P. Loppnau

发表

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity*

J. Min, C. Arrowsmith, M. Schapira, 2008, Journal of Biological Chemistry.

Isolation and disruption of the melanin pathway polyketide synthase gene of the softwood deep stain fungus Ceratocystis resinifera.

C. Breuil, P. Tanguay, P. Loppnau, 2004, Fungal genetics and biology : FG & B.

Canadian populations and melanin biosynthetic genes of Ceratocystis resinifera

P. Loppnau, 2003 .

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

Jeffrey R. Whiteaker, Ben C. Collins, Jacob J. Kennedy, 2015, Nature Methods.

Apollo-NADP+: a spectrally tunable family of genetically encoded sensors for NADP+

Cindy V. Bui, William D. Cameron, S. Gräslund, 2016, Nature Methods.

Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins*

Matthieu Schapira, Ke Liu, Peter Loppnau, 2015, The Journal of Biological Chemistry.

Target highlights in CASP13: Experimental target structures through the eyes of their authors

K. Fidelis, G. Phillips, J. Moult, 2019, Proteins.

Discovery of a chemical probe for PRDM9

E. Guccione, C. Arrowsmith, M. Schapira, 2019, Nature Communications.

Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA

T. Hughes, Chao Xu, J. Min, 2018, The Journal of Biological Chemistry.

Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status

J. Min, Min Wang, Sizhuo Chen, 2021, The Journal of biological chemistry.

Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.

J. Min, J. Côté, P. Loppnau, 2020, Cell reports.

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex

J. Min, J. Côté, P. Loppnau, 2019, bioRxiv.

High throughput production of recombinant human proteins for crystallography.

E. Salah, O. Gileadi, C. Smee, 2008, Methods in molecular biology.

A screening strategy for heterologous protein expression in Escherichia coli with the highest return of investment.

P. Loppnau, D. Cossar, Benny Pacheco, 2012, Protein expression and purification.

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

Peter Loppnau, Sergio Grinstein, Richard F. Collins, 2013, Nature.

Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.

J. Min, P. Loppnau, A. Dong, 2021, Biochemical and biophysical research communications.

A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II

Xinghua Guo, J. Greenblatt, J. Min, 2022, Nature Communications.

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and mono-Methylated H3K9 Peptide

J. Min, C. Arrowsmith, A. Bochkarev, 2007 .

WDR5 in complex with unmodified H3K4 peptide

J. Min, C. Arrowsmith, J. Weigelt, 2006 .

Species level identification of conifer associated Ceratocystis sapstain fungi by PCR-RFLP on a beta-tubulin gene fragment.

C. Breuil, P. Loppnau, 2003, FEMS microbiology letters.

A spontaneous albino mutant of Ceratocystis resinifera results from a point mutation in the polyketide synthase gene, PKS1.

C. Breuil, P. Tanguay, L. Bernier, 2006, Canadian journal of microbiology.

Structure-Activity Relationship of USP5 Inhibitors.

C. Arrowsmith, M. Schapira, R. Al-awar, 2021, Journal of medicinal chemistry.

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain

P. Atadja, E. Li, C. Arrowsmith, 2018, SLAS discovery : advancing life sciences R & D.

Structural basis of allele variation of human thiopurine‐S‐methyltransferase

Xiaodong Cheng, M. Vedadi, A. Bochkarev, 2007, Proteins.

Structure and mechanism of spermidine synthases.

J. Min, A. Pegg, A. Plotnikov, 2007, Biochemistry.

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

Min Gyu Lee, J. Min, M. Lei, 2019, Nature Communications.

Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins

J. Greenblatt, A. Koide, S. Koide, 2015, PloS one.

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.

Matthieu Schapira, Abdellah Allali-Hassani, John Moult, 2009, The Biochemical journal.

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

Alexey Bochkarev, Wolfram Tempel, Anne Mulichak, 2007, Molecular and biochemical parasitology.

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

R. Reinhardt, J. Min, Sara Weirich, 2017, Nature Communications.

H 3 K 14 ac is linked to methylation of H 3 K 9 by the triple Tudor domain of SETDB 1

R. Reinhardt, J. Min, Sara Weirich, 2017 .

Structural Basis of Substrate-binding Specificity of Human Arylamine N-Acetyltransferases*

Ludmila Dombrovsky, Wolfram Tempel, Peter Loppnau, 2007, Journal of Biological Chemistry.

SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses

M. Vedadi, Sumera Perveen, E. Bouřa, 2023, Biochimica et Biophysica Acta (BBA) - General Subjects.

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

P. Fish, M. Schapira, M. Vedadi, 2021, SLAS Discovery.

A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19

M. Vedadi, Sumera Perveen, P. Loppnau, 2020, bioRxiv.

Structural Basis of the Chromodomain of Cbx3 Bound to Methylated Peptides from Histone H1 and G9a

H. Ouyang, J. Min, J. Zang, 2012, PloS one.

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.

R. Sternglanz, J. Min, M. Vedadi, 2007, Structure.

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation

M. Blackman, A. Wernimont, D. Baker, 2019, Proceedings of the National Academy of Sciences.

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

P. Fish, M. Schapira, M. Vedadi, 2021, bioRxiv.

Crystal structure of human nuclear pore complex component NUP43

Chao Xu, J. Min, A. Wernimont, 2015, FEBS letters.

RPRD 1 A and RPRD 1 B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser 5 Dephosphorylation

A. Emili, Xinghua Guo, Joyce Li, 2014 .

An allosteric inhibitor of protein arginine methyltransferase 3.

Jian Jin, Matthieu Schapira, Alena Siarheyeva, 2012, Structure.

Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

Rafael Najmanovich, Alexey Bochkarev, Abdellah Allali-Hassani, 2007, PLoS biology.

Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern

S. Li, T. Kaneko, P. Stogios, 2021, JCI insight.

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

Min Gyu Lee, J. Min, M. Lei, 2019, Nature Communications.

Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins*

J. Min, Xiao Liang, P. Loppnau, 2016, The Journal of Biological Chemistry.

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway

J. Min, P. Loppnau, W. Tempel, 2018, Nature Chemical Biology.

Structural basis for molecular recognition and presentation of histone H3 By WDR5

Alexey Bochkarev, Abdellah Allali-Hassani, Peter Loppnau, 2006, The EMBO journal.

RPRD1A and RPRD1B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser5 Dephosphorylation

A. Emili, Xinghua Guo, Joyce Li, 2014, Nature Structural &Molecular Biology.

Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1

J. Min, M. Lei, P. Loppnau, 2017, The Journal of Biological Chemistry.

Epitope-resolved serology test differentiates the clinical outcome of COVID-19 and identifies defects in antibody response in SARS-CoV-2 variants

P. Stogios, T. Skarina, E. Evdokimova, 2021, medRxiv.

Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin

E. Wanker, C. Arrowsmith, S. Lea, 2022, bioRxiv.

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

A. Heck, C. Arrowsmith, A. Lemak, 2021, Communications Biology.

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

A. Heck, C. Arrowsmith, A. Lemak, 2021, bioRxiv.

Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems

C. Arrowsmith, A. Lemak, A. Holehouse, 2019, The Journal of Biological Chemistry.

An intact SAM‐dependent methyltransferase fold is encoded by the human endothelin‐converting enzyme‐2 gene

A. Bochkarev, A. Plotnikov, P. Loppnau, 2009, Proteins.

Structural basis for a novel interaction between TXNIP and Vav2

P. Loppnau, W. Tempel, Yanli Liu, 2016, FEBS letters.

Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A

A. Bochkarev, A. Plotnikov, A. Schuetz, 2007, Proteins.

Correction: Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

Janet M. Thornton, Abdellah Allali-Hassani, Alexander N. Plotnikov, 2007, PLoS Biology.

Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.

T. Hughes, J. Min, M. Lei, 2021, Biochimica et biophysica acta. Gene regulatory mechanisms.

Structural basis for substrate recognition by the human N-terminal methyltransferase 1

J. Min, P. Loppnau, W. Tempel, 2015, Genes & development.

Crystal Structure of Human Spermine Synthase

Peter Loppnau, Jinrong Min, J. Min, 2008, Journal of Biological Chemistry.

Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine

J. Min, C. Arrowsmith, J. Weigelt, 2008 .

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

R. Reinhardt, J. Min, Sara Weirich, 2017, Nature Communications.

Structural and histone binding studies of the chromo barrel domain of TIP60

J. Min, M. Lei, P. Loppnau, 2018, bioRxiv.

Crystal structure of DPF3b in complex with an acetylated histone peptide.

P. Loppnau, W. Tempel, Yanli Liu, 2016, Journal of structural biology.

Crystal Structure of Human Cytosolic 5′-Nucleotidase II

K. Walldén, P. Nordlund, S. Gräslund, 2007, Journal of Biological Chemistry.

Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3).

J. Walker, A. Allali-Hassani, P. Loppnau, 2008, Structure.

Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

J. Min, Y. Dou, P. Loppnau, 2018, Genes & development.

Crystal structure of chromo barrel domain of RBBP1.

M. Lei, P. Loppnau, Yanjun Li, 2018, Biochemical and biophysical research communications.

Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine

C. Arrowsmith, J. Weigelt, A. Bochkarev, 2006 .

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase*

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, The Journal of Biological Chemistry.

A chemical probe to modulate human GID4 Pro/N-degron interactions

S. Knapp, J. Min, C. Arrowsmith, 2023, bioRxiv.

Crystal structure of chromo barrel domain of RBBP1

M. Lei, P. Loppnau, Yanjun Li, 2018, bioRxiv.

A small molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II

Xinghua Guo, J. Greenblatt, J. Min, 2022, bioRxiv.

Crystal Structure Analysis of Kelch protein from Plasmodium falciparum

C. Bountra, C. Arrowsmith, S. Gräslund, 2015 .

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity*

C. Arrowsmith, M. Schapira, T. Lewis, 2008, Journal of Biological Chemistry.

A resource to enable chemical biology and drug discovery of WDR Proteins

Anthony D. Keefe, Christopher J. Mulhern, S. Kearnes, 2024, bioRxiv.

Target highlights in CASP13: experimental target structures through the eyes of their authors. Proteins: Structure,

Gutsche, K. Fidelis, G. Phillips, 2019 .