E. Zhang

发表

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

J. Warmus, J. Sebolt-Leopold, Chunhong Yan, 2004, Nature Structural &Molecular Biology.

Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.

N. Powell, Michael D. Kaufman, S. D. Emerson, 2007, Analytical biochemistry.

Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2007, Bioorganic & medicinal chemistry letters.

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2005, Bioorganic & medicinal chemistry letters.

Efficient and Selective Construction of Pyrrolo(3,2-d)pyrimidine Derivatives

E. Zhang, Qiufei Hou, Jingshing Wu, 2014 .

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).

J. Warmus, A. Bridges, W. Leopold, 2008, Bioorganic & medicinal chemistry letters.

Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

J. Warmus, J. Sebolt-Leopold, Chunhong Yan, 2005, Nature Structural &Molecular Biology.

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2007, Bioorganic & medicinal chemistry.

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2.

M. Adler, M. Whitlow, E. Zhang, 2005, Bioorganic & medicinal chemistry letters.

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.

M. Adler, M. Whitlow, E. Zhang, 2006, Bioorganic & Medicinal Chemistry Letters.

The discovery of glycine and related amino acid-based factor Xa inhibitors.

Mostofa A Hena, V. Sahasrabudhe, E. Zhang, 2006, Bioorganic & medicinal chemistry.

Structure‐based Drug Design of Pyrrolidine‐1, 2‐dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors

E. Zhang, Tom McClanahan, A. Casimiro-Garcia, 2007, Chemical biology & drug design.

The Discovery of (2R,4R)‐N‐(4‐chlorophenyl)‐N‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2H)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

L. Chi, E. Zhang, Tom McClanahan, 2007, Chemical biology & drug design.

Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.

R. Nutt, A. Tulinsky, E. Dempsey, 1996, Journal of medicinal chemistry.

Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.

D. Boschelli, D. W. Fry, S. Trumpp-Kallmeyer, 2000, Journal of medicinal chemistry.

Co-crystal structure and inhibition of factor Xa by PD0313052 identifies structurally stabilized active site residues of factor Xa and prothrombinase.

M. Harris, E. Zhang, Jennifer M. Thorn, 2005, Biochemistry.

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.

R. St Charles, A. Tulinsky, E. Zhang, 1999, Journal of molecular biology.

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.

Mostofa A Hena, B. Finzel, R. Gilbertsen, 2012, Bioorganic & medicinal chemistry letters.

The molecular environment of the Na+ binding site of thrombin.

A. Tulinsky, E. Zhang, A Tulinsky, 1997, Biophysical chemistry.

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.

A. Tulinsky, K. Håkansson, R. Arni, 1998, Biochemistry.

Pyrido[2,3-d]pyrimidin-7-one Inhi-bitors of Cyclin-Dependent Kinases.

D. Boschelli, S. Trumpp-Kallmeyer, D. Mcnamara, 2001 .

Transformation of the marine natural product cyclotheonamide A by aqueous base. X-ray analysis of a novel ligand complexed with human α-thrombin

A. Tulinsky, E. Zhang, B. Maryanoff, 1996 .

Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.

J H Matthews, R. St Charles, A. Tulinsky, 1999, Journal of medicinal chemistry.