M. Collins

发表

Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.

L. Funk, P. Kung, J. Meng, 2008, Bioorganic & medicinal chemistry letters.

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.

M. Poss, D. Langley, K. Yeung, 2018, Angewandte Chemie.

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

A. Vaz, P. Baran, M. Collins, 2014, Journal of medicinal chemistry.

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines.

Julien C. Vantourout, J. Mousseau, Cian Kingston, 2019, Journal of the American Chemical Society.

Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.

Maximilian D Palkowitz, M. Poss, Simon Kolb, 2022, Journal of the American Chemical Society.

Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain expos

Wei Liu, Huichun Zhu, Dac Dinh, 2014, Journal of medicinal chemistry.

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.

M. Poss, D. Langley, K. Yeung, 2018, Angewandte Chemie.

Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant

Huichun Zhu, Benjamin J. Burke, John Charles Kath, 2014 .

Conformational Studies and Atropisomerism Kinetics of the ALK Clinical Candidate Lorlatinib (PF-06463922) and Desmethyl Congeners.

N. Sach, M. Collins, P. Richardson, 2016, Angewandte Chemie.

Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry.

M. Tran-Dube, J. Warmus, M. Collins, 2015, The Journal of organic chemistry.

Practical and innate C–H functionalization of heterocycles

N. Sach, P. Baran, M. Collins, 2012, Nature.

Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds

Lijie Sun, J. Mousseau, P. Baran, 2018, Science.

A new reagent for direct difluoromethylation.

D. Blackmond, P. Baran, M. Collins, 2012, Journal of the American Chemical Society.

Scalable, Chemoselective Ni-Electrocatalytic Sulfinylation of Aryl Halides with SO 2

P. Baran, M. Collins, T. Lou, 2022 .

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

N. Sach, W. Farrell, J. Mousseau, 2017, Journal of the American Chemical Society.

Strain-release amination

N. Sach, P. Baran, M. Collins, 2016, Science.

Hindered dialkyl ether synthesis with electrogenerated carbocations

D. Blackmond, P. Baran, M. Collins, 2019, Nature.

Intramolecular [2 + 2] cycloaddition and sequential ring expansion

Wei Zhang, M. Collins, P. Dowd, 1995 .

Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation.

P. Baran, M. Collins, Jason Ge, 2014, Angewandte Chemie.

Preparation and purification of zinc sulfinate reagents for drug discovery

P. Baran, M. Collins, Y. Ishihara, 2013, Nature Protocols.

C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase

P. Baran, M. Collins, Yuki Yabe, 2014, Journal of the American Chemical Society.

Development of a Late-Stage Diversification Strategy for the 4- and 5-Positions of 4,5,6-Trisubstituted Indazoles.

M. Tran-Dube, M. Collins, Fen Wang, 2020, Organic letters.

1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for ortho/meta-substituted arenes

Julien C. Vantourout, J. Mousseau, P. Baran, 2021, Proceedings of the National Academy of Sciences.

Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.

N. Sach, Hong Shen, M. McTigue, 2014, Journal of medicinal chemistry.

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquin

K. Gajiwala, N. Sach, P. Kung, 2017, Journal of medicinal chemistry.

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.

P. Kung, S. Yamazaki, M. Edwards, 2016, Journal of medicinal chemistry.

Design and Synthesis of Pyridone-Containing 3 , 4-Dihydroisoquinoline-1 ( 2 H ) ‐ ones as a Novel Class of Enhancer of Zeste Homolog 2 ( EZH 2 ) Inhibitors

P. Kung, S. Yamazaki, M. Edwards, 2016 .

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.

P. Kung, S. Yamazaki, M. Edwards, 2016, Journal of Medicinal Chemistry.

Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO2

P. Baran, M. Collins, T. Lou, 2022, Angewandte Chemie.

Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.

N. Sach, M. McTigue, Sergei L Timofeevski, 2023, Journal of medicinal chemistry.

Abstract PR10: Is CNS availability for oncology a no-brainer? Discovery of PF-06463922, a novel small molecule inhibitor of ALK/ROS1 with preclinical brain availability and broad spectrum potency against ALK-resistant mutations.

N. Sach, M. McTigue, H. Zou, 2013 .

A new reagent for direct difluoromethylation.

D. Blackmond, P. Baran, M. Collins, 2012, Journal of the American Chemical Society.

Rhodium(III)-Catalyzed C-H Activation: Ligand-Controlled Regioselective Synthesis of 4-Methyl-Substituted Dihydroisoquinolones.

N. Sach, M. Tran-Dube, M. Collins, 2019, Organic letters.

N. Sach, H. Zou, R. Kania, 2014 .