S. Conway

发表

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.

S. Knapp, P. Brennan, C. Schofield, 2012, Journal of medicinal chemistry.

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains.

S. Knapp, O. Fedorov, P. Brennan, 2013, MedChemComm.

Small molecules as tools to study the chemical epigenetics of lysine acetylation.

S. Conway, M. Schiedel, 2018, Current opinion in chemical biology.

Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide Derivatives

A. Burgess, A. Bullock, B. Catimel, 2015 .

Purinergic Receptor-Stimulated IP3-Mediated Ca2+ Release Enhances Neuroprotection by Increasing Astrocyte Mitochondrial Metabolism during Aging

J. Lechleiter, S. Conway, Jun Wu, 2007, The Journal of Neuroscience.

High-density functional-RNA arrays as a versatile platform for studying RNA-based interactions

J. O. Phillips, S. Conway, J. Healy, 2018, Nucleic acids research.

CH-01 is a Hypoxia-Activated Prodrug That Sensitizes Cells to Hypoxia/Reoxygenation Through Inhibition of Chk1 and Aurora A

E. Hammond, I. Pires, S. Conway, 2013, ACS chemical biology.

Interaction of th Channel , MscS , through Lipid In Pockets

I. Booth, T. Rasmussen, S. Conway, 2019 .

Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

E. Hammond, L. Folkes, S. Conway, 2021, Cell chemical biology.

Mechanism of ligand-gated potassium efflux in bacterial pathogens

I. Booth, T. Rasmussen, T. Roosild, 2010, Proceedings of the National Academy of Sciences.

Bifunctional Molecules beyond PROTACs.

S. Conway, 2020, Journal of medicinal chemistry.

Hypoxia-activated pro-drugs of the KDAC inhibitor vorinostat (SAHA)

E. Hammond, L. Folkes, S. Conway, 2019, Tetrahedron.

Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs

E. Hammond, M. Stratford, S. Conway, 2016, Nature Protocols.

Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor.

A. Galione, G. Bultynck, S. Conway, 2011, Chemical communications.

A type 2 Ferrier rearrangement-based synthesis of D-myo-inositol 1,4,5-trisphosphate

A. Slawin, G. Bultynck, S. Conway, 2009 .

Mitochondrial β-amyloid in Alzheimer's disease.

J. Ainge, F. Gunn-Moore, S. Conway, 2011, Biochemical Society transactions.

Zap‐Pano: a Photocaged Prodrug of the KDAC Inhibitor Panobinostat

E. Hammond, S. Conway, Anna Skwarska, 2021, ChemMedChem.

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain

P. Biggin, O. Fedorov, E. Hammond, 2020, Journal of medicinal chemistry.

Chemische Epigenetik: der Einfluss chemischer und chemo‐biologischer Techniken auf die Zielstruktur‐Validierung von Bromodomänen

S. Conway, Jos J. A. G. Kamps, M. Schiedel, 2019, Angewandte Chemie.

Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains

S. Knapp, G. Morris, P. Biggin, 2022, ACS chemical biology.

Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism

E. Hammond, K. Leszczynska, S. Conway, 2020, iScience.

Synthesis and biological evaluation of a novel cardiolipin affinity matrix.

Meng-Xin Yin, A. Holmes, R. Wettenhall, 2009, Organic & biomolecular chemistry.

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.

P. Hawkins, L. Stephens, A. Burgess, 2010, Organic & biomolecular chemistry.

Development of isotope-enriched phosphatidylinositol-4- and 5-phosphate cellular mass spectrometry probes

V. Flemington, A. Saunders, S. Conway, 2020, Chemical science.

A synthesis of dioctanoyl phosphatidylinositol

S. Conway, Thomas S. Elliott, Joseph A. Nemeth, 2009 .

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi.

P. Biggin, D. Hewings, Laura E. Jennings, 2020, ACS infectious diseases.

Correction to Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions.

M. Höss, R. Paton, D. Hewings, 2016, ACS chemical biology.

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

S. Knapp, O. Fedorov, B. Marsden, 2011, Journal of medicinal chemistry.

Celebrating the Medicinal Chemistry of Gunda Georg and Shaomeng Wang.

M. Bolognesi, S. Conway, 2021, Journal of medicinal chemistry.

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.

D. Jane, B. Clark, S. Conway, 2001, Bioorganic & medicinal chemistry letters.

CORRECTIONS

S. Kliewer, S. Prusiner, S. DeArmond, 1894, The Lancet.

Inositol 1,4,5-trisphosphate receptors in the heart.

M. Bootman, H. Roderick, S. Conway, 2004, Biological research.

A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction**

Stefan Knapp, Robert S Paton, Susanne Müller, 2014, Angewandte Chemie.

Facile one-pot synthesis of 5-substituted hydantoins.

R. G. Murray, S. Conway, D. M. Whitehead, 2008, Organic & biomolecular chemistry.

The use of phosphate bioisosteres in medicinal chemistry and chemical biology

S. Conway, Thomas S. Elliott, Yulin Ye, 2012 .

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.

P. Biggin, A. Mapp, E. Hammond, 2018, Bioorganic & medicinal chemistry.

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

S. Knapp, O. Fedorov, P. Brennan, 2013, Journal of medicinal chemistry.

Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists.

D. Fayuk, L. Khiroug, N. Avlonitis, 2009, Organic & biomolecular chemistry.

TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1.

S. Conway, 2008, Chemical Society reviews.

In vitro photo-release of a TRPV1 agonist.

S. Conway, B. Agate, R. H. Scott, 2006, Bioorganic & medicinal chemistry letters.

Wavelength-orthogonal photolysis of neurotransmitters in vitro.

N. Emptage, Mike L Hart, C. McDougall, 2012, Chemical communications.

Isoxazole‐Derived Amino Acids are Bromodomain‐Binding Acetyl‐Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3

T. Heightman, D. Hewings, Timothy P. C. Rooney, 2016, Angewandte Chemie.

Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives.

S. Conway, G. Miller, 2007, Natural product reports.

CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes

E. Hammond, L. Folkes, S. Conway, 2016, ACS central science.

Two Color Imaging of Different Hypoxia Levels in Cancer Cells

E. Hammond, S. Faulkner, S. Conway, 2023, Journal of the American Chemical Society.

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

S. Knapp, O. Fedorov, M. Bunnage, 2014, Journal of the American Chemical Society.

Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications

R. Lerner, P. Vogt, M. Manz, 2021, Nature Chemistry.

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate

M. Berridge, M. Bootman, H. Roderick, 2004, The Journal of cell biology.

Efficient synthesis of 2-nitroimidazole derivatives and the bioreductive clinical candidate Evofosfamide (TH-302)

E. Hammond, M. Stratford, S. Conway, 2015 .

Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

D. Newman, S. Conway, K. Costa, 2017, Science.

NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

A. Galione, V. Cerundolo, G. Churchill, 2012, Current Biology.

Small molecule inhibitors of bromodomain-acetyl-lysine interactions.

M. Höss, R. Paton, D. Hewings, 2015, ACS chemical biology.

Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy.

E. Hammond, S. Conway, I. Mistry, 2017, International journal of radiation oncology, biology, physics.

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

Russell G. Jones, M. Bootman, C. Thompson, 2007, Immunity.

Chapter 22 – Emerging Epigenetic Therapies—Bromodomain Ligands

D. Hewings, Timothy P. C. Rooney, S. Conway, 2015 .

Hypoxia-Activated, Small-Molecule-Induced Gene Expression.

E. Hammond, S. Conway, L. Bouchez, 2018, ACS chemical biology.

PPIs as therapeutic targets for anticancer drug discovery: the case study of MDM2 and BET bromodomain inhibitors

Maria M. M. Santos, S. Conway, Margarida Espadinha, 2020 .

Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.

Laura E. Jennings, S. Conway, Brian G. Wilson, 2014, Future medicinal chemistry.

Epigenetics: Novel Therapeutics Targeting Epigenetics.

W. Greenlee, P. Woster, G. Georg, 2015, Journal of medicinal chemistry.

Quantitative hopanoid analysis enables robust pattern detection and comparison between laboratories

D. Newman, G. Kulkarni, S. Conway, 2015, Geobiology.

Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy

M. Bootman, H. Roderick, O. Ritter, 2009, Proceedings of the National Academy of Sciences.

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes

M. Berridge, M. Bootman, H. Roderick, 2006, Journal of Cell Science.

2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels.

M. Berridge, M. Bootman, H. Roderick, 2003, Cell calcium.

Regulation of InsP3 receptor activity by neuronal Ca2+‐binding proteins

M. Berridge, M. Bootman, H. Roderick, 2004, The EMBO journal.

Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1.

M. Bootman, H. Roderick, S. Conway, 2007, Cell calcium.

Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization.

M. Bootman, A. Holmes, S. Conway, 2003, The Biochemical journal.

Regulation of InsP 3 receptor activity by neuronal Ca 2 þ-binding proteins

M. Berridge, M. Bootman, H. Roderick, 2013 .

Distinct Intracellular Calcium Transients in Neurites and Somata Integrate Neuronal Signals

M. Zochowski, P. Koulen, B. Ehrlich, 2002, The Journal of Neuroscience.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS chemical biology.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS infectious diseases.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, Journal of medicinal chemistry.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS chemical neuroscience.

Caged AG10: new tools for spatially predefined mitochondrial uncoupling.

N. Avlonitis, C. McDougall, S. Conway, 2009, Molecular bioSystems.

Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils.

M. Bootman, N. Hogg, E. McNeill, 2007, Cell calcium.

Epigenetics: novel therapeutics targeting epigenetics.

P. Woster, G. Georg, S. Conway, 2015, Journal of medicinal chemistry.

Bromodomains: are readers right for epigenetic therapy?

S. Conway, 2012, ACS medicinal chemistry letters.

The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction

H. Llewelyn Roderick, Martin D. Bootman, Michael J. Berridge, 2004, Journal of Cell Science.

TRPing the Switch on Pain: An Introduction to the Chemistry and Biology of Capsaicin and TRPV1

S. Conway, 2008 .

The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease.

F. Gunn-Moore, S. Conway, Frank J Gunn-Moore, 2010, The Biochemical journal.

Engineering transkingdom signalling in plants to control gene expression in rhizosphere bacteria

Barney A. Geddes, Amber L Thompson, P. Poole, 2019, Nature Communications.

Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets.

I. Booth, T. Rasmussen, S. Conway, 2019, Journal of molecular biology.

The synthesis of membrane permeant derivatives of myo-inositol 1,4,5-trisphosphate

M. Bootman, H. Roderick, A. Holmes, 2006 .

phosphorylation : role of the F 0 / F 1-ATPase Ca 2 + activation of heart mitochondrial oxidative

V. Mootha, J. Walker, W. Koch, 2000 .

A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

W. Yue, P. Vogt, A. Martinelli, 2020, Advanced science.

Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors

Noah R. Flynn, G. Miller, S. Conway, 2021, Metabolites.

Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).

A. Holmes, R. Billington, S. Conway, 2004, The Biochemical journal.

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System

J. Naismith, J. Benesch, I. Booth, 2017, Biochemistry.

Understanding the Structural Requirements for Activators of the Kef Bacterial Potassium Efflux System

G. Morris, I. Booth, T. Rasmussen, 2014, Biochemistry.

KefF, the Regulatory Subunit of the Potassium Efflux System KefC, Shows Quinone Oxidoreductase Activity

I. Booth, T. Rasmussen, S. Conway, 2011, Journal of bacteriology.

Bürgenstock 2012: Reflections on stereochemistry.

S. Conway, 2013, Nature chemistry.

Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals

D. Jane, S. Conway, P. Howson, 2003, British journal of pharmacology.

Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery

J. Mottram, A. Wilkinson, S. Conway, 2023, bioRxiv.

(-)-CHANA, a fluorogenic probe for detecting amyloid binding alcohol dehydrogenase HSD10 activity in living cells.

F. Gunn-Moore, K. Musílek, Xiaoguang Li, 2010, ACS chemical biology.

Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

D. Newman, S. Conway, K. Costa, 2017, Science.

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes

M. Berridge, M. Bootman, H. Roderick, 2006, Journal of Cell Science.

AMP binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system

J. Naismith, J. Benesch, I. Booth, 2017 .

Inositol 1 , 4 , 5-trisphosphate supports the arrhythmo-genic action of endothelin-1 on ventricular cardiac

M. Berridge, M. Bootman, H. Roderick, 2006 .

Chemical epigenetics: the impact of chemical- and chemical biology techniques on bromodomain target validation.

S. Conway, M. Schiedel, D. Ascough, 2019, Angewandte Chemie.

Antibody-Based Imaging of Bioreductive Prodrug Release in Hypoxia

S. Conway, A. Wallabregue, Ester M Hammond, 2023, JACS Au.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS medicinal chemistry letters.

Virtual Special Issue: Epigenetics 2022.

D. Huryn, C. Lindsley, D. Liotta, 2022, ACS pharmacology & translational science.