D. Dougan

发表

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.

J. R. Somoza, D. McRee, Biching Sang, 2004, Structure.

Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae

D. McRee, C. Mol, R. Swanson, 2003, Journal of bacteriology.

Structural Basis for Iron Binding and Release by a Novel Class of Periplasmic Iron-Binding Proteins Found in Gram-Negative Pathogens

D. McRee, A. Schryvers, R. Skene, 2004, Journal of bacteriology.

Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.

T. Kojima, M. Yabuki, Sei Yoshida, 2013, Journal of medicinal chemistry.

Novel Anion-independent Iron Coordination by Members of a Third Class of Bacterial Periplasmic Ferric Ion-binding Proteins*

D. McRee, A. Schryvers, D. Dougan, 2005, Journal of Biological Chemistry.

Presence of ferric hydroxide clusters in mutants of Haemophilus influenzae ferric ion-binding protein A.

D. McRee, A. Schryvers, R. Skene, 2003, Biochemistry.

Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors.

J. Lawson, M. Hixon, D. Dougan, 2016, Bioorganic & medicinal chemistry letters.

Haemophilus influenzae Acid : l-Alanine Ligase ( MurC ) from-Acetylmuramic N Complexes of UDP-Assembled Substrate-and Product-Bound Crystal Structures of Active Fully

D. McRee, C. Mol, R. Swanson, 2003 .

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.

M. Hixon, C. Grimshaw, R. de Jong, 2013, Bioorganic & medicinal chemistry letters.

Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.

C. Mol, V. Feher, Lihong Shi, 2010, Bioorganic & medicinal chemistry letters.

Reduction in diffuso‐convective disturbances in nanovolume protein crystallization experiments

R. Stevens, E. Abola, D. McRee, 2005 .

Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.

Biching Sang, C. Mol, D. Dougan, 2011, Bioorganic & medicinal chemistry letters.

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

D. Hosfield, R. Swanson, A. Brooun, 2004 .

Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase.

J. Lawson, D. Dougan, B. Knight, 2015, Journal of medicinal chemistry.

Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors.

J. Lawson, M. Hixon, D. Dougan, 2017, Bioorganic & Medicinal Chemistry Letters.

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.

J. Kunitomo, Toshimasa Tanaka, C. Mol, 2009, Journal of medicinal chemistry.

Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.

J. Kunitomo, Toshimasa Tanaka, C. Mol, 2009, Bioorganic & medicinal chemistry.

A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.

Toshimasa Tanaka, Biching Sang, C. Mol, 2012, Bioorganic & medicinal chemistry.

Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.

Lihong Shi, Petro Halkowycz, D. Dougan, 2011, Bioorganic & medicinal chemistry letters.

High Resolution Structure of an Alternate Form of the Ferric Ion Binding Protein from Haemophilus influenzae *

D. McRee, A. Schryvers, R. Skene, 2003, The Journal of Biological Chemistry.

Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design.

J. Lawson, D. Balakrishna, D. Dougan, 2021, Journal of medicinal chemistry.

Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase*

K. Wilson, Biching Sang, C. Mol, 2004, Journal of Biological Chemistry.

Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis*

D. Hosfield, R. Swanson, D. Dougan, 2004, Journal of Biological Chemistry.

Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.

M. Yabuki, Sei Yoshida, T. Ishikawa, 2013, Bioorganic & medicinal chemistry.

Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.

C. Mol, M. Yabuki, Sei Yoshida, 2013, Bioorganic & medicinal chemistry.

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety.

L. Qin, S. Gay, D. Dougan, 2021, Journal of medicinal chemistry.

Crystal Structure of Pasteurella haemolytica Ferric Ion-binding Protein A Reveals a Novel Class of Bacterial Iron-binding Proteins*

Leslie W. Tari, Stephen R. Shouldice, D. McRee, 2003, Journal of Biological Chemistry.

The structure of the ferric siderophore binding protein FhuD complexed with gallichrome

H. Vogel, S. Ku, D. Dougan, 2000, Nature Structural Biology.

Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.

Toshimasa Tanaka, Biching Sang, C. Mol, 2012, Bioorganic & medicinal chemistry.

Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1.

J. Lawson, Christopher Mcbride, P. Farrell, 2016, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway

C.-H. Chen, Kenjiro Sato, D. Dougan, 2023, Journal of medicinal chemistry.

Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 2.

J. Lawson, Christopher Mcbride, P. Farrell, 2016, Bioorganic & medicinal chemistry letters.

Structure-based drug design of novel ASK1 inhibitors using an integrated lead optimization strategy.

A. Fanjul, Petro Halkowycz, D. Dougan, 2017, Bioorganic & medicinal chemistry letters.

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.

A. Ivetac, E. Bradshaw-Pierce, Petro Halkowycz, 2017, ACS medicinal chemistry letters.

Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3 character and an exquisite selectivity profile.

Christopher Mcbride, A. Ivetac, Petro Halkowycz, 2020, Bioorganic & medicinal chemistry letters.

Toshimasa Tanaka, Biching Sang, C. Mol, 2012, Bioorganic & medicinal chemistry.

Identification of AHCY inhibitors using novel high-throughput mass spectrometry.

J. Lawson, T. Kawamoto, H. Kimura, 2017, Biochemical and biophysical research communications.

Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.

Jangir Selimkhanov, J. Ermolieff, D. Dougan, 2024, Journal of medicinal chemistry.