D. Hewings

发表

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.

S. Knapp, P. Brennan, C. Schofield, 2012, Journal of medicinal chemistry.

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains.

S. Knapp, O. Fedorov, P. Brennan, 2013, MedChemComm.

Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights

M. Bogyo, I. Wertz, D. Hewings, 2017, The FEBS journal.

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

M. Bogyo, W. Forrest, N. Popovych, 2018, Nature Communications.

Activity‐based probes for the multicatalytic proteasome

M. Bogyo, I. Wertz, D. Hewings, 2017, The FEBS journal.

The Synthesis and Crystal Structures of Two Hydrogen-Bonded N-Oxides

James A. Lee, J. E. Thomson, S. Davies, 2014, Journal of Chemical Crystallography.

Synthesis and Crystal Structures of N-Aryl-N-methylaminocyclohexanols

James A. Lee, J. E. Thomson, S. Davies, 2013, Journal of Chemical Crystallography.

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi.

P. Biggin, D. Hewings, Laura E. Jennings, 2020, ACS infectious diseases.

Correction to Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions.

M. Höss, R. Paton, D. Hewings, 2016, ACS chemical biology.

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

S. Knapp, O. Fedorov, B. Marsden, 2011, Journal of medicinal chemistry.

Ammonium-directed olefinic epoxidation: kinetic and mechanistic insights.

James A. Lee, J. E. Thomson, R. Compton, 2012, The Journal of organic chemistry.

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.

P. Biggin, A. Mapp, E. Hammond, 2018, Bioorganic & medicinal chemistry.

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

S. Knapp, O. Fedorov, P. Brennan, 2013, Journal of medicinal chemistry.

Isoxazole‐Derived Amino Acids are Bromodomain‐Binding Acetyl‐Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3

T. Heightman, D. Hewings, Timothy P. C. Rooney, 2016, Angewandte Chemie.

Synthesis and Crystal Structures of (RS,RS,RS)- and (1RS,2RS,3SR)-3-(N-Methylamino)cyclohexane-1,2-diol

James A. Lee, J. E. Thomson, S. Davies, 2013, Journal of Chemical Crystallography.

Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.

W. Pao, B. Kuhn, A. Kuglstatter, 2022, Journal of medicinal chemistry.

Small molecule inhibitors of bromodomain-acetyl-lysine interactions.

M. Höss, R. Paton, D. Hewings, 2015, ACS chemical biology.

Chapter 22 – Emerging Epigenetic Therapies—Bromodomain Ligands

D. Hewings, Timothy P. C. Rooney, S. Conway, 2015 .

Developing inhibitors of bromodomain-histone interactions

D. Hewings, 2014 .

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

M. Bogyo, W. Forrest, N. Popovych, 2018, Nature Communications.

Organocatalytic Removal of Formaldehyde Adducts from RNA and DNA Bases

Ash A. Alizadeh, Luzi J. Barandun, D. Kurtz, 2015, Nature chemistry.

Preclinical characterization of a next generation brain permeable, paradox breaker BRAF inhibitor.

R. Dummer, A. Brigo, M. Bacac, 2021, Clinical cancer research : an official journal of the American Association for Cancer Research.

Discovery of Orally Available and Brain Penetrant AEP Inhibitors.

R. Hochstrasser, D. Hewings, Nenad Manevski, 2023, Journal of medicinal chemistry.