K. Zobel

发表

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

Erinna F. Lee, W. D. Fairlie, Brian J. Smith, 2007, Cell Death and Differentiation.

Structure-guided design of a selective BCL-X(L) inhibitor.

Brian J. Smith, J. Baell, P. Colman, 2013, Nature chemical biology.

Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors

H. Maecker, K. Deshayes, K. Zobel, 2012, Science Signaling.

MAPK Activation by Members of the TNF Family of Receptors Cellular Inhibitors of Apoptosis Are Global Regulators

H. Maecker, K. Deshayes, K. Zobel, 2012 .

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Vishva M. Dixit, V. Dixit, J. Blankenship, 2007, Cell.

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation*

W. Fairbrother, K. Deshayes, K. Zobel, 2008, Journal of Biological Chemistry.

Phosphate ester serum albumin affinity tags greatly improve peptide half-life in vivo.

D. Combs, M. Beresini, K. Zobel, 2003, Bioorganic & medicinal chemistry letters.

Further insights into the effects of pre-organizing the BimBH3 helix.

Brian J. Smith, D. Huang, W. Fairbrother, 2014, ACS chemical biology.

X Chromosome-linked Inhibitor of Apoptosis Regulates Cell Death Induction by Proapoptotic Receptor Agonists

A. Ashkenazi, W. Fairbrother, H. Wong, 2009, The Journal of Biological Chemistry.

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

S. Hymowitz, A. M. Giannetti, W. Fairbrother, 2011, Science.

Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.

N. Skelton, K. Deshayes, A. Cochran, 2001, Biochemistry.

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

A. Schier, M. Bertrand, P. Vandenabeele, 2011, Neoplasia.

Selective Inhibitors of G2019S-LRRK2 Kinase Activity.

H. Carlisle, J. Bright, K. Zobel, 2020, Journal of medicinal chemistry.

cIAP 1 and TAK 1 Protect Cells from TNF-induced Necrosis by Preventing RIP 1 / RIP 3-Dependent Reactive Oxygen Species Production

Pieter, P. Vandenabeele, N. Vanlangenakker, 2018 .

Albumin affinity tags increase peptide half-life in vivo.

D. Combs, R. Lazarus, M. Beresini, 2002, Bioorganic & medicinal chemistry letters.

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

S. Hymowitz, W. Fairbrother, K. Deshayes, 2009, ACS chemical biology.

c-IAP1 AND c-IAP2 ARE CRITICAL MEDIATORS OF TNF α -INDUCED NF- κ B ACTIVATION

W. Fairbrother, K. Deshayes, K. Zobel, 2008 .

Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.

S. Fulda, K. Deshayes, K. Debatin, 2011, Neoplasia.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Zhaoyang Wen, Brigitte Maurer, Vickie Tsui, 2012, Journal of medicinal chemistry.

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

M. Bertrand, P. Vandenabeele, S. Fulda, 2011, Cell Death and Differentiation.

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Vishva M Dixit, V. Dixit, J. Blankenship, 2007, Cell.

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Melinda M. Mulvihill, J. DeVoss, W. Fairbrother, 2018, Molecular cell.

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

D. Arnott, J. Blankenship, W. Fairbrother, 2009, The Biochemical journal.

Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner

S. Fulda, K. Deshayes, K. Debatin, 2013, Oncogene.

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

Brian J. Smith, D. Huang, W. Fairbrother, 2013, ACS chemical biology.

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Brian J. Smith, C. Tse, A. Petros, 2014, ACS medicinal chemistry letters.

The development of peptide-based tools for the analysis of angiogenesis.

Judith E. Flores, K. Deshayes, Simon-Peter Williams, 2011, Chemistry & biology.

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

L. Bullinger, K. Döhner, R. Schlenk, 2016, Oncotarget.

Origins of PDZ Domain Ligand Specificity

Sachdev S Sidhu, Nicholas J Skelton, S. Sidhu, 2003, The Journal of Biological Chemistry.

Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins*

Erinna F. Lee, P. Colman, M. Perugini, 2009, The Journal of Biological Chemistry.

Crystal structure of Bcl-xL in complex with ABT-737

Erinna F. Lee, Brian J. Smith, P. Colman, 2007 .

Internal motions prime cIAP1 for rapid activation

T. Matsui, T. Weiss, J. Blankenship, 2014, Nature Structural &Molecular Biology.

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

W. Fairbrother, K. Deshayes, K. Zobel, 2006, ACS chemical biology.

Limitations to the application of molecularly targeted cancer therapies are the inability to accurately match patient with effective treatment and the absence of a prompt readout of posttreatment response

Judith E. Flores, K. Deshayes, Simon-Peter Williams, 2011 .