R. Houssin

发表

New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.

T. Taverne, J. Goossens, C. Charlier, 2004, Journal of medicinal chemistry.

A new bithiazole derivative with intercalative properties.

R. Houssin, J. Hénichart, N. Helbecque, 1986, Journal of biomolecular structure & dynamics.

Metal-complexing, DNA-binding and DNA-cleaving properties of a synthetic molecule AMBIGLU, a simplified model for the study of bleomycin

C. Bailly, R. Houssin, J. Hénichart, 1989 .

DNA-binding and DNA-cleaving properties of a synthetic model AGAGLU related to the antitumour drugs AMSA and bleomycin.

C. Bailly, R. Houssin, J. Hénichart, 1988, Biochemical and biophysical research communications.

Copper(II)- and iron(II)-complexes of methyl 2-(2-aminoethyl)-aminomethyl-pyridine-6-carboxyl-histidinate (AMPHIS), a peptide mimicking the metal-chelating moiety of bleomycin. An ESR investigation.

R. Houssin, J. Hénichart, J. Catteau, 1985, Biochemical and biophysical research communications.

DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.

C. Bailly, P. Colson, C. Houssier, 2001, Biochemistry.

Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.

A. Lemoine, G. Laconde, A. Farce, 2007, Bioorganic & medicinal chemistry letters.

One-electron oxidation of ergothioneine and analogues investigated by pulse radiolysis: redox reaction involving ergothioneine and vitamin C.

E. Land, R. Bensasson, R. Houssin, 1996, The Biochemical journal.

Synthesis and DNA-binding study of a thiazole-containing analog of netropsin

C. Bailly, R. Houssin, J. Hénichart, 2009 .

N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.

R. Houssin, J. Hénichart, N. Mestdagh, 2001, Bioorganic & medicinal chemistry letters.

Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives.

J. Goossens, L. Goossens, R. Houssin, 2002, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of tripeptide derivatives of Cbz-Gly-Leu-Trp-OBzl(CF3)2 as NK1/NK2 ligands

J. Goossens, R. Houssin, J. Hénichart, 1999, Letters in Peptide Science.

Is the bithiazole moiety of bleomycin a classical intercalator?

R. Houssin, J. Hénichart, N. Helbecque, 1985, Nucleic acids research.

Antitumor combilexin. A thiazole-containing analogue of netropsin linked to an acridine chromophore.

M. Waring, C. Bailly, P. Colson, 1994, Bioconjugate chemistry.

New substance P receptor antagonists. Conception, synthesis and biological evaluation of spirolactam derivatives and their tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 and lactam pseudopeptide derivatives

J. Goossens, L. Goossens, R. Houssin, 2000, Letters in Peptide Science.

A flexible approach to the design of new potent substance P receptor ligands

J. Goossens, L. Goossens, R. Houssin, 2001, The Journal of pharmacy and pharmacology.

Conformation of the tripeptide Cbz‐Pro‐Leu‐Trp‐OBzl(CF3)2 deduced from two‐dimensional 1H‐NMR and conformational energy calculations is related to its affinity for NK1‐receptor

P. Chavatte, J. Goossens, L. Goossens, 2001, Journal of peptide science : an official publication of the European Peptide Society.

Synthetic model of a bleomycin metal complex

R. Houssin, J. Hénichart, J. Catteau, 1982 .

Bioactive conformations of peptides and mimetics as milestones in drug design: Investigation of NK1 receptor antagonists

R. Houssin, J. Hénichart, S. Goldstein, 2004, Letters in Peptide Science.

Indolizino[1,2-b]quinolines Derived from A–D Rings of Camptothecin: Synthesis and DNA Interaction

C. Bailly, P. Colson, C. Houssier, 2003, Journal of enzyme inhibition and medicinal chemistry.

CONCEPTION, SYNTHESE ET EVALUATION PHARMACOLOGIQUE DE PYRROLO(3,4-b)QUINOLEINES CONDENSEES, LIGANDS POTENTIELS DE L'ADN

C. Bailly, R. Houssin, J. Hénichart, 2003 .

DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline derivatives as cytotoxic agents.

C. Bailly, P. Colson, J. Goossens, 2004, Journal of medicinal chemistry.

Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.

Valérie Choesmel, Catherine Michaux, T. Taverne, 2002, Bioorganic & medicinal chemistry letters.

A new synthesis of N‐alkyl pyrazolidine‐3,5‐diones and tetrahydropyridazine‐3,6‐diones

S. Yous, R. Houssin, J. Hénichart, 2000 .

Synthesis of two new thiazole-containing oligopeptides as potential DNA minor groove binding analogs of netropsin

C. Bailly, R. Houssin, J. Hénichart, 1991 .

Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II.

C. Bailly, P. Renard, B. Pfeiffer, 1999, Bioorganic & medicinal chemistry letters.

A New Synthesis of N‐Alkyl Pyrazolidine‐3,5‐diones and Tetrahydropyridazine‐3,6‐diones.

S. Yous, R. Houssin, J. Hénichart, 2001 .

Synthesis of condensed quinolines and quinazolines as DNA ligands.

C. Bailly, J. Goossens, R. Houssin, 2004, Bioorganic & medicinal chemistry.

Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-arylcarboxamidopyrrolo-2-carboxyanilides.

C. Bailly, P. Colson, C. Houssier, 2000, Bioorganic & medicinal chemistry letters.

Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.

C. Bailly, J. Goossens, R. Houssin, 2008, Journal of medicinal chemistry.

Synthesis of an azabicycloalkane amino acid scaffold as potential rigid dipeptide mimetic

R. Houssin, J. Hénichart, B. Rigo, 2002 .

Condensation of p-benzoquinone with 4-cyano- and 4-nitroanilines. An extension of the Nenitzescu reaction

C. Vaccher, R. Houssin, J. Hénichart, 1980 .

Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines.

C. Bailly, J. Goossens, N. Pommery, 2003, Bioorganic & medicinal chemistry letters.

A short and unequivocal synthesis of 5‐aminotetrazolo[1,5‐a]‐quinazoline as a tricyclic analogue of 4‐(3‐bromoanilino)‐6,7‐dimethoxyquinazoline (PD 153035)

R. Houssin, E. Bencteux, 1997 .

Metalation of 4-oxazolinyloxazole derivatives. A convenient route to 2,4-bifunctionalized oxazoles.

R. Houssin, J. Hénichart, A. Couture, 2002, The Journal of organic chemistry.

New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agents.

A. Lemoine, N. Pommery, R. Houssin, 2004, Bioorganic & medicinal chemistry letters.

Conformationally constrained dipeptides. Obtention of enantiomerically pure 6‐acetamido‐5‐oxo‐1,2,3,5,6,7‐hexahydro‐3‐indolizine carboxylic acid

L. Goossens, R. Houssin, J. Hénichart, 2000 .

Complexation of copper(II) by a peptide hybrid of bleomycin and amsacrine. Circular dichroism and electron spin resonance studies.

C. Bailly, R. Houssin, J. Hénichart, 1987, Journal of inorganic biochemistry.

Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives.

J. Goossens, L. Goossens, R. Houssin, 2002, Bioorganic & medicinal chemistry.

Molecular interaction between bleomycin and amsacrine in the presence of cupric ions.

B. Hecquet, R. Houssin, J. Hénichart, 1986, Journal of inorganic biochemistry.

Depsipeptide analogs of the antitumor drug distamycin containing thiazole amino acids residues

C. Bailly, R. Houssin, J. Hénichart, 1988 .

Synthesis, determination of sequence selective DNA minor groove binding and biological evaluation of hybrid bithiazole-linked netropsin derivatives

C. Bailly, J. Lown,, J. Zimmermann, 1992 .

Aminoalkyl derivatives of 2,4′-bithiazole-4-carboxylic acid, the intercalating part of bleomycin

R. Houssin, J. Hénichart, J. Bernier, 1984 .

Studies on pyrrolidinones. Synthesis of new α‐pyridones derivatives

R. Houssin, D. Couturier, Laurent Legentil, 2003 .

Electrophilic Nitration of Electron-Rich Acetophenones

R. Houssin, J. Hénichart, P. Cotelle, 2005 .

Synthesis of a novel conformationally restricted Val‐Phe dipeptidomimetic

A. Farce, R. Houssin, J. Hénichart, 2006, Journal of peptide science : an official publication of the European Peptide Society.

Structure du methyl-1 salicyloyl-4 thiosemicarbazide

R. Houssin, J. Hénichart, C. Gors, 1979 .

A new scaffold for dipeptide β‐turn mimetics: Expeditious synthesis of an unsaturated 6,5‐fused bicyclic lactam

R. Houssin, J. Hénichart, B. Rigo, 1999 .

Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.

C. Bailly, P. Colson, C. Houssier, 2002, Journal of medicinal chemistry.

Influence of the methyl substituents of a thiazole-containing lexitropsin on the mode of binding to DNA.

C. Bailly, P. Colson, C. Houssier, 1995, Anti-cancer drug design.

Structure-neuromuscular blocking activity relationships of ketophosphonium salts.

R. Houssin, J. Hénichart, M. Foulon, 1980, Journal of pharmaceutical sciences.

Potent and selective farnesyl transferase inhibitors.

P. Chavatte, J. Goossens, N. Pommery, 2004, Journal of medicinal chemistry.

Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors.

C. Supuran, J. Wouters, B. Masereel, 2009, European journal of medicinal chemistry.

Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.

J. Goossens, S. Yous, R. Houssin, 2002, Journal of Medicinal Chemistry.

Synthesis and Pharmacological Evaluation of New Pyrazolidine-3,5-diones as AT1 Angiotensin II Receptor Antagonists

J. Goossens, S. Yous, R. Houssin, 2000 .

Synthesis of 1,4-diazepin-5-ones under microwave irradiation and their reduction products

R. Houssin, J. Hénichart, R. Millet, 2007 .

Synthesis and biological evaluation of conformationally restricted derivatives of tryptophan as NK1/NK2 ligands

P. Chavatte, J. Goossens, R. Houssin, 1999, Letters in Peptide Science.

Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.

P. Chavatte, A. Lemoine, A. Farce, 2006, European journal of medicinal chemistry.

Design, synthesis, DNA binding, and biological activity of a series of DNA minor-groove-binding intercalating drugs.

C. Bailly, N. Pommery, R. Houssin, 1989, Journal of pharmaceutical sciences.

SYNTHESIS AND STRUCTURE OF 1,2,4-TRIAZOLINE-5-THIONES HAVING A DIALKYLAMINOETHYL SUBSTITUENT AT THE 3 OR 4 POSITION

R. Houssin, J. Hénichart, B. Lablanche, 1977 .

In vitro and in vivo evaluation of two rational-designed nonpeptidic farnesyltransferase inhibitors on HT29 human colon cancer cell lines.

A. Lemoine, J. Goossens, N. Pommery, 2006, Oncology research.

Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.

P. Chavatte, J. Goossens, J. Pommery, 2002, Journal of medicinal chemistry.

Binding properties and DNA sequence-specific recognition of two bithiazole-linked netropsin hybrid molecules.

M. Waring, C. Bailly, P. Colson, 1992, Biochemistry.

Cyclisation de dinitrodiarylamines en nitro-3 carbazoles inhibition sterique de la substitution nucleophile SNAr par effet ortho d'un groupement methyle

R. Houssin, J. Hénichart, J. Bernier, 1979 .

Opiate receptor interaction of a new analgesic drug 2-piperidinoethyl dibenzylglycolate.

R. Houssin, J. Hénichart, J. Bernier, 1985, Chemico-Biological Interactions.

A Convenient and General Method for the Preparation of tert-Butoxycarbonylaminoalkanenitriles and Their Conversion to Mono-tert-butoxycarbonylalkanediamines

R. Houssin, J. Hénichart, J. Bernier, 1988 .

A high performance liquid chromatographic method for the quantitation of flecainide in plasma.

M. Lhermitte, R. Houssin, F. Broly, 1991, Biomedical chromatography : BMC.

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

P. Chavatte, J. Mergny, P. Roussel, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of 6-phenyl and 6-styrylthiazolo[3,2-b] [1,2,4]triazoles

R. Houssin, J. Hénichart, J. Bernier, 1986 .

Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity.

C. Sergheraert, A. Lemoine, N. Pommery, 2005, Chemical & pharmaceutical bulletin.

Conformational analysis by 13C spin–lattice relaxation times. Evidence for an intramolecular CH … N hydrogen-bond in a 4H-1,2,4-triazole derivative

R. Houssin, J. Hénichart, 1981 .

Chemical, physicochemical and crystallographical studies in the 1,2,4‐triazole series

R. Houssin, J. Hénichart, F. Baert, 1977 .

DNA-sequence specific recognition by a thiazole analogue of netropsin: a comparative footprinting study.

M. Waring, C. Bailly, R. Houssin, 1991, Nucleic acids research.

Comparative subcellular distribution of the copper complexes of bleomycin-A2 and deglycobleomycin-A2.

C. Bailly, R. Houssin, J. Hénichart, 1994, Anti-cancer drugs.

Synthesis of some spin-labeled bithiazoles, Useful probes for studying bleomycin-DNA binding

R. Houssin, J. Hénichart, J. Bernier, 1984 .

Major metabolites of zolpidem: expeditious synthesis and mass spectra.

M. Lhermitte, R. Houssin, J. Hénichart, 2006, Chemical & pharmaceutical bulletin.

Synthesis of 8‐Substituted Tetrahydro‐γ‐carbolines.

A. Bridoux, L. Goossens, R. Houssin, 2006 .