Haimin Lei

发表

A Series of New Ligustrazine-Triterpenes Derivatives as Anti-Tumor Agents: Design, Synthesis, and Biological Evaluation

J. Chen, Yanyi Xing, Bing Xu, 2015, International journal of molecular sciences.

Comprehensive screening of 63 coloring agents in cosmetics using matrix solid-phase dispersion and ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry.

Q. Ma, Penglong Wang, Haimin Lei, 2019, Journal of chromatography. A.

Ligustrazinyl amides: a novel class of ligustrazine-phenolic acid derivatives with neuroprotective effects

Bing Xu, Fuhao Chu, Yuzhong Zhang, 2015, Chemistry Central Journal.

Quinone Derivatives from the Genus Rubia and Their Bioactivities

Congmin Liu, Qiang Li, Penglong Wang, 2014, Chemistry & biodiversity.

Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells

Bing Xu, Yuzhong Zhang, Xin Xu, 2017, Chemistry Central Journal.

Prostate-Specific Membrane Antigen and Esterase Dual Responsive Camptothecin–Oligopeptide Self-Assembled Nanoparticles for Efficient Anticancer Drug Delivery

F. Gao, Runping Liu, Bing Xu, 2021, International journal of nanomedicine.

Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application.

Xing-jie Liang, Bing Xu, Penglong Wang, 2019, ACS nano.

A Series of Oleanolic Acid Derivatives as Anti-Hepatitis B Virus Agents: Design, Synthesis, and in Vitro and in Vivo Biological Evaluation

Wenqiang Yan, Bing Xu, Fuhao Chu, 2016, Molecules.

Ligustrazine-Oleanolic Acid Glycine Derivative, G-TOA, Selectively Inhibited the Proliferation and Induced Apoptosis of Activated HSC-T6 Cells

Fuhao Chu, Yuzhong Zhang, Penglong Wang, 2016, Molecules.

Rapid detection of pesticide residues in Chinese herbal medicines by molecularly imprinted membrane electrospray ionization mass spectrometry

Shanshan Jia, Haimin Lei, Tianyi Li, 2020, Chinese Chemical Letters.

A novel long-acting oxyntomodulin analogue eliminates diabetes and obesity in mice.

Tao Ma, Bing Xu, Penglong Wang, 2020, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of ligustrazine - betulin amino-acid/dipeptide derivatives as anti-tumor agents.

Bing Xu, Penglong Wang, Haimin Lei, 2019, European journal of medicinal chemistry.

The Profiling and Identification of the Absorbed Constituents and Metabolites of Guizhi Decoction in Rat Plasma and Urine by Rapid Resolution Liquid Chromatography Combined with Quadrupole-Time-of-Flight Mass Spectrometry

Haimin Lei, Lishi Zhang, B. Fan, 2016, International journal of molecular sciences.

Synthesis of Novel Baicalein Amino Acid Derivatives and Biological Evaluation as Neuroprotective Agents

Tao Ma, Shuqi Zhou, Bing Xu, 2019, Molecules.

Bioactive Components from Qingwen Baidu Decoction against LPS-Induced Acute Lung Injury in Rats

Penglong Wang, Haimin Lei, Qi Zhang, 2017, Molecules.

A New Ligustrazine Derivative-Selective Cytotoxicity by Suppression of NF-κB/p65 and COX-2 Expression on Human Hepatoma Cells. Part 3

Wenqiang Yan, Bing Xu, Fuhao Chu, 2015, International journal of molecular sciences.

Revealing the Toxicity-Enhancing Essence of Glycyrrhiza on Genkwa Flos Based on Ultra-high-performance Liquid Chromatography Coupled With Quadrupole-Orbitrap High-Resolution Mass Spectrometry and Self-Assembled Supramolecular Technology

Q. Ma, Penglong Wang, Haimin Lei, 2021, Frontiers in Chemistry.

Injectable Carrier-Free Hydrogel Dressing with Anti-Multidrug-Resistant Staphylococcus aureus and Anti-Inflammatory Capabilities for Accelerated Wound Healing.

Bing Xu, Penglong Wang, Haimin Lei, 2022, ACS applied materials & interfaces.

Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect.

Bing Xu, Penglong Wang, Haimin Lei, 2019, European journal of medicinal chemistry.

In vitro Evaluation of Antiviral Activity of Tea Seed Saponins against Porcine Reproductive and Respiratory Syndrome Virus

Haimin Lei, Junxing Zhao, Hongquan Li, 2015, Antiviral therapy.

Antiviral activities of natural compounds derived from traditional chinese medicines against porcine circovirus type 2 (PCV2)

Haimin Lei, Junxing Zhao, Hongquan Li, 2015, Biotechnology and Bioprocess Engineering.

Antiviral activity and underlying molecular mechanisms of Matrine against porcine reproductive and respiratory syndrome virus in vitro.

Haimin Lei, Hongquan Li, Jun-ping He, 2014, Research in veterinary science.

Review of Constituents and Biological Activities of Triterpene Saponins from Glycyrrhizae Radix et Rhizoma and Its Solubilization Characteristics

B. Liu, Tao Ma, Penglong Wang, 2020, Molecules.

Synthesis and biological activity of glycyrrhetinic acid derivatives as antitumor agents.

Feng Gao, Tao Ma, Bing Xu, 2019, European journal of medicinal chemistry.

Revealing the active ingredients of the traditional Chinese medicine decoction by the supramolecular strategies and multitechnologies.

Penglong Wang, Haimin Lei, Yaozhi Zhang, 2022, Journal of ethnopharmacology.

Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate.

Q. Ma, Penglong Wang, Haimin Lei, 2020, Journal of pharmaceutical and biomedical analysis.

Synergistic Effect of Berberine-Based Chinese Medicine Assembled Nanostructures on Diarrhea-Predominant Irritable Bowel Syndrome In Vivo

F. Gao, Siyuan Lv, Bing Xu, 2020, Frontiers in Pharmacology.

A new strategy based on acid-alkali complexation for rapidly and accurately fishing phytochemicals in Sennae Folium

Bing Xu, Penglong Wang, Haimin Lei, 2020, Chinese herbal medicines.

Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-induced Inhibiting Multidrug-Resistant Staphylococcus aureus.

Guangrui Huang, Bing Xu, Penglong Wang, 2019, ACS applied materials & interfaces.

In-vitro and in-vivo comparison of T-OA microemulsions and solid dispersions based on EPDC

Penglong Wang, Haimin Lei, P. Hou, 2015, Drug development and industrial pharmacy.

Preparation and Evaluation of Solid Dispersions of A New Antitumor Compound Based on Early-Stage Preparation Discovery Concept

Haimin Lei, Q. Tan, P. Hou, 2013, AAPS PharmSciTech.

Synthesis and biological activity evaluation of podophyllotoxin-linked bile acid derivatives as potential anti-liver cancer agents.

Bing Xu, Penglong Wang, Haimin Lei, 2022, Bioorganic chemistry.

Design, synthesis and cytotoxic evaluation of novel betulonic acid-diazine derivatives as potential antitumor agents

F. Gao, Yuzhong Zhang, Penglong Wang, 2022, Frontiers in Chemistry.

Explore bioactive ingredients and potential mechanism of Houpo Mahuang decoction for chronic bronchitis based on UHPLC-Q exactive orbitrap HRMS, network pharmacology, and experiment verification.

F. Gao, Nan Wang, Nan Wang, 2022, Journal of ethnopharmacology.

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis

Feng Gao, Yuzhong Zhang, Penglong Wang, 2019, Molecules.

Systems pharmacology and GC-MS metabolomics reveal the efficacy and mechanisms of zedoary oil on acute liver injury induced by oxidative stress.

Hongcai Shang, Haimin Lei, Jia Zheng, 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Natural Small-Molecule-Based Carrier-Free Self-Assembly Library Originated from Traditional Chinese Herbal Medicine

Penglong Wang, Haimin Lei, Xuehao Tian, 2022, ACS omega.

Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine

Penglong Wang, Haimin Lei, Yaozhi Zhang, 2022, Journal of nanobiotechnology.

Synthesis and biological evaluation of new peroxo-bridged diosgenin derivatives

J. Chen, Wenqiang Yan, Bing Xu, 2017 .

Post-Chromatographic Dicationic Ionic Liquid-Based Charge Complexation for Highly Sensitive Analysis of Anionic Compounds by Ultra-High-Performance Supercritical Fluid Chromatography Coupled with Electrospray Ionization Mass Spectrometry.

Q. Ma, Haimin Lei, H. Bai, 2020, Analytical chemistry.

Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents.

K. Fang, Tao Ma, Bing Xu, 2018, European journal of medicinal chemistry.

An Overview of Structurally Modified Glycyrrhetinic Acid Derivatives as Antitumor Agents

K. Fang, Bing Xu, Penglong Wang, 2017, Molecules.

PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates

Tao Ma, Bing Xu, Penglong Wang, 2018, International journal of molecular sciences.

Self-assembled nanoparticles of natural phytochemicals (berberine and 3,4,5-methoxycinnamic acid) originated from traditional Chinese medicine for inhibiting multidrug-resistant Staphylococcus aureus.

Bing Xu, Penglong Wang, Haimin Lei, 2020, Current drug delivery.

Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination

Tao Ma, Bing Xu, Penglong Wang, 2019, Acta pharmaceutica Sinica. B.

Novel Neuroprotective Lead Compound Ligustrazine Derivative Mass Spectrometry Fragmentation Rule and Metabolites in Rats by LC/LTQ-Orbitrap MS

K. Fang, Tao Ma, Penglong Wang, 2018, Molecules.

A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats

Yuzhong Zhang, Penglong Wang, Haimin Lei, 2015, International journal of molecular sciences.

Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia

Qiang Li, Penglong Wang, Haimin Lei, 2013, Chemistry Central Journal.

Chemical composition analysis of pomegranate seeds based on ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry.

Meng Chen, Q. Ma, Penglong Wang, 2020, Journal of pharmaceutical and biomedical analysis.

Multi-functional self-assembly nanoparticles originating from small molecule natural product for oral insulin delivery through modulating tight junctions

Bing Xu, Penglong Wang, Haimin Lei, 2022, Journal of Nanobiotechnology.

Combination of amino acid/dipeptide with ligustrazine-betulinic acid as antitumor agents.

Bing Xu, Fuhao Chu, Xin Xu, 2017, European journal of medicinal chemistry.

Identification of a Quality Marker of Vinegar-Processed Curcuma Zedoaria on Oxidative Liver Injury

Penglong Wang, Haimin Lei, J. Chen, 2019, Molecules.

Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents

K. Fang, Tao Ma, Penglong Wang, 2018, Molecules.

Natural Carrier-Free Binary Small Molecule Self-Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response.

Penglong Wang, Haimin Lei, Yaozhi Zhang, 2022, Small.

Oleanolic acid synthetic oligoglycosides: a review on recent progress in biological activities.

Fuhao Chu, Xin Xu, Penglong Wang, 2014, Die Pharmazie.

Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

Fuhao Chu, Yuzhong Zhang, Qiang Li, 2013, Molecules.

Berberine-Based Heterogeneous Linear Supramolecules Neutralized the Acute Nephrotoxicity of Aristolochic Acid by the Self-Assembly Strategy.

A. Xu, Guangrui Huang, Penglong Wang, 2021, ACS applied materials & interfaces.

Betulinic Acid-Nitrogen Heterocyclic Derivatives: Design, Synthesis, and Antitumor Evaluation in Vitro

Penglong Wang, Haimin Lei, Wen Li, 2020, Molecules.

New Synthesis Method for Sultone Derivatives: Synthesis, Crystal Structure and Biological Evaluation of S-CA

Wenqiang Yan, Bing Xu, Fuhao Chu, 2015, Molecules.

Synthesis and Biological Evaluation of New Ligustrazine Derivatives as Anti-Tumor Agents

Qiang Li, Xin Xu, Penglong Wang, 2012, Molecules.

Induction of apoptosis by an oleanolic acid derivative in SMMC-7721 human hepatocellular carcinoma cells is associated with mitochondrial dysfunction

Penglong Wang, Haimin Lei, Hongquan Li, 2017, Oncology letters.

Preparation and Evaluation of Solid Dispersions of A New Antitumor Compound Based on Early-Stage Preparation Discovery Concept

Haimin Lei, Q. Tan, P. Hou, 2013, AAPS PharmSciTech.

Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents

Bing Xu, Fuhao Chu, Yuzhong Zhang, 2014, Molecules.

The novel glycyrrhetinic acid-tetramethylpyrazine conjugate TOGA induces anti-hepatocarcinogenesis by inhibiting the effects of tumor-associated macrophages on tumor cells.

Zihui Xu, Bing Xu, Haimin Lei, 2020, Pharmacological research.

Impact of nonsteroidal aromatase inhibitors on steroid profile in a Chinese population

Tianqi Chen, Yanyi Xing, Bing Xu, 2017, Medicine.

BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation

N. Zhang, Wuwen Feng, Bing Xu, 2019, International journal of molecular sciences.

Oleanolic Acid-amino Acids Derivatives: Design, Synthesis, and Hepatoprotective Evaluation In Vitro and In Vivo

K. Fang, Fuhao Chu, Penglong Wang, 2018, Molecules.

Design and synthesis of novel anti-multidrug-resistant staphylococcus aureus derivatives of glycyrrhetinic acid by blocking arginine biosynthesis, metabolic and H2S biogenesis

F. Gao, Haimin Lei, Desheng Cai, 2022, Bioorganic Chemistry.

Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory and analgesic agent

F. Gao, Bing Xu, Haimin Lei, 2022, RSC advances.

Tetrahydropalmatine triggers angiogenesis via regulation of arginine biosynthesis.

Bing Xu, Penglong Wang, Haimin Lei, 2020, Pharmacological research.

A New Oleanolic Acid Derivative against CCl4-Induced Hepatic Fibrosis in Rats

Wenqiang Yan, Bing Xu, Fuhao Chu, 2017, International journal of molecular sciences.

Origin and Formation Mechanism Investigation of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang by Isothermal Titration Calorimetry

K. Fang, Yuzhong Zhang, Penglong Wang, 2017, Molecules.

Compositions, Formation Mechanism, and Neuroprotective Effect of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang

Wenqiang Yan, Yuzhong Zhang, Penglong Wang, 2016, Molecules.

Sodium tanshinone IIA sulfonate affects Marek’s disease virus replication by inhibiting gB expression

Haimin Lei, Jianqin Xu, Hongquan Li, 2016, Pharmaceutical biology.

[Determination of migration of perfluorooctanoic acid and perfluorooctane sulfonic acid from food contact materials by ionic liquid-based dispersive liquid-liquid microextraction and ultra-performance liquid chromatography-tandem mass spectrometry].

Q. Ma, Penglong Wang, Haimin Lei, 2018, Se pu = Chinese journal of chromatography.

Separation and analysis of flavonoid chemical constituents in flowers of Juglans regia L. by ultra‐high‐performance liquid chromatography‐hybrid quadrupole time‐of‐flight mass spectrometry

Q. Ma, Penglong Wang, Haimin Lei, 2019, Journal of pharmaceutical and biomedical analysis.

[A new saponin from Koelreuteria paniculata].

Wenhan Lin, Haimin Lei, D. Bai, 2007, Yao xue xue bao = Acta pharmaceutica Sinica.

Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents

Wenbo Guo, Bing Xu, Fuhao Chu, 2016, Chemistry Central Journal.

Design, Synthesis, and Cytotoxic Analysis of Novel Hederagenin–Pyrazine Derivatives Based on Partial Least Squares Discriminant Analysis

Meng Chen, K. Fang, Tao Ma, 2018, International journal of molecular sciences.

Preparation and physicochemical characterization of a solid dispersion of (3, 5, 6-trimethylpyrazin-2-yl) methyl 3-methoxy-4-[(3, 5, 6-trimethylpyrazin-2-yl) methoxy] benzoate (VA-T) and polyvinylpyrrolidone.

Xingbin Yin, Jian Ni, Haimin Lei, 2015, Chinese journal of natural medicines.

Neuroprotection by new ligustrazine-cinnamon acid derivatives on CoCl2-induced apoptosis in differentiated PC12 cells.

Wenqiang Yan, Bing Xu, Fuhao Chu, 2018, Bioorganic chemistry.

Synthesis and protective effect of new ligustrazine derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells. Part 2

Bing Xu, Fuhao Chu, Yuzhong Zhang, 2015 .

An overview on structural modifications of ligustrazine and biological evaluation of its synthetic derivatives

Fuhao Chu, Yuzhong Zhang, Xin Xu, 2015, Research on Chemical Intermediates.

Anti-tumor effects of novel alkannin derivatives with potent selectivity on comprehensive analysis

F. Gao, Bing Xu, Haimin Lei, 2023, Phytomedicine.

Integrative multi-omics unravels the amelioration effects of Zanthoxylum bungeanum Maxim. on non-alcoholic fatty liver disease.

Fuhao Chu, Penglong Wang, Haimin Lei, 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

A metal ions-mediated natural small molecules carrier-free injectable hydrogel achieving laser-mediated photo-Fenton-like anticancer therapy by synergy apoptosis/cuproptosis/anti-inflammation

Penglong Wang, Haimin Lei, Linying Wu, 2023, Bioactive Materials.

Natural small molecule self-assembled hydrogel inhibited tumor growth and lung metastasis of 4T1 breast cancer by regulating the CXCL1/2-S100A8/9 axis

Penglong Wang, Haimin Lei, Yaozhi Zhang, 2022, Materials & Design.

Baicalin ameliorates multidrug-resistant Pseudomonas aeruginosa induced pulmonary inflammation in rat via arginine biosynthesis.

Ying Lin, Yue Zhang, Wei Xie, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Protection of a new heptapeptide from Carapax trionycis against carbon tetrachloride-induced acute liver injury in mice.

Yuzhong Zhang, Qiang Li, Xin Xu, 2013, Chemical & pharmaceutical bulletin.

Design, synthesis and evaluation of new ligustrazine derivatives as potential plasma-stable neuroprotective agents.

Wenqiang Yan, Bing Xu, Yuzhong Zhang, 2017, MedChemComm.

The Anti-atherosclerosis Mechanism of Ziziphora clinopodioides Lam. Based On Network Pharmacology

Haimin Lei, Xue-Bo Yan, Dong-Qing An, 2023, Cell Biochemistry and Biophysics.

Synthesis and biological activity evaluation of novel peroxo-bridged derivatives as potential anti-hepatitis B virus agents.

Wenqiang Yan, Bing Xu, Fuhao Chu, 2017, MedChemComm.

Synthesis and biological evaluation of T-OA analogues as the cytotoxic agents

Fuhao Chu, Yuzhong Zhang, Xin Xu, 2015, Research on Chemical Intermediates.

Carrier-Free Binary Self-Assembled Nanomedicines Originated from Traditional Herb Medicine with Multifunction to Accelerate MRSA-Infected Wound Healing by Antibacterial, Anti-Inflammation and Promoting Angiogenesis

Penglong Wang, Haimin Lei, Yaozhi Zhang, 2023, International journal of nanomedicine.

Specificity and potency of curcumin derivative 64PH in inhibiting HepG2 human hepatocellular carcinoma cell proliferation

Jingguo Chen, Haimin Lei, Qiaowei Zheng, 2017 .