J. Dowden

发表

Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1.

R. Parry, S. Ward, J. Dowden, 2011, Organic & biomolecular chemistry.

Alkaloid inspired spirocyclic oxindoles from 1,3-dipolar cycloaddition of pyridinium ylides.

Maliha Uroos, W. Lewis, J. Dowden, 2013, Organic & biomolecular chemistry.

Iron-Catalyzed Indolizine Synthesis from Pyridines, Diazo Compounds, and Alkynes.

J. Dowden, A. Pordea, Timothy Douglas, 2017, Organic letters.

Olefin metathesis in non-degassed solvent using a recyclable, polymer supported alkylideneruthenium

J. Dowden, J. Savovic, J. Savović, 2001 .

Chiral bisfunctionalization of substrates: a powerful strategy for the asymmetric synthesis of C2 symmetric compounds and its application to the synthesis of enantiomerically pure trans-1,3-dithiane 1,3-dioxide

J. Dowden, V. Aggarwal, G. Evans, 1992 .

Stereoselective Synthesis of Tetrahydroindolizines through the Catalytic Formation of Pyridinium Ylides from Diazo Compounds.

J. Dowden, J. Day, Ben McKeever-Abbas, 2016, Angewandte Chemie.

Synthetic developments in host–guest chemistry

J. Dowden, J. Kilburn, P. T. Wright, 1994 .

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases.

Wei Hong, R. Parry, S. Ward, 2010, Bioorganic & medicinal chemistry letters.

An unusual silicon mediated transannular cyclopropanation.

W. Lewis, J. Dowden, Bingxin You, 2013, Chemical communications.

Caged-iron chelators a novel approach towards protecting skin cells against UVA-induced necrotic cell death.

C. Pourzand, J. Dowden, J. Savovic, 2006, The Journal of investigative dermatology.

Modified synthesis and binding properties of a peptide receptor

J. Dowden, J. Kilburn, P. Edwards, 1997 .

Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5.

Y. Hatanaka, J. Dowden, G. Holman, 2002, The Biochemical journal.

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)

I. Dreveny, J. Dowden, U. Muhsen, 2020, The Biochemical journal.

A novel linker for the attachment of alcohols to solid supports

J. Pilard, N. Turner, S. Flitsch, 1998 .

A concise route to tiazofurin

B. Potter, J. Dowden, Christelle Moreau, 2002 .

Therapeutic potential of phosphoinositide 3-kinase inhibitors.

P. Finan, S. Ward, J. Dowden, 2003, Chemistry & biology.

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist

M. Hohenegger, B. Potter, A. Flügel, 2009, Proceedings of the National Academy of Sciences.

Calculating singlet excited states: Comparison with fast time-resolved infrared spectroscopy of coumarins.

I. Clark, M. Towrie, N. Besley, 2015, The Journal of chemical physics.

Inhibitors of p56lck: assessing their potential as tools for manipulating T-lymphocyte activation

S. Ward, J. Dowden, 2001 .

Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells.

Alexander M. Lewis, A. Galione, A. Arredouani, 2008, Cell calcium.

CHEMICAL SYNTHESIS OF THE NOVEL CA2+ MESSENGER NAADP

A. Galione, B. Potter, J. Dowden, 2005, Nucleosides, nucleotides & nucleic acids.

Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate.

A. Galione, B. Potter, J. Dowden, 2004, Angewandte Chemie.

Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release.

A. Galione, B. Potter, G. Churchill, 2006, Chemistry & biology.

Novel Mechanism of Inhibition of Elastase by β-Lactams Is Defined by Two Inhibitor Crystal Complexes*

P. Taylor, M. Walkinshaw, N. Turner, 1999, The Journal of Biological Chemistry.

Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).

A. Galione, S. Vasudevan, R. Parkesh, 2007, Organic & biomolecular chemistry.

Software tools for green and sustainable chemistry

J. Hirst, J. Twycross, J. Dowden, 2022, Current Opinion in Green and Sustainable Chemistry.

Novel octavalent cross-linker displays efficient trapping of protein–protein interactions† †Electronic supplementary information (ESI) available: General experimental details and characterisation data for compounds 1–3. See DOI: 10.1039/b701542a Click here for additional data file. Click here for ad

M. Welham, S. Foster, A. Blake, 2007, Chemical communications.