S. Leit

发表

Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors.

A. Kalita, A. Macleod, O. Moradei, 2006, Bioorganic & medicinal chemistry letters.

4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors.

A. Kalita, M. Robert, O. Moradei, 2008, Bioorganic & medicinal chemistry letters.

Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.

Daniel Delorme, A. Kalita, M. Robert, 2003, Journal of medicinal chemistry.

N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.

M. Robert, A. Macleod, O. Moradei, 2007, Bioorganic & medicinal chemistry letters.

Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.

O. Moradei, S. Leit, S. Fréchette, 2007, Journal of medicinal chemistry.

Potent and Selective TYK2-JH1 Inhibitors Highly Efficacious in Rodent Model of Psoriasis.

Markus K. Dahlgren, J. McElwee, Mee Shelley, 2022, Bioorganic & medicinal chemistry letters.

Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes

P. Marchetti, D. Eizirik, L. Marselli, 2020, Diabetes, obesity & metabolism.

Pre-clinical evaluation of TYK2 inhibitors for human beta cell protection in type 1 diabetes

P. Marchetti, D. Eizirik, L. Marselli, 2020 .

Design and synthesis of a novel class of histone deacetylase inhibitors.

S. Leit, S. Fréchette, G. Bouchain, 2001, Bioorganic & medicinal chemistry letters.

SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).

A. Kalita, O. Moradei, S. Leit, 2009, Bioorganic & medicinal chemistry letters.

Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses

A. Boulares, B. Osborne, L. Miele, 2022, Frontiers in Immunology.

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.

C. Maroun, S. Leit, M. Fournel, 2009, Bioorganic & medicinal chemistry letters.

Direct Synthesis of Previously Inaccessible Bridgehead Azabicyclics by Intramolecular Cyclization of α-Sulfonamido and α-Sulfonimido Radicals

J. Gallucci, C. Ra, S. Leit, 2001 .

The First Examples of Bridgehead Bicyclic Sultams

S. Leit, Leo A. Paquette and, 1999 .

Intramolecular Cyclization of Radicals Generated from α-Halomethylsulfonamides

S. Leit, L. Paquette, 1999 .

Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.

A. Kalita, A. Macleod, S. Leit, 2002, Cancer research.

(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors

A. Kalita, A. Macleod, O. Moradei, 2004 .

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

B. Delabarre, L. Tong, Eric Therrien, 2019, Nature.

Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.

Isabelle Paquin, Daniel Delorme, A. Kalita, 2008, Journal of medicinal chemistry.

Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.

Daniel Delorme, O. Moradei, S. Leit, 2002, Journal of medicinal chemistry.

(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.

A. Kalita, A. Macleod, O. Moradei, 2004, Bioorganic & medicinal chemistry letters.

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

B. Delabarre, L. Tong, Eric Therrien, 2019, Nature.

Targeting Cblb-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cells responses

A. Boulares, B. Osborne, L. Miele, 2022, bioRxiv.

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.

S. Leit, Zuomei Li, J. Rahil, 2009, Bioorganic & medicinal chemistry letters.

Sulfamides as novel histone deacetylase inhibitors.

Alain Ajamian, Sylvain Lefebvre, Alina Nicolescu, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.

A. Kalita, M. Robert, A. Macleod, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.

J. McElwee, Phani Ghanakota, Wenyan Miao, 2023, Journal of Medicinal Chemistry.