Yuanyuan Zhang

发表

Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.

Z. Chen, Kaixian Chen, Hualiang Jiang, 2016, Organic & biomolecular chemistry.

Small Molecule Inhibitors Targeting New Targets of Protein-Protein Interactions

C. Luo, Linjuan Li, Chen Wang, 2018 .

Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations.

Cheng Luo, Zhifeng Chen, Kongkai Zhu, 2018, Bioorganic chemistry.

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.

Kaixian Chen, Hualiang Jiang, Jingwei Shao, 2019, European journal of medicinal chemistry.

Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis

Yuanyuan Zhang, Guang-ming Li, Jian-Gao Fan, 2021, Acta pharmacologica Sinica.

Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay.

Kaixian Chen, Hualiang Jiang, C. Luo, 2018, Bioorganic & medicinal chemistry.

Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.

Hao Jiang, Cheng Luo, Fei Ye, 2017, Journal of medicinal chemistry.

Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys

Chen Wang, C. Luo, Yuanyuan Zhang, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis

Yuanyuan Zhang, Bing Zhou, Guang-ming Li, 2022, Bioengineered.

Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex

C. Luo, Hao Zhang, Yuanyuan Zhang, 2021, Acta Pharmacologica Sinica.

Cocrystal Prediction of Bexarotene by Graph Convolution Network and Bioavailability Improvement

Xiaomin Luo, Kaixian Chen, Yuanyuan Zhang, 2022, Pharmaceutics.

L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression

Kaixian Chen, Hualiang Jiang, C. Luo, 2022, Journal for ImmunoTherapy of Cancer.

Cyclization strategy leads to highly potent Bromodomain and extra-terminal (BET) Bromodomain inhibitors for the treatment of acute liver injury.

Kaixian Chen, C. Luo, Yuanyuan Zhang, 2022, European journal of medicinal chemistry.

Inhibition of autophagy by a small molecule through covalent modification of LC3.

Kaixian Chen, Hualiang Jiang, Junyan Lu, 2021, Angewandte Chemie.

p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization

Kaixian Chen, Hualiang Jiang, C. Luo, 2019, Theranostics.

Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.

Z. Chen, Hualiang Jiang, M. Zheng, 2017, Bioorganic & medicinal chemistry letters.

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

H. Ding, Shijie Chen, Yuanyuan Zhang, 2021, Acta Pharmacologica Sinica.

Function and inhibition of Haspin kinase: targeting multiple cancer therapies by antimitosis.

Y. Liu, Hongliu Yang, Yuanyuan Zhang, 2022, The Journal of pharmacy and pharmacology.

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors.

Kaixian Chen, Hualiang Jiang, C. Luo, 2019, European journal of medicinal chemistry.

Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.

Hao Jiang, Cheng Luo, Zhifeng Chen, 2017, Organic & biomolecular chemistry.

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.

Cheng Luo, Hualiang Jiang, Kongkai Zhu, 2017, Journal of medicinal chemistry.

Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

C. Luo, Yuanyuan Zhang, Kai-xian Chen, 2021, Acta Pharmacologica Sinica.

Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

C. Luo, Chuan-peng Liu, Yuanyuan Zhang, 2021, Acta pharmacologica Sinica.

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Hao Jiang, C. Luo, H. Ding, 2018, Acta Pharmacologica Sinica.

Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury.

C. Luo, Yuanyuan Zhang, Guang-ming Li, 2021, Clinical science.

Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays.

Cheng Luo, Pan Xu, Yan Liu, 2016, Bioorganic & medicinal chemistry letters.

Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays

Jin Zhang, Yuanyuan Zhang, Shijie Chen, 2016, J. Chem. Inf. Model..

Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.

Kaixian Chen, Hualiang Jiang, J. Min, 2021, Journal of medicinal chemistry.

Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening

Kaixian Chen, Hualiang Jiang, C. Luo, 2019, RSC advances.

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

C. Luo, H. Ding, Shijie Chen, 2021, Acta Pharmacologica Sinica.

An ATG4B inhibitor blocks autophagy and sensitizes Sorafenib inhibition activities in HCC tumor cells.

W. Wan, Yuanyuan Zhang, Naixia Zhang, 2023, Bioorganic & medicinal chemistry.

PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma

Kaixian Chen, Hao Jiang, C. Luo, 2021, Theranostics.

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion

Kaixian Chen, Hualiang Jiang, C. Luo, 2020, Advanced science.

Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.

Z. Chen, Kaixian Chen, Hualiang Jiang, 2018, Bioorganic & medicinal chemistry.

Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis

Yuanyuan Zhang, Guang-ming Li, Cui-cui Shi, 2021, Acta Pharmacologica Sinica.

Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation

C. Luo, Yuanyuan Zhang, Guang-ming Li, 2021, Molecular medicine reports.

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Hao Jiang, C. Luo, H. Ding, 2018, Acta Pharmacologica Sinica.

Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer.

Hualiang Jiang, Fei Li, Yuanyuan Zhang, 2023, Cell reports.

Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma

Kaixian Chen, Hualiang Jiang, M. Zheng, 2018, Oncogenesis.

Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.

Z. Chen, Kunqian Yu, Kaixian Chen, 2017, MedChemComm.

Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression

J. Shim, Yongjun Dang, Yuanyuan Zhang, 2023, Journal of Clinical Investigation.

Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.

Z. Chen, Kaixian Chen, Hualiang Jiang, 2016, Organic & biomolecular chemistry.

Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor.

Yuanyuan Zhang, Daohai Du, Cheng Luo, 2024, Journal of medicinal chemistry.

Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays

Kaixian Chen, Hualiang Jiang, M. Zheng, 2016, J. Chem. Inf. Model..