J. Ohren

发表

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

J. Warmus, J. Sebolt-Leopold, Chunhong Yan, 2004, Nature Structural &Molecular Biology.

Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.

J. Ohren, L. Royer, Kimberly A Stevens, 2009, Bioorganic & medicinal chemistry.

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Daniel F Ortwine, J. A. Spicer, W. Denny, 2007, Journal of medicinal chemistry.

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).

J. Warmus, A. Bridges, W. Leopold, 2008, Bioorganic & medicinal chemistry letters.

Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU)

N. Chirgadze, J. Ohren, Cindy Spessard, 2007, Protein science : a publication of the Protein Society.

Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

J. Warmus, J. Sebolt-Leopold, Chunhong Yan, 2005, Nature Structural &Molecular Biology.

Ligand-protein interactions of selective casein kinase 1δ inhibitors.

K. Walton, M. Hayward, Travis T Wager, 2013, Journal of medicinal chemistry.

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.

J. Chen, N. Powell, J. Ohren, 2013, Bioorganic & medicinal chemistry letters.

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

D. Bechtold, A. Loudon, E. Maywood, 2010, Proceedings of the National Academy of Sciences.

Inhibitors of Bcr-abl... breaking new ground again

J. Sebolt-Leopold, J. Ohren, 2006, Nature chemical biology.

The Use of Biochemical and Biophysical Tools for Triage of High‐Throughput Screening Hits – A Case Study with Escherichia coli Phosphopantetheine Adenylyltransferase

J. Ohren, R. Sarver, J. Miller, 2010, Chemical biology & drug design.

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

Alla Karnovsky, J Richard Miller, V Hayden Thomas, 2009, Proceedings of the National Academy of Sciences.

Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.

B. Beattie, E. Fauman, B. Finzel, 2008, Journal of structural biology.

The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.

R. Viola, C. R. Faehnle, Xuying Liu, 2008, Acta crystallographica. Section D, Biological crystallography.

Structural asymmetry and intersubunit communication in muscle creatine kinase.

R. Viola, J. Ohren, P. Edmiston, 2007, Acta crystallographica. Section D, Biological crystallography.

The mitogen-activated protein kinase pathway for molecular-targeted cancer treatment.

J. Sebolt-Leopold, R. Herrera, J. Ohren, 2007, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.

Hairong Zhou, J. Ohren, L. Royer, 2008, Bioorganic & medicinal chemistry.

Selective Inhibition of Casein Kinase 1ϵ Minimally Alters Circadian Clock Period

A. Loudon, E. Maywood, M. Hastings, 2009, Journal of Pharmacology and Experimental Therapeutics.

Selective Inhibition of Casein Kinase 1 Epsilon Minimally Alters Circadian Clock Period

A. Loudon, E. Maywood, K. Walton, 2009 .

Dynamic light-scattering analysis of full-length human RPA14/32 dimer: purification, crystallization and self-association.

G. Borgstahl, J. Ohren, J. Habel, 2001, Acta crystallographica. Section D, Biological crystallography.

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.

Jason M. Edmonds, David R. Anderson, R. Kurumbail, 2014, The Biochemical journal.

Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.

Daniel P. Walker, Dean M. Messing, A. Wittwer, 2018, ACS medicinal chemistry letters.

Central Modulation of Circadian Rhythm via CK1 Inhibition for Psychiatric Indications

Travis T Wager, J. Ohren, J. Offord, 2011 .

Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.

J. Ohren, A. Geyer, A. Casimiro-Garcia, 2011, Journal of medicinal chemistry.

The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.

Grover L Waldrop, B. Finzel, G. Waldrop, 2006, Biochemistry.

Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

S. Kazmirski, J. Penzotti, H. Tecle, 2009, Bioorganic & medicinal chemistry letters.

Phosphopantetheine Adenylyltransferase from Escherichia coli: Investigation of the Kinetic Mechanism and Role in Regulation of Coenzyme A Biosynthesis

J. Ohren, W. T. Mueller, R. Sarver, 2007, Journal of bacteriology.

Phosphopantetheine Adenylyltransferase from Escherichia coli: Investigation

Heather, J. Ohren, W. T. Mueller, 2007 .

A new branch in the family: structure of aspartate-beta-semialdehyde dehydrogenase from Methanococcus jannaschii.

R. Viola, C. R. Faehnle, J. Ohren, 2005, Journal of molecular biology.

Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.

R. Viola, J. Ohren, Gwenn G. Parungao, 2019, Acta crystallographica. Section F, Structural biology communications.

Phosphopantetheine Adenylyltransferase from Escherichia coli: Investigation of the Kinetic Mechanism and Role in Regulation of Coenzyme A Biosynthesis

J. Ohren, W. T. Mueller, R. Sarver, 2007, Journal of bacteriology.

The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.

R. T. Carroll, Xiaohong Liu, J. Rubin, 2006, Bioorganic & medicinal chemistry letters.

Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior.

K. Walton, Travis T Wager, J. Ohren, 2014, ACS Chemical Neuroscience.

Selective Inhibition of Casein Kinase 1 Epsilon Minimally Alters Circadian Clock Period

E. Maywood, J. Ohren, K. Fisher, 2009 .