O. Mirguet

发表

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

S. Robson, G. Drewes, M. Bantscheff, 2011, Nature.

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).

David M. Wilson, P. Bamborough, R. Prinjha, 2012, Bioorganic & medicinal chemistry letters.

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.

Christophe Simon, P. Bamborough, R. Prinjha, 2014, Journal of medicinal chemistry.

A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.

C. Demangel, C. Tarnus, O. Mirguet, 2011, Chemistry.

Discovery and characterization of small molecule inhibitors of the BET family bromodomains.

P. Bamborough, R. Prinjha, R. Grimley, 2011, Journal of medicinal chemistry.

A new AMPK activator, GSK773, corrects fatty acid oxidation and differentiation defect in CPT2-deficient myotubes

O. Mirguet, Yann Lamotte, S. Mouillet-Richard, 2018, Human molecular genetics.

Discovery of Pyridones As Oral AMPK Direct Activators.

E. Nicodème, L. Trottet, O. Mirguet, 2013, ACS medicinal chemistry letters.

Comparison of Soluble Guanylate Cyclase Stimulators and Activators in Models of Cardiovascular Disease Associated with Oxidative Stress

D. Behm, R. Coatney, R. Willette, 2012, Front. Pharmacol..

Gold‐Catalyzed Cyclizations of Alkynyl Silyl Enol Ethers: An Easy Access to Bicyclo[3.2.1]octanone Derivatives

O. Mirguet, V. Michelet, C. Péan, 2016 .

Tartgeting Non-alcoholic Fatty Liver Disease: Design, X-Ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of Serine/Threonine Kinase25.

Mélaine A. Kuenemann, L. Vuillard, L. Miallau, 2022, Bioorganic & medicinal chemistry letters.

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

M. Hann, D. Mole, J. Liddle, 2017, Bioorganic & medicinal chemistry letters.

From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

E. Nicodème, J. Kirilovsky, L. Trottet, 2012, Bioorganic & medicinal chemistry letters.

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

J. Iredale, S. Howie, J. Hughes, 2015, Nature Medicine.

Desymmetrization of hydrazinocyclohexadienes: a new approach for the synthesis of polyhydroxylated aminocyclohexanes.

O. Mirguet, T. Lecourt, L. Micouin, 2009, Organic letters.

Juniperanol: First total synthesis and evaluation in Type 2 Diabetes disease.

O. Mirguet, V. Michelet, A. Carrër, 2019, Bioorganic chemistry.

Rearrangement of beta-amino alcohols and application to the synthesis of biologically active compounds.

O. Mirguet, J. Cossy, D. G. Pardo, 2009, Chirality.

Design and synthesis of bridged piperidine and piperazine isosteres.

S. Hanessian, O. Mirguet, O. Saavedra, 2018, Bioorganic & medicinal chemistry letters.

Rearrangement of β-Amino Alcohols and Application to the Synthesis of Biologically Active Compounds

O. Mirguet, J. Cossy, D. G. Pardo, 2010 .

Ring Expansion: Synthesis of the Velbanamine Piperidine Core

O. Mirguet, J. Cossy, D. G. Pardo, 2002 .

A Formal Synthesis of (−)‐Paroxetine by Enantioselective Ring Enlargement of a Trisubstituted Prolinol

O. Mirguet, J. Desmurs, J. Cossy, 2002 .

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains.

P. Bamborough, R. Prinjha, C. Chung, 2013, Journal of medicinal chemistry.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Xiaozhong Zheng, D. Mole, D. Clapham, 2017, Journal of medicinal chemistry.

Deep generative models for ligand‐based de novo design applied to multi‐parametric optimization

Pierre Ducrot, Nicolas Do Huu, Olivier Mirguet, 2021, J. Comput. Chem..

Naphthyridines as Novel BET Family Bromodomain Inhibitors

Lionel Trottet, Antonia Lewis, Paul Bamborough, 2014, ChemMedChem.

Ring expansion: formal total synthesis of (−)-paroxetine

O. Mirguet, J. Desmurs, J. Cossy, 2001 .

Diastereoselective conjugate addition of organocuprates to chiral racemic olefinic amido esters. Formal total synthesis of paroxetine

O. Mirguet, J. Desmurs, J. Cossy, 2003 .

Ring Expansion: Formal Total Synthesis of (‐)‐Paroxetine.

O. Mirguet, J. Desmurs, J. Cossy, 2002 .

A short formal synthesis of paroxetine. Diastereoselective cuprate addition to a chiral racemic olefinic amido ester

O. Mirguet, J. Desmurs, J. Cossy, 2001 .