G. Snell

发表

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.

J. R. Somoza, D. McRee, Biching Sang, 2004, Structure.

Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐b]pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 1

H. Sugimoto, Toshimasa Tanaka, Biching Sang, 2019, ChemMedChem.

Structural Basis for Iron Binding and Release by a Novel Class of Periplasmic Iron-Binding Proteins Found in Gram-Negative Pathogens

D. McRee, A. Schryvers, R. Skene, 2004, Journal of bacteriology.

Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.

T. Kojima, M. Yabuki, Sei Yoshida, 2013, Journal of medicinal chemistry.

Structural and functional analysis of a potent sarbecovirus neutralizing antibody

Amalio Telenti, Katja Fink, Young-Jun Park, 2020, bioRxiv.

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

Amalio Telenti, Katja Fink, Young-Jun Park, 2020, Nature.

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.

Toshimasa Tanaka, Biching Sang, T. Kawamoto, 2018, Bioorganic & medicinal chemistry.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

M. Beltramello, A. Telenti, R. Spreafico, 2020, bioRxiv.

Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach.

H. Oki, Kotaro Sakamoto, G. Snell, 2017, Journal of medicinal chemistry.

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

M. Beltramello, E. Bernasconi, A. Walls, 2020, Cell.

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

M. Beltramello, M. Diamond, R. Spreafico, 2020, Science.

Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.

M. Klein, Biching Sang, G. Snell, 2016, Journal of molecular biology.

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

M. Beltramello, E. Bernasconi, A. Walls, 2020, Cell.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

P. Maes, L. Purcell, S. Whelan, 2022, bioRxiv.

Tackling COVID-19 with neutralizing monoclonal antibodies

L. Purcell, D. Veesler, D. Corti, 2021, Cell.

Insights into selectivity of STI571 [GleevecTM] from X-ray crystallography

K. Wilson, D. McRee, Devon A. Thompson, 2003 .

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

M. Beltramello, J. Chodera, A. Telenti, 2021, Cell.

ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

L. Purcell, B. Weynand, A. Walls, 2022, Science.

Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.

Biching Sang, T. Imada, Terufumi Takagi, 2019, Journal of medicinal chemistry.

Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.

C. Behnke, G. Snell, M. Tawada, 2016, Bioorganic & medicinal chemistry.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

A. Telenti, M. Diamond, L. Purcell, 2021, Nature.

X-ray sources and high-throughput data collection methods.

G. Snell, 2012, Methods in molecular biology.

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

A. Sette, A. Walls, D. Veesler, 2022, Science.

STRUCTURAL ANALYSIS OF THE MECHANISM OF INHIBITION AND ALLOSTERIC ACTIVATION OF THE KINASE DOMAIN OF HER 2

Toshimasa Tanaka, Biching Sang, J. Yano, 2011 .

The potent broadly neutralizing antibody VIR-3434 controls Hepatitis B and D Virus infection and reduces HBsAg in humanized mice

A. Telenti, L. Purcell, D. Belnap, 2022, bioRxiv.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

A. Telenti, R. Spreafico, L. Purcell, 2022, bioRxiv.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

P. Maes, L. Purcell, S. Whelan, 2022, Science.

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

A. Sette, A. Walls, D. Veesler, 2022, Science immunology.

Reduction in diffuso‐convective disturbances in nanovolume protein crystallization experiments

R. Stevens, E. Abola, D. McRee, 2005 .

Broad betacoronavirus neutralization by a stem helix–specific human antibody

M. Beltramello, A. Telenti, A. Walls, 2021, Science.

Structural and Kinetic Analysis of the Substrate Specificity of Human Fibroblast Activation Protein α*

K. Aertgeerts, Lihong Shi, A. Jennings, 2005, Journal of Biological Chemistry.

Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.

Biching Sang, C. Mol, D. Dougan, 2011, Bioorganic & medicinal chemistry letters.

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies

William T. Harvey, Kenneth G. C. Smith, A. Walls, 2021, medRxiv.

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

M. Beltramello, J. Chodera, A. Telenti, 2021, Nature.

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

M. Beltramello, M. Diamond, L. Purcell, 2023, bioRxiv.

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

A. Walls, D. Veesler, John E. Bowen, 2021, bioRxiv.

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody

M. Beltramello, A. Telenti, J. Bloom, 2021, bioRxiv.

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

M. Beltramello, A. Telenti, S. Whelan, 2021, bioRxiv.

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.

J. Kunitomo, Toshimasa Tanaka, C. Mol, 2009, Journal of medicinal chemistry.

Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.

J. Kunitomo, Toshimasa Tanaka, C. Mol, 2009, Bioorganic & medicinal chemistry.

A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.

Toshimasa Tanaka, Biching Sang, C. Mol, 2012, Bioorganic & medicinal chemistry.

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases.

Robert I. Davis, C. Heyser, G. Snyder, 2016, Journal of medicinal chemistry.

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.

M. Klein, Biching Sang, T. Arita, 2016, Bioorganic & medicinal chemistry.

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

Kenneth A. Matreyek, J. Bloom, D. Veesler, 2022, bioRxiv.

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

J. Bloom, S. Whelan, A. Walls, 2022, Science.

Predicting the mutational drivers of future SARS-CoV-2 variants of concern

Bryan D. Bryson, A. Telenti, B. Hie, 2021, Science Translational Medicine.

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

J. Bloom, S. Whelan, A. Walls, 2021, bioRxiv.

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate

M. Klein, Biching Sang, G. Snell, 2015, Nature Structural &Molecular Biology.

Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase*

K. Wilson, Biching Sang, C. Mol, 2004, Journal of Biological Chemistry.

Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability

Xingyue He, M. Klein, R. Tjhen, 2018, EMBO molecular medicine.

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Yoshikazu Ohta, Tomoyasu Ishikawa, Andy Jennings, 2011, The Journal of Biological Chemistry.

Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonis

Biching Sang, T. Imada, R. Skene, 2018, Journal of medicinal chemistry.

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

William T. Harvey, Kenneth G. C. Smith, A. Walls, 2021, Nature.

Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.

M. Yabuki, Sei Yoshida, T. Ishikawa, 2013, Bioorganic & medicinal chemistry.

Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists

Biching Sang, R. Skene, G. Snell, 2019, ChemMedChem.

Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

Terufumi Takagi, Kotaro Sakamoto, G. Snell, 2017, Bioorganic & medicinal chemistry.

SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies

Kenneth G. C. Smith, A. Walls, D. Veesler, 2021 .

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

A. Telenti, M. Diamond, C. Gustafsson, 2021, Nature.

Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants

A. Walls, D. Veesler, L. Carter, 2021, bioRxiv.

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

M. Beltramello, A. Telenti, S. Whelan, 2021, Cell.

Conformational Flexibility in Crystal Structures of Human 11β-Hydroxysteroid Dehydrogenase Type I Provide Insights into Glucocorticoid Interconversion and Enzyme Regulation*

D. Hosfield, K. Aertgeerts, R. Skene, 2005, Journal of Biological Chemistry.

Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

M. Beltramello, J. Chodera, A. Telenti, 2021, bioRxiv.

SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern

A. Telenti, A. Walls, D. Veesler, 2021, Science.

Broad sarbecovirus neutralization by a human monoclonal antibody

M. Beltramello, A. Telenti, J. Bloom, 2021, Nature.

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

D. Fremont, M. Diamond, L. Purcell, 2022, Nature Communications.

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor

C. Behnke, G. Snell, Y. Imaeda, 2016, ACS medicinal chemistry letters.

ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

L. Purcell, B. Weynand, A. Walls, 2022, bioRxiv.

Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants.

A. Walls, D. Veesler, L. Carter, 2021, Science.

SARS-CoV-2 spike conformation determines plasma neutralizing activity

A. Walls, D. Veesler, N. Iqbal, 2021, bioRxiv.

SARS-CoV-2 immune evasion by variant B.1.427/B.1.429

A. Telenti, A. Walls, D. Veesler, 2021, bioRxiv.

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

M. Beltramello, M. Diamond, L. Purcell, 2023, bioRxiv.

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

M. Beltramello, A. Telenti, M. Diamond, 2020, Nature.

Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.

C. Behnke, G. Snell, Koji Watanabe, 2018, Bioorganic & medicinal chemistry.

Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10

Toshimasa Tanaka, Biching Sang, T. Kawamoto, 2019 .

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.

M. Klein, R. Tjhen, Biching Sang, 2019, ACS medicinal chemistry letters.

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

Anthony Ivetac, Ankita Srivastava, Andy Jennings, 2014, Nature.

Crystal Structure of Pasteurella haemolytica Ferric Ion-binding Protein A Reveals a Novel Class of Bacterial Iron-binding Proteins*

Leslie W. Tari, Stephen R. Shouldice, D. McRee, 2003, Journal of Biological Chemistry.

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Graham W. Taylor, William L. Hamilton, Joshua B. Singer, 2021, Nature.

Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.

Toshimasa Tanaka, Biching Sang, C. Mol, 2012, Bioorganic & medicinal chemistry.

A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

A. Telenti, R. Spreafico, L. Purcell, 2023, Nature.

A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery

M. Beltramello, A. Telenti, A. Walls, 2021, bioRxiv.

Tackling COVID-19 with neutralizing monoclonal antibodies

L. Purcell, D. Veesler, D. Corti, 2021, Cell.

Novel approach of fragment-based lead discovery applied to renin inhibitors.

H. Oki, Toshimasa Tanaka, C. Behnke, 2016, Bioorganic & medicinal chemistry.

Neutralization, effector function and immune imprinting of Omicron variants.

M. Beltramello, M. Diamond, L. Purcell, 2023, Nature.

Toshimasa Tanaka, Biching Sang, C. Mol, 2012, Bioorganic & medicinal chemistry.

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

A. Walls, D. Veesler, John E. Bowen, 2022, Science.

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

M. Beltramello, J. Chodera, A. Telenti, 2021, Cell.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and 2 in vivo activity against SARS-CoV-2 3

L. Purcell, E. Cameroni, S. Bianchi, 2022 .