Runling Wang

发表

Novel Inhibitor Design for Hemagglutinin against H1N1 Influenza Virus by Core Hopping Method

K. Chou, Xiaobo Li, Shu-Qing Wang, 2011, PloS one.

Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics

K. Chou, Shu-Qing Wang, Wei-Ren Xu, 2013, Drug design, development and therapy.

Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach

K. Chou, Shu-Qing Wang, Wei-Ren Xu, 2012, PloS one.

Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level through molecular docking and molecular dynamics

Runling Wang, Ying-Hong Ma, Rui-Rui Wang, 2020, Journal of biomolecular structure & dynamics.

Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar.

Kuo-Chen Chou, Wei-Ren Xu, Run-Ling Wang, 2011, Protein and peptide letters.

The derivatives of oseltamivir design passing through the important cleft of neuraminidase against influenza virus by de novo design

Shu-Qing Wang, Runling Wang, Wei-bing Zhang, 2014 .

Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation

Runling Wang, Ying-Hong Ma, Rui-Rui Wang, 2020, Journal of biomolecular structure & dynamics.

Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitors.

Hua Sun, Peng Yu, Yongming Zhang, 2015, Bioorganic & medicinal chemistry letters.

Design, sythesis and evaluation of a series of 3- or 4-alkoxy substituted phenoxy derivatives as PPARs agonists

Z. Shen, Yi Huan, Shu-Qing Wang, 2017, Oncotarget.

Design potential selective inhibitors for human leukocyte common antigen-related (PTP-LAR) with fragment replace approach

Runling Wang, Zhihui Zheng, Xin-Hua Lu, 2019, Journal of biomolecular structure & dynamics.

Synthesis, evaluation, molecular dynamics simulation and targets identification of novel pyrazole-containing imide derivatives

Shu-Qing Wang, Runling Wang, Ying-Hong Ma, 2020, Journal of biomolecular structure & dynamics.

Exploring the effect of inhibitor AKB‐9778 on VE‐PTP by molecular docking and molecular dynamics simulation

Runling Wang, Ying-Hong Ma, Rui-Rui Wang, 2019, Journal of cellular biochemistry.

Identification of novel inhibitor of protein tyrosine phosphatases delta: structure-based pharmacophore modeling, virtual screening, flexible docking, molecular dynamics simulation, and post-molecular dynamics analysis

Runling Wang, Zhihui Zheng, Xin-Hua Lu, 2020, Journal of biomolecular structure & dynamics.

Study of SHP-2 (PTPN11) allosterism on structural movement using solution perturbed molecular dynamics simulation

Chenglung Chen, Xiaobo Li, Runling Wang, 2016 .

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors

Shu-Qing Wang, Wei-Ren Xu, Runling Wang, 2012, PloS one.

SAHA-based novel HDAC inhibitor design by core hopping method.

Xiaobo Li, Shu-Qing Wang, Wei-Ren Xu, 2014, Journal of molecular graphics & modelling.

Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors.

Wei-Ren Xu, Runling Wang, Xian-Chao Cheng, 2015, European journal of medicinal chemistry.

Exploring the effect of E76K mutation on SHP2 cause gain‐of‐function activity by a molecular dynamics study

Runling Wang, Ying-Hong Ma, Wei-Ya Li, 2018, Journal of cellular biochemistry.

Molecular docking, 3D-QSAR and structural optimization on imidazo-pyridine derivatives dually targeting AT1 and PPARγ

Shu-Qing Wang, Wei-Ren Xu, Runling Wang, 2017, Oncotarget.

Identification of protein tyrosine phosphatase 1B (PTP1B) inhibitors through De Novo Evoluton, synthesis, biological evaluation and molecular dynamics simulation.

Runling Wang, Liang Zhou, Jingwei Wu, 2020, Biochemical and biophysical research communications.

Efficient enzymatic synthesis of L-rhamnulose and L-fuculose.

P. Wang, Runling Wang, Kenneth Huang, 2016, Bioorganic & medicinal chemistry letters.

Poly[[bis(μ-4,4′-bipyridine-κ2 N:N′)copper(I)] perchlorate 0.24-hydrate]

Runling Wang, Cheng-Zhi Xie, Xue-Jun Yao, 2012, Acta crystallographica. Section E, Structure reports online.

Synthesis, bioactivity, 3D-QSAR studies of novel dibenzofuran derivatives as PTP-MEG2 inhibitors

Runling Wang, Ying-Hong Ma, Xian-Chao Cheng, 2017, Oncotarget.

Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Shu-Qing Wang, Runling Wang, Zhihui Zheng, 2020, Journal of biomolecular structure & dynamics.

Identification of potential leukocyte antigen-related protein (PTP-LAR) inhibitors through 3D QSAR pharmacophore-based virtual screening and molecular dynamics simulation

Runling Wang, Zhihui Zheng, Xin-Hua Lu, 2020, Journal of biomolecular structure & dynamics.

Identification of the potential dual inhibitor of protein tyrosine phosphatase sigma and leukocyte common antigen-related phosphatase by virtual screen, molecular dynamic simulations and post-analysis

Runling Wang, Ying-Hong Ma, Liang Zhou, 2019, Journal of biomolecular structure & dynamics.

Design, synthesis, biological evaluation, common feature pharmacophore model and molecular dynamics simulation studies of ethyl 4-(phenoxymethyl)-2-phenylthiazole-5-carboxylate as Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors

Runling Wang, Zhihui Zheng, Huan Zhang, 2020, Journal of biomolecular structure & dynamics.

Design, Synthesis, Biological Activity and Molecular Dynamics Studies of Specific Protein Tyrosine Phosphatase 1B Inhibitors over SHP-2

Xiaobo Li, Shu-Qing Wang, Runling Wang, 2013, International journal of molecular sciences.

Scaffold-based selective SHP2 inhibitors design using core hopping, molecular docking, biological evaluation and molecular simulation.

Runling Wang, Xin-Hua Lu, Ying-Hong Ma, 2020, Bioorganic chemistry.

Synthesis, crystal structure and magnetic properties of a trinuclear Cu(II)-pyrazolate complex containing μ 3-OH

Runling Wang, Jing-Yuan Xu, Jian-Shi Lou, 2009 .

The Discovery of a Novel and Selective Inhibitor of PTP1B Over TCPTP: 3D QSAR Pharmacophore Modeling, Virtual Screening, Synthesis, and Biological Evaluation

Wei-Ren Xu, De-Xin Kong, Run-Ling Wang, 2014, Chemical biology & drug design.

An Approach to Optically Pure Bridging Chiral p-tert-Butylcalix[4]arenes through a Homologous Anionic Ortho-Fries Rearrangement.

Jun‐Min Liu, Runling Wang, Wen-Shan Liu, 2016, The Journal of organic chemistry.

Bridging Chiral Calix[4]arenes: Description, Optical Resolution, and Absolute Configuration Determination

Jun‐Min Liu, Runling Wang, Fengxia An, 2016 .

Tuning the reaction rates of fluoride probes for detection in aqueous solution

B. Wang, Runling Wang, Kaili Ji, 2016 .

Synthesis, α-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones.

Hua Sun, Peng Yu, Yongming Zhang, 2015, Bioorganic & medicinal chemistry letters.

Ethyl 4-[(4-chlorophenoxy)methyl]-2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate

Shu-Qing Wang, Runling Wang, Wei-Li Dong, 2011, Acta crystallographica. Section E, Structure reports online.

Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives.

Hua Sun, Peng Yu, Yongming Zhang, 2017, Bioorganic & medicinal chemistry letters.

Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: α-Glucosidase and α-Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects.

Hua Sun, Peng Yu, Runling Wang, 2017, Journal of agricultural and food chemistry.

Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as α-glucosidase inhibitors.

Hua Sun, Peng Yu, Yang Yang, 2016, European journal of medicinal chemistry.

Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines.

Cheng Luo, Peng George Wang, Binghe Wang, 2016, European journal of medicinal chemistry.

Design, synthesis, biological evaluation and molecular dynamics simulation studies of imidazolidine-2,4-dione derivatives as novel PTP1B inhibitors.

Runling Wang, Zhihui Zheng, Xin-Hua Lu, 2021, Biochemical and biophysical research communications.

Three new powerful oseltamivir derivatives for inhibiting the neuraminidase of influenza virus.

Kuo-Chen Chou, Xian-Chao Cheng, Run-Ling Wang, 2010, Biochemical and biophysical research communications.

Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study.

Runling Wang, Ying-Hong Ma, Wei-Ya Li, 2023, Journal of biomolecular structure & dynamics.

Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.

Runling Wang, Ying-Hong Ma, Rui-Rui Wang, 2020, Bioorganic chemistry.

Exploring the reason for increased activity of SHP2 caused by D61Y mutation through molecular dynamics

Hui Zhou, Ying Ma, Shan Du, 2019, Comput. Biol. Chem..

Exploring the effect of D61G mutation on SHP2 cause gain of function activity by a molecular dynamics study

Wen-Yan Jin, Run-Ling Wang, Wen-Shan Liu, 2018, Journal of biomolecular structure & dynamics.

Design of specific inhibitors of the protein tyrosine phosphatase SHP-2 by virtual screening and core hopping method

Shu-Qing Wang, Wei-Ren Xu, Runling Wang, 2014 .

Structure-based discovery of a specific SHP2 inhibitor with enhanced blood-brain barrier penetration from PubChem database.

Runling Wang, Xin-Hua Lu, Ying-Hong Ma, 2022, Bioorganic chemistry.

The design of novel inhibitors for treating cancer by targeting CDC25B through disruption of CDC25B-CDK2/Cyclin A interaction using computational approaches

Xiu-Bo Chen, Run-Ling Wang, Wei-Li Dong, 2017, Oncotarget.

Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone

Jun Zhang, Wei-Ren Xu, Xian-Chao Cheng, 2014, Drug design, development and therapy.

Allosteric inhibitors of SHP2: an updated patent review (2015-2020).

Runling Wang, Huan Zhang, Jingwei Wu, 2020, Current medicinal chemistry.

Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout.

Runling Wang, Huan Zhang, Jingwei Wu, 2019, Bioorganic & medicinal chemistry letters.

Multitargeted bioactive ligands for PPARs discovered in the last decade

Runling Wang, Jun Zhang, Xin Liu, 2016, Chemical biology & drug design.

Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ by core hopping of telmisartan

Jun Zhang, Wei-Ren Xu, Xian-Chao Cheng, 2017, Journal of biomolecular structure & dynamics.

Agonist and antagonist recognition studies for oestrogen receptor by molecular dynamics simulation

Xiaobo Li, Shu-Qing Wang, Runling Wang, 2013 .

Design, synthesis, biological evaluation and molecular dynamics simulation studies of (R)-5-methylthiazolidin-4-One derivatives as megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) inhibitors for the treatment of type 2 diabetes

Runling Wang, Ying-Hong Ma, Jingwei Wu, 2019, Journal of biomolecular structure & dynamics.

Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation

Liang Zhou, Wen-Yan Jin, Wei-Ya Li, 2019, Journal of Computer-Aided Molecular Design.

1-(4-Methoxyphenyl)-3-methyl-1H-1,2,4-triazol-5(4H)-one

Bing Liu, Weiren Xu, Guilong Zhao, 2008, Acta crystallographica. Section E, Structure reports online.

Scaffold-based novel SHP2 allosteric inhibitors design using Receptor-Ligand pharmacophore model, virtual screening and molecular dynamics

Ying Ma, Hong-Lian Li, Wen-Yan Jin, 2018, Comput. Biol. Chem..

Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold.

Runling Wang, Xian-Chao Cheng, Rong-Rong Li, 2012, Bioorganic & medicinal chemistry.

3D QSAR Pharmacophore Based Virtual Screening for Identification of Potential Inhibitors for CDC25B

Xiubo Chen, Hui Zhou, Ying Ma, 2018, Comput. Biol. Chem..

Design, synthesis, biological evaluation and molecular dynamics of LAR inhibitors

Run-Ling Wang, Ying-Zhan Sun, Jing-Wei Wu, 2021, Comput. Biol. Chem..

Exploring the mechanism of the potent allosteric inhibitor compound2 on SHP2 WT and SHP2F285S by molecular dynamics study.

Runling Wang, Xin-Hua Lu, Ying-Hong Ma, 2020, Journal of molecular graphics & modelling.

N,N′-Diacetyl-N′-[(4-nitrophenoxy)acetyl]acetohydrazide

Runling Wang, Weiren Xu, Guilong Zhao, 2009, Acta crystallographica. Section E, Structure reports online.

Exploring the cause of the inhibitor 4AX attaching to binding site disrupting protein tyrosine phosphatase 4A1 trimerization by molecular dynamic simulation

Runling Wang, Ma Ying, Li Wei-ya, 2019, Journal of biomolecular structure & dynamics.

MOLECULAR DYNAMICS SIMULATION OF POINT MUTATIONS OF ARG 221 IN THE ACTIVE SITE OF PROTEIN TYROSINE PHOSPHATASE 1B

Runling Wang, Xian-Chao Cheng, Weiren Xu, 2009 .

Synthesis and biological evaluation of novel N‐aryl‐ω‐(benzoazol‐2‐yl)‐sulfanylalkanamides as dual inhibitors of α‐glucosidase and protein tyrosine phosphatase 1B

Hua Sun, Peng Yu, Runling Wang, 2018, Chemical biology & drug design.

Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K

Runling Wang, Xin-Hua Lu, Ying-Hong Ma, 2021, Molecular diversity.

Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K

Runling Wang, Xin-Hua Lu, Ying-Hong Ma, 2021, Molecular Diversity.

Virtual screening, optimization, and identification of a novel specific PTP-MEG2 Inhibitor with potential therapy for T2DM

Runling Wang, Lei Dong, Wei-ren Xu, 2016, Oncotarget.

Exploring the effect of aplidin on low molecular weight protein tyrosine phosphatase by molecular docking and molecular dynamic simulation study

Run-Ling Wang, Ying Ma, Xin-Hua Lu, 2019, Comput. Biol. Chem..

Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ by core hopping of telmisartan

Shu-Qing Wang, Wei-Ren Xu, Runling Wang, 2017, Journal of biomolecular structure & dynamics.

Molecular dynamics study of CDC25BR492L mutant causing the activity decrease of CDC25B.

Runling Wang, Ying-Hong Ma, Wen-yu Yang, 2021, Journal of molecular graphics & modelling.