Hequan Yao

发表

Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.

J. Xu, Xiao-ming Wu, H. Cai, 2016, European journal of medicinal chemistry.

Efficient palladium(II)-catalyzed homocoupling of thiazole-4-carboxylic or oxazole-4-carboxylic derivatives

Xiao-ming Wu, Yue Huang, Hequan Yao, 2011 .

Library Construction and Biological Evaluation of Enmein‐Type Diterpenoid Analogues as Potential Anticancer Agents

Xiao-ming Wu, H. Cai, Shengtao Xu, 2013, ChemMedChem.

Development and strategies of CDK4/6 inhibitors.

Hequan Yao, Kejiang Lin, Pingping Chen, 2019, Future medicinal chemistry.

Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives.

Xiao-ming Wu, H. Cai, Shengtao Xu, 2014, Bioorganic & medicinal chemistry letters.

Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine.

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2015, Organic & biomolecular chemistry.

Pd(II)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage.

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2012, Chemical communications.

Palladium(II)-catalyzed oxidative Heck coupling of thiazole-4-carboxylates

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2011 .

Rh(III)-catalyzed cyclization reaction of azoles with alkynes: efficient synthesis of azole-fused-pyridines.

Yue Huang, Hequan Yao, Jinyi Xu, 2015, Organic & biomolecular chemistry.

6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents.

Zhe-Sheng Chen, Shengtao Xu, Hequan Yao, 2017, Journal of natural products.

Controllable Pd-Catalyzed Allylation of Indoles with Skipped Enynes: Divergent Synthesis of Indolenines and N-Allylindoles.

Hequan Yao, A. Lin, Xinxin Fang, 2018, Organic letters.

A novel synthetic approach to the bicyclo[5.3.1]undecan-11-one framework of vinigrol.

Hequan Yao, G. Lin, Bingfeng Sun, 2014, Organic & biomolecular chemistry.

Synthesis, Biological Evaluation of Fluorescent 23-Hydroxybetulinic Acid Probes, and Their Cellular Localization Studies.

W. Ye, Xiao-ming Wu, Shengtao Xu, 2018, ACS medicinal chemistry letters.

Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents.

Shengtao Xu, Hequan Yao, Jinyi Xu, 2017, European journal of medicinal chemistry.

Novel and Potent Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease from Natural (±)-7,8-Dihydroxy-3-methyl-isochroman-4-one

Pengfei Zhang, Hequan Yao, Jinyi Xu, 2022, Molecules.

Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells

Hequan Yao, Yijun Chen, Shuzhen Wang, 2018, Scientific Reports.

Characteristics of parathyroid hormone-1 receptor agonists and antagonists.

Hequan Yao, Kejiang Lin, Xuanyi Li, 2019, Future medicinal chemistry.

Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.

Shengtao Xu, Hequan Yao, Jinyi Xu, 2019, European journal of medicinal chemistry.

Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.

Honghao Sun, Shengtao Xu, Hequan Yao, 2018, European journal of medicinal chemistry.

Recent developments in peptide macrocyclization

Jie Wu, Hequan Yao, Jian Tang, 2018 .

Organocatalytic 1,5-trifluoromethylthio-sulfonylation of vinylcyclopropane mediated by visible light in the water phase

Hequan Yao, Jinyi Xu, Hong Yao, 2020 .

Identification of a Potent Oridonin Analog for Treatment of Triple-Negative Breast Cancer.

Zhe-Sheng Chen, Dong-Hua Yang, Shengtao Xu, 2020, Journal of medicinal chemistry.

Synthesis and biological evaluation of ambradiolic acid as an inhibitor of glycogen phosphorylase.

W. Ye, Xiao-ming Wu, Jieyun Jiang, 2015, Fitoterapia.

Targeting the TGF-β signaling pathway for fibrosis therapy: a patent review (2015–2020)

Hequan Yao, Yinqiu Xu, Xuanyi Li, 2021, Expert opinion on therapeutic patents.

Synthesis and β-adrenergic blocking activity of oxime ether hybrids derived from a natural isochroman-4-one.

Xiao-ming Wu, Hequan Yao, Yi-qun Tang, 2013, Chinese journal of natural medicines.

Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors

Sheng Jiang, Hequan Yao, Jinyi Xu, 2011, Molecules.

Suppression of endothelial cell adhesion by XJP-1, a new phenolic compound derived from banana peel.

Q. Guo, Xiao-ming Wu, Hequan Yao, 2012, Vascular pharmacology.

Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates.

Zhe-Sheng Chen, Xiao-ming Wu, Shengtao Xu, 2014, ACS medicinal chemistry letters.

Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria.

Zhe-Sheng Chen, Dong-Hua Yang, Shanshan Luo, 2016, Journal of medicinal chemistry.

Nickel-Catalyzed Reductive 1,2-Dialkynylation of Alkenes Bearing an 8-Aminoquinoline Directing Group.

Hequan Yao, A. Lin, Songjin Guo, 2019, Organic letters.

Copper-catalyzed [3 + 2] annulation of ethynyl epoxides with malononitrile to access highly substituted dihydrofurans with an all-carbon quaternary stereocenter

Yue Huang, Hequan Yao, Xuanyi Li, 2019, Organic Chemistry Frontiers.

An approach to unsymmetrical 3,3′-diindolylmethanes through Pd-catalyzed cascade Heck cyclization of allenamides and o-ethynylanilines

Jiayi Chen, Hequan Yao, A. Lin, 2021 .

Copper(II)-catalyzed oxidation of 4-carboxythiazolines and 4-carboxyoxazolines to 4-carboxythiazoles and 4-carboxyoxazoles

Xiao-ming Wu, Yue Huang, Hequan Yao, 2011 .

Environmental-benign oxidation of 2-oxazolines to oxazoles by dioxygen as the sole oxidant

Xiao-ming Wu, Yue Huang, Hequan Yao, 2011 .

Palladium-Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes.

Hequan Yao, A. Lin, Zhenbo Yuan, 2019, Angewandte Chemie.

Palladium-catalyzed asymmetric carbamoyl-carbonylation of alkenes

Hequan Yao, A. Lin, Qiu-Xiao Li, 2021, Science China Chemistry.

Recent Advances on Construction of Pyrrolophenanthridone Skeleton

Hequan Yao, Jinyi Xu, Wei Cong, 2014 .

Discovery of novel hybrids containing clioquinol-1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease.

Pengfei Zhang, Hequan Yao, Jinyi Xu, 2022, European journal of medicinal chemistry.

Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives.

Xiao-ming Wu, H. Cai, Shengtao Xu, 2014, Fitoterapia.

Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives.

Hequan Yao, Jinyi Xu, Jing Shang, 2014, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of 1,2,4-triazole bearing 5-substituted biphenyl-2-sulfonamide derivatives as potential antihypertensive candidates.

Xiao-ming Wu, Shengtao Xu, Jieyun Jiang, 2013, Bioorganic & medicinal chemistry.

Targeting the LPA1 signaling pathway for fibrosis therapy: a patent review (2010-present)

Hequan Yao, Kejiang Lin, Xuanyi Li, 2022, Expert opinion on therapeutic patents.

Discovery of trans-3-(pyridin-3-yl)acrylamide-derived sulfamides as potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors for the potential treatment of cancer.

Kuojun Zhang, Zheng-chao Tu, Dong Chen, 2019, Bioorganic & medicinal chemistry letters.

Palladium-Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes.

Hequan Yao, A. Lin, Zhenbo Yuan, 2019, Angewandte Chemie.

Palladium-Catalyzed Remote 1,n-Arylamination of Unactivated Terminal Alkenes

Hequan Yao, A. Lin, Xinxin Fang, 2019, ACS Catalysis.

Nigegladines A-C, Three Thymoquinone Dimers from Nigella glandulifera.

Hequan Yao, Jie Tian, Xiaobing Wang, 2017, Organic letters.

Synthesis of A B C-ring subunit of C-nor-D-homo-steroidal alkaloids: towards the total synthesis of cyclopamine.

Hequan Yao, Lingyi Kong, Hong Bin Sun, 2013, Chinese journal of natural medicines.

Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Hequan Yao, Jinyi Xu, Yilin Jia, 2022, ACS chemical neuroscience.

Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents.

Luyong Zhang, Jun O. Liu, Hongbin Sun, 2012, Bioorganic & medicinal chemistry letters.

Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H2O2-Induced Apoptosis.

Shengtao Xu, Hequan Yao, Jinyi Xu, 2017, ACS medicinal chemistry letters.

Copper-catalyzed C5-selective thio/selenocyanation of 8-aminoquinolines

Hequan Yao, Jinyi Xu, Tongen Wang, 2017 .

Palladium-Catalyzed Cascade Heck Cyclization To Access Bisindoles.

Jiayi Chen, Hequan Yao, A. Lin, 2018, Organic letters.

A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway.

Zhe-Sheng Chen, Dong-Hua Yang, Shanshan Luo, 2017, Journal of medicinal chemistry.

The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents.

Yihua Zhang, H. Cai, Shengtao Xu, 2012, European journal of medicinal chemistry.

Synthesis and Anti-tumor Activity of 14-O-Derivatives of Natural Oridonin

Luyong Zhang, Yihua Zhang, Hequan Yao, 2011 .

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.

Guangyu Wang, Shengtao Xu, Hequan Yao, 2019, European journal of medicinal chemistry.

Palladium-Catalyzed Hydroalkylation of Alkynes with Cyclopropanols: Access to γ,δ-Unsaturated Ketones

Shang Gao, Yue Huang, Hequan Yao, 2018, Advanced Synthesis & Catalysis.

Controllable Rh(III)-Catalyzed Annulation between Salicylaldehydes and Diazo Compounds: Divergent Synthesis of Chromones and Benzofurans.

Shang Gao, Hequan Yao, P. Sun, 2016, Organic letters.

Intramolecular Remote C-H Activation via Sequential 1,4-Palladium Migration To Access Fused Polycycles.

Hequan Yao, H. Weng, A. Lin, 2019, Organic letters.

Cu(i)-Catalyzed oxidative homo-coupling of thiazoline-4-carboxylates: synthesis of 4,4'-bithiazoline derivatives.

Yue Huang, Hequan Yao, Xinxin Fang, 2016, Organic & biomolecular chemistry.

Rh(III)-Catalyzed synthesis of pyrazolo[1,2-a]cinnolines from pyrazolidinones and diazo compounds

Jiayi Chen, Hequan Yao, A. Lin, 2018 .

Rh(III)-Catalyzed Cascade Annulation/C-H Activation of o-Ethynylanilines with Diazo Compounds: One-Pot Synthesis of Benzo[a]carbazoles via 1,4-Rhodium Migration.

Hequan Yao, A. Lin, Meng Gu, 2016, Organic letters.

Rh(III)-Catalyzed Redox-Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones.

Hequan Yao, Peng Sun, A. Lin, 2016, The Journal of organic chemistry.

Multiple Roles of the Pyrimidyl Group in the Rhodium‐Catalyzed Regioselective Synthesis and Functionalization of Indole‐3‐carboxylic Acid Esters

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2016 .

Rh(III)-catalyzed redox-neutral annulation of azo and diazo compounds: one-step access to cinnolines

Xiao-ming Wu, Yue Huang, Hequan Yao, 2016 .

Synthesis of Heterocycle-fused Pyridine N-Oxides from Oximes and Diazo Compounds via RhIII-Catalyzed CH Activation and Annulation

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2015 .

Solvent-controlled switchable C-H alkenylation of 4-aryl-1H-pyrrole-3-carboxylates: application to the total synthesis of (±)-rhazinilam.

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2014, Organic letters.

1,6-Conjugated addition-mediated [4 + 1] annulation: an approach to 2,3-dihydrobenzofurans

Yue Huang, Hequan Yao, A. Lin, 2018 .

Aryl–aryl coupling via palladium-catalyzed C–P/C–H bond cleavage

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2013 .

Site-Selective Palladium-Catalyzed 1,1-Arylamination of Terminal Alkenes

Hequan Yao, A. Lin, Qiu-Xiao Li, 2021, CCS Chemistry.

Organocatalyzed [3 + 2] Annulation of Cyclopropenones and β-Ketoesters: An Approach to Substituted Butenolides with a Quaternary Center.

Hequan Yao, Xuanyi Li, A. Lin, 2017, Organic letters.

Indium-mediated Palladium-catalyzed Allylic Alkylation of Isatins with Alkynes

Hequan Yao, A. Lin, Zijun Wu, 2018 .

Palladium-catalyzed allylic alkylation with internal alkynes to construct C–C and C–N bonds in water

Hequan Yao, Shang Gao, A. Lin, 2017 .

First total synthesis of antihypertensive natural products S-(+)-XJP and R-(-)-XJP.

Xiao-ming Wu, Jieyun Jiang, Hequan Yao, 2014, Organic & biomolecular chemistry.

(±)-Melicolones A and B, rearranged prenylated acetophenone stereoisomers with an unusual 9-oxatricyclo[3.2.1.1(3,8)]nonane core from the leaves of Melicope ptelefolia.

Hequan Yao, Xiaobing Wang, L. Kong, 2015, Organic letters.

Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation.

Guangyu Wang, Shengtao Xu, Hequan Yao, 2017, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.

Honghao Sun, Shengtao Xu, Hequan Yao, 2019, European journal of medicinal chemistry.

Cooperative Palladium/Proline-Catalyzed Direct α-Allylic Alkylation of Ketones with Alkynes.

Hequan Yao, Chi Yang, A. Lin, 2016, Organic letters.

Construction of indoloquinolinones via Pd(II)-catalyzed tandem CC/CN bond formation: application to the total synthesis of isocryptolepine

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2014 .

Metal-Free Synthesis of N-(Pyridine-2-yl)amides from Ketones via Selective Oxidative Cleavage of C(O)-C(Alkyl) Bond in Water.

Honghao Sun, Shengtao Xu, Hequan Yao, 2018, The Journal of organic chemistry.

Efficient and selective cleavage of the t-butoxycarbonyl group from di-t-butylimidodicarbonate using catalytic bismuth(III) bromide in acetonitrile

Hequan Yao, Biaolin Yin, Sheng Jiang, 2009 .

Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes

Hequan Yao, A. Lin, Zhe Guan, 2020, Nature Communications.

Palladium-Catalyzed Asymmetric C-C Bond Activation/Carbonylation of Cyclobutanones.

W. Li, Hequan Yao, A. Lin, 2022, Organic letters.

Palladium-Catalyzed Asymmetric Dearomative Carbonylation of Indoles.

Hequan Yao, Yunchu Zhang, A. Lin, 2022, Organic letters.

Catalyst‐Controlled Regiodivergent Dehydrogenative Heck Reaction of 4‐Arylthiophene/Furan‐3‐Carboxylates

Hequan Yao, Shang Gao, A. Lin, 2016 .

Solvent-Controlled C2/C5-Regiodivergent Alkenylation of Pyrroles.

Shang Gao, Yue Huang, Hequan Yao, 2015, Chemistry.

Metal-free C5-selective halogenation of quinolines under aqueous conditions

Hequan Yao, Jinyi Xu, Tongen Wang, 2017 .

FeCl3 and ether mediated direct intramolecular acylation of esters and their application in efficient preparation of xanthone and chromone derivatives

Sai-Sai Xie, Hequan Yao, Xiaobing Wang, 2014 .

Cu/Pd cooperatively catalyzed tandem C-N and C-P bond formation: access to phosphorated 2H-indazoles.

Weiwei Wei, Hequan Yao, Xuanyi Li, 2017, Organic & biomolecular chemistry.

Design, Synthesis and Pharmacological Evaluation of Novel NO‐Releasing Benzimidazole Hybrids as Potential Antihypertensive Candidate

Yunman Li, Xiao-ming Wu, Hequan Yao, 2015, Chemical biology & drug design.

1,6‐Addition Arylation of para‐Quinone Methides: An Approach to Unsymmetrical Triarylmethanes

Hequan Yao, Shang Gao, A. Lin, 2016 .

Tandem 1,6-addition/cyclization/vinylcyclopropane rearrangement at low temperature under metal-free conditions: an approach to spiro[4.5]cyclohexadienones.

Jie Wu, Hequan Yao, A. Lin, 2017, Chemical communications.

Bifunctional Organo/Metal Cooperatively Catalyzed [3 + 2] Annulation of para-Quinone Methides with Vinylcyclopropanes: Approach to Spiro[4.5]deca-6,9-diene-8-ones.

Weiwei Wei, Hequan Yao, A. Lin, 2016, Organic letters.

Rh(iii)-Catalyzed C–H activation/annulation of salicylaldehydes with sulfoxonium ylides for the synthesis of chromones

Jiayi Chen, Hequan Yao, A. Lin, 2019, Organic Chemistry Frontiers.

Pd(II)-Catalyzed oxidative dearomatization of indoles: substrate-controlled synthesis of indolines and indolones

Shang Gao, Hequan Yao, A. Lin, 2017 .

Cascade Radical 1,6-Addition/Cyclization of para-Quinone Methides: Leading to Spiro[4.5]deca-6,9-dien-8-ones.

Hequan Yao, A. Lin, Rui Pan, 2018, Organic letters.

Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides.

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2015, Chemical communications.

Organocatalyzed Asymmetric 1,6-Conjugate Addition of para-Quinone Methides with Dicyanoolefins.

Weiwei Wei, Hequan Yao, Xuanyi Li, 2016, Organic letters.

Palladium-Catalyzed Dearomative Allylic Alkylation of Indoles with Alkynes To Synthesize Indolenines with C3-Quarternary Centers.

Hequan Yao, Shang Gao, A. Lin, 2016, Organic letters.

Efficient construction of fused indolines with a 2-quaternary center via an intramolecular Heck reaction with a low catalyst loading.

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2012, Organic letters.

Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.

T. Lu, Xiao-ming Wu, Xiaojing Huang, 2014, Organic & biomolecular chemistry.

Synthesis of Spiropentadiene Pyrazolones by Rh(III)-Catalyzed Formal sp3 C-H Activation/Annulation.

Hequan Yao, A. Lin, Meng Gu, 2017, Organic letters.

Oxidation of 4-carboxylate thiazolines to 4-carboxylate thiazoles by molecular oxygen

Xiao-ming Wu, Yue Huang, Hequan Yao, 2010 .

Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.

Chenzhong Liao, Yiwu Yao, Zheng-chao Tu, 2015, Journal of medicinal chemistry.

Organocatalyzed Formal [4+2] Cycloaddition of in situ Generated Azoalkenes with Arylacetic Acids: An Efficient Approach to the Synthesis of 4,5-Dihydropyridazin-3(2H)-ones

Jie Wu, Hequan Yao, Xuanyi Li, 2015 .

[3 + 2] Cycloaddition Reaction of in Situ Formed Azaoxyallyl Cations with Aldehydes: An Approach to Oxazolidin-4-ones.

Hequan Yao, Chi Yang, A. Lin, 2016, Organic letters.

Concise total syntheses of Marinoquinolines A–C

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2012 .

Silver-Catalyzed Cascade 1,6-Addition/Cyclization of para-Quinone Methides with Propargyl Malonates: An Approach to Spiro[4.5]deca-6,9-dien-8-ones.

Hequan Yao, A. Lin, Zhenbo Yuan, 2017, The Journal of organic chemistry.

1,6-Conjugated Addition-Mediated [2+1] Annulation: Approach to Spiro[2.5]octa-4,7-dien-6-one.

Jie Wu, Hequan Yao, Xuanyi Li, 2015, The Journal of organic chemistry.

Isolation and biomimetic synthesis of (±)-calliviminones A and B, two novel Diels–Alder adducts, from Callistemon viminalis

Jun Luo, Hequan Yao, Xiaobing Wang, 2015 .

Palladium-Catalyzed Allenamide Carbopalladation/Allylation with Active Methine Compounds.

Ruibo Li, Hequan Yao, A. Lin, 2021, Organic letters.

A [4 + 1] annulation of ortho-electrophile-substituted para-quinone methides for the synthesis of indanes and isoindolines

Yue Huang, Hequan Yao, Zhenbo Yuan, 2019, Organic Chemistry Frontiers.

Rhodium(III)-Catalyzed Intramolecular Olefin Hydroarylation of Aromatic Aldehydes Using a Transient Directing Group.

Yue Huang, Hequan Yao, Siwei Chen, 2019, Organic letters.

Enantioselective Syntheses of 2-Azabicyclo[2.2.1]heptanes via Brønsted Acid Catalyzed Ring-Opening of meso-Epoxides.

Hequan Yao, A. Lin, M. Cai, 2022, Organic letters.

Pd-Catalyzed Alkyne Insertion/C-H Activation/[4 + 2] Carboannulation of Alkenes to the Synthesis of Polycyclics.

Hequan Yao, Siwei Chen, A. Lin, 2019, Organic letters.

Palladium-Catalyzed Asymmetric Sequential Hydroamination of 1,3-Enynes: Enantioselective Syntheses of Chiral Imidazolidinones.

Hequan Yao, A. Lin, Xinxin Fang, 2022, Journal of the American Chemical Society.

Accessing 1,3-Dienes via Palladium-Catalyzed Allylic Alkylation of Pronucleophiles with Skipped Enynes.

Hequan Yao, Chi Yang, Shang Gao, 2017, Organic letters.

Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors.

Xiao-ming Wu, H. Cai, Shengtao Xu, 2015, Bioorganic & medicinal chemistry letters.

An efficient synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide

Hequan Yao, Jinyi Xu, Jie Liu, 2015 .

Novel hybrids of natural isochroman-4-one bearing N-substituted isopropanolamine as potential antihypertensive candidates.

Xiao-ming Wu, Xiaojing Huang, Jieyun Jiang, 2013, Bioorganic & medicinal chemistry.

Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity.

Xiao-ming Wu, Jieyun Jiang, Hequan Yao, 2012, Bioorganic & medicinal chemistry.

Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4.

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2012, Bioorganic & medicinal chemistry letters.

Pd(II)-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center.

Xiao-ming Wu, Yue Huang, Hequan Yao, 2016, Organic & biomolecular chemistry.

First total synthesis of tenuifolin via PIFA mediated oxidative biaryl coupling

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2011 .

Palladium‐catalyzed Oxa‐[4+2] Annulation of para‐Quinone Methides

Hequan Yao, A. Lin, Zhenbo Yuan, 2017 .

Redox-Neutral Atom-Economic Pd(0)-Catalyzed Dearomatization of β-Naphthols with Alkynes toward Naphthalenones.

Hequan Yao, A. Lin, Zijun Wu, 2018, Organic letters.

Synthesis and Biological Evaluation of Oxygen‐containing Heterocyclic Ring‐fused 23‐Hydroxybetulinic Acid Derivatives as Antitumor Agents

W. Ye, Xiao-ming Wu, Jieyun Jiang, 2015, Chemical biology & drug design.

Design, synthesis and antitumor activity of triterpenoid pyrazine derivatives from 23-hydroxybetulinic acid.

W. Ye, Xiao-ming Wu, Shengtao Xu, 2015, European journal of medicinal chemistry.

Synthesis, in vitro and in vivo antitumor activity of pyrazole-fused 23-hydroxybetulinic acid derivatives.

W. Ye, Xiao-ming Wu, Jieyun Jiang, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and antitumor activity of novel 3-oxo-23-hydroxybetulinic acid derivatives.

W. Ye, Xiao-ming Wu, Shengtao Xu, 2014, European journal of medicinal chemistry.

Direct C3-alkenylation of pyridin-4(1H)-one via oxidative Heck coupling

Xiao-ming Wu, Yue Huang, Hequan Yao, 2013 .

Direct C3‐Alkenylation of Pyridin‐4(1H)‐one via Oxidative Heck Coupling.

Xiao-ming Wu, Yue Huang, Hequan Yao, 2013 .

Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells.

Yuetong Wang, Xiao-ming Wu, H. Cai, 2013, European journal of medicinal chemistry.

Spectroscopic characterizations, X-ray studies, and electronic circular dichroism calculations of two alkaloid triterpenoids

Hequan Yao, Xiaobing Wang, L. Kong, 2011 .

Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation.

Xiao-ming Wu, H. Cai, Shengtao Xu, 2013, European journal of medicinal chemistry.

The Conversion of Oridonin to Spirolactone‐Type or Enmein‐Type Diterpenoid: Synthesis and Biological Evaluation of ent‐6,7‐seco‐Oridonin Derivatives as Novel Potential Anticancer Agents.

Yihua Zhang, H. Cai, Shengtao Xu, 2012 .

Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.

Sai-Sai Xie, Hequan Yao, Xiaobing Wang, 2013, European journal of medicinal chemistry.

Synthetic study on neoponkoranol and its side chain epimer as potent α-glucosidase inhibitors, optimization of protecting group

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2013 .

Discovery of Novel 4-Arylisochromenes as Anticancer Agents Inhibiting Tubulin Polymerization.

Honghao Sun, Shengtao Xu, Hequan Yao, 2018, ACS medicinal chemistry letters.

Facile construction of pyrrolophenanthridone skeleton via a one-pot intramolecular Heck reaction and oxidation

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2014 .

Bistabercarpamines A and B, first vobasinyl-chippiine-type bisindole alkaloid from Tabernaemontana corymbosa

Hequan Yao, L. Kong, Junsong Wang, 2014 .

Insights into drug discovery from natural products through structural modification.

Hequan Yao, Jinyi Xu, Jichao Chen, 2015, Fitoterapia.

Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists.

Xiao-ming Wu, Jieyun Jiang, Hequan Yao, 2012, Bioorganic & Medicinal Chemistry.

Highly efficient oxidation of 2-imidazoline-5-carboxylic derivatives to imidazole-5-carboxylic derivatives by dioxygen

Xiao-ming Wu, Yue Huang, Hequan Yao, 2012 .

Construction of 3,6-anhydrohexosides via intramolecular cyclization of triflates and its application to the synthesis of natural product isolated from leaves of Sauropus rostratus.

Xiao-ming Wu, Hequan Yao, G. Tanabe, 2014, Organic Letters.

Practical Synthesis of Neoponkoranol and its Related Sulfonium Salt, an Optimised Protocol using Isopropylidene as an Effective Protecting Group

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2013 .

Highly Efficient Oxidation of 2‐Imidazoline‐5‐carboxylic Derivatives to Imidazole‐5‐carboxylic Derivatives by Dioxygen.

Xiao-ming Wu, Yue Huang, Hequan Yao, 2012 .

Oxidation of 1-benzyldihydroisoquinolines or 1-benzyltetrahydroisoquinolines with dioxygen to 1-benzoylisoquinolines

Xiao-ming Wu, Yue Huang, Hequan Yao, 2011 .

Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor.

Hongbin Sun, Hequan Yao, L. Kong, 2012, Bioorganic & medicinal chemistry letters.

Chemical space exploration based on recurrent neural networks: applications in discovering kinase inhibitors

Xuanyi Li, Hequan Yao, Kejiang Lin, 2020, Journal of Cheminformatics.

Discovery of CDK4 inhibitors by convolutional neural networks.

Xinhao Lin, Kejiang Lin, Yinqiu Xu, 2019, Future medicinal chemistry.

Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes

Hequan Yao, A. Lin, Zhe Guan, 2020, Nature Communications.

Rh(III)-Catalyzed Oxidative C-H Activation/Annulation of Salicylaldehydes with Masked Enynes for the Synthesis of Chromones.

Yue Huang, Hequan Yao, Jian-ping Zhu, 2022, The Journal of organic chemistry.

Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site.

Honghao Sun, Shengtao Xu, Hequan Yao, 2019, Bioorganic chemistry.

Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.

Zhe-Sheng Chen, Dong-Hua Yang, Honghao Sun, 2018, Journal of medicinal chemistry.

Macrocyclization of peptidoarylacetamides with self-assembly properties through late-stage palladium-catalyzed C(sp2)▬H olefination

Jie Wu, Hequan Yao, Huan Wang, 2019, Science Advances.

A pair of tirucallane C27-triterpenoid cyclopentenone epimers from the stem barks of Aphanamixis grandifolia

Hequan Yao, Xiaobing Wang, L. Kong, 2012 .

Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry.

Yiwu Yao, Zheng-chao Tu, Sheng Jiang, 2013, Bioorganic & medicinal chemistry letters.

Cobalt-catalyzed carbon-sulfur/selenium bond formation: synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines.

Shengtao Xu, Hequan Yao, Jinyi Xu, 2018, Organic & biomolecular chemistry.

A new approach to the bicyclo[3.3.1]nonane framework of huperzine A-like molecules via palladium-catalyzed intramolecular γ-arylation

Hequan Yao, G. Lin, Bingfeng Sun, 2012, Science China Chemistry.

Synthesis and Biological Evaluation of Novel Pentacyclic Triterpene Derivatives as Potential PPARγ Agonists

Jun O. Liu, Hongbin Sun, Hequan Yao, 2012 .

New Set of Isobaric Labeling Reagents for Quantitative 16Plex Proteomics.

Yan Ren, Shuwei Li, Hequan Yao, 2023, Analytical chemistry.

Stereoselective Synthesis of Tetrahydropyran D‐Ring of Methyl Sartortuoate

Hequan Yao, Yuan Gao, Xingdong Xu, 2009 .

Synthesis of 13-β-elemene ester derivatives and evaluation of their antioxidant activity in human umbilical vein endothelial cells.

Xiao-ming Wu, Hequan Yao, Jing Shang, 2015, Chinese journal of natural medicines.

Synthesis of 3-Benzoyl Acrylates/Acrylamides via Dehydrogenation of 3-Benzoyl Propionates/Propionamides Using IBX/p-TsOH

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2010 .

Novel hybrids of natural β-elemene bearing isopropanolamine moieties: Synthesis, enhanced anticancer profile, and improved aqueous solubility.

Shengtao Xu, Hequan Yao, Jinyi Xu, 2017, Fitoterapia.

The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules

Hequan Yao, Kejiang Lin, Xuanyi Li, 2019, Molecules.

Rhodium-Catalyzed Hydroacylation of para-Quinone Methides with Salicylaldehydes: An Approach to α,α-Diaryl-2-Hydroxy Acetophenones.

Shang Gao, Hequan Yao, Chi Yang, 2016, The Journal of organic chemistry.

An overview of neural networks for drug discovery and the inputs used

Kejiang Lin, Yinqiu Xu, Hequan Yao, 2018, Expert opinion on drug discovery.

Corrigendum to “A pair of tirucallane C27-triterpenoid cyclopentenone epimers from the stem barks of Aphanamixis grandifolia” [Tetrahedron Lett. 53 (2012) 1705–1709]

Hequan Yao, Xiaobing Wang, L. Kong, 2012 .

Ligand-Controlled, Palladium-Catalyzed Asymmetric [4+4] and [2+4] Cycloadditions.

Hequan Yao, Qiu-Xiao Li, Rui Pan, 2021, Organic letters.

A Partial Synthesis of 23-Hydroxybetulonic Acid and 23-Hydroxybetulinic Acid Starting from Betulinic Acid

Xiao-ming Wu, Hequan Yao, Jinyi Xu, 2012 .

Discovery of novel antitumor nitric oxide-donating β-elemene hybrids through inhibiting the PI3K/Akt pathway.

Shengtao Xu, Pengfei Zhang, Hequan Yao, 2017, European journal of medicinal chemistry.

Rhodium-catalyzed intermolecular enantioselective Alder–ene type reaction of cyclopentenes with silylacetylenes

Jiajia Li, Hequan Yao, Miaomiao Li, 2021, Nature Communications.

[3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2-Alkenylindoles: An Approach to Tetrahydro-β-carbolinones.

Yue Huang, Hequan Yao, Xiaoying Xu, 2017, Organic letters.

Cobalt-Catalyzed Dearomatization of Indoles via Transfer Hydrogenation To Afford Polycyclic Indolines.

Hequan Yao, Siwei Chen, M. Cai, 2021, Organic letters.

[3 + 3] Cycloaddition of Azides with in Situ Formed Azaoxyallyl Cations To Synthesize 1,2,3,4-Tetrazines.

Hequan Yao, Xiaoying Xu, Panpan Li, 2018, Organic letters.

Discovery of a Novel, Potent, Orally Active, and Safe Inhibitor Targeting Human Mitochondrial RNA Polymerase.

Tao Wang, Dong Yang, Zhe-Sheng Chen, 2023, Journal of medicinal chemistry.

Library Construction and Biological Evaluation of Enmein‐Type Diterpenoid Analogues as Potential Anticancer Agents

Xiao-ming Wu, H. Cai, Shengtao Xu, 2013, ChemMedChem.

Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells.

Yuetong Wang, Xiao-ming Wu, H. Cai, 2013, European journal of medicinal chemistry.

Pd(II)-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center.

Xiao-ming Wu, Yue Huang, Hequan Yao, 2016, Organic & biomolecular chemistry.

First total synthesis of antihypertensive natural products S-(+)-XJP and R-(-)-XJP.

Xiao-ming Wu, Jieyun Jiang, Hequan Yao, 2014, Organic & biomolecular chemistry.

Comparative Bioinformatics and Experimental Analysis of the Intergenic Regulatory Regions of Bacillus cereus hbl and nhe Enterotoxin Operons and the Impact of CodY on Virulence

Xiao-ming Wu, H. Cai, Shengtao Xu, 2016 .

Neural networks in drug discovery: current insights from medicinal chemists.

Xuanyi Li, Kejiang Lin, Yinqiu Xu, 2019, Future medicinal chemistry.

Enantioselective Synthesis of Bicyclo[3.2.1]octadienes via Palladium-Catalyzed Intramolecular Alkene-Alkyne Coupling Reaction.

Hequan Yao, Qiu-Xiao Li, Aijun Lin, 2023, Angewandte Chemie.

Palladium-catalyzed allylic alkylation with internal alkynes to construct C–C and C–N bonds in water

Hequan Yao, Shang Gao, Zijun Wu, 2017 .

Three-component approach to modular synthesis of tetra-substituted furans and pyrroles

Hequan Yao, Xuanyi Li, Jie Zhu, 2024, Organic Chemistry Frontiers.

Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.

T. Lu, Xiao-ming Wu, Xiaojing Huang, 2014, Organic & biomolecular chemistry.