Kathrine J. Smith

发表

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Naturally Processed HLA Class II Peptides Reveal Highly Conserved Immunogenic Flanking Region Sequence Preferences That Reflect Antigen Processing Rather Than Peptide-MHC Interactions1

Maria V. Tejada-Simon, Tim Elliott, A. Hill, 2001, The Journal of Immunology.

Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell Function

David A. Hafler, Katarzyna Bourcier, D. Hafler, 2003, The Journal of experimental medicine.

Complexed with a Peptide from Human Myelin Basic Protein

Don C. Wiley, D. Wiley, K. Wucherpfennig, 1998 .

Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

Don C. Wiley, D. Wiley, K. Wucherpfennig, 1998, The Journal of experimental medicine.

Peptide-MHC Interactions Reflect Antigen Processing Rather Than Flanking Region Sequence Preferences That Reveal Highly Conserved Immunogenic Naturally Processed HLA Class II Peptides

Tim Elliott, V. Adrian, T. Elliott, 2001 .

Crystal structures of ASK1‐inhibtor complexes provide a platform for structure‐based drug design

I. Wall, P. Rowland, R. Tanner, 2013, Protein science : a publication of the Protein Society.

A functional Kv1.2-hERG chimaeric channel expressed in Pichia pastoris

P. Carter, Kathrine J. Smith, Tim S. Munsey, 2014, Scientific Reports.

Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Acta crystallographica. Section F, Structural biology communications.

Production and crystallization of MHC class I B allele single peptide complexes

D. Stuart, J. Bell, A. McMichael, 1996, FEBS letters.

The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.

J. Irving, Zhengrong Zhu, D. Lomas, 2021, Bioorganic & medicinal chemistry letters.

Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Bioorganic & medicinal chemistry letters.

Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Bioorganic & medicinal chemistry letters.

Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1

I. Hiles, Kathrine J. Smith, Michael J. Mullin, 2021, Biotechnology Letters.

Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.

A. Hovnanian, J. Liddle, P. Thomas, 2019, Bioorganic & medicinal chemistry letters.

A potent and selective Kallikrein-5 inhibitor delivers high pharmacological activity in Netherton Syndrome patient skin.

M. Lennon, A. Hovnanian, D. Grillot, 2021, The Journal of investigative dermatology.

Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators.

P. Woollard, K. Thewlis, S. Ward, 2011, Journal of medicinal chemistry.

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.

Paul W Smith, K. Thewlis, S. Ward, 2010, Journal of medicinal chemistry.

Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies

R. D. de Wildt, Kathrine J. Smith, J. Yates, 2020, mAbs.

The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

A. Reith, M. Wilkinson, Kathrine J. Smith, 2004, Structure.

Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8

D. Stuart, P. Klenerman, J. Bell, 1996, The Journal of experimental medicine.

TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide–HLA Complex

B. Jakobsen, J. Dukes, S. Harper, 2020, The Journal of Immunology.

Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure

D. Hafler, K. Wucherpfennig, D. Lim, 2001, Journal of Virology.

Crystal Structures of Hla-a*0201 Complexed with Antigenic Peptides with Either the Amino-or Carboxyl-terminal Group Substituted by a Methyl Group

D. Wiley, Kathrine J. Smith, Hwai-Chen Guo, 2022 .

Unlocking the secrets of the gatekeeper: methods for stabilizing and crystallizing GPCRs.

Shweta Singh, Michael M Hann, Bernadette Byrne, 2013, Biochimica et biophysica acta.

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Brian Clarke, Phil Jeffrey, P. Jeffrey, 2008, Journal of medicinal chemistry.

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

C. Dingwall, J. Mosley, P. Rowland, 2010, Bioorganic & medicinal chemistry letters.

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

M. Lonetto, A. Fosberry, Kathrine J. Smith, 2003, Protein science : a publication of the Protein Society.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

J. Irving, Zhengrong Zhu, D. Lomas, 2020, bioRxiv.

HLA-A2 subtypes are functionally distinct in peptide binding and presentation

H. Rammensee, S. Stevanović, S. Rowland-Jones, 1995, The Journal of experimental medicine.

Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.

D. Wiley, U. Utz, D. Garboczi, 1998, Immunity.

An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501.

D I Stuart, E Y Jones, D. Stuart, 1996, Immunity.

Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53.

D I Stuart, E Y Jones, K Harlos, 1996, Immunity.

Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

D. Wiley, K. Wucherpfennig, J. Pyrdol, 1998, The Journal of experimental medicine.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.