Wagdy M. Eldehna

发表

Recent advancements of coumarin-based anticancer agents: An up-to-date review.

T. Al-Warhi, Ahmed Sabt, Eslam B. Elkaeed, 2020, Bioorganic chemistry.

Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.

C. Supuran, Mohamed Fares, H. Abdel‐Aziz, 2016, European journal of medicinal chemistry.

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer.

C. Supuran, Ghada S. Hassan, H. Alkahtani, 2018, Bioorganic chemistry.

Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.

C. Supuran, Wagdy M. Eldehna, S. M. Abou-Seri, 2018, European journal of medicinal chemistry.

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights.

C. Supuran, V. Kryštof, Wagdy M. Eldehna, 2019, European journal of medicinal chemistry.

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.

C. Supuran, Ghada S. Hassan, H. Abdel‐Aziz, 2019, European journal of medicinal chemistry.

Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.

Abdullah A. Elgazar, C. Supuran, V. Kryštof, 2020, European journal of medicinal chemistry.

Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties

Hazem A. Ghabbour, Hatem A. Abdel-Aziz, Mohamed Fares, 2016, Molecules.

Identification of a New Potential SARS-COV-2 RNA-Dependent RNA Polymerase Inhibitor via Combining Fragment-Based Drug Design, Docking, Molecular Dynamics, and MM-PBSA Calculations

T. Al-Warhi, Wagdy M. Eldehna, Sara T. A. Al-Rashood, 2020, Frontiers in Chemistry.

Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides.

Mamdouh M. Ali, Abeer E E Mahmoud, Wagdy M. Eldehna, 2019, European journal of medicinal chemistry.

Synthesis, Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents

Khalid A. Al-Rashood, Hatem A. Abdel-Aziz, Mohamed Fares, 2015, International journal of molecular sciences.

GC/MS Profiling, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase and Anti-Hyaluronidase Activities of a Stenocarpus sinuatus Leaves Extract

Wagdy M. Eldehna, Sara T. A. Al-Rashood, Nada M. Mostafa, 2022, Plants.

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

G. Piazza, A. Keeton, S. Afifi, 2017, PloS one.

Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation

Ghada S. Hassan, H. Alkahtani, Wagdy M. Eldehna, 2020, Marine drugs.

Synthesis, Crystal Structure, and Biological Activity of cis/trans Amide Rotomers of (Z)-N -(2-Oxoindolin-3-ylidene)formohydrazide

H. Fun, H. Abdel‐Aziz, Wagdy M. Eldehna, 2014 .

Design, Synthesis and Antitubercular Activity of Certain Nicotinic Acid Hydrazides

Mohamed Fares, H. Abdel‐Aziz, Wagdy M. Eldehna, 2015, Molecules.

Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights.

M. Abdelgawad, Sami I. Alzarea, R. B. Bakr, 2020, Bioorganic & medicinal chemistry.

Synthesis, in vitro biological evaluation and in silico studies of certain arylnicotinic acids conjugated with aryl (thio)semicarbazides as a novel class of anti-leishmanial agents.

Tamer M. Ibrahim, F. Boeckler, Mohamed Fares, 2019, European journal of medicinal chemistry.

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2020, Molecules.

Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules

Ahmed Sabt, Wagdy M. Eldehna, G. H. Al-Ansary, 2021, Molecules.

In-Silico targeting of SARS-CoV-2 NSP6 for drug and natural products repurposing

Tamer M. Ibrahim, M. El-Hadidi, Ahmed E. Abdelkader, 2022, Virology.

Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer

Abdullah A. Elgazar, Wagdy M. Eldehna, Fardous F. El-Senduny, 2021, Journal of enzyme inhibition and medicinal chemistry.

Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2

Wagdy M. Eldehna, I. Eissa, Ahmed B. M. Mehany, 2022, Molecules.

Recombinant human growth hormone improves the immune status of rats with septic encephalopathy: The role of VEGFR2 in the prevalence of endoplasmic reticulum stress repair module

Wagdy M. Eldehna, Ahmed M. El Kerdawy, W. Wadie, 2021, International Immunopharmacology.

Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review

Wagdy M. Eldehna, E. Elkaeed, Mohammed A. S. Abourehab, 2022, Frontiers in Pharmacology.

Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer.

Wagdy M. Eldehna, H. Ghabbour, Nasser S Al-Shakliah, 2018, Bioorganic chemistry.

Synthesis, Crystal Study, and Anti-Proliferative Activity of Some 2-Benzimidazolylthioacetophenones towards Triple-Negative Breast Cancer MDA-MB-468 Cells as Apoptosis-Inducing Agents

H. Abdel‐Aziz, Wagdy M. Eldehna, H. Ghabbour, 2016, International journal of molecular sciences.

Induction of ROS‑mediated cell death and activation of the JNK pathway by a sulfonamide derivative.

R. Ahmad, H. Abdel‐Aziz, Wagdy M. Eldehna, 2019, International journal of molecular medicine.

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells

M. Abdelgawad, S. N. Bukhari, M. M. Al-Sanea, 2021, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones.

H. Abdel‐Aziz, Wagdy M. Eldehna, Hany S. Ibrahim, 2015, European journal of medicinal chemistry.

Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity

C. Supuran, Wagdy M. Eldehna, A. Nocentini, 2022, Journal of enzyme inhibition and medicinal chemistry.

Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity.

Mohamed A. Abdelrahman, C. Supuran, H. Abdel‐Aziz, 2022, Bioorganic chemistry.

Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors

Tamer M. Ibrahim, C. Supuran, C. Capasso, 2021, International journal of molecular sciences.

3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies.

C. Supuran, M. M. Al-Sanea, H. Abdel‐Aziz, 2020, European journal of medicinal chemistry.

Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.

Mohamed A. Abdelrahman, C. Supuran, Wagdy M. Eldehna, 2019, European journal of medicinal chemistry.

Novel 6-Phenylnicotinohydrazide Derivatives: Design, Synthesis and Biological Evaluation as a Novel Class of Antitubercular and Antimicrobial Agents.

H. Abdel‐Aziz, Wagdy M. Eldehna, H. Ghabbour, 2017, Biological & pharmaceutical bulletin.

Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies.

Wagdy M. Eldehna, Mohamed S. Nafie, A. Belal, 2022, Bioorganic chemistry.

Computational Prediction of the Potential Target of SARS‐CoV‐2 Inhibitor Plitidepsin via Molecular Docking, Dynamic Simulations and MM‐PBSA Calculations

H. Abdel‐Aziz, Wagdy M. Eldehna, Sara T. A. Al-Rashood, 2021, Chemistry & biodiversity.

A patent review of anticancer CDK2 inhibitors (2017–present)

Mohamed A. Abdelrahman, Mohamed Fares, Wagdy M. Eldehna, 2022, Expert opinion on therapeutic patents.

New [1,2,4]triazolo[4,3‐c]quinazoline derivatives as vascular endothelial growth factor receptor‐2 inhibitors and apoptosis inducers: Design, synthesis, docking, and antiproliferative evaluation

Wagdy M. Eldehna, I. Eissa, Mohamed S Alesawy, 2022, Archiv der Pharmazie.

Modulation of endoplasmic reticulum stress response in gut-origin encephalopathy: Impact of vascular endothelial growth factor receptor-2 manipulation.

Wagdy M. Eldehna, Ahmed M. El Kerdawy, W. Wadie, 2020, Life sciences.

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

G. Piazza, A. Kadi, A. Keeton, 2017, Drug design, development and therapy.

In Silico Docking, Resistance Modulation and Biofilm Gene Expression in Multidrug-Resistant Acinetobacter baumannii via Cinnamic and Gallic Acids

Wagdy M. Eldehna, W. Elkhatib, Sara T. A. Al-Rashood, 2022, Antibiotics.

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2022, Scientific Reports.

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents

G. Piazza, A. Keeton, H. Abdel‐Aziz, 2018, Journal of enzyme inhibition and medicinal chemistry.

Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2–STAT3 pathway

R. Ahmad, H. Abdel‐Aziz, Wagdy M. Eldehna, 2018, OncoTargets and therapy.

Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

H. Abdel‐Aziz, Wagdy M. Eldehna, K. Amin, 2022, Journal of enzyme inhibition and medicinal chemistry.

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

Wagdy M. Eldehna, N. El-Deeb, I. Eissa, 2022, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Biophysical Insights into the Binding of a Potent Anti-Proliferative Non-symmetric Bis-isatin Derivative with Bovine Serum Albumin: Spectroscopic and Molecular Docking Approaches

H. Abdel‐Aziz, Wagdy M. Eldehna, M. Attia, 2017 .

Design, Synthesis, and Molecular Docking of 1-(1-(4-Chlorophenyl)-2-(phenylsulfonyl)ethylidene)-2-phenylhydrazine as Potent Nonazole Anticandidal Agent

H. Abdel‐Aziz, Wagdy M. Eldehna, H. Ghabbour, 2014 .

Development of Potent Nanosized Isatin-isonicotinohydrazide Hybrid for Management of Mycobacterium Tuberculosis.

Nahla A. Abdelshafi, Mohamed Fares, Mahmoud Elsabahy, 2021, International journal of pharmaceutics.

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

Wagdy M. Eldehna, I. Eissa, Ahmed B. M. Mehany, 2022, Journal of enzyme inhibition and medicinal chemistry.

2-((Benzimidazol-2-yl)thio)-1-arylethan-1-ones: Synthesis, crystal study and cancer stem cells CD133 targeting potential.

H. Fun, H. Abdel‐Aziz, Wagdy M. Eldehna, 2015, European journal of medicinal chemistry.

Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies

Wagdy M. Eldehna, M. M. Khalifa, I. Eissa, 2022, Journal of enzyme inhibition and medicinal chemistry.

Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies

Wagdy M. Eldehna, A. El-Taweel, Omnia Kutkat, 2022, International journal of molecular sciences.

In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

Wagdy M. Eldehna, O. A. Kamaly, Mahmoud A. El Hassab, 2022, International journal of molecular sciences.

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2022, Journal of enzyme inhibition and medicinal chemistry.

The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines

Wagdy M. Eldehna, N. Alhassan, S. Matou-Nasri, 2022, Frontiers in Pharmacology.

Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway

Wagdy M. Eldehna, N. El-Deeb, I. Eissa, 2022, PloS one.

GC/MS analysis and potential synergistic effect of mandarin and marjoram oils on Helicobacter pylori

Wagdy M. Eldehna, Sara T. A. Al-Rashood, Nada M. Mostafa, 2022, Journal of enzyme inhibition and medicinal chemistry.

Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors

H. Alkahtani, Wagdy M. Eldehna, S. M. Abou-Seri, 2022, Journal of enzyme inhibition and medicinal chemistry.

GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights

Mohamed A. Salem, Dina M El-Kersh, T. Al-Warhi, 2022, Journal of enzyme inhibition and medicinal chemistry.

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2022, Drug design, development and therapy.

DDDT_A_356988 1457..1471

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2022 .

Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2021, Journal of enzyme inhibition and medicinal chemistry.

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation.

Mamdouh M. Ali, Wagdy M. Eldehna, S. M. Abou-Seri, 2016, European journal of medicinal chemistry.

Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds.

H. Abdel‐Aziz, Wagdy M. Eldehna, Hany S. Ibrahim, 2014, European journal of medicinal chemistry.

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

H. Abdel‐Aziz, Wagdy M. Eldehna, H. Ghabbour, 2017, Journal of enzyme inhibition and medicinal chemistry.

Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer.

Tamer M. Ibrahim, Wagdy M. Eldehna, S. M. Abou-Seri, 2022, European journal of medicinal chemistry.

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives.

Mamdouh M. Ali, Wagdy M. Eldehna, S. M. Abou-Seri, 2016, European journal of medicinal chemistry.

Novel Thiazolidinone/Thiazolo[3,2-a]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation

Mohamed Fares, Mohamed El-Naggar, H. Abdel‐Aziz, 2018, Molecules.

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies

Ibrahim M. Ibrahim, Wagdy M. Eldehna, I. Eissa, 2023, PloS one.

Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies.

Wagdy M. Eldehna, N. El-Deeb, I. Eissa, 2023, Journal of biomolecular structure & dynamics.

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

Wagdy M. Eldehna, N. El-Deeb, I. Eissa, 2022, Journal of enzyme inhibition and medicinal chemistry.

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights

H. Abdel‐Aziz, T. Al-Warhi, Ahmed Sabt, 2020, Journal of enzyme inhibition and medicinal chemistry.

Design, Synthesis and In Vitro Antiproliferative Activity of Novel Isatin‐Quinazoline Hybrids

Mohamed Fares, H. Abdel‐Aziz, Wagdy M. Eldehna, 2015, Archiv der Pharmazie.

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

S. Carradori, C. Supuran, S. Dedhar, 2020, Metabolites.

An improved synthesis of pyrido[2,3-d]pyrimidin-4(1H)-ones and their antimicrobial activity.

Mohamed Fares, H. Abdel‐Aziz, Wagdy M. Eldehna, 2018, Organic & biomolecular chemistry.

Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis.

Mohamed A. Abdelrahman, C. Supuran, H. Abdel‐Aziz, 2020, European journal of medicinal chemistry.

Unexpected Synthesis, Single-Crystal X-ray Structure, Anticancer Activity, and Molecular Docking Studies of Certain 2–((Imidazole/Benzimidazol–2–yl)thio)–1–arylethanones

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2020, Crystals.

Solvent-Free Ring Cleavage Hydrazinolysis of Certain Biginelli Pyrimidines

H. Abdel‐Aziz, Wagdy M. Eldehna, H. Ghabbour, 2018 .

Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations.

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2021, Bioorganic chemistry.

Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.

C. Supuran, Wagdy M. Eldehna, Silvia Bua, 2017, European journal of medicinal chemistry.

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

L. Rashed, Ahmed Sabt, Wagdy M. Eldehna, 2018, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and in vitro anticancer evaluation of some fused indazoles, quinazolines and quinolines as potential EGFR inhibitors.

H. Abdel‐Aziz, Wagdy M. Eldehna, K. Amin, 2019, Bioorganic chemistry.

Synthesis and biological evaluation of 2-aminothiazole-thiazolidinone conjugates as potential antitubercular agents.

Riham F. George, Wagdy M. Eldehna, S. M. Abou-Seri, 2018, Future medicinal chemistry.

Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.

C. Supuran, Mohamed Fares, H. Abdel‐Aziz, 2017, Bioorganic & medicinal chemistry.

Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells.

F. Halaweish, Wagdy M. Eldehna, S. M. Abou-Seri, 2018, European journal of medicinal chemistry.

Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents.

Riham F. George, S. Bhakta, Wagdy M. Eldehna, 2018, European journal of medicinal chemistry.

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2022, RSC advances.

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

Mohamed A. Abdelrahman, C. Supuran, H. Abdel‐Aziz, 2022, Journal of enzyme inhibition and medicinal chemistry.

New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study

Abdullah A. Elgazar, D. G. Parambi, S. N. Bukhari, 2023, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, in Vitro and in Silico Studies of Some Novel 5-Nitrofuran-2-yl Hydrazones as Antimicrobial and Antitubercular Agents.

Mohamed Fares, H. Abdel‐Aziz, Wagdy M. Eldehna, 2015, Biological & pharmaceutical bulletin.

Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII

C. Supuran, Wagdy M. Eldehna, Eun‐Kyoung Bang, 2023, Journal of enzyme inhibition and medicinal chemistry.

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity.

Y. Pommier, K. Agama, Wagdy M. Eldehna, 2021, European journal of medicinal chemistry.

New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies.

Tamer M. Ibrahim, A. Bekhit, Ahmed Sabt, 2022, European journal of medicinal chemistry.

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors

T. Al-Warhi, Wagdy M. Eldehna, A. Nabil, 2022, Journal of enzyme inhibition and medicinal chemistry.

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Mohamed El-Naggar, H. Abdel‐Aziz, Wagdy M. Eldehna, 2018, Molecules.

One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents.

V. Kryštof, H. Abdel‐Aziz, Wagdy M. Eldehna, 2021, European journal of medicinal chemistry.

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

Y. Pommier, K. Agama, Wagdy M. Eldehna, 2021, Journal of enzyme inhibition and medicinal chemistry.

The Antioxidant and Enzyme Inhibitory Potential of n-Hexane-Extracted Oils Obtained from Three Egyptian Cultivars of the Golden Dewdrop Duranta erecta Linn. Supported by Their GC-MS Metabolome Analysis and Docking Studies

G. Zengin, S. Dall’Acqua, Wagdy M. Eldehna, 2022, Antioxidants.

Phytochemical Investigation of Egyptian Riverhemp: A Potential Source of Antileukemic Metabolites

Wagdy M. Eldehna, S. Ross, G. Fawzy, 2022, Journal of Chemistry.

GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of Syzygium cumini (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking Studies

Wagdy M. Eldehna, Sara T. A. Al-Rashood, S. Aly, 2021, Molecules.

The old world salsola as a source of valuable secondary metabolites endowed with diverse pharmacological activities: a review

Fatma M. Abdel Bar, Wagdy M. Eldehna, Mohammed A. S. Abourehab, 2022, Journal of enzyme inhibition and medicinal chemistry.

Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies

H. Abd-Alla, Heba-tollah M. Sweelam, Wagdy M. Eldehna, 2022, Metabolites.

Phytonutrients, Colorant Pigments, Phytochemicals, and Antioxidant Potential of Orphan Leafy Amaranthus Species

Wagdy M. Eldehna, S. Oba, Umakanta Sarker, 2022, Molecules.

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies

Faten Farouk, Wagdy M. Eldehna, Ayman Abo Elmaaty, 2023, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, Biological Evaluation and Molecular Docking of Certain Sulfones as Potential Nonazole Antifungal Agents

Muhammad A. Alsherbiny, Mohamed Fares, H. Abdel‐Aziz, 2016, Molecules.

Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal

Wagdy M. Eldehna, Sara T. A. Al-Rashood, Radwan S. El-Haggar, 2022, Drug delivery.

Chemical Constituents, Antioxidant, and Enzyme Inhibitory Activities Supported by In-Silico Study of n-Hexane Extract and Essential Oil of Guava Leaves

G. Zengin, S. Dall’Acqua, Wagdy M. Eldehna, 2022, Molecules.

Toward the Identification of Potential α-Ketoamide Covalent Inhibitors for SARS-CoV-2 Main Protease: Fragment-Based Drug Design and MM-PBSA Calculations

Mohamed Fares, H. Alkahtani, Wagdy M. Eldehna, 2021, Processes.

In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches

Tamer M. Ibrahim, Wagdy M. Eldehna, Sara T. A. Al-Rashood, 2021, Journal of enzyme inhibition and medicinal chemistry.

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

T. Al-Warhi, Wagdy M. Eldehna, Ahmed M. El Kerdawy, 2020, Journal of enzyme inhibition and medicinal chemistry.

Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators

T. Al-Warhi, Wagdy M. Eldehna, Mohamed S. Nafie, 2023, Journal of enzyme inhibition and medicinal chemistry.

Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies

M. M. Al-Sanea, H. Abdel‐Aziz, T. Al-Warhi, 2020, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents.

H. Abdel‐Aziz, Wagdy M. Eldehna, H. Mahrous, 2015, European journal of medicinal chemistry.

Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

Wagdy M. Eldehna, Hany S. Ibrahim, M. Elaasser, 2018, Journal of enzyme inhibition and medicinal chemistry.

Identification of Novel Cyanopyridones and Pyrido[2,3-d]pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies

T. Al-Warhi, Wagdy M. Eldehna, Mahmoud A. El Hassab, 2022, Pharmaceuticals.

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

C. Supuran, H. Abdel‐Aziz, T. Al-Warhi, 2022, Journal of enzyme inhibition and medicinal chemistry.

4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments.

C. Supuran, Mohamed Elagawany, Wagdy M. Eldehna, 2023, European journal of medicinal chemistry.

Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.

C. Supuran, Mohamed Fares, H. Abdel‐Aziz, 2022, European journal of medicinal chemistry.

Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors.

C. Supuran, Wagdy M. Eldehna, A. Nocentini, 2021, European journal of medicinal chemistry.

Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation.

Abdullah A. Elgazar, C. Supuran, F. Badria, 2021, European journal of medicinal chemistry.

Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities.

C. Supuran, M. Abdelgawad, M. M. Al-Sanea, 2021, European journal of medicinal chemistry.

Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors.

Tamer M. Ibrahim, C. Supuran, C. Capasso, 2021, European journal of medicinal chemistry.

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer

R. Ahmad, H. Abdel‐Aziz, T. Al-Warhi, 2021, Journal of enzyme inhibition and medicinal chemistry.

Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer.

C. Supuran, M. M. Al-Sanea, H. Abdel‐Aziz, 2020, ACS medicinal chemistry letters.

Discovery of potent dual-tailed benzenesulfonamide inhibitors of human carbonic anhydrases im-plicated in glaucoma and in vivo profiling of their intraocular pressure lowering action.

C. Supuran, E. Masini, T. Peat, 2020, Journal of medicinal chemistry.

Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies.

C. Supuran, H. Abdel‐Aziz, Wagdy M. Eldehna, 2019, Bioorganic chemistry.

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.

C. Supuran, D. Vullo, Ghada S. Hassan, 2019, Bioorganic chemistry.

Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.

S. Carradori, C. Supuran, S. Dedhar, 2020, Biophysical journal.

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors

C. Supuran, M. Abdelgawad, M. M. Al-Sanea, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors.

C. Supuran, H. Abdel‐Aziz, Wagdy M. Eldehna, 2019, European journal of medicinal chemistry.

Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity.

Mohamed A. Abdelrahman, C. Supuran, Ghada S. Hassan, 2019, Bioorganic chemistry.

Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights

Mohamed A. Abdelrahman, C. Supuran, Ghada S. Hassan, 2019, International journal of molecular sciences.

"A Sweet Combination": Developing saccharin and acesulfame K structures for selectively targeting the tumor-associated carbonic anhydrases IX and XII.

C. Supuran, Z. Alothman, H. Abdel‐Aziz, 2019, Journal of medicinal chemistry.

Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment

C. Supuran, H. Abdel‐Aziz, T. Al-Warhi, 2022, Journal of enzyme inhibition and medicinal chemistry.

Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells.

C. Supuran, Z. Alothman, Wagdy M. Eldehna, 2020, European journal of medicinal chemistry.

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

Mohamed A. Abdelrahman, C. Supuran, H. Abdel‐Aziz, 2019, Journal of enzyme inhibition and medicinal chemistry.

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

M. Abdelgawad, M. M. Al-Sanea, Wagdy M. Eldehna, 2020, Drug design, development and therapy.

Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

A. Hamed, Ghada S. Hassan, M. M. Al-Sanea, 2020, Journal of enzyme inhibition and medicinal chemistry.

Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents.

Abdul-Malek S. Al-Tamimi, C. Supuran, R. Ahmad, 2016, European journal of medicinal chemistry.

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

Ghada S. Hassan, H. Alkahtani, H. Abdel‐Aziz, 2019, Journal of enzyme inhibition and medicinal chemistry.

Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.

C. Supuran, Mohamed Fares, H. Abdel‐Aziz, 2017, European journal of medicinal chemistry.

Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking.

S. Zada, Mohamed Fares, Mamdouh M. Ali, 2015, European journal of medicinal chemistry.

One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors.

A. L. Fallacara, M. Botta, H. Abdel‐Aziz, 2018, Future medicinal chemistry.

Development of 2-oindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

R. Ahmad, H. Abdel‐Aziz, T. Al-Warhi, 2020, Journal of enzyme inhibition and medicinal chemistry.

Dual Targeting of VEGFR2 and C-Met Kinases via the Design and Synthesis of Substituted 3-(Triazolo-thiadiazin-3-yl)indolin-2-one Derivatives as Angiogenesis Inhibitors

Hamed I. Ali, Wagdy M. Eldehna, Hany S. Ibrahim, 2020, ACS omega.

GC/MS Profiling of the Essential Oil and Lipophilic Extract of Moricandia sinaica Boiss. and Evaluation of Their Cytotoxic and Antioxidant Activities

Wagdy M. Eldehna, Sara T. A. Al-Rashood, Mahmoud A. El Hassab, 2023, Molecules.

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

F. S. El-Tokhy, Wagdy M. Eldehna, Sara T. A. Al-Rashood, 2023, Molecules.

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis

Mohamed A. Abdelrahman, T. Al-Warhi, Wagdy M. Eldehna, 2022, Molecules.

Papaverinol-N-Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening

Mohamed H. Mahmoud, G. Batiha, Wagdy M. Eldehna, 2023, Molecules.

Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifolia

M. Rateb, Wagdy M. Eldehna, U. Abdelmohsen, 2023, Journal of enzyme inhibition and medicinal chemistry.

Development and Validation of High-Throughput Bioanalytical Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the Quantification of Newly Synthesized Antitumor Carbonic Anhydrase Inhibitors in Human Plasma

Mohamed A. Abdelrahman, Wagdy M. Eldehna, F. Elbarbry, 2020, Molecules.

Tetrahydrobenzo[h]quinoline derivatives as a novel chemotype for dual antileishmanial-antimalarial activity graced with antitubercular activity: Design, synthesis and biological evaluation.

Tamer M. Ibrahim, A. Bekhit, Wagdy M. Eldehna, 2023, European journal of medicinal chemistry.

Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

R. El-Shesheny, Mohamed Elagawany, Wagdy M. Eldehna, 2023, Journal of enzyme inhibition and medicinal chemistry.

An updated review of fatty acid residue-tethered heterocyclic compounds: synthetic strategies and biological significance

Ahmed Sabt, Wagdy M. Eldehna, G. H. Al-Ansary, 2023, RSC advances.

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

A. Hamed, H. Abdel‐Aziz, Wagdy M. Eldehna, 2017, Journal of enzyme inhibition and medicinal chemistry.

New apoptotic anti-triple-negative breast cancer theobromine derivative inhibiting EGFRWT and EGFRT790M: in silico and in vitro evaluation.

Ibrahim M. Ibrahim, Wagdy M. Eldehna, N. El-Deeb, 2023, Molecular diversity.

metabolites Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identiﬁcation, In Vitro, Modes of Action, and Molecular Docking Studies

H. Abd-Alla, Heba-tollah M. Sweelam, Wagdy M. Eldehna, 2022 .

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

C. Supuran, A. Angeli, Wagdy M. Eldehna, 2023, Journal of enzyme inhibition and medicinal chemistry.

Development of potent nanosized carbonic anhydrase inhibitor for targeted therapy of hypoxic solid tumors.

C. Supuran, Mahmoud Elsabahy, Wagdy M. Eldehna, 2022, International journal of pharmaceutics.

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease

Abdullah A. Elgazar, C. Supuran, Wagdy M. Eldehna, 2023, Journal of enzyme inhibition and medicinal chemistry.

Morphologic Design of Nanogold Carriers for a Carbonic Anhydrase Inhibitor: Effect on Ocular Retention and Intraocular Pressure.

C. Supuran, Mahmoud Elsabahy, Wagdy M. Eldehna, 2023, International journal of pharmaceutics.

WRH-2412 alleviates the progression of hepatocellular carcinoma through regulation of TGF-β/β-catenin/α-SMA pathway

H. Abdel‐Aziz, Wagdy M. Eldehna, K. Hashem, 2023, Journal of enzyme inhibition and medicinal chemistry.

2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling.

V. Kryštof, Wagdy M. Eldehna, D. Hendrychová, 2023, European journal of medicinal chemistry.

N-substituted-4-phenyl/benzylphthalazin-1-ones

H. Abdel‐Aziz, Wagdy M. Eldehna, Hany S. Ibrahim, 2015 .

In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches

Tamer M. Ibrahim, Wagdy M. Eldehna, Sara T. A. Al-Rashood, 2021, Journal of Enzyme Inhibition and Medicinal Chemistry.

1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights

T. Al-Warhi, Wagdy M. Eldehna, Mahmoud A. El Hassab, 2023, Molecules.

In silico identification of potential SARS COV-2 2′-O-methyltransferase inhibitor: fragment-based screening approach and MM-PBSA calculations

Tamer M. Ibrahim, H. Alkahtani, Wagdy M. Eldehna, 2021, RSC advances.

Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties.

Tamer M. Ibrahim, C. Supuran, Wagdy M. Eldehna, 2023, European journal of medicinal chemistry.

1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities.

Tamer M. Ibrahim, C. Supuran, H. Abdel‐Aziz, 2023, Journal of medicinal chemistry.

Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights

C. Supuran, Mohamed Elagawany, Wagdy M. Eldehna, 2023, Journal of Enzyme Inhibition and Medicinal Chemistry.

In silico screening of SARS-CoV2 helicase using African natural products: Docking and molecular dynamics approaches

Tamer M. Ibrahim, A. Bekhit, Wagdy M. Eldehna, 2023, Virology.

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity

H. Abdel‐Aziz, T. Al-Warhi, Wagdy M. Eldehna, 2022, Scientific Reports.

Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights.

Wagdy M. Eldehna, E. F. Khaleel, R. Badi, 2023, Bioorganic chemistry.

Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies

Wagdy M. Eldehna, M. M. Khalifa, I. Eissa, 2022, Molecules.

Theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation, in silico and preliminary kinetic studies

Abdullah A. Elgazar, Wagdy M. Eldehna, F. Badria, 2023, RSC advances.

Identification of novel ureido benzothiophenes as dual VEGFR-2/EGFR anticancer agents

T. Al-Warhi, Wagdy M. Eldehna, M. Elaasser, 2023, Bioorganic Chemistry.

Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles.

C. Supuran, Wagdy M. Eldehna, Ahmed M. El‐Dessouki, 2024, Journal of Medicinal Chemistry.

Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma.

C. Supuran, Wagdy M. Eldehna, A. Nocentini, 2024, Journal of medicinal chemistry.

Development of new thieno[2,3-d]pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities.

Wagdy M. Eldehna, R. Badi, E. El-Bastawissy, 2024, Bioorganic chemistry.

Phytochemical profiling and mechanistic evaluation of black garlic extract on multiple sclerosis rat model

T. Al-Warhi, Wagdy M. Eldehna, Nada M. Mostafa, 2023, Journal of Functional Foods.

An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review.

Ahmed Sabt, Wagdy M. Eldehna, E. F. Khaleel, 2024, Molecular diversity.

Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer.

Tamer M. Ibrahim, C. Supuran, F. Şahin, 2023, European journal of medicinal chemistry.

Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.

C. Supuran, Mohamed Fares, H. Abdel‐Aziz, 2017, Bioorganic & medicinal chemistry.

Novel N-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations

Wagdy M. Eldehna, Mahmoud A. El Hassab, E. F. Khaleel, 2023, Journal of enzyme inhibition and medicinal chemistry.

3-Acetyl-11-keto-β-boswellic Acid-Based Hybrids Alleviate Acetaminophen-Induced Hepatotoxicity in HepG2 by the Regulation of Inflammatory and Oxidative Stress Pathways: An Integrated Approach

Abdullah A. Elgazar, Wagdy M. Eldehna, Ramadan A. El-domany, 2023, ACS omega.