T. Sim

发表

Allosteric inhibitors of Bcr-abl–dependent cell proliferation

J. Mestan, D. Fabbro, N. Gray, 2006, Nature chemical biology.

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

John T. Powers, G. Daley, W. Jahnke, 2010, Nature.

1,4-dihydropyrazolo[4,3-d]imidazole phenyl derivatives: a novel type II Raf kinase inhibitors.

J. Hah, T. Sim, Junghun Lee, 2010, Bioorganic & medicinal chemistry letters.

Pharmacophore based 3D-QSAR study of VEGFR-2 inhibitors

Taebo Sim, Seung Joo Cho, F. A. Pasha, 2009, Medicinal Chemistry Research.

Natural and Synthetic Lactones Possessing Antitumor Activities

T. Sim, Younghoon Kim, Sandip Sengupta, 2021, International journal of molecular sciences.

A general strategy for creating "inactive-conformation" abl inhibitors.

Taebo Sim, Yi Liu, Yongping Xie, 2006, Chemistry & biology.

Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.

Jared L. Johnson, P. Sorger, N. Gray, 2019, Cell chemical biology.

Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β-cell apoptosis.

In-kyu Lee, K. Park, D. Jun, 2015, Cellular signalling.

Identification of a unique resorcylic acid lactone derivative that targets both lymphangiogenesis and angiogenesis.

H. Choi, J. H. Kim, Jin Hyoung Kim, 2019, Journal of medicinal chemistry.

Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis

S. Koo, In-kyu Lee, D. Ryu, 2013, Diabetes.

Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules

E. Zuiderweg, I. Shin, S. Park, 2017, Scientific Reports.

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.

D. Sabatini, N. Gray, Qingsong Liu, 2010, Journal of medicinal chemistry.

The first small molecules capable of strongly suppressing proliferation of cancer cells harboring BRAF class I/II/III mutations.

I. Shin, T. Sim, Namdoo Kim, 2020, Biochemical and biophysical research communications.

Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails

Kyung-Sook Chung, K. Lee, Jeon-Soo Shin, 2022, Journal of enzyme inhibition and medicinal chemistry.

Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug Resistance.

Seongshick Ryu, T. Sim, Younghoon Kim, 2022, Journal of medicinal chemistry.

AntitumorEffectsandMechanismsofAZD 4547 on FGFR 2-Deregulated Endometrial Cancer Cells

W. Hur, T. Sim, Hanna Cho, 2015 .

Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells

W. Hur, T. Sim, Hanna Cho, 2015, Molecular Cancer Therapeutics.

Discovery of 1-( 4-( 4-Propionylpiperazin-1-yl )-3-( trifluoromethyl ) phenyl )-9-( quinolin-3-yl ) benzo [ h ] [ 1 , 6 ] naphthyridin-2 ( 1 H )-one as a Highly Potent

N. Gray, Qingsong Liu, W. Hur, 2014 .

Development of ATP-competitive mTOR inhibitors.

D. Sabatini, N. Gray, Qingsong Liu, 2012, Methods in molecular biology.

Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.

Mi-hyun Kim, J. Hah, T. Sim, 2011, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9

N. Gray, I. Shin, Seongshick Ryu, 2021 .

Development of a Selective CDK 7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype Graphical

Charles Y. Lin, P. Sorger, N. Gray, 2019 .

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.

Charles Y. Lin, P. Sorger, N. Gray, 2019, Cell chemical biology.

Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

P. Sorger, R. Everley, S. Knapp, 2019, Cell chemical biology.

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.

N. Gray, Nicholas Kwiatkowski, T. Sim, 2018, ACS medicinal chemistry letters.

In situ imaging of quantum dot-AZD4547 conjugates for tracking the dynamic behavior of fibroblast growth factor receptor 3

T. Sim, Dong-Kwon Lim, Jiyeon Lee, 2017, International journal of nanomedicine.

Discovery of inhibitors that overcome the G1202R ALK Resistance Mutation

P. Jänne, N. Gray, H. Choi, 2016 .

Identification of Novel ROS Inducers: Quinone Derivatives Tethered to Long Hydrocarbon Chains.

W. Hur, T. Sim, Sandip Sengupta, 2015, Journal of medicinal chemistry.

Novel and Potent Small Molecules against Melanoma Harboring BRAF Class I/II/III Mutants for Overcoming Drug Resistance

I. Shin, Seongshick Ryu, T. Sim, 2021, International journal of molecular sciences.

effect through inhibition of hepatic gluconeogenesis Running title: Antidiabetic effect of ERRγ inverse agonist

In-kyu Lee, D. Ryu, Gil-Tae Gang, 2013 .

AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis

H. Yu, Dae-Yeul Yu, Yong-Keun Jung, 2022, Cell Death & Disease.

One step synthesis of quantum dot-magnetic nanoparticle heterodimers for dual modal imaging applications.

T. Sim, Jiyeon Lee, Gyoyeon Hwang, 2015, The Analyst.

A new quantum dot-platinum conjugate for self-assembled nanoconjugates by coordination bonding mediated recognition.

Rita Song, T. Sim, Jiyeon Lee, 2013, Chemical communications.

Asymmetric synthesis of (+)-lentiginosine using a chiral aziridine based approach

T. Sim, Hojong Yoon, K. Cho, 2014 .

Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.

N. Gray, S. Ficarro, J. Marto, 2019, Bioorganic & medicinal chemistry letters.

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

M. McKeown, Xiang Xu, Dennis L. Buckley, 2018, ACS chemical biology.

Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line.

S. Cho, J. Hah, T. Sim, 2010, Bioorganic & medicinal chemistry letters.

Aminoquinoline derivatives with antiproliferative activity against melanoma cell line.

S. Cho, J. Hah, T. Sim, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines Against Melanoma Cell Line

J. Hah, T. Sim, C. Oh, 2011 .

The efficient one-step chlorination of methylsulfanyl group on pyrimidine ring system with sulfuryl chloride

H. Choi, J. Hah, T. Sim, 2010 .

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1*

D. Sabatini, N. Gray, Qingsong Liu, 2009, Journal of Biological Chemistry.

Identification of methyl violet 2B as a novel blocker of focal adhesion kinase signaling pathway in cancer cells.

Jiyeon Lee, G. Han, T. Sim, 2013, Biochemical and biophysical research communications.

A general strategy for creating

M. Warmuth, N. Gray, G. Spraggon, 2006 .

Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I.

N. Gray, Jianwei Che, P. Ren, 2008, Bioorganic & medicinal chemistry letters.

Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.

N. Gray, Jianwei Che, P. Ren, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors.

W. Hur, T. Sim, E. Roh, 2018, Bioorganic & medicinal chemistry letters.

In vitro metabolism of an estrogen‐related receptor γ modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450s

In-kyu Lee, J. Shon, Kwang-Hyeon Liu, 2015, Biopharmaceutics & drug disposition.

Characterization of a highly selective inhibitor of the Aurora kinases.

S. Knapp, N. Gray, A. Chaikuad, 2017, Bioorganic & medicinal chemistry letters.

Novel small molecule Raf kinase inhibitors for targeted cancer therapeutics

T. Sim, Do-Hee Kim, Taebo Sim, 2012, Archives of Pharmacal Research.

Reducing Characteristics of Borohydride Exchange Resin–CuSO4 in Methanol

T. Sim, N. Yoon, 1997 .

Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2.

T. Sim, M. El-Gamal, C. Oh, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines.

T. Sim, M. El-Gamal, C. Oh, 2011, European journal of medicinal chemistry.

Stereoselective synthesis of (−)-8-epi-swainsonine starting with a chiral aziridine

H. Choi, T. Sim, E. Roh, 2013 .

Reducing Characteristics of Borohydride Exchange Resin‐CuSO4 in Methanol.

T. Sim, N. Yoon, 1997 .

Selective Reduction of $\alpha,\beta$-Unsaturated Ketones with Borohydride Exchange Resin-$CuSO_4$ in Methanol

T. Sim, N. Yoon, Taebo Sim, 1993 .

Synthesis of novel arylaminoquinazolinylurea derivatives and their antiproliferative activities against bladder cancer cell line.

T. Sim, E. Roh, J. Choi, 2016, Bioorganic & medicinal chemistry letters.

Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor.

N. Gray, J. Griffin, R. Stone, 2016, ACS medicinal chemistry letters.

Enantiospecific synthesis of carbapentostatins.

T. Sim, R. Mohareb, H. Rapoport, 2003, The Journal of organic chemistry.

Identification of a novel 5-amino-3-(5-cyclopropylisoxazol-3-yl)-1-isopropyl-1H-pyrazole-4-carboxamide as a specific RET kinase inhibitor.

I. Shin, T. Sim, N. Kim, 2017, European journal of medicinal chemistry.

Rhodium-catalyzed reductive cyclization of 1,6-enynes and stereoselective synthesis of the putative structure of lucentamycin A and its stereoisomers

H. Choi, J. Hah, T. Sim, 2012 .

Stereoselective total synthesis of the E-isomer of putative lucentamycin A

T. Sim, K. Selim, Baeck Kyoung Lee, 2012 .

A novel synthesis of 5-functionalized oxazolidin-2-ones from enantiomerically pure 2-substituted N-[(R)-(+)-alpha-methylbenzyl]aziridines.

H. Yun, T. Sim, H. Ha, 2003, The Journal of organic chemistry.

Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate.

T. Sim, H. S. Hahm, H. Ha, 2003, The Journal of organic chemistry.

A Concise and Efficient Total Synthesis of Militarinone D

T. Sim, Sandip Sengupta, U. Dash, 2015 .

Structural Revision of Baulamycin A and Structure-Activity Relationships of Baulamycin A Derivatives.

D. Oh, I. Shin, M. Bae, 2017, The Journal of organic chemistry.

A Concise Synthesis of Mupirocin H Using a Cross‐Metathesis‐Based Strategy

T. Sim, Sandip Sengupta, 2014 .

Synthesis of 1H‐Pyrazole‐1‐carboxamide Derivatives and Their Antiproliferative Activity against Melanoma Cell Line

T. Sim, M. El-Gamal, C. Oh, 2011, Archiv der Pharmazie.

Synthesis of quinolinylaminopyrimidines and quinazolinylmethylaminopyrimidines with antiproliferative activity against melanoma cell line

Jong Seung Kim, T. Sim, E. Roh, 2015, Journal of enzyme inhibition and medicinal chemistry.

A New Coupling Reaction of Alkyl Iodides with a,β-Unsaturated Esters Using Ni2B(cat.)-BER in Methanol.

T. Sim, N. Yoon, J. Choi, 1996 .

A new coupling reaction of alkyl iodides with α,β-unsaturated esters using Ni2B(cat.)-BER in methanol

T. Sim, N. Yoon, Jaesung Choi, 1996 .

Highly stereoselective synthesis of mupirocin H

T. Sim, Sandip Sengupta, H. Kim, 2017 .

An efficient synthesis of 1,4-dideoxy-1,4-imino-d- and l-arabinitol and 1,4-dideoxy-1,4-imino-d- and l-xylitol from chiral aziridines

H. Choi, T. Sim, W. Lee, 2013 .

An efficient and enantioselective total synthesis of naturally occurring L-783277

H. Choi, J. Hah, T. Sim, 2010 .

Novel stereoselective synthesis of functionalized oxazolidinones from chiral aziridines.

J. Chang, T. Sim, H. Ha, 2003, The Journal of organic chemistry.

Selective Reduction of α,β-Unsaturated Acid Derivatives Using Borohydride Exchange Resin-CuSO4 in Methanol

T. Sim, N. Yoon, 1995 .

Stereoselective Synthesis of (+)-Polyoxamic Acid Starting with a Chiral Aziridine

T. Sim, Hojong Yoon, 2013 .

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Sridhar Ramaswamy, Taebo Sim, Richard A Young, 2014, Nature.

Novel small molecule Raf kinase inhibitors for targeted cancer therapeutics

T. Sim, Do-Hee Kim, Taebo Sim, 2012, Archives of pharmacal research.

Discovery of a selective inhibitor of Doublecortin Like Kinase 1

Charles Y. Lin, W. Hahn, A. Look, 2020, Nature Chemical Biology.

Antitumor effects and molecular mechanisms of ponatinib on endometrial cancer cells harboring activating FGFR2 mutations

T. Sim, N. Kim, Yeonui Kwak, 2016, Cancer biology & therapy.

An efficient procedure for the preparation of (1S,3R)- and (1S,3S)-1-amino-3-(hydroxymethyl)cyclopentanes.

T. Sim, R. Mohareb, H. Rapoport, 2003, Chemical & pharmaceutical bulletin.

Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line.

J. Hah, T. Sim, M. El-Gamal, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione derivatives.

S. Ahn, J. Shin, T. Sim, 2003, Chemical & pharmaceutical bulletin.

Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function

Taebo Sim, Stefan Knapp, Panagis Filippakopoulos, 2010, Nature chemical biology.

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

N. Gray, Yanke Liang, Jinhua Wang, 2020, Cell.

Pharmacological Targeting of the Pseudokinase Her3

P. Jänne, N. Gray, K. Westover, 2014, Nature chemical biology.

Anti-Tumor Activity of AZD4547 Against NTRK1 Fusion Positive Cancer Cells Through Inhibition of NTRKs

T. Sim, Hanna Cho, T. Murakami, 2021, Frontiers in Oncology.

Chemical kinomics: a powerful strategy for target deconvolution.

Taebo Sim, Do-Hee Kim, T. Sim, 2010, BMB reports.

Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation.

P. Jänne, N. Gray, H. Choi, 2015, Journal of medicinal chemistry.

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors

P. Jänne, N. Gray, Xianming Deng, 2011, ACS medicinal chemistry letters.

First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.

N. Gray, W. Hur, H. Choi, 2018, Journal of medicinal chemistry.

Discovery of potent and selective covalent inhibitors of JNK.

Taebo Sim, Mario Niepel, Scott B Ficarro, 2012, Chemistry & biology.

Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies

A. Pae, Jung-Eun Park, T. Sim, 2016, Journal of enzyme inhibition and medicinal chemistry.

Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer.

C. Paweletz, P. Jänne, L. Sholl, 2016, Cancer discovery.

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

S. Knapp, N. Gray, Xianming Deng, 2013, European journal of medicinal chemistry.

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1

U. McDermott, N. Gray, Xianming Deng, 2011, ACS medicinal chemistry letters.

Procaspase activating compound 1 controls tetracycline repressor-regulated gene expression system

Jiyeon Lee, T. Sim, Chiman Song, 2018, Bioscience reports.

Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion.

W. Hur, Hyomin K. Lee, T. Sim, 2017, Biochimica et biophysica acta. General subjects.

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.

J. Caldwell, N. Gray, O. Ohmori, 2006, Bioorganic & medicinal chemistry letters.

Structure-based optimization and biological evaluation of trisubstituted pyrazole as a core structure of potent ROS1 kinase inhibitors.

Byung Sun Park, M. M. Al-Sanea, T. Sim, 2014, Bioorganic & medicinal chemistry.

Development of small molecules targeting the pseudokinase Her3.

P. Jänne, N. Gray, K. Westover, 2015, Bioorganic & medicinal chemistry letters.

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.

Taebo Sim, Sang Min Lim, John Hunter, 2014, Angewandte Chemie.

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.

R. Xavier, S. Schreiber, A. Shamji, 2016, ACS chemical biology.

Expanding the Diversity of Allosteric Bcr-Abl Inhibitors†

G. Rummel, N. Gray, Xianming Deng, 2010, Journal of medicinal chemistry.

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

P. Cohen, N. Gray, K. Westover, 2014, Journal of medicinal chemistry.

Development of 'DFG-out' inhibitors of gatekeeper mutant kinases.

N. Gray, H. Choi, J. Griffin, 2012, Bioorganic & medicinal chemistry letters.

A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.

Taebo Sim, Yongping Xie, Nathanael S Gray, 2010, Journal of medicinal chemistry.

Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.

James D. Griffin, Andrew L. Kung, Taebo Sim, 2010, Blood.

Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer

Taebo Sim, Takayuki Kosaka, Nathanael S. Gray, 2016, Clinical Cancer Research.

A Pyrazolo[3,4-d]pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants.

T. Sim, Hanna Cho, N. Kim, 2016, Journal of medicinal chemistry.

Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines.

J. Hah, T. Sim, C. Oh, 2010, Bioorganic & medicinal chemistry letters.

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

Rachel G Liao, S. Gaudet, P. Jänne, 2014, Proceedings of the National Academy of Sciences.

Suppression of TRPM7 enhances TRAIL‐induced apoptosis in triple‐negative breast cancer cells

T. Sim, Chiman Song, Ki-Bong Oh, 2020, Journal of cellular physiology.

In silico Ligand-Based (LB) and Docking-Based (DB) 3D-QSAR Study of Potent Chk2 Inhibitors

Taebo Sim, Seung Joo Cho, Muhammad Muddassar, 2007, 2007 Frontiers in the Convergence of Bioscience and Information Technologies.

Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1.

M. Yaffe, N. Gray, Kyung S. Lee, 2022, Journal of medicinal chemistry.

Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach.

N. Gray, Qingsong Liu, J. Griffin, 2015, Blood.

New diarylamides and diarylureas possessing 8-amino(acetamido)quinoline scaffold: synthesis, antiproliferative activities against melanoma cell lines, kinase inhibition, and in silico studies.

H. Choi, T. Sim, M. El-Gamal, 2013, European journal of medicinal chemistry.

New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: design, synthesis, and antiproliferative activity against melanoma cell line.

J. Hah, T. Sim, M. El-Gamal, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanoma.

J. Hah, T. Sim, J. Choi, 2010, Bioorganic & medicinal chemistry letters.

Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as potent ALK-L1196M inhibitors

H. Seo, T. Sim, K. Selim, 2019, Journal of enzyme inhibition and medicinal chemistry.

Covalent Guanosine Mimetic Inhibitors of G12C KRAS.

Taebo Sim, Sang Min Lim, John Hunter, 2017, ACS medicinal chemistry letters.

Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors.

N. Gray, Tinghu Zhang, Xianming Deng, 2016, ACS medicinal chemistry letters.

Identification of novel resorcinol amide derivatives as potent and specific pyruvate dehydrogenase kinase (PDHK) inhibitors.

In-kyu Lee, I. Shin, T. Sim, 2019, Journal of medicinal chemistry.

Raman-Based in Situ Monitoring of Changes in Molecular Signatures during Mitochondrially Mediated Apoptosis

Ji Hye Lee, I. Shin, T. Sim, 2019, ACS omega.

N-Myristoylated c-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum upon Binding to an Allosteric Inhibitor*

N. Gray, Xianming Deng, M. Seeliger, 2009, The Journal of Biological Chemistry.

Design and Synthesis of New [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Potential Antiproliferative Agents

M. M. Al-Sanea, T. Sim, E. Roh, 2015 .

Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.

Bongjin Moon, Jung-Eun Park, T. Sim, 2013, Bioorganic & medicinal chemistry letters.

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability.

D. Sabatini, N. Gray, Qingsong Liu, 2011, Bioorganic & medicinal chemistry letters.

Two-photon probes for the endoplasmic reticulum: its detection in a live tissue by two-photon microscopy.

B. Cho, T. Sim, Seunghye Choi, 2020, Chemical communications.

A New Coupling Reaction of Alkyl Iodides with Electron Deficient Alkenes Using Nickel Boride (cat.)-Borohydride Exchange Resin in Methanol.

T. Sim, N. Yoon, M. Joung, 1997, The Journal of organic chemistry.

Novel Small Molecules Capable of Blocking mtRAS-Signaling Pathway

Seongshick Ryu, T. Sim, Chaeyoung Lee, 2021, Frontiers in Oncology.

Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.

H. Choi, Sunghoon Kim, I. Shin, 2021, Journal of medicinal chemistry.

Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277.

W. Hur, H. Choi, N. Jeon, 2017, Journal of medicinal chemistry.

Anti-cancer effects of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives on hepatocellular carcinoma harboring FGFR4 activation

I. Shin, Seongshick Ryu, T. Sim, 2021, Neoplasia.

Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers.

I. Shin, Seongshick Ryu, T. Sim, 2020, European journal of medicinal chemistry.

Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs

W. Hur, T. Sim, Eun‐Kyoung Bang, 2018, Chemical biology & drug design.

Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules

E. Zuiderweg, I. Shin, Nak-Kyoon Kim, 2017, Scientific Reports.