P. Czabotar

发表

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

Erinna F. Lee, W. D. Fairlie, Brian J. Smith, 2007, Cell Death and Differentiation.

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands*

Erinna F. Lee, W. D. Fairlie, Brian J. Smith, 2009, The Journal of Biological Chemistry.

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

Erinna F. Lee, W. D. Fairlie, A. Strasser, 2007, Science.

BCL-2 family antagonists for cancer therapy

P. Colman, P. Czabotar, G. Lessene, 2008, Nature Reviews Drug Discovery.

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

C. Scott, A. Roberts, S. Cory, 2006, Cancer cell.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

W. D. Fairlie, P. Colman, M. Perugini, 2008, Cell Death and Differentiation.

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.

W. D. Fairlie, Brian J. Smith, J. Baell, 2011, Journal of medicinal chemistry.

Structure-guided design of a selective BCL-X(L) inhibitor.

Brian J. Smith, J. Baell, P. Colman, 2013, Nature chemical biology.

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Peter E. Czabotar, A. Strasser, Jerry M. Adams, 2013, Nature Reviews Molecular Cell Biology.

The regulation of necroptosis by post-translational modifications

J. Sandow, P. Czabotar, James M. Murphy, 2021, Cell Death & Differentiation.

Studies of structural changes in the M2 proton channel of influenza A virus by tryptophan fluorescence.

Stephen R. Martin, A. Hay, P. Czabotar, 2004, Virus research.

VDAC2 and the BCL-2 family of proteins

G. Dewson, P. Czabotar, Zheng Yuan, 2021, Biochemical Society transactions.

Further insights into the effects of pre-organizing the BimBH3 helix.

Brian J. Smith, D. Huang, W. Fairbrother, 2014, ACS chemical biology.

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Erinna F. Lee, W. D. Fairlie, Peter M. Colman, 2013, Cell.

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.

C. Day, Jerry M. Adams, G. Dewson, 2009, Molecular cell.

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.

M. Wright, P. Colman, Jinhua Lu, 2012, Immunity.

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

J. Sandow, Cheree Fitzgibbon, J. Garnier, 2021, Nature Communications.

The Structural Basis of Necroptotic Cell Death Signaling.

P. Czabotar, James M. Murphy, E. Petrie, 2019, Trends in biochemical sciences.

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Brian J. Smith, J. Sandow, Weiwen Dai, 2018, Nature Communications.

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

A. M. Neale, G. Naselli, L. Harrison, 2018, Proceedings of the National Academy of Sciences.

Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.

T. Triglia, A. Cowman, W. Tham, 2022, Structure.

High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL.

Erinna F. Lee, W. D. Fairlie, Brian J. Smith, 2009, Angewandte Chemie.

Dynamic reconfiguration of pro‐apoptotic BAK on membranes

J. Sandow, G. Dewson, P. Czabotar, 2021, The EMBO journal.

BAK core dimers bind lipids and can be bridged by them

Eugene A. Kapp, Brian J. Smith, J. Gulbis, 2020, Nature Structural & Molecular Biology.

Structure of detergent-activated BAK dimers derived from the inert monomer.

Michelle S. Miller, P. Colman, Rachel T. Uren, 2021, Molecular cell.

Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies

A. Koide, S. Koide, J. Sandow, 2020, Proceedings of the National Academy of Sciences.

Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.

T. Triglia, A. Cowman, J. McCauley, 2021, Structure.

A new crystal form of GABARAPL2

G. Dewson, P. Czabotar, R. Birkinshaw, 2021, Acta crystallographica. Section F, Structural biology communications.

Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association.

E. Bordignon, I. Usón, P. Czabotar, 2020, Structure.

Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2.

Brian J. Smith, J. Baell, P. Colman, 2021, Journal of medicinal chemistry.

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

P. Colman, Rachel T. Uren, G. Dewson, 2014, Molecular cell.

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia.

E. Thompson, A. Roberts, D. Huang, 2018, Cancer discovery.

BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia.

I. Wicks, N. Huntington, A. Lew, 2021, Blood advances.

Relating SMCHD1 structure to its function in epigenetic silencing

M. Blewitt, P. Czabotar, James M. Murphy, 2020, Biochemical Society transactions.

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.

M. Dawson, A. Garnham, D. Huang, 2017, ACS medicinal chemistry letters.

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

M. Wright, A. Purcell, Meredith O'Keeffe, 2020, eLife.

Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling

Laura F. Dagley, J. Sandow, P. Czabotar, 2022, Cell Death & Disease.

Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes*

H. Bujard, A. Cowman, T. Tsuboi, 2016, The Journal of Biological Chemistry.

Identification of regions within the third FnIII-like domain of the IL-5Ralpha involved in IL-5 interaction.

P. Czabotar, C. Sanderson, J. Holland, 2000, Cytokine.

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

Brian J. Smith, M. Perugini, C. Dogovski, 2011, Archives of biochemistry and biophysics.

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.

Brian J. Smith, J. Baell, G. Nikolakopoulos, 2014, ACS medicinal chemistry letters.

Identification of residues involved in binding of IL5 to βcom using βIL3 and βcom chimeras

P. Czabotar, C. Sanderson, J. Holland, 1999 .

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

J. Silke, P. Czabotar, James M. Murphy, 2018, Cell Death & Differentiation.

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Erinna F. Lee, W. D. Fairlie, J. Baell, 2013, Journal of medicinal chemistry.

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

Brian J. Smith, T. Triglia, A. Cowman, 2015, Nature Structural &Molecular Biology.

Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis*

Erinna F. Lee, W. D. Fairlie, P. Colman, 2011, The Journal of Biological Chemistry.

Crystal Structure of the Entire Ectodomain of gp130

M. Pocock, D. Hilton, P. Czabotar, 2010, The Journal of Biological Chemistry.

Molecular biology of Bax and Bak activation and action.

G. Dewson, R. Kluck, P. Czabotar, 2011, Biochimica et biophysica acta.

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

Gerbrand J. van der Heden van Noort, H. Ovaa, J. Newman, 2020, The EMBO journal.

Mechanism and inhibition of SARS-CoV-2 PLpro

H. Ovaa, J. Newman, D. Komander, 2020, bioRxiv.

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

A. Strasser, A. Delbridge, L. Whitehead, 2018, Cell.

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.

Erinna F. Lee, W. D. Fairlie, Brian J. Smith, 2017, Molecular cell.

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition

M. Perugini, R. Dobson, J. Gerrard, 2013, Plant Molecular Biology.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Toru Okamoto, Renwick C J Dobson, Donald Metcalf, 2013, Immunity.

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

Cheree Fitzgibbon, J. Hildebrand, P. Gooley, 2021, Cell Death & Differentiation.

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

A. Koide, S. Koide, N. Kannan, 2021, Nature Communications.

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Erinna F. Lee, Laura F. Dagley, P. Colman, 2019, Nature Chemical Biology.

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Erinna F. Lee, P. Colman, P. Bouillet, 2008, The Journal of cell biology.

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Erinna F. Lee, Brian J. Smith, P. Colman, 2007, Proceedings of the National Academy of Sciences.

Cell death and the mitochondria: therapeutic targeting of the BCL‐2 family‐driven pathway

P. Czabotar, G. Lessene, A. Vom, 2014, British journal of pharmacology.

The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs

A. Strasser, P. Czabotar, G. Lessene, 2021, Nature Reviews Cancer.

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Erinna F. Lee, Brian J. Smith, P. Colman, 2016, Genes & development.

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation.

P. Czabotar, R. Birkinshaw, 2017, Seminars in cell & developmental biology.

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

W. Alexander, R. Dobson, A. Wilks, 2014, Proceedings of the National Academy of Sciences.

Potent inhibition of Necroptosis by simultaneously targeting multiple effectors of the pathway.

Cheree Fitzgibbon, J. Hildebrand, J. Silke, 2020, ACS chemical biology.

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Brian J. Smith, J. Sandow, Weiwen Dai, 2018, Nature Communications.

Evolutionary divergence of the necroptosis effector MLKL

D. Vaux, J. Murphy, J. Hildebrand, 2016, Cell Death and Differentiation.

From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors

Ying Zhang, P. Czabotar, G. Lessene, 2023, Journal of medicinal chemistry.

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

W. Patrick, N. Kannan, J. Sandow, 2020, Nature Communications.

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Victoria E. Jackson, M. Brown, J. Reveille, 2020, Nature Communications.

Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

Matthew E. Ritchie, Sarah A Kessans, G. Kay, 2015, Proceedings of the National Academy of Sciences.

Cytosolic Bax

C. Borner, N. Raulf, U. Maurer, 2012, Journal of Biological Chemistry.

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.

P. Colman, S. Yao, Jerry M. Adams, 2014, Archives of biochemistry and biophysics.

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

N. Kannan, J. Sandow, Cheree Fitzgibbon, 2020, Nature Communications.

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins.

T. Moldoveanu, P. Czabotar, 2019, Cold Spring Harbor perspectives in biology.

Ensemble Properties of Bax Determine Its Function.

P. Colman, J. Sandow, R. Kluck, 2018, Structure.

Bax activation by Bim?

P. Colman, P. Czabotar, D. Huang, 2009, Cell Death and Differentiation.

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

J. Sandow, G. Dewson, M. Lazarou, 2019, The EMBO journal.

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

Brian J. Smith, D. Huang, W. Fairbrother, 2013, ACS chemical biology.

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

P. Colman, A. Roberts, D. Huang, 2019, Nature Communications.

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

P. Colman, D. Huang, I. Majewski, 2019, Nature Communications.

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax

Erinna F. Lee, M. Hinds, G. Dewson, 2015, Cell Death and Disease.

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum*

Brian J. Smith, A. Cowman, O. Clarke, 2012, The Journal of Biological Chemistry.

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues

J. Sandow, M. Blewitt, T. Willson, 2020, Science Signaling.

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Brian J. Smith, C. Tse, A. Petros, 2014, ACS medicinal chemistry letters.

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.

Brian J Smith, Nathan Toovey, Jonathan B Baell, 2014, Journal of medicinal chemistry.

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

A. Cowman, W. Wong, P. Barlow, 2019, Cellular microbiology.

Multiple BCL2 mutations co-occurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax.

E. Thompson, A. Roberts, D. Huang, 2020, Blood.

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Brian J. Smith, M. Ménard, Jerry M. Adams, 2014, Proceedings of the National Academy of Sciences.

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

E. Thompson, A. Roberts, D. Huang, 2019, British journal of haematology.

Evidence That Focal Adhesion Complexes Power Bacterial Gliding Motility

Erinna F. Lee, Peter E. Czabotar, A. Strasser, 2022 .

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.

W. Alexander, J. Hildebrand, J. Silke, 2014, The Biochemical journal.

The hinge domain of the epigenetic repressor Smchd1 adopts an unconventional homodimeric configuration.

M. Blewitt, P. Czabotar, James M. Murphy, 2016, The Biochemical journal.

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

J. Newman, D. Komander, B. C. Lechtenberg, 2022, Frontiers in Chemistry.

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.

A. Woods, D. Zaller, D. Hilton, 2013, Biochemical Journal.

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation

Michelle S. Miller, Brian J. Smith, P. Colman, 2022, Cell Death & Differentiation.

Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

Christopher J. Tonkin, A. Cowman, J. Sandow, 2018, Nature.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

Detection of Multiple Recurrent Novel BCL2 Mutations Co-Occurring with BCL2 Gly101Val in Patients with Chronic Lymphocytic Leukemia on Long Term Venetoclax

E. Thompson, A. Roberts, D. Huang, 2019, Blood.

Yeast- and antibody-based tools for studying tryptophan C-mannosylation

Nichollas E. Scott, A. Lo, P. Czabotar, 2021, Nature Chemical Biology.

Crystal structure of Bcl-xL in complex with ABT-737

Erinna F. Lee, Brian J. Smith, P. Colman, 2007 .

Bcl-2 family proteins as therapeutic targets.

P. Czabotar, G. Lessene, 2010, Current pharmaceutical design.

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

J. Silke, P. Czabotar, James M. Murphy, 2018, Cell Death & Differentiation.

Preparing Samples for Crystallization of Bcl-2 Family Complexes.

P. Czabotar, M. Kvansakul, 2016, Methods in molecular biology.

Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

Christopher J. Tonkin, A. Cowman, J. Sandow, 2018, Nature.

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

P. Colman, G. Dewson, P. Czabotar, 2015, Cell Death and Disease.

A tale of two domains – a structural perspective of the pseudokinase, MLKL

P. Czabotar, James M. Murphy, Peter E. Czabotar, 2015, The FEBS journal.

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface

I. Wicks, S. Masters, D. De Nardo, 2018, The Journal of allergy and clinical immunology.

Structural plasticity underpins promiscuous binding of the prosurvival protein A1.

M. Hinds, C. Day, P. Czabotar, 2008, Structure.

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics.

A. Cowman, Jenn K Thompson, P. Czabotar, 2018, European journal of medicinal chemistry.

Supplemental Data Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

C. Day, Jerry M. Adams, G. Dewson, 2008 .

Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly.

Shane A. Seabrook, W. Im, J. Newman, 2015, Cell reports.

Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

Christopher J. Tonkin, A. Cowman, J. Sandow, 2018, Nature.

The Merozoite Surface Protein 1 Complex Is a Platform for Binding to Human Erythrocytes by Plasmodium falciparum*

H. Bujard, A. Cowman, M. Perugini, 2014, The Journal of Biological Chemistry.

Mechanisms of BCL-2 family proteins in mitochondrial apoptosis

A. García-Sáez, P. Czabotar, 2023, Nature Reviews Molecular Cell Biology.

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

A. Strasser, W. Alexander, D. Hilton, 2013, Immunity.

Characterisation of a novel A1-specific monoclonal antibody

P. Czabotar, M. Herold, Margs S. Brennan, 2014, Cell Death and Disease.

Molecular biology of Bax and Bak activation and action.

G. Dewson, R. Kluck, P. Czabotar, 2011, Biochimica et biophysica acta.

Cytosolic Bax

C. Borner, N. Raulf, U. Maurer, 2012, The Journal of Biological Chemistry.

Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization

Laura F. Dagley, A. Koide, S. Koide, 2023, Nature communications.

Preparing Samples for Crystallization of Bcl-2 Family Complexes.

P. Czabotar, M. Kvansakul, 2016, Methods in molecular biology.

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition

M. Perugini, R. Dobson, J. Gerrard, 2013, Plant Molecular Biology.

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

P. Colman, Rachel T. Uren, G. Dewson, 2014, Molecular cell.

Death at a funeral: Activation of the dead enzyme, MLKL, to kill cells by necroptosis.

P. Czabotar, K. Davies, James M. Murphy, 2024, Current opinion in structural biology.

The hinge domain of the epigenetic repressor Smchd1 adopts an unconventional homodimeric configuration.

M. Blewitt, P. Czabotar, James M. Murphy, 2016, The Biochemical journal.

Determination of Pseudokinase-ligand Interaction by a Fluorescence-based Thermal Shift Assay

J. Silke, P. Czabotar, N. Nicola, 2014 .

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Brian J. Smith, Jerry M. Adams, G. Dewson, 2014, Proceedings of the National Academy of Sciences.