M. Fournel

发表

Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors.

A. Kalita, A. Macleod, O. Moradei, 2006, Bioorganic & medicinal chemistry letters.

4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors.

A. Kalita, M. Robert, O. Moradei, 2008, Bioorganic & medicinal chemistry letters.

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

Sylvain Lefebvre, Daniel Delorme, A. Kalita, 2008, Molecular Cancer Therapeutics.

Potent preclinical antitumor activity of MGCD265, an oral Met/VEGFR kinase inhibitor in phase II clinical development, in combination with taxanes or erlotinib.

C. Maroun, M. Fournel, J. Besterman, 2010 .

Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.

Daniel Delorme, A. Kalita, M. Robert, 2003, Journal of medicinal chemistry.

N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.

M. Robert, A. Macleod, O. Moradei, 2007, Bioorganic & medicinal chemistry letters.

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn

M. Fournel, A. Veillette, L. Chow, 1992, The Journal of experimental medicine.

Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.

O. Moradei, S. Leit, S. Fréchette, 2007, Journal of medicinal chemistry.

Functional Diversification of euANT/PLT Genes in Oryza sativa Panicle Architecture Determination

J. Tregear, H. Adam, S. Jouannic, 2021, Frontiers in Plant Science.

Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines.

J. M. Lee, P. Branton, M. Fournel, 1996, Oncogene.

Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.

Eric Therrien, M. Fournel, Zuomei Li, 2015, Bioorganic & medicinal chemistry letters.

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes

M. Fournel, A. Veillette, R. Weil, 1996, The Journal of experimental medicine.

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

M. Fournel, A. Veillette, L. Chow, 1993, Nature.

Comparative study of the sugar chains of factor VIII purified from human plasma and from the culture media of recombinant baby hamster kidney cells.

A. Kobata, M. Fournel, K. Furukawa, 1992, The Journal of biological chemistry.

Design and synthesis of a novel class of histone deacetylase inhibitors.

S. Leit, S. Fréchette, G. Bouchain, 2001, Bioorganic & medicinal chemistry letters.

Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase

S. Latour, M. Fournel, A. Veillette, 1997, Molecular and cellular biology.

SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).

A. Kalita, O. Moradei, S. Leit, 2009, Bioorganic & medicinal chemistry letters.

The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation.

M. Fournel, A. Veillette, A. Veillette, 1990, Oncogene.

Regulation of Zap-70 by Src Family Tyrosine Protein Kinases in an Antigen-specific T-cell Line (*)

M. Fournel, A. Veillette, R. Weil, 1995, The Journal of Biological Chemistry.

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.

C. Maroun, S. Leit, M. Fournel, 2009, Bioorganic & medicinal chemistry letters.

Down-regulation of Human DNA-(Cytosine-5) Methyltransferase Induces Cell Cycle Regulators p16 ink4A and p21WAF/Cip1 by Distinct Mechanisms*

A. Macleod, M. Fournel, J. Besterman, 1999, The Journal of Biological Chemistry.

Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.

A. Kalita, A. Macleod, S. Leit, 2002, Cancer research.

(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors

A. Kalita, A. Macleod, O. Moradei, 2004 .

Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene.

S. Lemieux, C. Kozak, L. Matis, 1994, Oncogene.

Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.

Isabelle Paquin, Daniel Delorme, A. Kalita, 2008, Journal of medicinal chemistry.

Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.

Daniel Delorme, O. Moradei, S. Leit, 2002, Journal of medicinal chemistry.

(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.

A. Kalita, A. Macleod, O. Moradei, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.

Alain Ajamian, Sylvain Lefebvre, Alina Nicolescu, 2009, Bioorganic & medicinal chemistry letters.

Sulfamides as novel histone deacetylase inhibitors.

Alain Ajamian, Sylvain Lefebvre, Alina Nicolescu, 2009, Bioorganic & medicinal chemistry letters.

Oncogenic activation of p59fyn tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation, tyrosine 528.

M. Fournel, A. Veillette, D Davidson, 1994, The Journal of biological chemistry.

MGCD265, an oral Met/VEGFR multitargeted receptor tyrosine kinase inhibitor, in combination with erlotinib: Phase I clinical experience.

M. Mehran, A. Tolcher, K. Papadopoulos, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.

A. Kalita, M. Robert, A. Macleod, 2008, Bioorganic & medicinal chemistry letters.

Conserved cysteine residues are critical for the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck.

M. Fournel, A. Veillette, S. Dumont, 1993, The Journal of biological chemistry.

Comparison of the in vivo survival of human factor VIII with and without von Willebrand factor in the hemophilic dog.

V. Marder, M. Fournel, P. Fay, 1986, Thrombosis research.

Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

T. Pawson, M. Fournel, A. Veillette, 1992, Oncogene.

Abstract 930: Preclinical characterization of MG516, a novel inhibitor of receptor tyrosine kinases involved in resistance to targeted therapies.

C. Maroun, S. Raeppel, A. Vaisburg, 2013 .

312 A Novel Assay for the Met Inhibitory Activity of MGCD265 in Plasma From Solid Tumor Patients in a Dose Escalating Phase I Study

G. Shapiro, H. Hurwitz, C. Maroun, 2012 .

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

A. Kalita, M. Robert, A. Macleod, 2008, Molecular Cancer Therapeutics.