D. Walter

发表

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4.

Yifan Liu, T. Donohoe, D. Walter, 2017, Angewandte Chemie.

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors

O. Fedorov, J. Elkins, S. Ward, 2021, Journal of medicinal chemistry.

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.

S. Senger, P. Beswick, Robert J Gleave, 2010, Bioorganic & medicinal chemistry letters.

The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells

M. Lynch, J. Richardson, N. Upton, 2012, Brain pathology.

The synthesis of (+)-nemorensic acid

T. Donohoe, D. Walter, C. Frampton, 2000 .

Preparation of (+)-nemorensic acid and approaches to nemorensine using the partial reduction of electron deficient furans

T. Donohoe, D. Walter, Jean-Baptiste Guillermin, 2002 .

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.

P. Beswick, Robert J Gleave, D. Walter, 2010, Bioorganic & medicinal chemistry letters.

3.06 – Ketones Bearing an α,β-Aryl or -Hetaryl Substituent

D. Walter, 1995 .

Synthesis of indoles : Efficient functionalisation of the 7-position

Nicolas Charrier, E. Demont, R. Dunsdon, 2006 .

Synthesis of 3,5,7-substituted indoles via heck cyclisation

Nicolas Charrier, E. Demont, R. Dunsdon, 2005 .

Sequential radical macrocyclisation-transannulation approach to ring-fused bicycles

D. Walter, G. Pattenden, A. Smithies, 1994 .

Radical-mediated synthesis of α- C -glycosides based on N -acyl galactosamine

T. Gallagher, D. Walter, R. SanMartin, 2000 .

Allylation with Pummerer-generated substituted vinylthionium ions

D. Walter, J. Michael, R. Hunter, 1994 .

A new route to highly functionalized heterocyclic rings.

J. Board, D. Walter, P. Parsons, 2007, The Journal of organic chemistry.

CASCADE RADICAL MEDIATED MACROCYCLISATION-TRANSANNULATION REACTIONS LEADING TO RING-FUSED BICYCLES

D. Walter, G. Pattenden, D. Tapolczay, 1996 .

Sequential Radical Macrocyclisation‐Transannulation Approach to Ring‐ Fused Bicycles.

D. Walter, G. Pattenden, A. Smithies, 1994 .

Galacto, gluco, manno, and disaccharide-based C-glycosides of 2-amino-2-deoxy sugars.

T. Gallagher, Yan Liu, D. Walter, 2002, Organic letters.

Regioselective allylation of enol silyl ethers with γ-heterosubstituted vinylthionium ions

D. Walter, J. Michael, R. Hunter, 1994 .

Allylation with substituted vinylthionium ions from SnCl4 ionisation of 1,3- and 3,3-bis(alkyl/phenylthio) propenes

D. Walter, J. Michael, R. Hunter, 1994 .

A cascade macrocyclisation-transannulation approach to polycycle constructions

D. Walter, G. Pattenden, M. Begley, 1994 .

Radical-Mediated Synthesis of α-C-Glycosides Based on N-Acyl Galactosamine.

T. Gallagher, D. Walter, R. SanMartin, 2001 .

Synthesis and reactivity of a novel group of hydroxylamine-containing 2π- and 4π-components

T. Gallagher, D. Walter, C. Frampton, 1998 .

Allylation with Pummerer Generated Substituted Vinylthionium Ions.

D. Walter, J. Michael, R. Hunter, 1994 .

Partial reduction of 3-heteroatom substituted 2-furoic acids: the role of an ortho group in viability and stereoselectivity

T. Donohoe, D. Walter, C. Frampton, 2002 .

Silyl substituted furans in the stereoselective Birch reduction

T. Donohoe, D. Walter, Jean-Baptiste Guillermin, 2001 .

A Lewis acid promoted oxidative cyclization.

T. Donohoe, D. Walter, Paul C. M. Winship, 2009, The Journal of organic chemistry.

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production in vivo

P. Jeffrey, C. Dingwall, E. Demont, 2007 .

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.

P. Jeffrey, C. Dingwall, E. Demont, 2007, Journal of neurochemistry.

Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist

T. Zollner, D. Walter, A. Steinmeyer, 2023, Journal of medicinal chemistry.

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.

P. Beswick, Robert J Gleave, D. Walter, 2010, Bioorganic & medicinal chemistry letters.

(E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-2'-(methanesulfonyl)-4-methylvalerohydrazide (Ro 32-7315), a selective and orally active inhibitor of tumor necrosis factor-alpha convertase.

J. Kneer, D. Walter, R. Devos, 2002, The Journal of pharmacology and experimental therapeutics.

Mechanism of action of species‐selective P2X7 receptor antagonists

W. C. Clay, D. Walter, A. Michel, 2009, British journal of pharmacology.

Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis.

Andreas Steinmeyer, Olaf Peters, Gernot Langer, 2019, Journal of medicinal chemistry.

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Brian Clarke, Phil Jeffrey, P. Jeffrey, 2008, Journal of medicinal chemistry.

Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.

Andreas Steinmeyer, Marcus Koppitz, Andrea Rotgeri, 2019, Bioorganic & medicinal chemistry letters.

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

C. Dingwall, J. Mosley, P. Rowland, 2010, Bioorganic & medicinal chemistry letters.

Bace-1 Inhibitors Using Novel Edge-to-Face Interaction with Arg-296

C. Howes, C. Dingwall, J. Mosley, 2010 .

A novel oxidative cyclisation onto vinyl silanes.

T. Donohoe, D. Walter, B. S. Pilgrim, 2010, Chemical communications.

Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.

S. Senger, P. Beswick, E. Demont, 2010, Bioorganic & medicinal chemistry letters.

Negative and positive allosteric modulators of the P2X(7) receptor.

D. Walter, A. Michel, L. Chambers, 2008, British journal of pharmacology.

A novel cyclisation strategy for the synthesis of lactonamycin: A new route to highly functionalised heterocyclic rings

J. Board, P. Hitchcock, Florian Wakenhut, 2006 .

Metabolism and Pharmacokinetics of JM6 in Mice: JM6 Is Not a Prodrug for Ro-61-8048

C. Dominguez, D. Winkler, M. Beconi, 2012, Drug Metabolism and Disposition.

Prodrug for Ro-61-8048

C. Dominguez, D. Winkler, M. Beconi, 2012 .

Microsoft Word-75872698-file00.docx

D. Winkler, M. Beconi, K. Lyons, 2012 .

Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.

S. Senger, P. Beswick, Robert J Gleave, 2010, Bioorganic & medicinal chemistry letters.

Metabolism and Pharmacokinetics of JM6 in Mice: JM6 Is Not a Prodrug for Ro-61-8048

C. Dominguez, D. Winkler, M. Beconi, 2012, Drug Metabolism and Disposition.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.

P. Beswick, Robert J Gleave, D. Walter, 2010, Bioorganic & medicinal chemistry letters.