Jing-Jer Lin

发表

Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone.

J. Chiou, Hsu-Shan Huang, Y. Fong, 2003, Journal of medicinal chemistry.

The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein.

Chun-Chen Kuo, Jing-Jer Lin, Chi-Fang Wu, 2007, The Biochemical journal.

The U 3 small nucleolar ribonucleoprotein component Imp 4 p is a telomeric DNA-binding protein

Chun-Chen Kuo, Jing-Jer Lin, Wu Chi-Fang, 2007 .

The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation

S. Teng, Jing-Jer Lin, S. Tseng, 2006, Nucleic acids research.

Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues.

Hsu-Shan Huang, Jing-Jer Lin, Jing-Ru Jhan, 2009, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of anthra [ 1 , 9-cd ] pyrazol-6 ( 2 H )-one scaffold derivatives as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2015 .

Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2015 .

Inhibition of Cancer Cell Migration and Invasion through Suppressing the Wnt1-mediating Signal Pathway by G-quadruplex Structure Stabilizers*

Zi-Fu Wang, Jing-Jer Lin, T. Tseng, 2014, The Journal of Biological Chemistry.

c‐Jun N‐terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104

S. Hung, Chao-Hsiung Lin, Yeu Su, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells

Jing-Jer Lin, Jing-Ru Jhan, Hsi-Hsien Hsieh, 2017, Journal of Cell Science.

Facile synthesis toward the construction of an activity probe library for glycosidases.

L. Lo, Yaw-Kuen Li, Jing-Jer Lin, 2006, Carbohydrate research.

Synthesis of Activity Probes for β‐Xylosidase

L. Lo, Yaw-Kuen Li, Yen-Ru Pan, 2006 .

Design and synthesis of class-selective activity probes for protein tyrosine phosphatases.

Hsin‐Yi Wang, L. Lo, Jing-Jer Lin, 2002, Journal of proteome research.

Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation

Jin-Qiu Zhou, Jing-Jer Lin, Yi-Chien Lin, 2009, Cell Research.

The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells.

Shu-Chun Lin, J. Shih, Yen-Ru Pan, 2006, Cancer letters.

An in vitro assay for saccharomyces telomerase requires EST1

Jing-Jer Lin, V. Zakian, 1995, Cell.

Binding and Partial Denaturing of G-quartet DNA by Cdc13p ofSaccharomyces cerevisiae *

J. Shih, Jing-Jer Lin, Yi-Chien Lin, 2001, The Journal of Biological Chemistry.

Exposure of Single-stranded Telomeric DNA Causes G2/M Cell Cycle Arrest in Saccharomyces cerevisiae *

Jing-Jer Lin, Mei-Yu Chen, Chen-Yi Wang, 2003, The Journal of Biological Chemistry.

Dynamic DNA Shortening by Telomere-Binding Protein Cdc13.

Hung-Wen Li, R. Ohniwa, Jing-Jer Lin, 2021, Journal of the American Chemical Society.

Nuclear βII-Tubulin Associates with the Activated Notch Receptor to Modulate Notch Signaling

C. Shih, S. Shen, R. Hsieh, 2004, Cancer Research.

Genetic analysis reveals essential and non-essential amino acids within the telomeric DNA-binding interface of Cdc13p.

Y. Wu Lee, Jing-Jer Lin, Yi-Chien Lin, 2007, The Biochemical journal.

Multiple Pif1 helicases are required to sequentially disrupt G-quadruplex structure and unwind duplex DNA.

Hung-Wen Li, Chia-Ying Lu, Jing-Jer Lin, 2016, Biochemical and biophysical research communications.

A Novel Carbazole Derivative, BMVC: a Potential Antitumor Agent and Fluorescence Marker of Cancer Cells

P. Lou, Cheng-Chung Chang, Chin-Tin Chen, 2004, Chemistry & biodiversity.

Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones.

M. Preobrazhenskaya, J. Balzarini, A. Shtil, 2009, Bioorganic & medicinal chemistry.

Sequential Loading of Saccharomyces cerevisiae Ku and Cdc13p to Telomeres*

Yan-Hwa Wu Lee, Jing-Jer Lin, Yi-Hsuan Chiang, 2009, Journal of Biological Chemistry.

Telomere and telomerase as targets for anti-cancer and regeneration therapies

Yi-Hsin Hsu, Jing-Jer Lin, 2005, Acta Pharmacologica Sinica.

Design, synthesis, and evaluation of cell permeable probes for protein kinases

S. Fu, L. Lo, Jing-Jer Lin, 2016 .

Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives.

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2012, European journal of medicinal chemistry.

G-Quadruplex Stabilizer 3,6-Bis(1-Methyl-4-Vinylpyridinium)Carbazole Diiodide Induces Accelerated Senescence and Inhibits Tumorigenic Properties in Cancer Cells

P. Lou, Cheng-Chung Chang, Chin-Tin Chen, 2008, Molecular Cancer Research.

Human telomerase inhibition and cytotoxicity of regioisomeric disubstituted amidoanthraquinones and aminoanthraquinones.

Hsu-Shan Huang, Yu-Cheng Lu, Jing-Jer Lin, 2005, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2016 .

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

Y. Yen, Shih-Hsiung Wu, Hsu-Shan Huang, 2015, Oncotarget.

Structure-based design, synthesis and biological evaluation of novel anthra[1,2-d]imidazole-6,11-dione homologues as potential antitumor agents.

Hsu-Shan Huang, Jing-Jer Lin, Dah-Shyong Yu, 2013, European journal of medicinal chemistry.

Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative.

P. Lou, Cheng-Chung Chang, Chin-Tin Chen, 2004, Analytical chemistry.

A Fluorescent Anti-Cancer Agent, 3,6-bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide, Stains G-Quadruplexes in Cells and Inhibits Tumor Growth.

Cheng-Chung Chang, Jing-Jer Lin, Ta-Chau Chang, 2015, Current topics in medicinal chemistry.

Synthesis and Evaluation of Activity-Based Probes Carrying a 5′-Fluorosulfonylbenzoyl Adenosine Moiety for Protein Kinases

L. Lo, Jing-Jer Lin, Yu-Ling Hsu, 2013 .

Induction of senescence in cancer cells by the G‐quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity

Cheng-Chung Chang, Cheng-Chung Chang, Jing-Jer Lin, 2012, British journal of pharmacology.

Synthesis, Telomerase Evaluation and Anti‐Proliferative Studies on Various Series of Diaminoanthraquinone‐Linked Aminoacyl Residue Derivatives

Hsu-Shan Huang, Jing-Jer Lin, K. Huang, 2012, Archiv der Pharmazie.

Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives.

Hsu-Shan Huang, Jing-Jer Lin, Yi-Hsuan Chiang, 2008, Bioorganic & medicinal chemistry.

Synthesis and human telomerase inhibition of a series of regioisomeric disubstituted amidoanthraquinones.

Hsu-Shan Huang, Jing-Jer Lin, K. Huang, 2007, Chemical & pharmaceutical bulletin.

NSC746364, NSC746365, and NSC746366: the spectra of cytotoxicity and molecular correlates of response to telomerase activity

Hsu-Shan Huang, Jing-Jer Lin, K. Huang, 2010, Anti-cancer drugs.

Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones.

D. Chang, Hsu-Shan Huang, Jing-Jer Lin, 2012, European journal of medicinal chemistry.

Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.

Tsung-Chih Chen, J. Guh, D. Chang, 2013, European journal of medicinal chemistry.

Rapid and selective isolation of β‐xylosidase through an activity‐based chemical approach

L. Lo, Yaw-Kuen Li, Yen-Ru Pan, 2006 .

Study of the preferred modification sites of the quinone methide intermediate resulting from the latent trapping device of the activity probes for hydrolases.

L. Lo, Jing-Jer Lin, H. Liao, 2004, Biochemical and biophysical research communications.

Crystal Structure of Yeast Cytosine Deaminase

Yi-Hsin Hsu, Yi-Hsin Hsu, A. H. Wang, 2003, Journal of Biological Chemistry.

Crystallization and preliminary crystallographic analysis of yeast cytosine deaminase.

Yi-Hsin Hsu, Jing-Jer Lin, S. Liaw, 2003, Acta crystallographica. Section D, Biological crystallography.

Development of a Plate-Based Assay Platform to Monitor Cellular SHP2 Phosphatase Activity During Erythroid Differentiation

Chun-Chen Kuo, L. Lo, Jing-Jer Lin, 2012 .

Depleting Components of the THO Complex Causes Increased Telomere Length by Reducing the Expression of the Telomere-Associated Protein Rif1p

Jing-Jer Lin, T. Yu, Chen-Yi Wang, 2012, PloS one.

Interaction of Saccharomyces Cdc13p with Pol1p, Imp4p, Sir4p and Zds2p is involved in telomere replication, telomere maintenance and cell growth control.

Shih-Yin Tsai, Jing-Jer Lin, Jing-Jer Lin, 2004, Nucleic acids research.

Development and evaluation of novel phosphotyrosine mimetic inhibitors targeting the Src homology 2 domain of signaling lymphocytic activation molecule (SLAM) associated protein.

L. Lo, Jing-Jer Lin, Chi-Yuan Chu, 2013, Journal of medicinal chemistry.

Induction of global stress response in Saccharomyces cerevisiae cells lacking telomerase.

S. Teng, Jing-Jer Lin, Hung-Lin Chen, 2002, Biochemical and biophysical research communications.

Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis

C. Chi, S. Lo, Muh-Hwa Yang, 2014, Oncotarget.

Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents

P. Lou, Cheng-Chung Chang, Chin-Tin Chen, 2015, Nucleic acids research.

Conformational transition of a hairpin structure to G-quadruplex within the WNT1 gene promoter.

S. Hsu, Ming-hao Li, Zi-Fu Wang, 2015, Journal of the American Chemical Society.

A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer

Tai-Lin Chen, Te-Chang Lee, Jing-Jer Lin, 2017, Neoplasia.

CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner

Jing-Jer Lin, Wey-Jinq Lin, Hsi Chang, 2021, The Journal of biological chemistry.

Overexpression of the Pituitary Tumor Transforming Gene Induces p53-dependent Senescence through Activating DNA Damage Response Pathway in Normal Human Fibroblasts*

Yi-Hsin Hsu, P. Lou, C. Chiang, 2010, The Journal of Biological Chemistry.

Chromosome positional effects of gene expressions after cellular senescence.

Yi-Hsin Hsu, Jing-Jer Lin, Hung-Lin Chen, 2004, Biochemical and biophysical research communications.

Selective activation of SHP2 activity by cisplatin revealed by a novel chemical probe-based assay.

Chun-Chen Kuo, L. Lo, Jing-Jer Lin, 2010, Biochemical and biophysical research communications.

Development of activity-based probes with tunable specificity for protein tyrosine phosphatase subfamilies

Chun-Chen Kuo, L. Lo, Jing-Jer Lin, 2010 .

Investigation of DNA–protein recognition by satellite hole spectra of labeling dye

Ji-Yen Cheng, Kai-Chun Lin, Jing-Jer Lin, 2002 .

Association of pituitary tumor transforming gene expression with early oral tumorigenesis and malignant progression of precancerous lesions

Yi-Hsin Hsu, P. Lou, C. Chiang, 2011, Head & neck.

Pif1 regulates telomere length by preferentially removing telomerase from long telomere ends

Hung-Wen Li, Chia-Ying Lu, Jing-Jer Lin, 2014, Nucleic acids research.

Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α

M. Lei, B. Freeman, Jia Sun, 2011, Cell Research.

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase

Jing-Jer Lin, T. Yu, Yu-wen Kao, 2014, Proceedings of the National Academy of Sciences.

The addition of a spin column step in the telomeric repeat application protocol removes telomerase inhibitors.

Jing-Jer Lin, Fong-Chun Huang, Ying-Chieh Chen, 2015, Analytical biochemistry.

Establishing cell-based reporter systems for the analysis of hTERT expression.

J. Shih, Jing-Jer Lin, Yi-Yuan Huang, 2007, Methods in molecular biology.

(A)BC excinuclease: the Escherichia coli nucleotide excision repair enzyme

A. Sancar, J. Lin, Jing-Jer Lin, 1992, Molecular microbiology.

Specific Binding of Single-stranded Telomeric DNA by Cdc13p ofSaccharomyces cerevisiae *

J. Lin, J. Shih, Jing-Jer Lin, 2001, The Journal of Biological Chemistry.

Modulation of yeast telomerase activity by Cdc13 and Est1 in vitro

Hung-Wen Li, Chia-Ying Lu, Jing-Jer Lin, 2016, Scientific Reports.

Aconitamide, a Novel Alkaloid from the Roots of Aconitum carmichaeli

Y. Kuo, L. Lo, Jing-Jer Lin, 2013 .

Sequential Phosphorylation of Hepatitis C Virus NS5A Protein Requires the ATP-Binding Domain of NS3 Helicase

Y. Lai, L. Lo, Ming-Jiun Yu, 2022, Journal of virology.

The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo.

J. Lin, Jing-Jer Lin, V. Zakian, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Active Site of (A)BC Excinuclease AND MUTANTS OF UvrB REVEAL A DIRECT ROLE IN 3’ AND AN INDIRECT ROLE IN

J. Hearst, A. Sancar, Jing-Jer Lin, 2001 .

Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.

J. M. Lee, J. Lin, Jing-Jer Lin, 2000, Nucleic acids research.

Active site of (A)BC excinuclease. I. Evidence for 5' incision by UvrC through a catalytic site involving Asp399, Asp438, Asp466, and His538 residues.

A. Sancar, J. Lin, Jing-Jer Lin, 1992, The Journal of biological chemistry.

Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro.

J. Lin, Jing-Jer Lin, V. Zakian, 1994, Nucleic acids research.

Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis

C. Chi, S. Lo, Muh-Hwa Yang, 2014, Oncotarget.