical case reports.