C. Milite

发表

Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors

A. Mai, G. Sbardella, S. Castellano, 2016, ChemMedChem.

Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI‐1)

E. Novellino, A. Mai, G. Sbardella, 2010, ChemMedChem.

Highly efficient synthesis and chemical separation of 5-amino- and 7-amino-4-hydroxy-2-naphthoic acids

P. Campiglia, G. Sbardella, S. Castellano, 2007 .

Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans.

S. Kelly, D. Lamb, B. Maresca, 2013, The Journal of antimicrobial chemotherapy.

Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach.

G. Bifulco, S. Castellano, C. Milite, 2016, Chemistry.

Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation

G. Sbardella, Shavali Shaik, Tara H. W. Dobson, 2017, Molecular Cancer Research.

Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors

A. Mai, G. Sbardella, S. Castellano, 2016, ChemMedChem.

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.

Barbara Costa, Ettore Novellino, Luciana Marinelli, 2014, Journal of medicinal chemistry.

Reverse transcriptase inhibition potentiates target therapy in BRAF-mutant melanomas: effects on cell proliferation, apoptosis, DNA-damage, ROS induction and mitochondrial membrane depolarization

L. Fattore, R. Mancini, D. Malpicci, 2020, Cell communication and signaling : CCS.

Highly enantioselective organocatalytic α-amination reactions of aryl oxindoles: developing designer multifunctional alkaloid catalysts.

C. Barbas, C. Milite, Gloria Hernández-Torres, 2010, Organic letters.

A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

G. Sbardella, S. Castellano, C. Milite, 2015 .

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

E. Novellino, F. Da Settimo, S. Taliani, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.

E. Novellino, G. Greco, F. Da Settimo, 2012, Journal of medicinal chemistry.

Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines.

E. Novellino, A. Bertamino, I. Gomez-Monterrey, 2013, Bioorganic & medicinal chemistry letters.

Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.

E. Novellino, F. Da Settimo, S. Taliani, 2019, European journal of medicinal chemistry.

Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).

L. Altucci, A. Mai, G. Sbardella, 2011, Bioorganic & medicinal chemistry.

Identification of Structural Features of 2‐Alkylidene‐1,3‐Dicarbonyl Derivatives that Induce Inhibition and/or Activation of Histone Acetyltransferases KAT3B/p300 and KAT2B/PCAF

E. Novellino, A. Mai, G. Sbardella, 2015, ChemMedChem.

Straightforward, metal-free, and stereoselective synthesis of 9-oxo- and 10-hydroxy-2(E)-decenoic acids, important components of honeybee (Apis mellifera) secretions

G. Sbardella, S. Castellano, C. Milite, 2012 .

Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.

E. Novellino, Xiaodong Cheng, G. Sbardella, 2019, Journal of medicinal chemistry.

The emerging role of lysine methyltransferase SETD8 in human diseases

A. Mai, G. Sbardella, S. Castellano, 2016, Clinical Epigenetics.

Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors.

A. Mai, G. Sbardella, P. Lavia, 2011, Journal of medicinal chemistry.

Reverse transcriptase inhibitors promote the remodeling of nuclear architecture and induce autophagy in prostate cancer cells.

D. Trisciuoglio, G. Sbardella, P. Lavia, 2020, Cancer letters.

The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells

A. Mai, E. Miele, G. Battaglia, 2017, Oncotarget.

The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells

A. Mai, E. Miele, G. Battaglia, 2017, Oncotarget.

CARM1 modulators affect epigenome of stem cells and change morphology of nucleoli.

J. Suchánková, S. Legartová, S. Kozubek, 2015, Physiological research.

Design, synthesis and biological evaluation of new small molecule modulators of Arginine methyltransferases

C. Milite, 2011 .

Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

E. Novellino, A. Mai, G. Sbardella, 2012, Journal of medicinal chemistry.

Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice

Kristen H. Jardine, B. Winters, G. Sbardella, 2022, Learning & memory.

Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach

G. Sbardella, M. Bedford, L. Bonnefond, 2022, Journal of medicinal chemistry.

A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.

E. Novellino, A. Mai, G. Sbardella, 2015, Journal of medicinal chemistry.

Exploiting the 4-Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO).

E. Novellino, F. Da Settimo, S. Taliani, 2017, Journal of medicinal chemistry.

p300/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear

Carlos M. Coelho, R. Marek, T. Bredy, 2012, The Journal of Neuroscience.

Lysine methyltransferase inhibitors: where we are now

G. Sbardella, S. Castellano, Alessandra Feoli, 2021, RSC chemical biology.

Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors

E. Novellino, P. Grieco, A. Bertamino, 2013, Journal of amino acids.

Patent evaluation of WO2019209182 (A1) 2019-10-31 (Conjugated Oligoelectrolytes as Antimicrobial Agents)

C. Milite, Ciro Milite, 2020, Expert opinion on therapeutic patents.