Guangtao Zhang

发表

Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.

Ming-Ming Zhou, S. Mujtaba, L. Zeng, 2013, Journal of medicinal chemistry.

Characterization of the sugar-O-methyltransferase LobS1 in lobophorin biosynthesis

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2013, Applied Microbiology and Biotechnology.

Host-dependent heterologous expression of berninamycin gene cluster leads to linear thiopeptide antibiotics.

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2021, Organic & biomolecular chemistry.

Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase.

Siwen Niu, Changsheng Zhang, J. Ju, 2011, Journal of the American Chemical Society.

Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Haibo Zhang, Siwen Niu, Changsheng Zhang, 2011, The Journal of Antibiotics.

Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation

Siwen Niu, Yiguang Zhu, Changsheng Zhang, 2012, Applied and Environmental Microbiology.

X‐ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper‐dependent hydrophobic pocket

Y. Pommier, R. Shoemaker, J. Tropea, 2011, FEBS letters.

BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy.

Ming-Ming Zhou, I. Osman, M. Ohlmeyer, 2013, Cancer research.

Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160.

Jinsong Liu, Yiguang Zhu, Changsheng Zhang, 2012, Journal of natural products.

A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds

Yiguang Zhu, Liping Zhang, Changsheng Zhang, 2021, Science China Chemistry.

Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019

Fang Peng, Qingbo Zhang, Liping Zhang, 2020, RSC advances.

Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation

P. Wright, M. Montminy, Ming-Ming Zhou, 2014, Proceedings of the National Academy of Sciences.

Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032.

Qingbo Zhang, Changsheng Zhang, Wenjun Zhang, 2014, Journal of natural products.

Characterizing amosamine biosynthesis in amicetin reveals AmiG as a reversible retaining glycosyltransferase.

Jinsong Liu, Yiguang Zhu, Changsheng Zhang, 2013, Journal of the American Chemical Society.

Designandin silicoscreeningof inhibitorsofthecholeratoxin

Guangtao Zhang, 2009 .

Design and in silico screening of inhibitors of the cholera toxin

Guangtao Zhang, 2009, Expert opinion on drug discovery.

Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis.

Weiming Zhu, Yiguang Zhu, Qingbo Zhang, 2016, ACS chemical biology.

Assembly Line and Post-PKS Modifications in the Biosynthesis of Marine Polyketide Natural Products

Lijuan Wang, Yiguang Zhu, Qingbo Zhang, 2019 .

Scaling the druggability landscape of human bromodomains, a new class of drug targets.

Ming-Ming Zhou, R. Sanchez, Guangtao Zhang, 2012, Journal of medicinal chemistry.

Inhibiteurs de bromodomaines comme modulateurs d'expression génique

Ming-Ming Zhou, S. Mujtaba, M. Ohlmeyer, 2012 .

Heronamides D-F, polyketide macrolactams from the deep-sea-derived Streptomyces sp. SCSIO 03032.

Yiguang Zhu, Changsheng Zhang, Wenjun Zhang, 2014, Journal of natural products.

Design, synthesis, and evaluation of bisubstrate analog inhibitors of cholera toxin.

Guangtao Zhang, 2008, Bioorganic & medicinal chemistry letters.

Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2015, Chembiochem : a European journal of chemical biology.

Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams

Hongbo Jin, Qingbo Zhang, Liping Zhang, 2019, Marine drugs.

Development on the Synthesis of Phosphodieseterase Type 5 (PDE5) Inhibitors

Y. Ma, Guangtao Zhang, 2013 .

Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.

Ming-Ming Zhou, L. Zeng, Natasha Moshkina, 2012, The Journal of Biological Chemistry.

New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039

Haibo Zhang, Yiguang Zhu, Qingbo Zhang, 2012, The Journal of Antibiotics.

In silico molecular docking, preclinical evaluation of spiroindimicins A-D, lynamicin A and D isolated from deep marine sea derived Streptomyces sp. SCSIO 03032

Haibo Zhang, Yiguang Zhu, Qingbo Zhang, 2014, Interdisciplinary Sciences: Computational Life Sciences.

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

Aristotelis Tsirigos, Iannis Aifantis, Ming-Ming Zhou, 2014, Cell reports.

Copper(II), Cobait(II) and Nickel(II) Complexes of N-(O,O-Diisopropyl, Phosph0Ryl)Alanine

Yangzhong Liu, Guangtao Zhang, Qing-liang Liu, 1998 .

PREPARATION OF GLYCOSYL DIMETHYLTHIOPHOSPHATES AND THEIR APPLICATION AS GLYCOSYL DONORS

Guangtao Zhang, Biao Yu, S. Deng, 1998 .

Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis.

Hongbo Jin, Liping Zhang, Changsheng Zhang, 2020, Organic letters.

Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis.

Wenjun Zhang, R. Shi, Haibo Zhang, 2014, Angewandte Chemie.

A new hypervalent iodine(iii/v) oxidant and its application to the synthesis of 2H-azirines†

Guangtao Zhang, Yunfei Du, Ji-You Sun, 2019, Chemical science.

TFA-sensitive arylsulfonylthiourea-assisted synthesis of N,N'-substituted guanidines.

Guangtao Zhang, E. Fan, Zhongsheng Zhang, 2003, The Journal of organic chemistry.

TBHP/AIBN-Mediated Synthesis of 2-Amino-thioazoles from Active Methylene Ketones and Thiourea under Metal-free Conditions

Guangtao Zhang, D. Zhang-Negrerie, Yunfei Du, 2018 .

Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

Qingbo Zhang, Changsheng Zhang, Wenjun Zhang, 2021, Molecules.

Proazaphosphatrane P(RNCH2CH2)3N (R=Me, i‐Pr)‐Catalyzed Isomerization of Allylaromatics, Allyl Phenyl Sulfide, Allyl Phenyl Sulfone, and bis‐Allylmethylene Double Bond‐Containing Compounds

Guangtao Zhang, Zhengkun Yu, Liandi Wang, 2006 .

Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

F. Maxfield, Guangtao Zhang, J. Warren, 2010, Proceedings of the National Academy of Sciences.

Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase.

Weiming Zhu, Yiguang Zhu, Changsheng Zhang, 2012, Organic letters.

Inhibition of amyloid β‐peptide production by blockage of β‐secretase cleavage site of amyloid precursor protein

Guangtao Zhang, C. Chae, G. Olson, 2007 .

Cascade Formation of C3‐Unsymmetric Spirooxindoles via PhI(OAc)2‐Mediated Oxidative C−C/C−N Bond Formation

Guangtao Zhang, D. Zhang-Negrerie, Yunfei Du, 2018 .

Dissecting glycosylation steps in lobophorin biosynthesis implies an iterative glycosyltransferase.

Yiguang Zhu, Changsheng Zhang, Guangtao Zhang, 2013, Organic letters.

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams† †Electronic supplementary information (ESI) available: The experimental procedures, materials, and characterization of the compounds. See DOI: 10.1039/c6sc03875a Click here

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2016, Chemical science.

Synthesis of Neomycin Analogs to Investigate Aminoglycoside-RNA Interactions

R. Griffey, P. Seeberger, Guangtao Zhang, 2003 .

Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy.

Y. Pommier, R. Shoemaker, J. Tropea, 2011, Journal of structural biology.

Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]

Y. Pommier, A. Monks, R. Shoemaker, 2009, Journal of Pharmacology and Experimental Therapeutics.

Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2012, Journal of the American Chemical Society.

Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.

Qiang Zhang, Jun Yao, Min Tao, 2014, Cancer cell.

Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.

Ming-Ming Zhou, L. Zeng, A. Plotnikov, 2014, Chemistry & biology.

Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition*

Ming-Ming Zhou, L. Zeng, Natasha Moshkina, 2012, The Journal of Biological Chemistry.

Discovery of Chemical Inhibitors of Human Bromodomains.

Ming-Ming Zhou, Steven G. Smith, Guangtao Zhang, 2015, Chemical reviews.

NVP-BEZ235, a novel dual PI3K-mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells.

Gang Zhao, Guangtao Zhang, Guangtong Zhou, 2015, Cancer letters.

Insights into caerulomycin A biosynthesis: a two-component monooxygenase CrmH-catalyzed oxime formation.

R. Shi, Weiming Zhu, Yiguang Zhu, 2013, Journal of the American Chemical Society.

Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth

Ming-Ming Zhou, L. Zeng, Yao-yao Xu, 2018, Proceedings of the National Academy of Sciences.

Carboxyl formation from methyl via triple hydroxylations by XiaM in xiamycin A biosynthesis.

R. Shi, Yiguang Zhu, Qingbo Zhang, 2012, Organic letters.

Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2017, Applied Microbiology and Biotechnology.

Synthesis of trifluoromethylated 2H-azirines through Togni reagent-mediated trifluoromethylation followed by PhIO-mediated azirination

Guangtao Zhang, Yunfei Du, Ji-You Sun, 2018, Beilstein journal of organic chemistry.

Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2017, Applied Microbiology and Biotechnology.

Cooperation between a Coenzyme A-Independent Stand-Alone Initiation Module and an Iterative Type I Polyketide Synthase during Synthesis of Mycobacterial Phenolic Glycolipids

L. Quadri, Guangtao Zhang, J. Warren, 2009, Journal of the American Chemical Society.

Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay.

W. Strittmatter, Guangtao Zhang, J. Burke, 2007, Assay and drug development technologies.

Cellular inhibition of Chk 2 kinase and potentiation of camptothecins and radiation by the novel Chk 2 inhibitor PV 1019

Y. Pommier, A. Monks, R. Shoemaker, 2009 .

Characterization of a Sugar‐O‐methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity

Siwen Niu, Changsheng Zhang, J. Ju, 2011, Chembiochem : a European journal of chemical biology.

Investigation of Conjugated Soybean Oil as Drying Oils and CLA Sources

K. Doll, Guangtao Zhang, J. Verkade, 2012 .

Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis.

Wenjun Zhang, R. Shi, Haibo Zhang, 2014, Angewandte Chemie.

Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams.

Changsheng Zhang, Wenjun Zhang, Guangtao Zhang, 2016, Current topics in medicinal chemistry.

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams

Yiguang Zhu, Qingbo Zhang, Liping Zhang, 2016, Chemical science.