A. Walker

发表

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).

David M. Wilson, P. Bamborough, R. Prinjha, 2012, Bioorganic & medicinal chemistry letters.

Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.

P. Bamborough, R. Angell, A. Walker, 2008, Bioorganic & medicinal chemistry letters.

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.

Christophe Simon, P. Bamborough, R. Prinjha, 2014, Journal of medicinal chemistry.

Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain

Anthony R. Fehr, A. Leung, A. Walker, 2022, Bioorganic & Medicinal Chemistry.

Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Acta crystallographica. Section F, Structural biology communications.

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

C. Chung, D. Mole, J. Liddle, 2017, Nature Communications.

Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Bioorganic & medicinal chemistry letters.

Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Bioorganic & medicinal chemistry letters.

6,6'-Bis(2-hydroxyphenyl)-2,2'-bipyridine manganese(III) complexes: a novel series of superoxide dismutase and catalase mimetics.

G. Tranter, A. Walker, S. Doctrow, 2001, Bioorganic & medicinal chemistry letters.

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

M. Hann, D. Mole, J. Liddle, 2017, Bioorganic & medicinal chemistry letters.

Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.

A. Hovnanian, J. Liddle, P. Thomas, 2019, Bioorganic & medicinal chemistry letters.

A potent and selective Kallikrein-5 inhibitor delivers high pharmacological activity in Netherton Syndrome patient skin.

M. Lennon, A. Hovnanian, D. Grillot, 2021, The Journal of investigative dermatology.

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

J. Iredale, S. Howie, J. Hughes, 2015, Nature Medicine.

Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity.

Paul Bamborough, Penny A. Smee, P. Bamborough, 2008, Bioorganic & medicinal chemistry letters.

Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series.

K. Lackey, R. Mook, A. Walker, 2006, Bioorganic & medicinal chemistry letters.

p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.

J. B. Buckton, Penny A. Smee, P. Bamborough, 2009, Journal of medicinal chemistry.

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.

Paul Bamborough, Penny A. Smee, P. Bamborough, 2008, Bioorganic & medicinal chemistry letters.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Xiaozhong Zheng, D. Mole, D. Clapham, 2017, Journal of medicinal chemistry.

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.

Paul Bamborough, P. Bamborough, R. Angell, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.

R. Prinjha, P. Soden, C. Chung, 2021, Journal of medicinal chemistry.

GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice

J. Schofield, M. Convery, Xiping Zhang, 2021, The Journal of biological chemistry.

Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain

Anthony R. Fehr, A. Leung, A. Walker, 2022, bioRxiv.

Use of Graphics for Studies with Small Sample Sizes: A Simulated Case Study of an Early-Phase Asset for Treatment of Type 2 Diabetes Mellitus

Denise Shortino, Ann Louise Walker, Andrew Miskell, 2012 .

Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity.

P. Bamborough, R. Angell, A. Walker, 2008, Bioorganic & medicinal chemistry letters.