P. Vianello

发表

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).

S. Pang, G. Trainor, M. Poss, 2009, Bioorganic & medicinal chemistry letters.

Regioselective halogenation of aminopyrimidinyl-pyrrole carboxylic acid derivatives

M. Nesi, P. Vianello, E. Vanotti, 2009 .

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

Paola Storici, Cristina Alli, Maurizio Rocchetti, 2007, Molecular Cancer Therapeutics.

Generation of Specific Deoxynojirimycin-type Inhibitors of the Non-lysosomal Glucosylceramidase*

H. Overkleeft, G. Koomen, P. Vianello, 1998, The Journal of Biological Chemistry.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

S. Minucci, C. Mercurio, L. Moretti, 2017, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of derivatives structurally related to nimesulide

G. Rossoni, P. Vianello, F. Berti, 1996 .

PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

D. Ballinari, V. Croci, P. Cappella, 2006, Clinical Cancer Research.

Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin αVβ3

T. Bandiera, D. Volpi, A. Galvani, 2004 .

Synthesis, modelling, and μ-opioid receptor affinity of N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes

D. Colombo, S. Villa, L. Toma, 2000 .

Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.

A. Mai, S. Minucci, C. Mercurio, 2015, ACS medicinal chemistry letters.

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.

S. Minucci, C. Mercurio, C. So, 2020, ACS medicinal chemistry letters.

Tranylcypromine‐Based LSD1 Inhibitors: Structure‐Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation

A. Mai, S. Minucci, C. Mercurio, 2020, ChemMedChem.

Classical and new proving methodology: Provings of Plumbum metallicum and Piper methysticum and comparison with a classical proving of Plumbum metallicum

P. Vianello, F. Boso, G. Manuele, 2005, Homeopathy.

Aminopyridines: selective AuroraA inhibitors

P. Vianello, 2007 .

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.

J. Bischoff, C. Mercurio, A. Vulpetti, 2006, Bioorganic & medicinal chemistry letters.

Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches

G. Rastelli, L. Costantino, P. Vianello, 1999, Medicinal research reviews.

New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications

G. Rastelli, L. Costantino, P. Vianello, 1997 .

Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase

G. Rastelli, L. Costantino, P. Vianello, 1997 .

Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors.

G. Rastelli, L. Costantino, P. Vianello, 1999, Journal of medicinal chemistry.

Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors.

G. Rastelli, L. Costantino, P. Vianello, 1996, Journal of medicinal chemistry.

Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

A. Isacchi, A. Montagnoli, R. D'Alessio, 2010, Journal of medicinal chemistry.

Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor.

A. Isacchi, E. Casale, C. Mercurio, 2009, Journal of medicinal chemistry.

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

Paola Storici, Maurizio Rocchetti, Enrico Pesenti, 2006, Journal of medicinal chemistry.

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.

A. Vulpetti, F. Roletto, P. Cappella, 2005, Journal of medicinal chemistry.

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.

V. Croci, D. Volpi, F. Roletto, 2010, Bioorganic & medicinal chemistry.

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.

A. Mai, S. Minucci, M. Tortorici, 2014, European journal of medicinal chemistry.

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling.

D. Anderson, T. Kuntzweiler, D. Colombo, 1998, Journal of medicinal chemistry.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

S. Minucci, C. Mercurio, L. Moretti, 2017, Journal of medicinal chemistry.

Nicotinoyl azide (NCA)-mediated Mitsunobu reaction: An expedient one-pot transformation of alcohols into azides

M. Varasi, P. Vianello, G. Papeo, 2004 .

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

S. Minucci, C. Mercurio, M. Villa, 2017, Future medicinal chemistry.

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.

A. Mai, S. Minucci, C. Mercurio, 2016, Journal of medicinal chemistry.

Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.

A. Mai, S. Minucci, C. Mercurio, 2015, European journal of medicinal chemistry.

Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells

A. Mai, S. Minucci, C. Mercurio, 2015 .

Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.

Andrew Tebben, Jonathan Lippy, Michele Modugno, 2012, Bioorganic & medicinal chemistry letters.

Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A.

C. Mercurio, M. Villa, M. Varasi, 2015, European journal of medicinal chemistry.

Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors.

A. Isacchi, G. Canevari, E. Felder, 2014, Bioorganic & medicinal chemistry.

Synthesis and Pharmacological Evaluation of Derivatives Structurally Related to Nimesulide.

G. Rossoni, P. Vianello, F. Berti, 1996 .

Study of the antisecretory and antiulcer mechanisms of a new indenopirydazinone derivative in rats.

P. Vianello, M. Chiavarini, M. Impicciatore, 1997, Pharmacological research.

Synthesis and mu-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives.

S. Villa, W. Fratta, P. Vianello, 1998, Farmaco.

Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.

A. Lavecchia, L. Marinelli, A. Albinati, 2000, Journal of medicinal chemistry.