J. Sánchez-Arias

发表

Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.

O. Rabal, J. Oyarzábal, J. Sánchez-Arias, 2018, ACS chemical neuroscience.

Impairment of the modulation by glucose of hepatic gluconeogenesis in the genetically obese (fa/fa) Zucker rat.

C. Lechuga, J. E. Felíu, J. Sánchez-Arias, 1995, Endocrinology.

CM352 Reduces Brain Damage and Improves Functional Recovery in a Rat Model of Intracerebral Hemorrhage

J. Oyarzábal, T. Sobrino, F. Campos, 2017, Journal of the American Heart Association.

Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage.

O. Rabal, J. Oyarzábal, J. Paramo, 2015, Journal of medicinal chemistry.

Amylin as a potential link between type 2 diabetes and alzheimer disease

M. Luquin, M. Riverol, E. Erro, 2019, Annals of neurology.

Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.

O. Rabal, J. Oyarzábal, J. Sánchez-Arias, 2017, ACS chemical neuroscience.

Decreased responsiveness of basal gluconeogenesis to insulin action in hepatocytes isolated from genetically obese (fa/fa) Zucker rats.

C. Lechuga, J. E. Felíu, J. Sánchez-Arias, 1994, Endocrinology.

Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents.

O. Rabal, J. Oyarzábal, Hongyu Ma, 2018, ACS medicinal chemistry letters.

Effect of adrenalectomy and glucocorticoid treatment on the levels of an insulin-sensitive glycosyl-phosphatidylinositol in isolated rat hepatocytes

J. E. Felíu, J. Mato, J. Sánchez-Arias, 1990, Molecular and Cellular Endocrinology.

Modulation of gluconeogenesis by epinephrine in hepatocytes isolated from genetically obese (fa/fa) Zucker rats.

J. E. Felíu, J. Sánchez-Arias, B. Samper, 2000, Archives of biochemistry and biophysics.

Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors

R. Franco, J. Sánchez-Arias, M. Aymerich, 2016, Molecular Neurobiology.

Insulin resistance in genetically obese (fa/fa) rats: changes in the glycosyl-phosphatidylinositol signaling system in isolated hepatocytes.

J. E. Felíu, J. Mato, J. Sánchez-Arias, 1994, Endocrinology.

Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead.

O. Rabal, J. Oyarzábal, Hongyu Ma, 2015, Journal of medicinal chemistry.

Development of a new oxygen consumption rate assay in cultures of Acanthamoeba (Protozoa: Lobosea) and its application to evaluate viability and amoebicidal activity in vitro.

J. Copa-Patiño, J. Sánchez-Arias, J. Pérez-Serrano, 2015, Experimental parasitology.

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.

O. Rabal, J. Oyarzábal, J. Sánchez-Arias, 2016, Journal of medicinal chemistry.

Two Affinity Sites of the Cannabinoid Subtype 2 Receptor Identified by a Novel Homogeneous Binding Assay

J. Lanciego, R. Franco, O. Rabal, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes

J. Lanciego, R. Franco, Gemma Navarro, 2018, Front. Neuroanat..

Changes in the insulin-sensitive glycosyl-phosphatidyl-inositol signalling system with aging in rat hepatocytes.

J. E. Felíu, J. Mato, J. Sánchez-Arias, 1993, European journal of biochemistry.

Transport in isolated rat hepatocytes of the phospho-oligosaccharide that mimics insulin action. Effects of adrenalectomy and glucocorticoid treatment.

J. E. Felíu, J. Mato, J. Sánchez-Arias, 1991, The Biochemical journal.

Impairment of glycosyl-phosphatidylinositol-dependent insulin signaling system in isolated rat hepatocytes by streptozotocin-induced diabetes.

J. E. Felíu, J. Mato, J. Sánchez-Arias, 1992, Endocrinology.

Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy.

J. Martinez-Climent, F. Prósper, X. Agirre, 2018, Journal of medicinal chemistry.

Interictal amylin levels in chronic migraine patients: A case-control study

M. Luquin, P. Irimia, E. Martı́nez-Vila, 2020, Cephalalgia : an international journal of headache.

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer’s Disease Mice

G. Perea, R. Franco, O. Rabal, 2017, Neuropsychopharmacology.

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

J. Martinez-Climent, F. Prósper, J. Martín-Subero, 2017, Nature Communications.

Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease

J. Lanciego, R. Franco, J. Oyarzábal, 2019, Molecular neurobiology.

Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease

J. Lanciego, J. Oyarzábal, Gemma Navarro, 2019, Molecular Neurobiology.

Effect of streptozotocin diabetes on the glycolytic flux and on fructose 2,6-bisphosphate levels in isolated rat enterocytes.

J. E. Felíu, J. Sánchez-Arias, I. Rossi, 1990, Metabolism: clinical and experimental.

Inducing heat shock protein 70 expression provides a robust anti-thrombotic effect with minimal bleeding risk

J. Oyarzábal, E. Guruceaga, R. Lecumberri, 2017, Thrombosis and Haemostasis.

Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.

O. Rabal, J. Oyarzábal, J. Sánchez-Arias, 2018, European journal of medicinal chemistry.

Multitarget Approach for the Treatment of Alzheimer`s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) covering diverse selectivity profiles.

O. Rabal, J. Oyarzábal, A. Pineda-Lucena, 2019, ACS chemical neuroscience.

Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer’s Disease

O. Rabal, J. Oyarzábal, V. Segura, 2019, Front. Aging Neurosci..

Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces.

J. Martinez-Climent, F. Prósper, X. Agirre, 2018, Journal of medicinal chemistry.

Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization.

H. Matter, A. Herling, J. Sánchez-Arias, 2013, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma.

F. Prósper, X. Agirre, J. Oyarzábal, 2021, Journal of medicinal chemistry.