H. Vankayalapati

发表

Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

D. V. Von Hoff, D. Bearss, L. Hurley, 2006, Molecular Cancer Therapeutics.

Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design.

D. V. Von Hoff, J. Saldanha, D. Bearss, 2003, Molecular cancer therapeutics.

Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.

Kazuo Shin-Ya, K. Shin‐ya, L. Hurley, 2002, Journal of the American Chemical Society.

Innovative therapy for Classic Galactosemia - tale of two HTS.

K. Wierenga, H. Vankayalapati, K Lai, 2012, Molecular genetics and metabolism.

Ligand‐based Discovery of Novel Small Molecule Inhibitors of RON Receptor Tyrosine Kinase

A. Welm, S. Raeppel, H. Vankayalapati, 2020, Molecular informatics.

Branching Morphogenesis Desmosomal Adhesion in Mammary Chemical Genetic Screen Reveals a Role for Developmental Biology

B. Welm, C. J. Leonard, D. Bearss, 2014 .

Discovery of Novel Inhibitors Targeting Multi-UDP-hexose Pyrophosphorylases as Anticancer Agents

H. Vankayalapati, Y. Zheng, M. Tang, 2020, Molecules.

In vitro and in vivo characterization of SGI-1252 , a small molecule inhibitor of JAK 2 Kausar

J. Prchal, D. Bearss, S. Warner, 2010 .

SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers

R. Bast, G. Calin, Y. Xi, 2022, The Journal of clinical investigation.

Stereoselective O-glycosylation reactions using glycosyl donors with diphenylphosphinate and propane-1,3-diyl phosphate leaving groups

Gurdial Singh, H. Vankayalapati, I. Tranoy, 2001 .

Chemical Genetic Screen Reveals a Role for Desmosomal Adhesion in Mammary Branching Morphogenesis

D. Shelton, B. Welm, C. J. Leonard, 2012, The Journal of Biological Chemistry.

Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors

Sunil Sharma, B. Graves, D. Bearss, 2017, bioRxiv.

A simple polar deacetylated caloporoside derivative is a positive modulator of the GABA(A) chloride channel complex in cortical mammalian neurones.

G. Lees, H. Vankayalapati, G. Singh, 2000, Bioorganic & medicinal chemistry letters.

Synthesis of fucosidase substrates using propane-1,3-diyl phosphate as the anomeric leaving group

Gurdial Singh, H. Vankayalapati, 1999 .

Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors.

K. Bhalla, R. Soldi, Sunil Sharma, 2015, Journal of medicinal chemistry.

(IFN)-dependent anti-tumor immunity through induction of Endogenous Retroviruses

J. Trent, R. Soldi, B. Weissman, 2020 .

Design and Synthesis of Fluoroquinophenoxazines That Interact with Human Telomeric G-Quadruplexes and Their Biological Effects 1

O. Fedoroff, L. Hurley, S. Rha, 2001 .

The small molecule BC-2059 inhibits Wnt-dependent gene transcription in cancer through disruption of the Transducin Beta-Like 1 (TBL1)-β-catenin protein complex

S. Batra, R. Salgia, K. Bhalla, 2021 .

Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects.

D. V. Von Hoff, O. Fedoroff, L. Hurley, 2001, Molecular cancer therapeutics.

Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.

Vijay Gokhale, Kazuo Shin-Ya, Daekyu Sun, 2005, Journal of the American Chemical Society.

Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents.

L. Hurley, H. Vankayalapati, Mu-yong Kim, 2003, Journal of medicinal chemistry.

Structure-activity analysis and cell-based optimization of human galactokinase inhibitors.

H. Vankayalapati, K Lai, Si Odejinmi, 2011, ACS medicinal chemistry letters.

A new glycosylation strategy for the synthesis of mannopyranosides

Gurdial Singh, H. Vankayalapati, 2000 .

Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.

L. Hurley, Adam Siddiqui-Jain, T. Dexheimer, 2005, Journal of medicinal chemistry.

Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity

L. Hurley, T. Dexheimer, H. Vankayalapati, 2005, Molecular Cancer Therapeutics.

Efficient stereocontrolled synthesis of C-glycosides using glycosyl donors substituted by propane 1,3-diyl phosphate as the leaving group

Gurdial Singh, H. Vankayalapati, 2001 .

Structure of a quinobenzoxazine--G-quadruplex complex by REDOR NMR.

A. Mehta, L. Hurley, H. Vankayalapati, 2004, Biochemistry.

Glycosylation Based on Glycosyl Phosphates as Glycosyl Donors

Gurdial Singh, H. Vankayalapati, Shende Jiang, 2002 .

Stereoselective synthesis of α-L-Fucp-(1,2)- and -(1,3)-β-D-Galp(1)-4-methylumbelliferone using glycosyl donor substituted by propane-1,3-diyl phosphate as leaving group

Gurdial Singh, H. Vankayalapati, 2000 .

Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Gaza Strip Palestinians

S. Perkins, J. Prchal, H. Vankayalapati, 2012 .

A computational study of structural differences of binding of NADP+ and G6P substrates to G6PD Mediterraneanc.563T, G6PD A-c.202A/c.376G, G6PD Cairoc.404C and G6PD Gazac.536A mutations.

J. Prchal, H. Vankayalapati, N. S. Reading, 2021, Blood cells, molecules & diseases.

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.

D. Bearss, S. Warner, H. Vankayalapati, 2013, Journal of medicinal chemistry.

Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors.

D. Bearss, S. Warner, H. Vankayalapati, 2017, Bioorganic & medicinal chemistry letters.

The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer

J. Trent, R. Soldi, B. Weissman, 2020, bioRxiv.

Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents.

Yong Xu, David Vollmer, Raymond Schuch, 2013, ACS medicinal chemistry letters.

Specific inhibition of the Akt1 pleckstrin homology domain by D-3-deoxy-phosphatidyl-myo-inositol analogues.

G. Powis, D. Mahadevan, E. Meuillet, 2003, Molecular cancer therapeutics.

A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma

J. Prchal, K. Pacak, F. Lorenzo, 2012, Journal of Molecular Medicine.

Novel homozygous VHL mutation in exon 2 is associated with congenital polycythemia but not with cancer.

J. Prchal, L. Lanikova, F. Lorenzo, 2013, Blood.

polycythemia but not with cancer mutation in exon 2 is associated with congenital VHL Novel homozygous

J. Prchal, L. Lanikova, F. Lorenzo, 2013 .

SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival

Angelique W Whitehurst, H. Vankayalapati, Angelique W. Whitehurst, 2016, Molecular and Cellular Biology.

Targeting Axl and Mer Kinases in Cancer

D. Bearss, S. Warner, H. Vankayalapati, 2011, Molecular Cancer Therapeutics.

Use of a Bacteriophage Lysin to Identify a Novel Target for Antimicrobial Development

Chad W. Euler, C. E. Stebbins, V. Fischetti, 2013, PloS one.

S110, a 5-Aza-2′-Deoxycytidine–Containing Dinucleotide, Is an Effective DNA Methylation Inhibitor In vivo and Can Reduce Tumor Growth

Peter A. Jones, D. Bearss, Jody C. Chuang, 2010, Molecular Cancer Therapeutics.

Molecular Cancer Therapeutics S 110 , a 5-Aza-2 ′-Deoxycytidine – Containing Dinucleotide , Is an Effective DNA Methylation Inhibitor In vivo and Can Reduce Tumor Growth

Peter A. Jones, D. Bearss, Jody C. Chuang, 2010 .

Inhibition of Nek2 by Small Molecules Affects Proteasome Activity

F. Zhan, G. Tricot, D. Bearss, 2014, BioMed research international.

Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.

Anupam Verma, D. Bearss, S. Warner, 2011, ACS medicinal chemistry letters.

The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin β-Like 1-β-Catenin Protein Complex

S. Batra, R. Salgia, R. Soldi, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Ruthenium(II)- and copper(I)-catalyzed synthesis of click-xylosides and assessment of their glycosaminoglycan priming activity.

Yiling Bi, H. Vankayalapati, M. Koketsu, 2017, Bioorganic & medicinal chemistry letters.

A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma

J. Prchal, K. Pacak, F. Lorenzo, 2013, Journal of Molecular Medicine.

Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria.

H. Vankayalapati, M. Tang, S. Odejinmi, 2011, Bioorganic & medicinal chemistry.

Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-β-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease.

M. Might, Yiling Bi, H. Vankayalapati, 2017, Bioorganic & medicinal chemistry letters.

A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel

R. Bast, Yan Wang, A. Ahmed, 2016, Clinical Cancer Research.

Abstract LB-296: Discovery of ARN-3261 as a potent, selective, orally available SIK2 inhibitor for treating ovarian, endometrial, primary peritoneal, fallopian tube, and triple negative breast cancers

R. Bast, A. Jazaeri, R. Coleman, 2017 .

Three Novel EPAS1/HIF2A Somatic and Germline mutations Associated with Polycythemia and Pheochromocytoma/Paraganglioma.

J. Prchal, K. Pacak, F. Lorenzo, 2012 .

Targeting Pim Kinases in Hematological Malignancies.

D. Bearss, J. Lamb, H. Vankayalapati, 2007 .

Targeting Axl Kinase in Hematological Malignancies.

D. Bearss, S. Warner, H. Vankayalapati, 2009 .

413 POSTER Discovery and characterization of a series of Axl kinase inhibitors using the CLIMB process

D. Bearss, J. Lamb, H. Vankayalapati, 2006 .

332 POSTER In vivo activity of SGI-1776, an orally active Pim kinase inhibitor

D. Bearss, S. Warner, H. Vankayalapati, 2008 .

The small molecule BC-2059 inhibits Wnt-dependent gene transcription in cancer through disruption of the Transducin Beta-Like 1 (TBL1)-β-catenin protein complex

S. Batra, R. Salgia, K. Bhalla, 2021 .

Structure-based design of novel anti-cancer agents targeting aurora kinases.

D. Bearss, D. Mahadevan, H. Vankayalapati, 2003, Current medicinal chemistry. Anti-cancer agents.

Abstract 3869: The reversible LSD1 inhibitor SP-2509 promotes anti-tumor immunity in small cell carcinoma of the ovary-hypercalcemic type (SCCOHT)

R. Soldi, H. Vankayalapati, M. Kaadige, 2019, Experimental and Molecular Therapeutics.

In vitro and in vivo characterization of SGI-1252, a small molecule inhibitor of JAK2.

J. Prchal, D. Bearss, S. Warner, 2011, Experimental hematology.