R. Matico

发表

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

Hongfeng Deng, G Joseph Franklin, Kenneth E Lind, 2012, Journal of medicinal chemistry.

Analysis of the interaction between human interleukin‐5 and the soluble domain of its receptor using a surface plasmon resonance biosensor

M. Doyle, P. Young, I. Chaiken, 1994, Journal of molecular recognition : JMR.

Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines*

J. Trill, C. Dingwall, J. Skehel, 2001, The Journal of Biological Chemistry.

Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery

Beth L. Pietrak, Marc A. Holbert, Yong Jiang, 2019, Scientific Reports.

TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4*

R. Matico, G. Wayne, G. Murphy, 2007, Journal of Biological Chemistry.

A bicistronic expression system for bacterial production of authentic human interleukin-18.

M. Mclaughlin, J. Trill, J. Kane, 2003, Protein expression and purification.

Nucleosome Binding Alters the Substrate Bonding Environment of Histone H3 Lysine 36 Methyltransferase NSD2.

V. Schramm, Marc A. Holbert, R. Matico, 2016, Journal of the American Chemical Society.

N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.

Colleen E. Keohane, J. Edwards, E. Jacoby, 2022, Journal of medicinal chemistry.

Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36

V. Schramm, S. Thrall, M. Huddleston, 2016, Proceedings of the National Academy of Sciences.

Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase **

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2020, Chembiochem : a European journal of chemical biology.

Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2020, bioRxiv.

Characterization of novel inhibition of indoleamine 2,3-dioxygenase by targeting its apo form.

Douglas W. Thomson, Rodrigo F. Ortiz-Meoz, G. Bergamini, 2018 .

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.

M. Jaye, J. Trill, R. Annan, 2009, Bioorganic & medicinal chemistry letters.

An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages.

D. Mcnulty, J. Strickler, M. Rosenberg, 1995, Gene.

Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery

Marc A. Holbert, Yong Jiang, L. Szewczuk, 2019, Scientific Reports.

Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins.

S. Carr, M. Doyle, Baoguang Zhao, 1995, The Journal of biological chemistry.

A Scalable Platform for Producing Recombinant Nucleosomes with Codified Histone Methyltransferase Substrate Preferences.

M. Huddleston, R. Matico, R. Kirkpatrick, 2019, Protein expression and purification.

A High-Throughput Screen for Endothelial Lipase Using HDL as Substrate

S. Thrall, M. Jaye, J. Trill, 2008, Journal of biomolecular screening.

Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).

Yun Ding, J. Cuozzo, D. Israel, 2015, ACS medicinal chemistry letters.

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Brian Clarke, Phil Jeffrey, P. Jeffrey, 2008, Journal of medicinal chemistry.

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.

R. Matico, C. Matheny, A. Malfait, 2015, Osteoarthritis and cartilage.

Kinetic characterization of the interaction of biotinylated human interleukin 5 with an Fc chimera of its receptor α subunit and development of an ELISA screening assay using real‐time interaction biosensor analysis

R. Hertzberg, P. Mcdonnell, I. Chaiken, 1995, Journal of molecular recognition : JMR.

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

C. Dingwall, J. Mosley, P. Rowland, 2010, Bioorganic & medicinal chemistry letters.

Bace-1 Inhibitors Using Novel Edge-to-Face Interaction with Arg-296

C. Howes, C. Dingwall, J. Mosley, 2010 .

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

J. Cuozzo, M. Clark, Raksha A. Acharya, 2012, Journal of medicinal chemistry.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.