Xiangqian Li

发表

Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.

Zhiyong Wu, Yingang Feng, Zhichao Zhang, 2013, European journal of medicinal chemistry.

Highly E-Selective Synthesis of α-Fluoro-β-arylalkenyl Sulfones from gem-Difluoroalkenes with Sodium Sulfinates.

Xiangqian Li, Yuxiu Li, Xiaowei Li, 2021, The Journal of organic chemistry.

An anthraquinone scaffold for putative, two-face Bim BH3 α-helix mimic.

Yingang Feng, Zhichao Zhang, T. Song, 2012, Journal of medicinal chemistry.

Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.

Xiangqian Li, B. Jiang, Dayong Shi, 2018, European journal of medicinal chemistry.

Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides

Meiling Zheng, Xiangqian Li, B. Jiang, 2020, British Journal of Pharmacology.

Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.

C. Li, Xiangqian Li, Dayong Shi, 2019, Molecular pharmaceutics.

Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor

Xiangqian Li, B. Jiang, Dayong Shi, 2017, British journal of pharmacology.

Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition

Xiangqian Li, B. Jiang, Dayong Shi, 2015, Marine drugs.

Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors.

C. Li, Xiangqian Li, B. Jiang, 2018, Bioorganic & medicinal chemistry letters.

A Unified Approach for Divergent Synthesis of Heterocycles via TMSOTf‐Catalyzed Formal [3+2] Cycloaddition of Electron‐Rich Alkynes

Xiangqian Li, Dayong Shi, Ping-Fan Chen, 2021, Advanced Synthesis & Catalysis.

Visible-light-promoted E-selective synthesis of α-fluoro-β-arylalkenyl sulfides via the deoxygenation/isomerization process.

Xiangqian Li, Yuxiu Li, Xiaowei Li, 2021, Chemical communications.

Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

Xiangqian Li, Xiaowei Li, Dayong Shi, 2019, Front. Chem..

Visible‐Light‐Promoted Oxy‐difluoroalkylation of Aryl Alkynes for the Synthesis of β ‐Fluoroenones and α ‐Difluoroalkyl Ketones

Xiangqian Li, Dayong Shi, Zhong Zhang, 2021 .

Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination.

Yingang Feng, Zhichao Zhang, T. Song, 2016, Angewandte Chemie.

Toward a Treatment of Cancer: Design and In Vitro/In Vivo Evaluation of Uncharged Pyrazoline Derivatives as a Series of Novel SHP2 Inhibitors

F. Liu, Xiangqian Li, T. Shi, 2022, International journal of molecular sciences.

Inhibitor binding sites in the protein tyrosine phosphatase SHP-2.

C. Meng, Zhengquan Gao, Xiangqian Li, 2020, Mini reviews in medicinal chemistry.

Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.

Zhiyong Wu, Zhichao Zhang, T. Song, 2013, European journal of medicinal chemistry.

Novel Mcl‐1/Bcl‐2 Dual Inhibitors Created by the Structure‐Based Hybridization of Drug‐Divided Building Blocks and a Fragment Deconstructed from a Known Two‐Face BH3 Mimetic

Zhichao Zhang, T. Song, Xiangqian Li, 2015, Archiv der Pharmazie.

Discovery of Novel Bromophenol-Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer.

Xiangqian Li, B. Jiang, Dayong Shi, 2019, Journal of medicinal chemistry.

Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects

Xiangqian Li, B. Jiang, Dayong Shi, 2015, International journal of molecular sciences.

Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking.

Zhichao Zhang, T. Song, Xiangqian Li, 2013, European journal of medicinal chemistry.

Visible light–initiated radical 1,3-difunctionalization of β,γ-unsaturated ketones

Xiangqian Li, Chenyang Zhao, Dayong Shi, 2022, Science advances.

AcOH-mediated aerobic oxidative synthesis of 2-thioalkylbenzothiazoles via a three-component reaction

Xiangqian Li, Yuxiu Li, Xiaowei Li, 2020, Tetrahedron Letters.

Nickel-Catalyzed Stereoselective Cascade C–F Functionalizations of gem-Difluoroalkenes

Xiangqian Li, Hongyun Qin, Yuxiu Li, 2023, ACS Catalysis.

Two‐Face, Two‐Turn α‐Helix Mimetics Based on a Cross‐Acridine Scaffold: Analogues of the Bim BH3 Domain

Chen Chen, Yingang Feng, Zhichao Zhang, 2014, Chembiochem : a European journal of chemical biology.

Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B.

Xiangqian Li, B. Jiang, Dayong Shi, 2017, European journal of medicinal chemistry.

Nickel-Catalyzed Arylation of C(sp3)-O Bonds in Allylic Alkyl Ethers with Organoboron Compounds.

Xiangqian Li, Yuxiu Li, Xiaowei Li, 2021, Organic letters.

Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents

Xiangqian Li, Meng Yang, B. Jiang, 2015, Marine drugs.

Rational Multitargeted Drug Design Strategy from the Perspective of a Medicinal Chemist.

S. Li, F. Liu, Xiangqian Li, 2021, Journal of medicinal chemistry.

Recent advances in transition-metal-catalyzed incorporation of fluorine-containing groups

Xiangqian Li, Xiaowei Li, Dayong Shi, 2019, Beilstein journal of organic chemistry.

Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review.

Xiangqian Li, B. Jiang, Dayong Shi, 2017, Mini-Reviews in Medical Chemistry.

Pan‐BH3 Mimetic S1 Exhibits Broad‐Spectrum Antitumour Effects by Cooperation between Bax and Bak

Zhichao Zhang, T. Song, Xiangqian Li, 2013, Basic & clinical pharmacology & toxicology.

3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.

Zhiyong Wu, Yingang Feng, Zhichao Zhang, 2013, Bioorganic & medicinal chemistry.

A novel fluorinated thiosemicarbazone derivative- 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway.

Xiangqian Li, B. Jiang, Dayong Shi, 2017, Biochemical and biophysical research communications.

Discovery of a Small‐Molecule pBcl‐2 Inhibitor that Overcomes pBcl‐2‐Mediated Resistance to Apoptosis

Zhichao Zhang, T. Song, Xiangqian Li, 2015, Chembiochem : a European journal of chemical biology.

A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway

Xiangqian Li, B. Jiang, Dayong Shi, 2018, Marine drugs.

16S rRNA Sequencing and Metagenomics Study of Gut Microbiota: Implications of BDB on Type 2 Diabetes Mellitus

Xiangqian Li, Dayong Shi, Jiao Luo, 2020, Marine drugs.

The design strategy of selective PTP1B inhibitors over TCPTP.

Xiangqian Li, Dayong Shi, XiangQian Li, 2016, Bioorganic & medicinal chemistry.

Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway

Huaizhi Wang, Xiangqian Li, B. Jiang, 2019, Cell Death & Disease.

Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation

Xiangqian Li, B. Jiang, Dayong Shi, 2017, Marine Drugs.

Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment.

C. Li, Xiangqian Li, B. Jiang, 2019, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety

Xiangqian Li, B. Jiang, Dayong Shi, 2015 .

Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.

C. Li, Xiangqian Li, B. Jiang, 2019, European journal of medicinal chemistry.

Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2.

Zhichao Zhang, T. Song, Xiangqian Li, 2014, Bioorganic & medicinal chemistry.

Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.

Xiangqian Li, B. Jiang, Dayong Shi, 2017, European journal of medicinal chemistry.

Corrigendum to “3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1” [Bioorg. Med. Chem. 21 (2013) 11–20]

Yingang Feng, Zhichao Zhang, T. Song, 2014 .

Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.

Zhiyong Wu, Yingang Feng, Zhichao Zhang, 2013, European journal of medicinal chemistry.