S. Connolly

发表

2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.

J. Tainer, R. Rosenfeld, A. Arvai, 2004, Journal of medicinal chemistry.

Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration.

S. Connolly, M. Skrinjar, A. Rosendahl, 2012, Biochemical pharmacology.

From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists.

G. Pairaudeau, A. Bailey, E. Cadogan, 2012, Bioorganic & medicinal chemistry letters.

Design driven HtL: The discovery and synthesis of new high efficacy β₂-agonists.

G. Pairaudeau, A. Bailey, E. Cadogan, 2011, Bioorganic & medicinal chemistry letters.

Design-driven LO: the discovery of new ultra long acting dibasic β2-adrenoceptor agonists.

G. Pairaudeau, A. Bailey, E. Cadogan, 2011, Bioorganic & medicinal chemistry letters.

AZD3199: A potent and selective β2-adrenergic receptor agonist with rapid onset of action

R. Austin, G. Pairaudeau, D. Nicholls, 2011, ATS 2011.

The In Vivo Profile Of AZD3199: A Novel, Fast Acting B2-Agonist With A Long Duration Of Action

G. Pairaudeau, D. Nicholls, S. Connolly, 2011, ATS 2011.

Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.

Didier Rognan, Chris de Graaf, Steve Price, 2009, Journal of medicinal chemistry.

Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action.

G. Pairaudeau, A. Bailey, E. Cadogan, 2014, ACS medicinal chemistry letters.

The discovery of AZD 3199 A new inhaled ultra-long acting 2 receptor agonist with rapid onset of action

David, A. Bailey, E. Cadogan, 2014 .

Characteristics of AZD9708, a novel, selective β2-adrenoceptor agonist with rapid onset and long duration of action.

R. Austin, E. Cadogan, D. Nicholls, 2012, Pulmonary pharmacology & therapeutics.

Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere.

D. Murray, S. Connolly, I. Walters, 2004, Bioorganic & medicinal chemistry letters.

Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2.

N. Gensmantel, H. Beaton, S. Connolly, 1994, Journal of medicinal chemistry.

Synthesis and X-ray crystallographic structure of the right-hand hemisphere of halicholactone and neohalicholactone

S. Connolly, M. Mahon, M. Wills, 1995 .

Small molecule antagonists of CCR8 inhibit eosinophil and T cell migration.

S. Connolly, M. Skrinjar, A. Rosendahl, 2011, Biochemical and biophysical research communications.

Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap.

D. Murray, M. Bernstein, R. Riley, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.

D. Murray, S. Connolly, I. Walters, 2002, Journal of medicinal chemistry.

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986).

S. Connolly, S. Swallow, H. Käck, 2016, Journal of medicinal chemistry.

The synthesis and biological activity of a novel series of 2-aryl penems.

S. Connolly, J. Walmsley, K. Moore, 1991, The Journal of antibiotics.

SYNTHESIS OF 2,5-DIHYDROFURANS VIA ALKYLIDENE CARBENE INSERTION REACTIONS

S. Connolly, M. Wills, L. F. Walker, 1998 .

Total Synthesis of Halicholactone and Neohalicholactone1

S. Connolly, M. Wills, D. Critcher, 1997 .

The total asymmetric synthesis of Halicholactone and Neohalicholactone

S. Connolly, M. Wills, D. Critcher, 1995 .

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase

J. Tainer, E. Getzoff, R. Rosenfeld, 2008, Nature chemical biology.

Evaluation of mesoporous SBA-15 for the controlled delivery of ciprofloxacin hydrochloride

S. Connolly, El-Sayed I. Ghaith, 2014 .

Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex.

W U Primrose, G. Roberts, G. Roberts, 1992, Journal of medicinal chemistry.

Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships.

Bo Nordén, Klaus Urbahns, B. Springthorpe, 2008, Journal of medicinal chemistry.

Patent Update: Inhibitors of the Phospholipases A2

S. Connolly, D. H. Robinson, 1993 .

Assembly and Self-Organization of Silver Nanocrystal Superlattices: Ordered “Soft Spheres”

B. Korgel, D. Fitzmaurice, S. Connolly, 1998 .

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).

Glen Andrews, Paul D Leeson, Anders Åberg, 2011, Bioorganic & medicinal chemistry letters.

Heterosupramolecular chemistry: toward the factory of the future

D. Fitzmaurice, N. Zaccheroni, S. Connolly, 1999 .

Patent Update: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: The search for inhibitors of the phospholipases A2

S. Connolly, D. H. Robinson, 1995 .

Small molecule antagonists of CCR8 inhibit eosinophil and T cell migration.

S. Connolly, M. Skrinjar, A. Rosendahl, 2011, Biochemical and biophysical research communications.