M. Flinspach

发表

Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.

T. Poulos, Haitao Ji, Huiying Li, 2003, Journal of medicinal chemistry.

The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis.

T. Poulos, P. Wang, Huiying Li, 2002, Biochemistry.

Molecular mechanism of the wake-promoting agent TAK-925

D. Rosenbaum, Y. Shimizu, M. Flinspach, 2022, Nature Communications.

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

A. Gibbs, S. Sutton, A. Shih, 2013, The Journal of Biological Chemistry.

A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ

B. Ueberheide, D. Yoshikami, H. M. Zhou, 2014, Proceedings of the National Academy of Sciences.

Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7

A. Gibbs, O. Libiger, A. Shih, 2019, The Journal of Biological Chemistry.

Double barrel shotgun scanning of the caveolin-1 scaffolding domain.

Gregory A Weiss, G. Weiss, T. Poulos, 2007, ACS chemical biology.

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

A. Gibbs, R. Swanson, T. Yaksh, 2017, Scientific Reports.

Functional Studies of Interaction Between Huwentoxin-IV and Voltage-Gated Sodium Channel Nav1.7

S. Edavettal, A. Shih, S. Bembenek, 2012 .

Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase

T. Poulos, Huiying Li, R. Silverman, 2004, Nature Structural &Molecular Biology.

Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases.

T. Poulos, Huiying Li, J. Igarashi, 2005, Biochemistry.

Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.

T. Poulos, Huiying Li, R. Silverman, 2004, Biochemistry.

Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (μ-TRTX-Hh2a).

M. Flinspach, A. Wickenden, N. Minassian, 2013 .