M. Persico

发表

Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.

G. Giannini, C. Fattorusso, C. Botta, 2011, Journal of medicinal chemistry.

Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis and SAR studies.

D. Taramelli, C. Fattorusso, E. Fattorusso, 2011, Bioorganic & medicinal chemistry.

Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids

M. Grimaldi, G. D’Errico, A. D'Ursi, 2016, Scientific Reports.

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.

E. Novellino, V. Yardley, D. Taramelli, 2007, Journal of medicinal chemistry.

Synthesis, Anticancer Activity and Computational SAR Analysis ofAcylsulfonylpiperazines Derivatives

L. Fajas, C. Fattorusso, M. Persico, 2017 .

Effects of Photons Irradiation on 18F-FET and 18F-DOPA Uptake by T98G Glioblastoma Cells

M. Persico, A. Facoetti, Manuela Marenco, 2020, Frontiers in Neuroscience.

Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.

G. Campiani, G. Scambia, Samanta Cimitan, 2009, Cancer research.

Silybins are stereospecific regulators of the 20S proteasome.

G. Tundo, M. Coletta, D. Milardi, 2022, Bioorganic & medicinal chemistry.

Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution

M. Coletta, M. Stefanelli, G. Tundo, 2022, Biomolecules.

Radium-223: Insight and Perspectives in Bone-metastatic Castration-resistant Prostate Cancer.

M. Persico, C. Aprile, L. Lodola, 2016, Anticancer research.

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

E. Novellino, M. Hamon, R. Budriesi, 2009, Journal of medicinal chemistry.

Further optimization of plakortin pharmacophore: structurally simple 4-oxymethyl-1,2-dioxanes with promising antimalarial activity.

S. Parapini, D. Taramelli, M. Lombardo, 2013, European journal of medicinal chemistry.

Radium-223 and metastatic castration-resistant prostate cancer: All that glitters is not gold

M. Persico, C. Aprile, L. Lodola, 2016, World journal of radiology.

New anticancer agents mimicking protein recognition motifs.

E. Novellino, D. Brancaccio, A. Carotenuto, 2013, Journal of medicinal chemistry.

A new class of antimalarial dioxanes obtained through a simple two-step synthetic approach: rational design and structure-activity relationship studies.

S. Parapini, D. Taramelli, V. Azzarito, 2011, Journal of medicinal chemistry.

Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity.

C. Fattorusso, M. Persico, F. Rondinelli, 2017, Progress in molecular and subcellular biology.

A multidisciplinary approach disclosing unexplored Aflatoxin B1 roles in severe impairment of vitamin D mechanisms of action

C. Fattorusso, A. Ritieni, M. Grosso, 2022, Cell Biology and Toxicology.

Uptake of 18F-FET and 18F-FCH in Human Glioblastoma T98G Cell Line after Irradiation with Photons or Carbon Ions

F. Corbella, M. Persico, A. Facoetti, 2017, Contrast media & molecular imaging.

Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro.

S. Parapini, D. Taramelli, A. Mozzarelli, 2019, ACS medicinal chemistry letters.

Thiazinoquinones as new promising multi-stage schistosomicidal compounds impacting Schistosoma mansoni and egg viability.

A. Pietrantoni, C. Fattorusso, M. Persico, 2019, ACS infectious diseases.

Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials.

E. Novellino, S. Parapini, D. Taramelli, 2010, Journal of natural products.

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.

A. Bergamini, E. Novellino, P. Huleatt, 2005, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.

E. Novellino, V. Yardley, S. Croft, 2008, Journal of medicinal chemistry.

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

E. Novellino, G. Maga, S. Gemma, 2005, Biochemistry.

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.

V. Yardley, D. Taramelli, S. Gemma, 2006, Bioorganic & medicinal chemistry letters.

Identification of the First Inhibitor of the GBP1:PIM1 Interaction. Implications for the Development of a New Class of Anticancer Agents against Paclitaxel Resistant Cancer Cells

E. Novellino, Ajay Kumar, G. Scambia, 2014, Journal of medicinal chemistry.

Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones

P. Cimino, A. Doménech‐Carbó, C. Fattorusso, 2017, Marine drugs.

A Divergent Enantioselective Synthesis of 9-J1-Phytoprostane and 9-A1-Phytoprostane Methyl Ester

R. Moratti, M. Persico, G. Zanoni, 2014 .

Marine inspired antiplasmodial thiazinoquinones: synthesis, computational studies and electrochemical assays

S. Parapini, D. Taramelli, A. Doménech‐Carbó, 2015 .

New Insights into the Structure–Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na+/Ca2+ Exchanger Isoforms

G. Caliendo, V. Santagada, E. Perissutti, 2021, Journal of medicinal chemistry.

Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone

S. Parapini, C. Fattorusso, M. Persico, 2020, Marine drugs.

The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism

R. Fattorusso, M. Lombardo, C. Fattorusso, 2017, Scientific Reports.

New antimalarial 3-methoxy-1,2-dioxanes: optimization of cellular pharmacokinetics and pharmacodynamics properties by incorporation of amino and N-heterocyclic moieties at C4

D. Taramelli, D. Dhavale, M. Lombardo, 2015 .

Optimized Synthesis and Antimalarial Activity of 1,2‐Dioxane‐4‐carboxamides

D. Taramelli, D. Dhavale, M. Lombardo, 2014 .

Endoperoxide polyketides from a Chinese Plakortis simplex: further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes.

S. Parapini, D. Taramelli, C. Fattorusso, 2014, Bioorganic & medicinal chemistry.

Hybrids between H2S-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells.

G. Caliendo, V. Santagada, E. Perissutti, 2021, European journal of medicinal chemistry.

Use of Integrated Computational Approaches in the Search for New Therapeutic Agents

Ettore Novellino, Marco Persico, Antonio Di Dato, 2016, Molecular informatics.

Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortis simplex.

O. Skorokhod, P. Arese, E. Schwarzer, 2015, Free radical biology & medicine.

Insight into the mechanism of action of plakortins, simple 1,2-dioxane antimalarials.

V. Barone, P. Cimino, B. Catalanotti, 2010, Organic & biomolecular chemistry.

Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents.

S. Parapini, D. Taramelli, G. Campiani, 2006, Journal of medicinal chemistry.

Investigation of the Bcl-2 multimerisation process: structural and functional implications.

G. Scambia, C. Fattorusso, C. Ferlini, 2011, Biochimica et biophysica acta.

A sensitive, rapid and inexpensive method to assess aluminium(III) ions in technetium eluates

M. Persico, C. Aprile, L. Lodola, 2014, Nuclear medicine communications.

Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

Gennaro Piccialli, Nicola Borbone, Marco Persico, 2012, Journal of medicinal chemistry.

Exploring the Photodynamic Properties of Two Antiproliferative Benzodiazopyrrole Derivatives

C. Altucci, C. Dell’Aversano, L. Tartaglione, 2020, International journal of molecular sciences.

Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue.

E. Novellino, G. Piccialli, L. Mayol, 2014, Organic & biomolecular chemistry.

99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits

M. Persico, G. Manfrinato, A. Sgarella, 2020, Contrast media & molecular imaging.

Using small molecules to overcome drug resistance induced by a viral oncogene.

B. Stockwell, M. Persico, I. Smukste, 2006, Cancer cell.

Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections

S. Parapini, C. Fattorusso, M. Persico, 2020, Molecules.

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.

Ettore Novellino, Marco Persico, Caterina Fattorusso, 2008, Journal of medicinal chemistry.

(99m)Tc-human serum albumin nanocolloids: particle sizing and radioactivity distribution.

M. Morandotti, P. Pallavicini, M. Persico, 2015, Journal of labelled compounds & radiopharmaceuticals.

Deficiencies in product labelling instructions and quality control directions for 99mTc radiopharmaceuticals

M. Persico, C. Aprile, L. Lodola, 2014, Nuclear medicine communications.

3-methoxy-1 , 2-dioxanes : optimization of cellular pharmacokinetics and pharmacodynamics properties by incorporation of amino and N-heterocyclic moieties at C 4 †

D. Taramelli, D. Dhavale, M. Lombardo, 2015 .

Cooperative Binding of the Cationic Porphyrin Tris-T4 Enhances Catalytic Activity of 20S Proteasome Unveiling a Complex Distribution of Functional States

M. Coletta, G. Tundo, R. Purrello, 2020, International journal of molecular sciences.

Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding

R. Paolesse, M. Coletta, M. Stefanelli, 2017, Scientific Reports.

Cationic porphyrins are tunable gatekeepers of the 20S proteasome† †Electronic supplementary information (ESI) available: It is reporting computational details, semi-log plots of residual CP activities, Molprobity results. See DOI: 10.1039/c5sc03312h

G. Tundo, M. Coletta, R. Purrello, 2015, Chemical science.

Role of Stereochemistry on the Biological Activity of Nature-Inspired 3-Br-Acivicin Isomers and Derivatives

S. Parapini, S. Bruno, C. Fattorusso, 2023, Molecules.

Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.

E. Novellino, V. Yardley, S. Croft, 2008, Journal of medicinal chemistry.

User-Centred Design of a Final Results Report for Participants in Multi-Sensor Personal Air Pollution Exposure Monitoring Campaigns

Dimitris Chapizanis, Thomas Maggos, Rok Novak, 2021, International journal of environmental research and public health.

Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells.

R. Pacchiana, M. Donadelli, S. Bruno, 2023, European journal of medicinal chemistry.

Tetrasubstituted Pyrrole Derivative Mimetics of Protein–Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells

P. Campiglia, C. Fattorusso, M. Persico, 2023, Molecules.

18F-FET and 18F-FCH uptake in human glioblastoma T98G cell lines

M. Persico, C. Aprile, L. Lodola, 2016, Radiology and oncology.

Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.

E. Novellino, S. Gemma, G. Campiani, 2010, Journal of medicinal chemistry.

Effects of L-DOPA Pretreatment on the Kinetics, Migration and Carbon Ion Radiation Response of T98G Cells

F. Valvo, R. Orecchia, M. Ciocca, 2018, AntiCancer Research.

In vitro study: binding of 99mTc-DPD to synthetic amyloid fibrils

M. Persico, M. Concardi, C. Aprile, 2015 .

Malignant Lymphoma Imaged by 18 F-Fluoro-Choline PET-CT in a Patient with Prostate Cancer : a Case Report and Review of Literature

M. Persico, C. Aprile, L. Lodola, 2017 .

GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1.

E. Novellino, G. Scambia, C. Fattorusso, 2015, European journal of medicinal chemistry.

Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.

E. Novellino, V. Yardley, S. Croft, 2009, Journal of medicinal chemistry.

Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.

Ettore Novellino, Marco Persico, Caterina Fattorusso, 2005, Journal of medicinal chemistry.

Exploring the antimalarial potential of the methoxy-thiazinoquinone scaffold: Identification of a new lead candidate.

S. Parapini, C. Fattorusso, M. Persico, 2019, Bioorganic chemistry.

Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging

P. Osmulski, M. Gaczynska, R. Purrello, 2023, Biomolecules.

G. Tundo, M. Coletta, R. Purrello, 2015, Chemical science.

Structural characterization of the porphyrins/proteasome interaction

M. Coletta, G. Tundo, M. Coletta, 2020 .

This is the author's final version of the contribution published as: Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortis simplex

P. Arese, E. Schwarzer, O. Taglialatela‐Scafati, 2019 .