Jang-Yang Chang

Hua-Lin Wu, Jang-Yang Chang, T. Cheng, 2020, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

H. Hsieh, T. Lien, J. Hsu, 2011, PloS one.

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition.

T. Yeh, J. Liou, Jang-Yang Chang, 2016, Organic & biomolecular chemistry.

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes.

J. Liou, Jang-Yang Chang, C. Kuo, 2015, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

J. Liou, Jang-Yang Chang, C. Kuo, 2011, Molecules.

Survivin – biology and potential as a therapeutic target in oncology

F. Tsai, Jang-Yang Chang, C. Cheung, 2013, OncoTargets and therapy.

Pharmacokinetics and protein binding of MPT0B292

J. Liou, Jang-Yang Chang, Jin‐ding Huang, 2017, Biopharmaceutics & drug disposition.

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells

Linyi Chen, Kelvin K. Tsai, Chih-Pin Chuu, 2013, PloS one.

Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells

Jang-Yang Chang, Chun-Cheng Lin, Cheng-Che Lee, 2015, PloS one.

Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors

Jang-Yang Chang, Cheng-Che Lee, Chien-Chang Huang, 2016, Scientific Reports.

The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b

C. Chen, R. Yang, Shiow-Ju Lee, 2022, Pharmaceutics.

O6‐methylguanine DNA methyltransferase repairs platinum‐DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma

Huai-chih Chiang, T. Tsou, Chien-Feng Li, 2015, International journal of cancer.

Phase II study of gemcitabine plus vinorelbine in the treatment of cisplatin‐resistant nasopharyngeal carcinoma

Jang-Yang Chang, T. Liu, R. Hong, 2006, Head & neck.

Expression of Epstein‐Barr virus‐encoded RNAs as a marker for metastatic undifferentiated nasopharyngeal carcinoma

H. Harn, K. Chow, T. Chao, 1996, Cancer.

Paclitaxel and Carboplatin-Induced Complete Remission in Peritoneal Carcinomatosis of Unknown Origin: A Report of Two Cases and Review of the Literature

T. Chao, Jang-Yang Chang, Yi-Ying Wu, 2010 .

Paclitaxel and carboplatin-induced complete remission in peritoneal carcinomatosis of unknown origin: a report of two cases and review of the literature.

T. Chao, Jang-Yang Chang, Yi-Ying Wu, 2010, Tumori.

Nephrotic Syndrome Associated with Thymoma

Jang-Yang Chang, Kwang-Yu Chang, Sheng-Yen Hsiao, 2014 .

Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2016, Cancer Causes & Control.

Phase I Dose-Escalation Study of SCB01A, a Microtubule Inhibitor with Vascular Disrupting Activity, in Patients with Advanced Solid Tumors.

W. Su, C. Yen, Chia‐Chi Lin, 2020, The oncologist.

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

H. Hsieh, M. Coumar, Huang-Hui Chen, 2009, Molecular Cancer.

LDOC1 (leucine zipper, down-regulated in cancer 1)

Jang-Yang Chang, J. Hsiao, 2017 .

Four new 6-nor5(6-->7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides.

Y. Kuo, Chi-I Chang, Jang-Yang Chang, 2005, Planta medica.

2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.

J. Liou, Jang-Yang Chang, C. Kuo, 2006, Journal of medicinal chemistry.

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

H. Hsieh, C. Liao, Su-Ying Wu, 2011, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.

H. Hsieh, N. Mahindroo, J. Liou, 2004, Journal of medicinal chemistry.

Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells.

Y. Kuo, Jang-Yang Chang, C. Kuo, 2004, Molecular pharmacology.

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

H. Hsieh, C. Chen, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2009, Journal of medicinal chemistry.

Synthesis of New Camptothecin Analogues with the E‐Lactone Ring Replaced by α,β‐Cyclohexenone

T. Chou, Jang-Yang Chang, T. Su, 2006 .

New analogues of AHMA as potential antitumor agents: synthesis and biological activity.

Shu-Yun Cheng, Jang-Yang Chang, Li-Tzong Chen, 2003, Bioorganic & medicinal chemistry.

4- and 5-aroylindoles as novel classes of potent antitubulin agents.

H. Hsieh, J. Liou, Jang-Yang Chang, 2007, Journal of medicinal chemistry.

Antitubulin agents for the treatment of cancer – a medicinal chemistry update

H. Hsieh, N. Mahindroo, J. Liou, 2006 .

Structure–Activity Relationship Studies of 3‐Aroylindoles as Potent Antimitotic Agents

Yi-Wei Chang, Hsing-Pang Hsieh, Uan-Kang Tan, 2006, ChemMedChem.

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

H. Hsieh, J. Liou, Jang-Yang Chang, 2008, Journal of medicinal chemistry.

Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.

P. Lyu, H. Hsieh, M. D. Chang, 2010, Journal of medicinal chemistry.

Tamoxifen accelerates proteasomal degradation of O6‐methylguanine DNA methyltransferase in human cancer cells

Jang-Yang Chang, Ching-Chuan Kuo, Jang-Yang Chang, 2007, International journal of cancer.

Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation.

Jang-Yang Chang, Li-Tzong Chen, T. Chou, 2002, Journal of medicinal chemistry.

Cytotoxic triterpenes from the aerial roots of Ficus microcarpa.

Y. Kuo, Y. Chiang, Jang-Yang Chang, 2005, Phytochemistry.

Antimutagenic constituents of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity.

Y. Kuo, Huang-Hui Chen, Jang-Yang Chang, 2011, Journal of agricultural and food chemistry.

Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling

H. Chiang, Chih-Pin Chuu, Jang-Yang Chang, 2013, International journal of molecular sciences.

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells.

Chi-Hung Lin, Y. Kuo, T. Chao, 2010, Biochemical pharmacology.

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia–mutated nuclear protein kinase activation

Jang-Yang Chang, C. Kuo, C. Ashendel, 2007, Molecular Cancer Therapeutics.

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana.

Y. Kuo, N. Yang, Jang-Yang Chang, 2007 .

Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: implication for carcinogenesis.

Ka-Wo Lee, Y. Jong, Chang-Shen Lin, 2010, Oral oncology.

2,2'-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls.

Y. Kuo, Jang-Yang Chang, C. Kuo, 2002, Journal of agricultural and food chemistry.

The c.1085A>G Genetic Variant of CSF1R Gene Regulates Tumor Immunity by Altering the Proliferation, Polarization, and Function of Macrophages

W. Su, Jang-Yang Chang, P. Lin, 2017, Clinical Cancer Research.

Identification of Prognostic Biomarkers Originating From the Tumor Stroma of Betel Quid-Associated Oral Cancer Tissues

Jia-Ling Yang, Su-Fang Lin, Ying-Chieh Ko, 2021, Frontiers in Oncology.

MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma

Jang-Yang Chang, S. Shiah, S. Chou, 2021, Cancers.

Index of Cancer-Associated Fibroblasts Is Superior to the Epithelial–Mesenchymal Transition Score in Prognosis Prediction

D. Robinson, Chung-Yen Lin, Sheng-Yao Su, 2020, Cancers.

New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment

Jang-Yang Chang, Shang-Hung Chen, 2019, International journal of molecular sciences.

Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines.

Y. Kuo, Chi-I Chang, Jang-Yang Chang, 2004, Journal of natural products.

Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.

Chi-Hung Lin, Ying-Ting Lin, H. Hsieh, 2003, Bioorganic & medicinal chemistry letters.

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.

H. Hsieh, J. Liou, Jang-Yang Chang, 2006, Journal of medicinal chemistry.

Novel mutation of topoisomerase I in rendering cells resistant to camptothecin.

Jang-Yang Chang, Li-Tzong Chen, Tsang-Wu Liu, 2002, Cancer research.

BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo

H. Hsieh, C. Chen, Shiow-Ju Lee, 2004, Cancer Research.

c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

S. Jiang, Y. Chuang, Su-Fang Lin, 2021, Theranostics.

Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent.

H. Hsieh, Jen‐Shin Song, J. Liou, 2003, Biochemical pharmacology.

IL‐8 induces miR‐424‐5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma

S. Jiang, M. Hsiao, Hsuan-Yu Peng, 2016, Molecular oncology.

Investigating the association between oral hygiene and head and neck cancer.

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2013, Oral oncology.

Kappa Light-Chain Multiple Myeloma with Myelomatous Pleural Effusion a Case Report and Review of the Literature

Jang-Yang Chang, Herng‐Sheng Lee, Shi-Hui Hwang, 1994 .

Novel Phosphoinositide 3-Kinase/mTOR Dual Inhibitor, NVP-BGT226, Displays Potent Growth-Inhibitory Activity against Human Head and Neck Cancer Cells In Vitro and In Vivo

C. Yen, Jang-Yang Chang, Kwang-Yu Chang, 2011, Clinical Cancer Research.

Cancer Therapy : Preclinical Novel Phosphoinositide 3-Kinase / mTOR Dual Inhibitor , NVP-BGT 226 , Displays Potent Growth-Inhibitory Activity against Human Head and Neck Cancer Cells In Vitro and In Vivo

C. Yen, Jang-Yang Chang, Kwang-Yu Chang, 2011 .

Downregulated miR329 and miR410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7b.

S. Jiang, I. Chang, M. Hsiao, 2014, Cancer research.

Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells

Kuan-Der Lee, Jang-Yang Chang, P. Chu, 2015, Cancer Cell International.

Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways

Wei-Sheng Wu, J. Hung, Song-Bin Chang, 2017, Scientific Reports.

Targeted Casp8AP2 methylation increases drug resistance in mesenchymal stem cells and cancer cells.

T. Huang, Kuan-Der Lee, Jang-Yang Chang, 2012, Biochemical and biophysical research communications.

Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells

Jang-Yang Chang, Chung-Hsing Chen, Yu-lin Chen, 2021, Scientific reports.

Oral hygiene and the overall survival of head and neck cancer patients

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2019, Cancer medicine.

The Influence of Prediagnosis Alcohol Consumption and the Polymorphisms of Ethanol-Metabolizing Genes on the Survival of Head and Neck Cancer Patients

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2018, Cancer Epidemiology, Biomarkers & Prevention.

Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2017, Scientific Reports.

Regular recreational physical activity and risk of head and neck cancer

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2017, BMC Cancer.

Alcohol Drinking Obliterates the Inverse Association Between Serum Retinol and Risk of Head and Neck Cancer

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2015, Medicine.

The interplay between alcohol consumption, oral hygiene, ALDH2 and ADH1B in the risk of head and neck cancer

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2014, International journal of cancer.

Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma.

M. Hsiao, Chi-Long Chen, Hsuan-Yu Peng, 2016, Cancer research.

A novel peroxisome proliferator-activated receptor &agr;/&ggr; agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

H. Hsieh, S. Chuang, Jang-Yang Chang, 2008, Anti-cancer drugs.

Up‐regulation of miR‐455‐5p by the TGF‐β–SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B

Chao-Min Cheng, Jang-Yang Chang, J. Hsiao, 2016, The Journal of pathology.

Reciprocal regulation of MicroRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells

C. Liao, W. Hung, A. Cheng, 2014, Molecular Cancer.

A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells

Y. Chuang, Yu-Tsen Chen, Hsin-Huei Chang, 2021, Journal of food and drug analysis.

Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2017, Scientific Reports.

Aurora kinase inhibitors in preclinical and clinical testing.

H. Hsieh, M. Coumar, Jang-Yang Chang, 2009, Expert opinion on investigational drugs.

Aurora kinase inhibitors in preclinical and clinical testing

Mohane Selvaraj Coumar, Jang-Yang Chang, H. Hsieh, 2009, Expert opinion on investigational drugs.

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Yu-Wei Chang, M. Lai, Chih-Yang Wang, 2018, Scientific Reports.

Downregulated miR 329 and miR 410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7 b

S. Jiang, I. Chang, M. Hsiao, 2014 .

Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification.

Chi-Ying F. Huang, Miao-Fen Chen, Kuan-Der Lee, 2013, Biochemical pharmacology.

Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness.

S. Tsai, H. Sun, J. Liou, 2017, Cancer research.

The Tumor Suppressor TGFBR3 Blocks Lymph Node Metastasis in Head and Neck Cancer

Jang-Yang Chang, Li‐Wha Wu, J. Hsiao, 2020, Cancers.

Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial–mesenchymal transition suppression and cell polarity disruption

Jang-Yang Chang, Chi-Yen Chang, Chi-Min Lin, 2018, Scientific Reports.

A Simplified Diagnostic Classification Scheme of Chemotherapy-Induced Peripheral Neuropathy

Chung-I Li, Jang-Yang Chang, Chou-Ching K Lin, 2020, Disease markers.

MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition

T. Hong, Jang-Yang Chang, Yuh-Ling Chen, 2023, Journal of Experimental & Clinical Cancer Research.

Lysosomal Cysteine Proteinase Cathepsin S as a Potential Target for Anti-Cancer Therapy

C. Wu, W. Chang, Jang-Yang Chang, 2007 .

Laminin γ2‐enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3‐dependent uptake by lymphatic endothelial cells

Wan-Ling Wu, Jang-Yang Chang, Jeffrey S. Chang, 2019, International journal of cancer.

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036.

T. Tsou, Jang-Yang Chang, K. Chou, 2011, Cancer letters.

Phase I and pharmacokinetic study of oral thalidomide in patients with advanced hepatocellular carcinoma

J. Whang‐Peng, Y. Chao, Jang-Yang Chang, 2006, Cancer Chemotherapy and Pharmacology.

Epidermal growth factor–induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up‐regulation of fibronectin

Wen-Chang Chang, Jang-Yang Chang, Kwang-Yu Chang, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Discoidin Domain Receptor-1 (DDR1) is Involved in Angiolymphatic Invasion in Oral Cancer

A. Cheng, Su-Fang Lin, Ying-Chieh Ko, 2020, Cancers.

Reciprocal regulation of MicroRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells

C. Liao, W. Hung, A. Cheng, 2014, Molecular Cancer.

A novel cancer therapeutic using thrombospondin 1 in dendritic cells.

M. Lai, Chi-Chen Lin, Chih-Yang Wang, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Development of nanoliposomal irinotecan (nal-IRI, MM-398, PEP02) in the management of metastatic pancreatic cancer

Yan-Shen Shan, Nai-Jung Chiang, Jang-Yang Chang, 2016, Expert opinion on pharmacotherapy.

MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma

Hsuan-Yu Peng, Shiow-Lian Catherine Jin, J. Liou, 2016, PloS one.

Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

J. Liou, Jang-Yang Chang, C. Kuo, 2018, Journal of Biomedical Science.

Hepatocellular Carcinoma with Intra-Atrial Tumor Thrombi

T. Chao, Jang-Yang Chang, T. Liu, 2004, Oncology.

Sequential therapy of neoadjuvant biochemotherapy with cetuximab, paclitaxel, and cisplatin followed by cetuximab‐based concurrent bioradiotherapy in high‐risk locally advanced oral squamous cell carcinoma: Final analysis of a phase 2 clinical trial

K. Tsai, C. Yen, Jang-Yang Chang, 2019, Head & neck.

Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives.

T. Chou, Jang-Yang Chang, Ching-Huang Chen, 2005, Bioorganic & medicinal chemistry.

Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

C. Wu, R. Chou, Jang-Yang Chang, 2007 .

Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2013, PloS one.

New Insights Into Oral Squamous Cell Carcinoma: From Clinical Aspects to Molecular Tumorigenesis

Jang-Yang Chang, Kwang-Yu Chang, Sheng-Yen Hsiao, 2021, International journal of molecular sciences.

Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK.

Shun-Fu Chang, J. Chiu, Jang-Yang Chang, 2013, Biochimica et biophysica acta.

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry.

H. Hsieh, W. Chang, Jang-Yang Chang, 2019, Biochimica et biophysica acta. Molecular cell research.

Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy

C. Chen, Jen‐Shin Song, Jinq-chyi Lee, 2022, Journal of medicinal chemistry.

A Phase I Study of Weekly Docetaxel, 24-Hour Infusion of High-Dose Fluorouracil/Leucovorin and Cisplatin in Patients with Advanced Gastric Cancer

J. Whang‐Peng, Jang-Yang Chang, T. Liu, 2002, Oncology.

Transcriptional Repression of O6-Methylguanine DNA Methyltransferase Gene Rendering Cells Hypersensitive to N,N′-Bis(2-chloroethyl)-N-nitrosurea in Camptothecin-Resistant Cells

Jang-Yang Chang, C. Kuo, Li‐Tzong Chen, 2008, Molecular Pharmacology.

Arginine deprivation as a new treatment strategy for head and neck cancer.

Jang-Yang Chang, C. Kuo, Jeffrey S. Chang, 2012, Oral oncology.

DNA Repair Enzyme, O6-Methylguanine DNA Methyltransferase, Modulates Cytotoxicity of Camptothecin-Derived Topoisomerase I Inhibitors

Jang-Yang Chang, C. Kuo, Jin-Fen Liu, 2006, Journal of Pharmacology and Experimental Therapeutics.

Antitumor Agents 126. Novel 4β-Substituted Anilino Derivatives of 3′,4′ -O, O-Didemethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

K. Lee, Jang-Yang Chang, Ya‐Ching Shen, 1993, Pharmaceutical Research.

Downregulation of a putative tumor suppressor BMP4 by SOX2 promotes growth of lung squamous cell carcinoma

C. Hsiung, S. Jiang, I. Chang, 2014, International journal of cancer.

Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy

Jang-Yang Chang, Yu-Min Yeh, Meng-Ru Shen, 2017, Scientific Reports.

Investigating the association between serum human papillomavirus type 16 E7 antibodies and risk of head and neck cancer

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2021, Cancer medicine.

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells.

W. Su, Chiou-Feng Lin, Jang-Yang Chang, 2014, Cancer letters.

A Comprehensive Analysis on the Association between Tobacco-Free Betel Quid and Risk of Head and Neck Cancer in Taiwanese Men

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2016, PloS one.

Investigating the association between diet and risk of head and neck cancer in Taiwan

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2017, Oncotarget.

Correction: Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1

S. Jiang, I. Chang, Jang-Yang Chang, 2016, Oncotarget.

Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1

S. Jiang, I. Chang, Jang-Yang Chang, 2015, Oncotarget.

Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo

T. Tsou, Jang-Yang Chang, C. Kuo, 2016, Oncotarget.

Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case-Control Study of Head and Neck Cancer.

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2019, Alcoholism, clinical and experimental research.

Phase I dose escalation study of sorafenib plus S-1 for advanced solid tumors

W. Su, Li‐Tzong Chen, Jang-Yang Chang, 2021, Scientific Reports.

Integrating Image-Based High-Content Screening with Mouse Models Identifies 5-Hydroxydecanoate as a Neuroprotective Drug for Paclitaxel-Induced Neuropathy

Meng-Ru Shen, Jang-Yang Chang, Jang-Yang Chang, 2015, Molecular Cancer Therapeutics.

Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036.

Jang-Yang Chang, K. Chou, Chia-Chi Lung, 2007, Biochemical pharmacology.

TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility

P. Lyu, Chih-Pin Chuu, Hsuan-Yu Peng, 2019, PloS one.

Tea Consumption and Risk of Head and Neck Cancer

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2014, PloS one.

Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma

J. Hung, S. Tzeng, Song-Bin Chang, 2014, Oncotarget.

Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells

W. Su, Jang-Yang Chang, Wen-Tsan Chang, 2010, Molecular Cancer.

Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation

M. Hsiao, Chi-Long Chen, Hsuan-Yu Peng, 2017, Scientific Reports.

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.

S. Pan, T. Yeh, J. Liou, 2014, Journal of medicinal chemistry.

Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2016, Cancer Causes & Control.

Synthesis and Structure–Activity Relationship of Salvinal Derivatives as Potent Microtubule Inhibitors

Chi-I Chang, J. Cherng, J. Lung, 2023, International journal of molecular sciences.

Phase I study of biweekly liposome irinotecan (PEP02, MM-398) in metastatic colorectal cancer failed on first-line oxaliplatin-based chemotherapy.

W. Su, Jang-Yang Chang, P. Lin, 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer

Jang-Yang Chang, P. Lin, K. Hsu, 2019, Scientific Reports.

Mechanistic basis of a combination D-penicillamine and platinum drugs synergistically inhibits tumor growth in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo.

T. Tsou, Jang-Yang Chang, C. Kuo, 2015, Biochemical pharmacology.

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.

J. Liou, Jang-Yang Chang, K. Nepali, 2019, European journal of medicinal chemistry.

Phase I study of biweekly gemcitabine followed by oxaliplatin and simplified 48‐h infusion of fluorouracil/leucovorin for advanced pancreatic cancer

J. Whang‐Peng, Chiun Hsu, Hsiu‐Po Wang, 2006, Journal of gastroenterology and hepatology.

Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial–mesenchymal transition suppression and cell polarity disruption

Jang-Yang Chang, Chi-Yen Chang, Chi-Min Lin, 2018, Scientific Reports.

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

J. Liou, Jang-Yang Chang, C. Kuo, 2013, PloS one.

Ubiquitin‐conjugating enzyme E2 B regulates the ubiquitination of O6‐methylguanine‐DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells

Jang-Yang Chang, C. Kuo, S. Hsu, 2018, Biochemical pharmacology.

Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

J. Liou, Jang-Yang Chang, C. Kuo, 2018, Journal of Biomedical Science.

Phase I–II trial of weekly gemcitabine plus high‐dose 5‐fluorouracil and leucovorin in advanced pancreatic cancer

J. Whang‐Peng, Chih-Hung Hsu, Y. Chao, 2006, Journal of gastroenterology and hepatology.

LONG‐TERM COMPLETE REMISSION OF METASTATIC GASTRIC CANCER AFTER WEEKLY DOCETAXEL, 24 H INFUSION OF HIGH‐DOSE 5‐FU/LEUCOVORIN AND CISPLATIN

J. Whang‐Peng, Jang-Yang Chang, T. Liu, 2005, Journal of gastroenterology and hepatology.

C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines.

Y. Kuo, Jang-Yang Chang, C. Kuo, 2006, Journal of natural products.

The interplay between oral microbiome, lifestyle factors and genetic polymorphisms in the risk of oral squamous cell carcinoma

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2018, Carcinogenesis.

Advances in Aurora kinase inhibitor patents

H. Hsieh, M. Coumar, Jang-Yang Chang, 2009, Expert opinion on therapeutic patents.

Modern staging and utility of PET imaging in esophageal cancer management.

Y. Yen, Jang-Yang Chang, J. Chao, 2008, Journal of the National Comprehensive Cancer Network : JNCCN.

Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors.

Jang-Yang Chang, C. Kuo, T. Liu, 2011, Free radical biology & medicine.

Novel Terpenoids from Calocedrus macrolepis var. formosana

Y. Kuo, Jang-Yang Chang, C. Kuo, 2011, Chemistry and Biodiversity.

Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Y. Kuo, Jang-Yang Chang, C. Kuo, 2011 .

Cytotoxic C(35) terpenoid cryptotrione from the bark of Cryptomeria japonica.

Sheng-Yang Wang, Y. Kuo, N. Yang, 2010, Organic letters.

Cytotoxic C35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica.

Sheng-Yang Wang, Y. Kuo, N. Yang, 2010 .

Labdanecaryophyllic Acid, a Novel Cytotoxic C35 Terpenoid from Calocedrus macrolepis var. formosana.

Y. Kuo, Jang-Yang Chang, C. Kuo, 2011 .

Survivin – biology and potential as a therapeutic target in oncology

F. Tsai, Jang-Yang Chang, C. Cheung, 2013, OncoTargets and therapy.

S. Jiang, I. Chang, Jang-Yang Chang, 2015, Oncotarget.

A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment

J. Whang‐Peng, A. Cheng, T. Chao, 2016, Journal of Biomedical Science.

Erratum: Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents (Bioorganic and Medicinal Chemistry Letters (2003) 13 (101) PII S0960894X02008508)

Chi-Hung Lin, Ying-Ting Lin, H. Hsieh, 2003 .

Novel Nrf2/ARE activator, trans-Coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38α/MAPKAPK-2 and PK-N3 signaling pathway.

Wei-min Liu, C. Shih, T. Yeh, 2015, Chemical research in toxicology.

Investigating the health disparities in the association between lifestyle behaviors and the risk of head and neck cancer

C. Yen, Wei‐Ting Lee, Jang-Yang Chang, 2020, Cancer science.

Downregulation of a putative tumor suppressor BMP4 by SOX2 promotes growth of lung squamous cell carcinoma

C. Hsiung, S. Jiang, I. Chang, 2014, International journal of cancer.

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells.

W. Su, Chiou-Feng Lin, Jang-Yang Chang, 2014, Cancer letters.

Recent advances in anti-survivin treatments for cancer.

J. Chang, R. Kanwar, J. Kanwar, 2010, Current medicinal chemistry.

Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification.

Chi-Ying F. Huang, Miao-Fen Chen, Kuan-Der Lee, 2013, Biochemical pharmacology.

Phase I study of liposome encapsulated irinotecan (PEP02) in advanced solid tumor patients

A. Cheng, Jang-Yang Chang, H. Shiah, 2008 .

Differences in the frequencies of K‐ras c12–13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method

Jang-Yang Chang, T. Liu, Jeffrey S. Chang, 2012, Environmental and molecular mutagenesis.

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells.

Chi-Hung Lin, Y. Kuo, T. Chao, 2010, Biochemical pharmacology.

Advances in Aurora kinase inhibitor patents

H. Hsieh, M. Coumar, Jang-Yang Chang, 2009, Expert opinion on therapeutic patents.