T. Stams

发表

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.

P. Atadja, W. Shao, Margaret R Pancost, 2011, Bioorganic & medicinal chemistry.

Antibacterial and Solubility Optimization of Thiomuracin A.

F. Lombardo, Jian Ding, J. Leeds, 2016, Journal of medicinal chemistry.

Production, purification, and crystallization of human interleukin‐1β converting enzyme derived from an Escherichia coli expression system

B. Grasberger, J. Koehn, R. Alexander, 1995, Protein science : a publication of the Protein Society.

The novolactone natural product disrupts the allosteric regulation of Hsp70.

Roman Kityk, M. Mayer, R. Riedl, 2015, Chemistry & biology.

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

Sarah L. Williams, W. Sellers, F. Lombardo, 2016, Journal of medicinal chemistry.

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

S. Blacklow, R. Chopra, M. Acker, 2018, Nature Communications.

Dual Allosteric Inhibition of SHP2 Phosphatase.

Sarah L. Williams, S. Blacklow, M. Glick, 2018, ACS chemical biology.

Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.

Sarah L. Williams, Robert Koenig, Mitsunori Kato, 2019, Journal of medicinal chemistry.

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

K. Stegmaier, S. Blacklow, M. Acker, 2017, Bioorganic & medicinal chemistry.

Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes.

A. Duttaroy, Jiaping Gao, Valerie Beaulieu, 2009, Journal of medicinal chemistry.

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.

Sarah L. Williams, W. Sellers, Z. Deng, 2020, Journal of medicinal chemistry.

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ping Zhu, Gang Liu, Peter Fekkes, 2016, Nature.

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.

Sarah L. Williams, Robert Koenig, Mitsunori Kato, 2019, Journal of medicinal chemistry.

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

Joshua M. Korn, W. Sellers, J. Korn, 2016, eLife.

Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

Xiang Xu, S. Blacklow, R. Chopra, 2016, Biochemistry.

Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.

W. Sly, S. Nair, A. Waheed, 1996, Proceedings of the National Academy of Sciences of the United States of America.

X-ray crystallographic studies of mammalian carbonic anhydrase isozymes.

D. Christianson, T. Stams, 2000, EXS.

Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: Molecular basis of isozyme‐drug discrimination

D. Silverman, P. Laipis, D. Christianson, 1998, Protein science : a publication of the Protein Society.

Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA.

S. Niranjanakumari, C. Fierke, D. Christianson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.

D. Chin, B. Lagu, B. Firestone, 2013, Journal of medicinal chemistry.

Ribonuclease P protein structure: evolutionary origins in the translational apparatus.

S. Niranjanakumari, C. Fierke, D. Christianson, 1998, Science.

Acylated-acyl carrier protein stabilizes the Pseudomonas aeruginosa WaaP lipopolysaccharide heptose kinase

D. Fabbro, E. Fang, R. Chopra, 2018, Scientific Reports.

The impact of structural biology in medicine illustrated with four case studies

T. Hu, S. Cowan-Jacob, T. Stams, 2017, Journal of Molecular Medicine.

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

S. Blacklow, R. Chopra, M. Acker, 2018, Nature Communications.

Structure of the MRAS–SHOC2–PP1C phosphatase complex

Kathryn A. Porter, G. Kerr, M. Eck, 2022, Nature.

A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine

W. Weihofen, Anke Bill, T. Stams, 2017, Scientific Reports.

Structure of human neutrophil collagenase reveals large S1′ specificity pocket

M. Walid Qoronfleh, Byron Rubin, R. Wahl, 1994, Nature Structural Biology.

[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.

D. Chin, W. Shao, Yun Feng, 2012, Journal of medicinal chemistry.

The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.

D. Sage, J. Koehn, B. Vash, 2009, Acta crystallographica. Section D, Biological crystallography.

Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.

D. Chin, W. Shao, Yun Feng, 2013, Journal of medicinal chemistry.