G. Phillips

发表

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry.

N. Sigal, D. Auld, M. Adler, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.

M. Adler, M. Whitlow, C. Mallari, 2018, Bioorganic & medicinal chemistry letters.

Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).

M. Adler, M. Whitlow, R. Pulk, 2009, Bioorganic & medicinal chemistry letters.

Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.

M. Adler, M. Whitlow, M. Morrissey, 2007, Bioorganic & medicinal chemistry.

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2016, Journal of medicinal chemistry.

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.

M. Adler, M. Whitlow, R. Feldman, 2007, Bioorganic & medicinal chemistry letters.

The In Vitro Pharmacology of GS-5759, A Novel Bifunctional Phosphodiesterase 4 Inhibitor and Long Acting β2-Adrenoceptor Agonist

M. Salmon, G. Phillips, C. Wright, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors.

H. Ye, J. Parkinson, G. Phillips, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase.

H. Ye, D. Davey, J. Parkinson, 2008, Bioorganic & Medicinal Chemistry Letters.

CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives.

D. Davey, G. Phillips, J. Onuffer, 2007, Bioorganic & medicinal chemistry letters.

CCR5 receptor antagonists: discovery and SAR study of guanylhydrazone derivatives.

D. Davey, G. Phillips, J. Onuffer, 2007, Bioorganic & medicinal chemistry letters.

1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.

Wei Xu, M. Adler, M. Whitlow, 2007, Bioorganic & medicinal chemistry letters.

Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.

J. Chandrasekhar, G. Phillips, R. Mourey, 2016, Bioorganic & medicinal chemistry letters.

Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif.

J. Chandrasekhar, M. Mcgrath, Fatima M Arjmand, 2020, ACS medicinal chemistry letters.

Solid phase synthesis of benzimidazolones

G. Wei, G. Phillips, 1998 .

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.

M. Whitlow, D. Davey, K. Eagen, 1998, Journal of medicinal chemistry.

Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors.

D. Davey, K. Eagen, M. Morrissey, 2003, Bioorganic & medicinal chemistry letters.

Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa.

Sung-Hou Kim, M. Adler, S. Kim, 2000, Biochemistry.

Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.

A. Beatty, M. Whitlow, D. Davey, 1999, Journal of medicinal chemistry.

Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin.

M. Whitlow, D. Davey, M. Morrissey, 1999, Acta crystallographica. Section D, Biological crystallography.

Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.

K. Eagen, M. Morrissey, G. Phillips, 2002, Bioorganic & medicinal chemistry.

Ethylaluminum dichloride catalyzed ene reactions of aldehydes with nonnucleophilic alkenes

G. Phillips, B. Snider, 1983 .

A fully synthetic route to the papulacandins. Stereo-specific spiroacetalization of a C-1-arylated methyl glycoside.

M. Ciufolini, S. Danishefsky, G. Phillips, 1987, Carbohydrate research.

On the communication of chirality from furanose and pyranose rings to monosaccharide side chains: anomalous results in the glucose series

S. Danishefsky, G. Phillips, P. Lartey, 1986 .

Solid phase synthesis of benzimidazoles

G. Wei, G. Phillips, 1996 .

Reaction of enol ethers with formaldehyde and organoaluminum compounds

G. Phillips, B. Snider, 1983 .

[1,2]-intramolecular ene reactions

G. Phillips, B. Snider, 1984 .

A rapid route to ergot precursors via aza-claisen rearrangement

S. Danishefsky, G. Phillips, 1984 .

Ethylaluminum dichloride catalyzed ene reactions of aldehydes with nonnucleophilic alkenes

G. Phillips, B. Snider, 1983 .

Ene reactions of 2-phosphonoacrylates

G. Phillips, B. Snider, 1983 .

Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2018, Journal of medicinal chemistry.

Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.

J. Chandrasekhar, M. Mcgrath, G. Phillips, 2017, Journal of medicinal chemistry.

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2016, Journal of medicinal chemistry.

Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.

J. Haeggström, M. Adler, M. Whitlow, 2008, Bioorganic & medicinal chemistry.

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.

M. Adler, M. Whitlow, R. Feldman, 2007, Bioorganic & medicinal chemistry letters.

Bifunctional Compounds for the Treatment of COPD

G. Phillips, M. Salmon, 2012 .

Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion.

Alaina L. Garland, R. Tarran, G. Phillips, 2013, American journal of physiology. Lung cellular and molecular physiology.

Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors*

Sanjay Ghosh, Douglas S. Auld, Wei Xia, 2002, The Journal of Biological Chemistry.

The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β2-adrenoceptor agonist in preclinical animal species

J. McDonald, M. Salmon, Kim Hartsough, 2014, Pharmacology research & perspectives.

GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells

M. Salmon, G. Phillips, R. Newton, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.

M. Adler, M. Whitlow, M. Ohlmeyer, 2007, Journal of medicinal chemistry.

Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents.

G. Phillips, R. Gomez, W. C. Lumma, 1992, Journal of medicinal chemistry.

M. Salmon, G. Phillips, R. Newton, 2017, Journal of Pharmacology and Experimental Therapeutics.